• Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii, an apicomplexan. (wikipedia.org)
  • Toxoplasma gondii is an important zoonotic protozoan parasite that can infect man and animals. (ac.ir)
  • Toxoplasma gondii variant influences clinical profile in human congenital and ocular toxoplasmosis. (frontiersin.org)
  • Toxoplasmosis is a systemic, parasitic disease caused by the protozoan Toxoplasma gondii. (athenslab.gr)
  • Toxoplasmosis, a common parasitic disease, is caused by Toxoplasma gondii , which infects approximately 30% of the world's population. (nature.com)
  • These data demonstrated that ME49Δ cdpk3 inoculation induced effective cellular and humoral immune responses against acute and chronic Toxoplasma infections with various strains and was a potential candidate to develop a vaccine against toxoplasmosis. (nature.com)
  • Toxoplasma gondii ( T. gondii ) is a common zoonotic intracellular parasite capable of infecting almost all warm-blooded animals, including humans 1 . (nature.com)
  • The above characteristics of Toxoplasma strains pose great challenges to the control of toxoplasmosis. (nature.com)
  • Thus, the development of an effective toxoplasmosis vaccine is critical for limiting the infection of various Toxoplasma strains. (nature.com)
  • Toxoplasma gondii is one of the most common parasitic infections of humans and warm-blooded vertebrates. (ac.ir)
  • Toxoplasma gondii is an obligatory intracellular parasite that causes a zoonotic disease capable of infecting nearly all warm-blooded hosts, including humans. (bvsalud.org)
  • Toxoplasmosis is an infection caused by a single-celled parasite called Toxoplasma gondii . (cdc.gov)
  • The Toxoplasma parasite can persist for long periods of time in the bodies of humans (and other animals), possibly even for a lifetime. (cdc.gov)
  • Severe toxoplasmosis, causing damage to the brain, eyes, or other organs, can develop from an acute Toxoplasma infection or one that had occurred earlier in life and is now reactivated. (cdc.gov)
  • Toxoplasmosis is a parasitic infection caused by Toxoplasma gondii . (glowm.com)
  • Approximately 1 to 2 cases of congenital toxoplasma occur per 10,000 children born. (glowm.com)
  • As the causative agent of toxoplasmosis, Toxoplasma gondii can infect all warm-blooded animals, affecting approximately 30% of the world's population [ 12 , 25 ]. (parasite-journal.org)
  • Despite of the low sample size se findings shed light on the host-pathogen interaction focusing on the genetically regulated type I/type III IFN axis that could lead to better management of Zika and other TORCH (Toxoplasma, Others, Rubella, Cytomegalovirus, Herpes) congenital infections. (bvsalud.org)
  • Toxoplasma gondii is a ubiquitous apicomplexan protozoal parasite of significant importance to human and animal health. (frontiersin.org)
  • Toxoplasma gondii and Neospora caninum are important protozoan parasites with worldwide distribution among warm-blooded animals. (biomedcentral.com)
  • Toxoplasma gondii and Neospora caninum are two closely related cyst-forming protozoan parasites with worldwide distribution among warm-blooded animals (de Barros et al. (biomedcentral.com)
  • Humans become infected by eating undercooked meat from infected animals and food and water contaminated with oocysts. (usda.gov)
  • In the present study, scientists review congenital toxoplasmosis in humans. (usda.gov)
  • However, it can infect most types of warm-blooded animals, including humans. (wikipedia.org)
  • Serotype I was the most frequent (38%), which was congruent with previous genotyping results in animals and humans of the same area. (frontiersin.org)
  • Toxoplasmosis is the most common parasitic infection worldwide, because it affects all homoeothermic species, including humans ( Montoya and Liesenfeld, 2004 ). (frontiersin.org)
  • It is transmitted to humans by eating poorly cooked meat from infected animals or ingesting oocysts through the handling of cat litter containing infected feces. (athenslab.gr)
  • However, the development of an effective toxoplasmosis vaccine in humans remains a challenge to date. (nature.com)
  • Domestic and other wild cats are the definitive hosts of T. gondii , and ingestion of oocysts excreted by cats is the main source of infection in intermediate hosts (humans and animals) 1 , 8 . (nature.com)
  • Feline species are the definitive host and its intermediate hosts are a wide range of warm-blooded animals and humans (Razzak et al. (ac.ir)
  • In humans, the located in the forest zone in the far north, borders Cameroon and disease is transmitted through the ingestion of the Equatorial Guinea Republic, through which it connects with the rest of the continent. (bvsalud.org)
