• Blood levels of phenytoin reflect only total serum concentration of the drug. (medscape.com)
  • Because CNS tissue levels are higher than in serum, levels may underestimate CNS concentrations of phenytoin. (medscape.com)
  • Intramuscular administration of a single dose of 600 mg of lincomycin produces average peak serum concentrations of 11.6 mcg/mL at 60 minutes and maintains therapeutic concentrations for 17 to 20 hours for most susceptible gram-positive organisms. (nih.gov)
  • A two hour intravenous infusion of 600 mg of lincomycin achieves average peak serum concentrations of 15.9 mcg/mL and maintains therapeutic concentrations for 14 hours for most susceptible gram-positive organisms. (nih.gov)
  • Concentrations of BVDV in serum and ileal tissues were measured, and BRV shedding in feces was determined. (avma.org)
  • To measure serum fibroblast growth factor-19 (FGF-19) concentration and gallbladder volume in healthy dogs before and after feeding to determine whether serum FGF-19 concentration increases following gallbladder contraction and to assess FGF-19 stability in blood samples kept under different storage conditions after collection in tubes containing no anticoagulant or in serum separator tubes. (avma.org)
  • Serum FGF-19 concentration was measured with a commercially available ELISA. (avma.org)
  • This testing may be appropriate in practices where women consistently visit their physician throughout pregnancy, but it is less feasible when analysis of serum ferritin concentration is unavailable or when prenatal care visits are sporadic. (cdc.gov)
  • In this study we examine demographic, behavioral, dietary, and occupational characteristics of Anniston survey participants as predictors of serum PCB concentrations. (cdc.gov)
  • Statistically significant positive associations were observed between serum PCB concentrations and age, race, residential variables, current smoking, and local fish consumption, as was a negative association with education level. (cdc.gov)
  • The absorption, distribution and excretion of test substance was determined by performing in vivo study in rats. (europa.eu)
  • Buxton ILO Chapter 2: Pharmcokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimiation in Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14e, (Brunton LL H Knollmann BC, eds) McGraw-Hill Education, 2023. (pharmacology2000.com)
  • EVALUATION FOR ACCEPTABLE INTAKE BIOLOGICAL DATA Biochemical aspects Absorption, distribution and excretion The absorption, distribution, and excretion of paraquat in experimental animals have been reviewed by WHO (1984). (inchem.org)
  • Absorption --After single oral-dose administration, the maximum observed plasma concentration (C max ) of tadalafil is achieved between 30 minutes and 6 hours (median time of 2 hours). (theodora.com)
  • Photoacoustic imaging works from the platform of the intrinsic absorption properties of the targeted biological tissue. (photonics.com)
  • When an ultrasonic transducer receives that wave, it reconstructs it in a process that allows scientists to produce an image showing the light absorption distribution in the tissue. (photonics.com)
  • Absorption, distribution, metabolism, and excretion (ADME) impact chemical concentration and activation of molecular initiating events of Adverse Outcome Pathways (AOPs) in cellular, tissue, and organ level targets. (epa.gov)
  • Procedures -Fresh frozen liver specimens (obtained via simulated needle-core and wedge biopsy), fresh hepatic tissue, and deparaffinized-archived specimens (0.5 to 14 years old) were analyzed for concentrations of copper, iron, and zinc by atomic absorption flame spectrometry. (avma.org)
  • Overview of Pharmacokinetics Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body-the time course of its absorption, bioavailability, distribution. (msdmanuals.com)
  • Tissue distribution and excretion of 14C- styrene in male and female rats. (cdc.gov)
  • The tissue distribution and excretion of styrene (100425) and its metabolites in the rat at various time intervals after oral administration was investigated. (cdc.gov)
  • Metabolism and excretion occur simultaneously with distribution, making the process dynamic and complex. (msdmanuals.com)
  • Samples of tissues, organs, and body fluids were prepared for quantitation of radioactivity. (cdc.gov)
  • Concentrations in all tissues and organs were below 1 microgram per gram or milliliter at 24 hours. (cdc.gov)
  • The distribution of the 14C-labelled test substance was studied using collected samples of blood, organs and tissues by radioassay. (europa.eu)
  • 89 Zr-AlbudAb tissue concentrations were quantified in organs of therapeutic significance, measuring standardized uptake value and tissue/plasma ratios. (nih.gov)
  • Haemodialysis removes the primary metabolites of linezolid to some extent, but the concentrations of these metabolites are still very considerably higher after dialysis than those in patients with normal renal function or mild to moderate renal insufficiency. (who.int)
