• abnormal
  • We have developed a transgenic mouse model of pathological angiogenesis that recapitulates many features of tumor blood vessels and vascular malformations through endothelial cell-specific hyperactivation of Akt.We will use this animal model to test the hypothesis that the combined use of pulsed dye laser to induce blood vessel injury, and rapamycin (applied topically) to inhibit angiogenesis will prevent the recurrence of abnormal blood vessels following laser treatment. (aslms.org)
  • Pressure within the bladder becomes abnormally high, causing abnormal function in the kidneys hence abnormally high pressure in the vascular system entering the kidneys. (wikipedia.org)
  • brain
  • Brain: Congenital malformation. (indigo.ca)
  • A consequence of this disproportionate brain growth appears to be a significantly increased risk of cerebellar tonsillar herniation (descent of the cerebellar tonsils through the foramen magnum of the skull, resembling a Chiari I malformation neuroradiologically) and ventriculomegaly/hydrocephalus. (wikipedia.org)
  • cerebral
  • Along with hemangiomas, the malformations result in severe headaches, cerebral hemorrhages, vomiting, meningism, seizures, acute strokes or progressive neurological deficits due to acute or chronic ischaemia caused by arteriovenous shunting. (wikipedia.org)
  • The hypothesis of a spontaneous origin in the current case of SP is supported by no evidence of associated anomalies, such as cerebral aneurysmal venous malformations, systemic angiomas, venous angioma dural malformation, internal cerebral vein aneurysm, and cavernous hemangiomas. (wikipedia.org)
  • The most general symptoms of a cerebral AVM include headaches and epileptic seizures, with more specific symptoms occurring that normally depend on the location of the malformation and the individual. (wikipedia.org)
  • anomalies
  • Although in these cases a complete ring of two patent aortic arches is not present, the term 'vascular ring' is the accepted generic term even in these anomalies. (wikipedia.org)
  • occurs
  • Category three, the most severe, occurs when the patient's malformations are so severe that the dilated vessels cause no distinction between artery and vein. (wikipedia.org)
  • tissue
  • In some cases the end of the smaller left aortic arch closes (left atretic arch) and the vascular tissue becomes a fibrous cord. (wikipedia.org)
  • usually
  • The right aortic arch is completing the vascular ring by passing to the right and then behind the esophagus and trachea to join the usually left-sided descending aorta. (wikipedia.org)
  • features
  • It is not clear if there are some features which are mandatory to make the diagnosis, but macrocephaly appears essentially universal though may not be congenital. (wikipedia.org)