• pharmacokinetic
  • For some substances, it is important to think of the human or animal body as being made up of several parts, each with their own affinity for the substance, and each part with a different biological half-life (physiologically-based pharmacokinetic modelling). (wikipedia.org)
  • drug
  • Although definitive indications for therapeutic monitoring of the analgesics are as yet not well defined, the need for drug concentration determination becomes critical in situations where overdose, abuse, or toxicity is suspected. (thefreelibrary.com)
  • These results would tend to lead the reader to think that ambazone would not be the best choice for treatment, because with such a low absorbance, there is going to have to be a greater concentration ingested to gain a positive effect from the drug. (wikipedia.org)
  • Such models are not as realistic as using washout functions fit to concentration that can have vanishingly small initial volumes of drug distribution An E2 (bicameral compartmental, biexponential) model illustrated in the top of the figure to the right can also be drawn as a variable volume model. (wikipedia.org)
  • The latter is not so useful as it cannot not tell when any particular half-life occurs, e.g., a half-life of concentration or of drug mass. (wikipedia.org)
  • There are circumstances where the half-life varies with the concentration of the drug. (wikipedia.org)
  • Thus the half-life, under these circumstances, is proportional to[dubious - discuss] the initial concentration of the drug A0 and inversely proportional to the zero-order rate constant k0 where: t 1 2 = 0.5 A 0 k 0 {\displaystyle t_{\frac {1}{2}}={\frac {0.5A_{0}}{k_{0}}}\,} This process[clarification needed] is usually a logarithmic process - that is, a constant proportion of the agent is eliminated per unit time. (wikipedia.org)
  • nuclear
  • The U.S. Nuclear Regulatory Commission (NRC) has LLW broken into three different classes: A, B, and C. These classes are based on the wastes' concentration, half-life, as well as what types of radionuclides it contains. (wikipedia.org)
  • Due to the concentration of nuclear technology and waste products in the East, South Carolina was receiving 80-90 percent of monthly volume of LLW generated commercially in the United States. (wikipedia.org)
  • increase
  • mean survival time (MST), percent increase of life span, survival rates, percent change in body weights and number of peritoneal cells. (wikipedia.org)
  • products
  • Coca leaf products are an integral part of the lives of the Andean peoples from both a cultural and traditional medicine perspective. (hindawi.com)
  • shown
  • The in vitro and in vivo studies have shown the contribution of the alternative CYP2D-mediated dopamine synthesis to the concentration of this neurotransmitter although the classic biosynthetic route to dopamine from tyrosine is active. (wikipedia.org)
  • certain
  • it is also produced by certain fungi and bacteria (genus: Lactobacillus, Clostridium, Pseudomonas, and Enterobacteriaceae) and acts as a potent anti-microbial against certain pathogenic strains of Escherichia coli (e.g., the O157:H7 strain) at sufficient concentrations. (wikipedia.org)
  • The effects of exercise on cognition have important implications for improving academic performance in children and college students, improving adult productivity, preserving cognitive function in old age, preventing or treating certain neurological disorders, and improving overall quality of life. (wikipedia.org)