  • It is also theoretically possible to 'eliminate' a disease in humans while the microbe remains at large, as in the case of neonatal tetanus, for which the World Health Organization (WHO) in 1989 declared a goal of global elimination by 1995. (cdc.gov)
  • The COUG genotype was first isolated from mountain lions in British Columbia, Canada during investigation of a waterborne outbreak of toxoplasmosis in humans. (frontiersin.org)
  • Due to high zoonotic potential and the risk of infection via shared marine food resources, these findings may also indicate potential health threats for other animals and humans. (frontiersin.org)
  • In intermediate hosts, T. gondii tachyzoites spread systemically, often causing subclinical infection in healthy animals and humans. (frontiersin.org)
  • Members of this group of parasites cause economically and medically important diseases in a varietyof animals, including humans. (pdfmedarticles.com)
  • While most feline infectious diseases affect only cats, and most human infectious diseases affect only humans, it is important to be aware that some of these diseases-called zoonotic diseases-can be transmitted between cats and people. (snapcats.org)
  • Many microorganisms that are pathogenic to humans and animals enter ambient waters after import from various point and diffuse sources. (nationalacademies.org)
  • Toxoplasmosis is also linked to increased risk behavior in humans a. (fermatslibrary.com)
  • Although diagnosis before death in animals other than humans is rare, trichinellosis may be suspected if there is a history of eating either rodents, wildlife carcasses, or raw, infected meat. (msdvetmanual.com)
  • Making sure that ingestion of viable Trichinella cysts in muscle does not occur is the best way to prevent disease in both animals and humans. (msdvetmanual.com)
  • Trichinellosis in Animals Trichinellosis is a zoonotic condition affecting mammals, including humans, birds and reptiles caused by infection with Trichinella sp. (msdvetmanual.com)
  • In Pregnant women with toxoplasmosis, the parasite can be transmitted to the foetus causing severe complications. (ac.ir)
  • Antibody formation elicited in response to the parasite converts the parasite from the trophozoite to the tissue cyst form, and the parasite no longer circulates in blood to cause congenital infection. (glowm.com)
  • T. gondii is an intracellular parasite that can infect almost all mammals and the importance of this parasite in food safety, human health and animal husbandry has been well recognized. (biomedcentral.com)
  • This protozoan parasite can cause serious toxoplasmosis, posing with a risk to public health. (parasite-journal.org)
  • High parasite burdens were observed in all tissues except the central nervous system, and toxoplasmosis with severe protozoal steatitis was the primary cause of death for all cases. (frontiersin.org)
  • Infections with toxoplasmosis are associated with a variety of neuropsychiatric and behavioral conditions. (wikipedia.org)
  • Ill-defi ned intestinal infections environment, direct contact with animals, or from person accounted for the greatest part of reported cases and 27% to person ( 5 ). (cdc.gov)
  • The present findings on human toxoplasmosis in Gabon suggest that at an older age, reactivation of old infections seems more frequent than new infections, as indicated by the presence of T. gondii using PCR among elevated IgG subjects without IgM. (bvsalud.org)
  • 1,000 animals over 24 years) were negative for prior cases of severe T. gondii -associated steatitis prior to the cases described herein, and no sublethal COUG T. gondii infections have been previously indentified in sea otters. (frontiersin.org)
  • The high flock and animal level seroprevalence of toxoplasmosis in sheep is a good marker of the potential risk for human infections. (biomedcentral.com)
  • The condition is usually caused by infections Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. (lecturio.com)
  • Some of these infections Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. (lecturio.com)
  • Three species of Chlamydia cause human disease, including sexually transmitted infections and respiratory infections. (msdmanuals.com)
  • Generally, there are no signs of the disease, and most infections in domestic and wild animals go undiagnosed. (msdvetmanual.com)
  • People with weakened immune systems are likely to experience headache, confusion, poor coordination, seizures, lung problems that may resemble tuberculosis or Pneumocystis jiroveci pneumonia (a common opportunistic infection that occurs in people with AIDS), or chorioretinitis caused by severe inflammation of the retina (ocular toxoplasmosis). (wikipedia.org)