  • Regarding adipose tissue, this trend was also observed, except for DDT and its metabolites whose values were far below the MRL. (scialert.net)
  • In vitro data suggests that metabolites are not expected to be pharmacologically active at observed metabolite concentrations. (theodora.com)
  • The levels of organochlorine residues in 40 samples of milk and 20 human adipose tissues from two locations in the northern of Côte d Ivoire were determined. (scialert.net)
  • This study revealed in general that the level of pesticides in samples of adipose tissue was higher than that in samples of milk from any source (city or rural). (scialert.net)
  • Indeed, while the average of 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT), predominant specie and its isomers in adipose tissue was 10.02 mg kg -1 in countryside and 6.93 mg kg -1 in the city, it was respectively 0.013 and 0.019 mg kg -1 in milk. (scialert.net)
  • Adipose tissue samples revealed the presence of polychlorinated biphenyl (PCB), Hexachlorobiphenyl (HCB) in addition to pesticides which are found in the milk Average concentrations of organochlorine pesticides in milk matrix were above the Maximum Residue Limits (MRL) of WHO. (scialert.net)
  • Human breast milk samples (40 samples) and adipose tissues (20 samples) were collected from mothers (17 to 56 years old, average age 30) living in two different locations in the north of Côte d Ivoire (Korhogo and Sinématiali) from 2004 to 2007. (scialert.net)
  • Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
  • Besides, a role could be ascribed to molecules secreted by the visceral adipose tissue that can impact on barrier functions. (hindawi.com)
  • In the transition from childhood to adolescence, it was verifiable that boys and young men differ in the amounts of adipose tissue. (bvsalud.org)
  • Steady-state plasma concentrations are attained within 5 days of once-daily dosing, and exposure is approximately 1.6-fold greater than after a single dose. (theodora.com)
  • Mean tadalafil concentrations measured after the administration of a single oral dose of 20 mg to healthy male subjects are depicted in Figure 1. (theodora.com)
  • 89 Zr-AlbudAb rapidly distributed throughout the vasculature, with tissue/plasma ratios in the liver, lungs, and heart relatively stable over 7 days post-dose, ranging between 0.1 and 0.5. (nih.gov)
  • Specifically, we delineate a method to identify genes that are related to ADME and can impact target tissue dose in response to chemical exposures. (epa.gov)
  • The computational method outlined in this work is applicable to any adverse outcome pathway, and provide a linkage between chemical exposure, target tissue dose, and adverse outcomes. (epa.gov)
  • Volume of distribution provides a reference for the plasma concentration expected for a given dose but provides little information about the specific pattern of distribution. (msdmanuals.com)
  • To better understand INSTI distribution and inform dosing selection we compared the pharmacology of two-dose boosted elvitegravir and unboosted bictegravir regimens in MSM. (cdc.gov)
  • Antiretroviral drugs were measured by LC-MS. RESULTS: Mean bictegravir plasma concentrations remained above the 95% protein-adjusted effective concentration 96 h after dosing [273 (95% CI: 164-456) ng/mL] whereas elvitegravir plasma concentrations became undetectable 48 h after the second dose. (cdc.gov)
  • Bictegravir and elvitegravir reached rectal tissues within 2 h after the first dose, and elvitegravir tissue concentrations [1.07 (0.38-13.51) ng/mg] were greater than bictegravir concentrations [0.27 (0.15-0.70) ng/mg]. (cdc.gov)
  • CONCLUSIONS: Whereas bictegravir plasma concentrations persist at least 4 days after a two-oral-dose HIV prophylaxis regimen, elvitegravir accumulates in mucosal tissues. (cdc.gov)
  • For each oxygen distribution, the oxygen enhancement ratio (OER) was calculated and the mean absorbed dose at which the tumor control probability (TCP) was 0.99 (D(99)) was determined using the linear-quadratic cell survival model (LQ model). (lu.se)
  • Application of a new system to a fresh skin site at weekly intervals continuously maintains therapeutic plasma concentrations of clonidine. (nih.gov)
  • Conclusions and Clinical Relevance -Retrospective measurement of copper and iron concentrations but not zinc concentrations in deparaffinized-archived liver specimens provided relevant information. (avma.org)
  • CONCLUSIONS: This study showed that applying a higher intra-peritoneal pressure during PIPAC treatment leads to a deeper penetration of doxorubicin in ovarian and caecum but does not affect distribution patterns. (bvsalud.org)
  • CONCLUSIONS: Our results indicate that an intermediate vascular density region exists where enhanced blood oxygen concentration may be beneficial for radiation response. (lu.se)
  • The authors conclude that there is a relationship between tissue distribution of styrene and kidney and liver toxicity. (cdc.gov)
