• Changes
  • Here we consider how other conformational changes in another serpin, antithrombin, can cause its inactivation with consequent thrombosis. (haematologica.org)
  • During their transport cycle, ATP-binding cassette (ABC) transporters undergo large-scale conformational changes between inward- and outward-facing states. (pnas.org)
  • Dual polarisation interferometry is a benchtop technique capable of measuring conformational changes in biomolecules in real time at very high resolution. (wikipedia.org)
  • By measuring their speed which ultimately depends on their hydrodynamic friction, conformational changes can be visualized. (wikipedia.org)
  • Recent improvements in using grid-based evaluation of energies, limiting the exploration of the conformational changes at only local areas (active sites) of interest, and improved tabling methods have significantly enhanced the performance of genetic algorithms and made them suitable for virtual screening applications. (wikipedia.org)
  • distinct
  • Conformational isomers are thus distinct from the other classes of stereoisomers (i. e. configurational isomers) where interconversion necessarily involves breaking and reforming of chemical bonds. (wikipedia.org)
  • Search
  • The search for other causes is important, as the conformational perturbation of normal antithrombin is likely to be a contributory cause to the sporadic and apparently idiopathic occurrence of venous thrombosis. (haematologica.org)
  • generally
  • There are generally considered three principle contributions to the conformational free energy: Bayer strain, defined as the strain arising from deformation of bond angles. (wikipedia.org)
  • directly
  • The existence of side-chain conformational substates in two systems is directly demonstrated using traditional X-ray crystallographic refinement methodologies. (rice.edu)