  • Signs and symptoms of ocular toxoplasmosis can include reduced vision, blurred vision, pain (often with bright light), redness of the eye, and sometimes tearing. (cdc.gov)
  • An ophthalmologist will provide the best care for ocular toxoplasmosis. (cdc.gov)
  • When acquired during pregnancy, toxoplasmosis often goes unrecognized in the mother, but it can produce a severe congenital infection with ocular and neurologic damage to the infant. (glowm.com)
  • Patients in this category suffer either from opacity of the ocular media (e.g., corneal edema, hyphema/hypopyon, cataract, etc.) or from retinal disease (e.g. (vin.com)
  • Both T. gondii and N. caninum are important protozoan parasites that infect a wide variety of warm-blooded animals, including bird species. (biomedcentral.com)
  • Human beings and other warm-blooded animals become infected primarily by ingesting food or water contaminated with sporulated oocysts or by ingesting meat that contain tissue cysts of T. gondii [ 6 , 8 - 11 ]. (biomedcentral.com)
  • Blindness may be caused by numerous systemic or neurological diseases. (vin.com)
  • From February 2020 to March 2022, four southern sea otters ( Enhydra lutris nereis ) stranded in California with severe protozoal steatitis and systemic toxoplasmosis. (frontiersin.org)
  • Systemic diseases such as sarcoidosis Sarcoidosis Sarcoidosis is a multisystem inflammatory disease that causes noncaseating granulomas. (lecturio.com)
  • With systemic and congenital disorders, extraocular manifestations are observed. (lecturio.com)
  • If a person becomes infected during pregnancy, a condition known as congenital toxoplasmosis may affect the child. (wikipedia.org)
  • Toxoplasmosis is usually spread by eating poorly cooked food that contains cysts, exposure to infected cat feces, and from an infected person to their baby during pregnancy. (wikipedia.org)
  • The pathogen can infect the fetus by congenital transmission during pregnancy. (ac.ir)
  • However, the fetus is at risk if the disease develops during pregnancy. (athenslab.gr)
  • 2005). T. gondii infection is usually asymptomatic in immunecompetent individuals, but it is particularly dangerous for pregnant women because the prevalence of toxoplasmosis increases during pregnancy throughout the second and Trimesters of pregnancy and congenital infection. (ac.ir)
  • This leaves about 62% of women at risk to acquire toxoplasmosis during pregnancy. (glowm.com)
  • Thus, fetal infection has not been reported in women with chronic toxoplasmosis that occurred before pregnancy. (glowm.com)
  • Congenital transmission of T. gondii during pregnancy has been regarded as a risk factor for the health of newborn infants. (biomedcentral.com)
  • [2] It may also be transmitted from mother to baby during pregnancy or at birth, resulting in congenital syphilis . (ipfs.io)
  • Young children and immunocompromised people, such as those with HIV/AIDS, those taking certain types of chemotherapy, or those who have recently received an organ transplant, may develop severe toxoplasmosis. (wikipedia.org)
  • Congenital fetal toxoplasmosis can cause severe abnormalities, including blindness, hydrocephalus, mental retardation, and can lead to endometrial or postnatal death. (athenslab.gr)
  • The severity of clinical disease in congenitally-infected infants is inversely related to the gestational age at the time of primary maternal infection with first-trimester maternal infection, leading to more severe manifestations (Hill and Dubey, 2002). (ac.ir)
  • Severe toxoplasmosis is more likely in individuals who have weak immune systems, though occasionally, even persons with healthy immune systems may experience eye damage from toxoplasmosis. (cdc.gov)
  • Who is at risk for developing severe toxoplasmosis? (cdc.gov)
  • What should I do if I think I am at risk for severe toxoplasmosis? (cdc.gov)
  • However, simple precautions, common sense, and good hygiene, including careful handling of litter boxes and treating cats with fleas and other parasites, can further reduce the risk of zoonotic disease. (snapcats.org)
  • Toxoplasmosis is an important zoonotic parasitic disease worldwide. (biomedcentral.com)
  • Laboratory test results are the most important parameter for the diagnosis and monitoring of all pathological conditions. (athenslab.gr)
  • The steps involved in the workup of a patient include naming, meshing, office testing, specific and nonspecific laboratory tests, specialty consultations, therapeutic tests, and diagnosis and treatment. (medscape.com)
  • The diagnosis of congenital toxoplasmosis presents limitations and therefore new options are necessary. (bvsalud.org)