  • Tissue samples weighing 100-200 mg were cut in duplicate from the liver, kidneys, spleen, heart, lungs and hind leg (gastrocnemius muscle) for radioassay. (europa.eu)
  • Distribution of angiopeptin was rapid, with the highest concentration appearing in the liver. (aspetjournals.org)
  • Objective -To determine whether metal concentrations in canine liver specimens were influenced by specimen size, assay variability, tissue processing (formalin fixation and deparaffinization), or storage in paraffin blocks. (avma.org)
  • Sample Population -Liver specimens (fresh frozen and deparaffinized) from 2 dogs with chronic hepatitis (high copper but unremarkable iron concentration [liver 1] and unremarkable copper but high iron concentration [liver 2]) as well as fresh and deparaffinized-archived liver specimens from 20 dogs with various hepatopathies. (avma.org)
  • variation was highest in liver 1 and deparaffinized-archived tissues. (avma.org)
  • A higher zinc concentration in deparaffinized-archived specimens masked a low zinc concentration in fresh liver tissue of 10 of 20 (50%) dogs. (avma.org)
  • The data revealed a considerable variability in concentrations of the immunoglobulins. (dtic.mil)
  • Confocal studies showed differential cellular and compartmental distribution of isozymes involved in glucose, glutamate, glutamine, lactate, and creatine metabolism. (molvis.org)
  • Results -Calves inoculated with BVDV 23025 or 17583 developed more severe clinical signs of disease (fever and diarrhea), more severe lymphopenia, and more severe lesions (alimentary epithelial necrosis, lymphoid depletion, and BVDV antigen deposition in lymphatic tissues), compared with calves inoculated with BVDV 713, 5521, or 17011. (avma.org)
  • The system enables simultaneous multicontrast imaging of hemoglobin concentration, blood flow speed, blood oxygen saturation, and lymphatic concentration. (photonics.com)
  • To test the independent system, team members performed multifunctional microscopic imaging of small animals in vivo evaluating hemoglobin concentration, blood flow speed, oxygen saturation, and lymphatic concentration. (photonics.com)
  • Across all tissues evaluated, the kidney tissue/plasma ratio was highest (0.5-1.5 range) with highest concentration in the renal cortex. (nih.gov)
  • Only kidney and nasal epithelium show specific tissue affinities at these early time intervals. (europa.eu)
  • To understand extravasation kinetics and extravascular organ concentrations of AlbudAbs in humans, we studied tissue distribution and elimination of a non-conjugated 89 Zr-labeled AlbudAb in healthy volunteers using positron emission tomography/computed tomography (PET/CT). (nih.gov)
  • Only unbound drug is available for passive diffusion to extravascular or tissue sites where the pharmacologic effects of the drug occur. (msdmanuals.com)
  • The long-circulating and higher tumor accumulation of E/PCF-NPs resulted in complete ablation of breast tumor tissue through the enhanced photothermal effect by NIR laser irradiation-mediated cell apoptosis. (dovepress.com)
  • The most pronounced radiation effect of increased pO(2) occurred with tumor tissue with 50% of the maximum vessel density used in the simulations. (lu.se)
  • After a drug enters the systemic circulation, it is distributed to the body's tissues. (msdmanuals.com)
  • Differing elvitegravir and bictegravir distribution may result in variable mucosal and systemic antiviral activity and can inform dosing strategies for event-driven HIV prevention. (cdc.gov)
  • 41 samples of melanoma tissue, normal fat and skin were excised from 15 patients during ILP. (ox.ac.uk)
  • The efficient DNeasy Blood & Tissue procedure enables high yields of total DNA from animal blood and tissue samples (see table Typical DNA yields from animal tissues using DNeasy Blood & Tissue Kits and figure DNA yields. DNA was purified from 100 µl whole blood using the DNeasy Blood & Tissue Kit. Goat : DNA was purified from 50 µl goat whole blood. Using more than 50 µl goat blood gave no significant increase in DNA yield. Chicken : DNA was purified from 5 µl chicken whole blood. Bird blood contains nucleated erythrocytes, giving higher DNA yields than mammalian blood. "> DNA yields ). (qiagen.com)
  • Distribution patterns were not different between the two groups but penetration depth in ovary and caecum samples was significantly deeper in group 20. (bvsalud.org)
  • METHODS: High-intensity ultrasound (HIUS) at 20 kilohertz with an output power of 70 W was applied on peritoneal tissue samples from fresh postmortem swine for different time intervals. (bvsalud.org)
  • They are characterized by their bioaccumulation properties in the fatty parts of biological beings, such as blood, breast milk and fatty tissues via the food chain ( Smith and Gangolli, 2002 ). (scialert.net)
  • Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of biological and small molecule therapeutics. (nih.gov)
  • Those factors make the method time-consuming and, to date, difficult to use in applications requiring the capture of the dynamic changes of functional information in biological tissues. (photonics.com)
