• genomes
  • 3. A cassette vector for cloning viral genomes, comprising, inserted therein, the nucleic acid sequence according to claim 1, said vector reading in the correct phase for the expression of said inserted molecule and having an active promoter molecule upstream thereof. (google.com)
  • Moreover, due to the limited success of bioinformatics in producing efficient DNA binding site prediction tools (large false positive rates are often associated with in-silico motif discovery / site search methods), there has been no systematic effort to computationally annotate these features in sequenced genomes. (wikipedia.org)
  • genes
  • Though the Inr element is not fully understood it has been recognized as the most frequently occurring sequence at the start site of genes in multiple species. (wikipedia.org)
  • Thus
  • Thus a consensus sequence is a model for a putative DNA binding site: it is obtained by aligning all known examples of a certain recognition site and defined as the idealized sequence that represents the predominant base at each position. (wikipedia.org)
  • Thus this PCR methodology using the consensus primer should be widely applicable for amplifying hemoglobin β chains from teleosts. (springer.com)
  • This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus was named CCCTC binding factor. (wikipedia.org)
  • promoters
  • Studies have shown that promoters with a functional Inr are more likely to lack a TATA box or to possess a degenerate TATA sequence. (wikipedia.org)
  • CTCF is thought to be a primary part of the activity of insulators, sequences that block the interaction between enhancers and promoters. (wikipedia.org)
  • Binding of targeting sequence elements by CTCF can block the interaction between enhancers and promoters, therefore limiting the activity of enhancers to certain functional domains. (wikipedia.org)
  • identical
  • The proposed active site of ADAM10 has been identified by sequence analysis, and is identical to enzymes in the Snake Venom metalloprotein domain family. (wikipedia.org)
  • annotation
  • Even though NCBI contemplates DNA binding site annotation in its reference sequences (RefSeq), most submissions omit this information. (wikipedia.org)
  • Examples
  • All the actual examples shouldn't differ from the consensus by more than a few substitutions, but counting mismatches in this way can lead to inconsistencies. (wikipedia.org)
  • Discuss the possible phenotypic consequences of these DNA sequence variation, give examples, if possible. (brainmass.com)
  • found
  • In a study of 1800+ distinct human promoter sequences it was found that 49% contain the Inr element while 21.8% contain the TATA box. (wikipedia.org)
  • They found that a region of 140 base pairs in the tissue-specific transcriptional enhancer element was sufficient for different levels of transcription enhancement in different tissues and sequences. (wikipedia.org)
  • Biology
  • Sequence logos can be generated using WebLogo, or using the Gestalt Workbench, a publicly available visualization tool written by Gustavo Glusman at the Institute for Systems Biology. (wikipedia.org)
  • contains
  • This region also contains four "GATC" sequences that are recognized by DNA adenine methylase (Dam), an enzyme that modifies the adenine base when this sequence is unmethylated or hemimethylated. (wikipedia.org)