  • The aim of this study is to better understand the role of real-time PCR in the blood of the mother and newborn as well as in the amniotic fluid and placenta in the diagnosis of congenital toxoplasmosis. (bvsalud.org)
  • Six (5.2%) newborns were diagnosed with congenital toxoplasmosis, and only cases with positive PCR in the amniotic fluid had correlation of the PCR result with the diagnosis of congenital infection. (bvsalud.org)
  • Both maternal and blood samples of newborns and placenta did not prove to be promising in the diagnosis of congenital toxoplasmosis. (bvsalud.org)
  • Serum WNV IgM can provide evidence for recent WNV infection, but in the absence of other findings does not establish the diagnosis of neuroinvasive disease (meningitis, encephalitis, acute flaccid paralysis). (basicmedicalkey.com)
  • 2019). Moreover, congenital transmission population. (bvsalud.org)
  • Mother-to-child (congenital) transmission. (cdc.gov)
  • 7) "Communicable disease" means an illness due to a specific microbiological or parasitic agent or its toxic products which arises through transmission of that agent or its products from an infected person, animal, or inanimate reservoir to a susceptible host, either directly or indirectly through an intermediate plant or animal host, vector, or the inanimate environment. (gamutonline.net)
  • 11) "Epidemiologically linked case" means a case in which the patient has/has had contact with one or more persons who have/had the disease, and transmission of the agent by the usual modes of transmission is plausible. (gamutonline.net)
  • To reduce cases of suicide attributable to T. gondii infection, it is recommended to implement some measures to prevent and control the transmission of the disease. (biomedcentral.com)
  • Eliminating transmission of a disease may also be considered, as in the case of yaws, the late noninfectious clinical manifestations remain of which but are not a danger to others. (cdc.gov)
  • Transmission of a zoonotic disease can potentially occur when a person comes into direct contact with secretions or excretions-such as saliva or feces-from an infected cat. (snapcats.org)
  • ABSTRACT Visceral leishmaniasis (VL) has shown endemic pattern and epidemic episodes in urban and rural areas, however, there are still gaps in knowledge with regards to disease transmission. (scielo.br)
  • Causes include congenital lesions (hydrocephalus), metabolic disease (hepatic encephalopathy), toxins (lead toxicity), and inflammatory or infectious CNS disease. (vin.com)
  • Reviews of serological studies have estimated that 30-50% of the global population has been exposed to and may be chronically infected with latent toxoplasmosis, although infection rates differ significantly from country to country. (wikipedia.org)
  • T. gondii infection causes toxoplasmosis, which is the leading cause of death associated with foodborne diseases in the United States. (mdpi.com)
  • Thus surveillance of T. gondii infection and the distribution of the oocysts in the living environments have been regarded as an important measure to prevent the disease. (biomedcentral.com)
  • Cryptosporidiosis in Animals Cryptosporidiosis is a highly prevalent gastrointestinal parasitic disease caused by protozoan species of the genus Cryptosporidium that infect a wide range of animals, including people. (merckvetmanual.com)
  • However, fatal neurological disease can occur, particularly in immunosuppressed individuals. (frontiersin.org)
  • Brucellosis, echinococcosis, salmonellosis, in their incidence but also in their severity, resulting in and toxoplasmosis were found to be the most common widely different clinical manifestations and potentially known causes of foodborne illnesses, being responsible involving long-term sequelae, although for their accurate for 70% of the DALY. (cdc.gov)
  • To initiate and sustain efforts for prevention and effects of foodborne diseases ( 2 ), and DALY is increasingly control of foodborne diseases, it is essential to used for a wide variety of illnesses ( 6 - 8 ). (cdc.gov)
  • Accurate knowledge of disease incidence and severity relevant data sources combined with the DALY metric is invaluable to competent national authorities for use to quantify the annual impact of foodborne illnesses in a in selecting appropriate management actions to reduce country in a format useful for policy decisions. (cdc.gov)
  • Recent changes in human demographics and food preferences, changes in food production and distribution systems, microbial adaptation, and lack of support for public health resources and infrastructure have led to the emergence of novel as well as traditional foodborne diseases. (cdc.gov)
  • Appreciate that any patient with foodborne illness may ing suspicious symptoms, disease clusters, and etiologic agents, represent the sentinel case of a more widespread outbreak. (cdc.gov)
  • 12) "Foodborne disease" means illness suspected by a health care provider to have resulted from consuming a contaminated food. (gamutonline.net)
  • 13) "Foodborne disease outbreak" means an incident in which two or more persons experience a similar illness after ingestion of a common food, and epidemiologic analysis implicates the food as the source of the illness. (gamutonline.net)
  • Chronic Granulomatous Disease can affect the fetus in utero and present as congenital abnormalities Congenital Abnormalities Malformations of organs or body parts during development in utero. (lecturio.com)
  • Infection has three stages: Acute toxoplasmosis is often asymptomatic in healthy adults. (wikipedia.org)
  • The toxoplasmic trophozoites causing acute toxoplasmosis are referred to as tachyzoites, and are typically found in various tissues and body fluids, but rarely in blood or cerebrospinal fluid. (wikipedia.org)
  • The tachyzoite form of the disease is responsible for the acute stage of the infection [ 13 ]. (biomedcentral.com)
  • There are two exceptions: even one case of botulism or chemical poisoning constitutes an outbreak if laboratory studies identify the causative agent in the food. (gamutonline.net)
  • ABSTRACT Chagas disease (CD) is a neglected tropical disease associated with poverty in which patients are surrounded by stigma. (scielo.br)
  • Due to the absence of obvious symptoms, hosts easily become infected with T. gondii and develop toxoplasmosis without knowing it. (wikipedia.org)
  • Acquired toxoplasmosis usually does not cause symptoms in patients with a complete immune system. (athenslab.gr)
  • What are the signs and symptoms of toxoplasmosis? (cdc.gov)
  • 6) "Clinical symptoms" means the subjective sensation of disease felt by the patient. (gamutonline.net)
  • [3] Syphilis has been known as " the great imitator " as it may cause symptoms similar to many other diseases. (ipfs.io)
  • [3] While secondary disease is known for the many different ways it can manifest, symptoms most commonly involve the skin, mucous membranes , and lymph nodes . (ipfs.io)
  • This study aimed to estimate the seroepidemiology of toxoplasmosis in Pregnant women who had referred to the Health Centers of Sanandaj in 2019. (ac.ir)
  • If you are already pregnant, you and your health care provider should discuss your risk for toxoplasmosis. (cdc.gov)
  • Early laboratory tests in rodent populations showed that pregnant rodents could safely use it, so doctors prescribed Thalidomide to treat morning sickness in pregnant women. (asu.edu)
  • This is a descriptive cohort study of pregnant women with toxoplasmosis followed up in Rio de Janeiro, Brazil. (bvsalud.org)
  • The Center for Disease Control recommends all pregnant women be tested. (ipfs.io)
  • 1) "CDC" means the Centers for Disease Control and Prevention, United States Department of Health and Human Services. (gamutonline.net)
  • The ITFDE considered more than 90 diseases and reviewed 30 of these in depth, including one noninfectious disease. (cdc.gov)
  • They rarely cause disease, in contrast to the parasitic ameba Entamoeba histolytica , which is a common cause of intestinal infection ( amebiasis). (msdmanuals.com)
  • Domestic cats and wild felids play a crucial role in the epidemiology of toxoplasmosis as the definitive hosts, through the shedding of millions of oocysts when infected [ 6 , 7 ]. (biomedcentral.com)
  • Improvements in HRQoL after hospital discharge are independent of imaging improvement, and there seems to be no association between HRQoL after hospital discharge and disease severity on hospital admission. (scielo.br)
  • These differences impact much of what we used to believe as facts about congenital toxoplasmosis (CT) and will be important in developing new recommendations for prevention of CT and the monitoring of women at risk for developing CT. (usda.gov)
  • Education about the primary prevention of toxoplasmosis has decreased the rate of primary infection, but it is still an important pathogen. (glowm.com)
  • These efforts could include screening by health care providers for BMI, food security, and social determinants of health, increased access to evidence-based pediatric weight management programs and food assistance resources, and state, community, and school resources to facilitate healthy eating, physical activity, and chronic disease prevention. (cdc.gov)
  • An important part of the work was to help identify key impediments to improved prevention and control of the diseases under discussion, even if the disease was not considered to have potential as a candidate for eradication. (cdc.gov)
  • In addition, she worked for four years as a consultant to a food company to develop a line of snacks that are healthy and that add functional ingredients, physiologically active compounds that bring health benefits, made from fruits and vegetables, enabling diet improvement, disease prevention and reduction of nutritional deficiencies. (thewholeportion.com)
  • Some metabolic defects are recessive genetic diseases and some people do not consider them to be birth defects. (smarthealthtalk.com)
  • Between the extremes of disease 'control' (reduction in incidence and/or prevalence) and 'eradication,' several intermediate levels of impact on diseases may be described. (cdc.gov)
  • Toxoplasmosis is common in AIDS patients. (athenslab.gr)
  • Many other prenatal screening tests routinely done in the United States are to detect even less common diseases. (glowm.com)
  • Placebo-controlled prospective trials have not been conducted to evaluate the effectiveness of the treatment of toxoplasmosis in utero . (glowm.com)
  • Answers to several sets of related and fundamental questions (summarized in Box 3-1 ) are imperative to facilitate the understanding of indicators of waterborne pathogens and emerging infectious diseases. (nationalacademies.org)
  • related disease outbreak. (cdc.gov)
  • These will frequently be accompanied by additional signs of clinical disease. (vin.com)
  • Tissue cysts form in the tissue of infected animals within a week of infection. (glowm.com)
  • Infection occurs when an animal eats meat with cysts containing the Trichinella larvae. (msdvetmanual.com)
  • The life cycle continues inside the animal, with larvae eventually migrating throughout the body, where they form cysts in muscles. (msdvetmanual.com)
  • Trichinosis is a parasitic disease caused by the growth of infective cysts in muscle tissue. (msdvetmanual.com)
  • Test results should be interpreted in relation to each individual case and family history, clinical findings and the results of other laboratory tests and information. (athenslab.gr)
  • CDC supports the findings in this report, which indicate a need for greater recognition of the potential to eradicate targeted diseases. (cdc.gov)
  • Our findings reveal a novel and concerning lesion pattern for sea otters with toxoplasmosis. (frontiersin.org)
  • In addition, recent studies have indicated that toxoplasmosis is a plausible risk factor for personality shifts and increased likelihood of reduced intelligence or schizophrenia [ 12 ]. (biomedcentral.com)
  • One of the first behavioral signs of inherited, degenerative diseases of the outer retina (commonly known as Progressive Retinal Atrophy, PRA) is loss of night vision as rods are affected before cones. (vin.com)
  • Frequently, owners will report sudden loss of vision, even though ophthalmic examination shows signs associated with chronic disease. (vin.com)
  • At present, people's demand for meat, eggs, and milk has increased gradually, which has also led to a considerable increase in the proportion of some traditional animal husbandry industries in the agricultural industrial structure. (ballyabio.com)
  • 3) Where a person in charge of a laboratory knows or suspects, as a result of analysis, examination or tests of or on a specimen, that an animal or another person is suffering from or has died from a communicable disease listed in Schedule B, he shall, within 7 days and in accordance with section 4, make a report to the medical health officer. (gov.bc.ca)
  • 3 In addition to the requirements of section 2, the administrator or other person in charge of a hospital shall, within 7 days, make a report to the medical health officer respecting a patient admitted to the hospital who is suffering from a reportable communicable disease or from rheumatic fever. (gov.bc.ca)
  • 10) "Epidemiological risk factors" means those attributes, behaviors, exposures, or other factors that alter the probability of disease. (gamutonline.net)
  • Parasitic infection increases risk-taking in a social, intermediate host carnivore annotated/explained version. (fermatslibrary.com)
  • And our materials explain that the scientific understanding of how genetics may affect disease risk and other aspects of a person's health is changing and will continue to change as more research is done. (kidneynotes.com)
  • APOE4 Alzheimer's gene: a variant of the APOE gene that has been strongly associated with a higher risk of developing Alzheimer's disease, a progressive brain disorder that affects memory, thinking, and behavior. (drpaulkilgore.com)