  • Positron emission tomography for bone imaging, as an in vivo tracer technique, allows the measurement of the regional concentration of radioactivity proportional to the image pixel values averaged over a region of interest (ROI) in bones. (wikipedia.org)
  • At 3 and 9 hr, the amount of radioactivity in most tissues of the mother was rapidly decreasing. (europa.eu)
  • No radioactivity was retained in any other fetal tissue. (europa.eu)
  • Pharmacokinetic studies and tissue distributions were performed and detected by an ultra-high performance liquid chromatography/mass spectrometry system. (dovepress.com)
  • The concentration in the fetuses was greater than that in maternal tissues but it decreases with time. (europa.eu)
  • These results are consistent with local adaptation to cool climate and suggest that this is underpinned by mechanisms that regulate embryonic utilisation of yolk reserves and its allocation towards tissue, rather than shifts in maternal investment of yolk content or composition. (lu.se)
  • Distribution --The mean apparent volume of distribution following oral administration is approximately 63 L, indicating that tadalafil is distributed into tissues. (theodora.com)
  • The apparent volume of distribution is the theoretical volume of fluid into which the total drug administered would have to be diluted to produce the concentration in plasma. (msdmanuals.com)
  • Many acidic drugs (eg, warfarin , aspirin ) are highly protein-bound and thus have a small apparent volume of distribution. (msdmanuals.com)
  • Many basic drugs (eg, amphetamine , meperidine ) are extensively taken up by tissues and thus have an apparent volume of distribution larger than the volume of the entire body. (msdmanuals.com)
  • In the human body, iron is present in all cells and has several vital functions -- as a carrier of oxygen to the tissues from the lungs in the form of hemoglobin (Hb), as a facilitator of oxygen use and storage in the muscles as myoglobin, as a transport medium for electrons within the cells in the form of cytochromes, and as an integral part of enzyme reactions in various tissues. (cdc.gov)
  • In the single non-pregnant female, the sites of localization were identical in the adult tissues: brain, nasal epithelium, bone, and renal and hepatic elimination are seen. (europa.eu)
  • Annexin V localization, indicative of apoptotic cell deletion, had an extensive distribution in the midgut, salivary glands and ovaries of pesticide-treated larvae. (bijensterfte.nl)
  • Cell death localization as a tool for a monitoring the subclinical and sub-lethal effects of external influences on honey bee larval tissues is discussed. (bijensterfte.nl)
  • The standardized uptake value (SUV) is defined as tissue concentration (KBq/ml) divided by activity injected normalized for body weight. (wikipedia.org)
  • This novel organ-specific distribution data for AlbudAbs in humans will facilitate a better selection of drug targets to prosecute using the AlbudAb platform and significantly contribute to modeling work optimizing dosing of therapeutic AlbudAbs in the clinic. (nih.gov)
  • Melphalan concentration and distribution in the tissues of tumour-bearing limbs treated by isolated limb perfusion. (ox.ac.uk)
  • Levels of melphalan (L-phenylalanine mustard) were measured in the tissues of tumour-bearing limbs treated by isolated limb perfusion (ILP). (ox.ac.uk)
  • Distribution is generally uneven because of differences in blood perfusion, tissue binding (eg, because of lipid content), regional pH, and permeability of cell membranes. (msdmanuals.com)
  • After a drug has entered tissues, drug distribution to the interstitial fluid is determined primarily by perfusion. (msdmanuals.com)
  • Precursor pool turnover rate, distribution volumes, and red blood cell-plasma concentration ratios were determined. (nih.gov)
  • Embryos from high altitudes also allocated relatively more energy towards tissue production, hatching with lower residual yolk: tissue ratios than low-altitude region embryos. (lu.se)
  • The data suggest that the tested pesticides induced apoptosis in tissues of honey bee larvae at the tested concentrations. (bijensterfte.nl)
  • The authors constructed a theoretical 3D model based on histological images to analyze the influence of vessel density and hemoglobin (Hb) concentration on the response to irradiation. (lu.se)
  • In many cases, transporters exhibit extremely high Gini coefficients, even when their supposed substrates might be expected to be available to all tissues, indicating a much higher degree of specialisation than is usually assumed. (biorxiv.org)
  • By contrast, the Gini coefficients for ABC transporters tend to be larger in cell lines than in tissues, implying that some kind of a selection process has taken place. (biorxiv.org)
  • It is indicated for the prophylaxis or treatment of mild to moderately severe upper respiratory tract infections caused by organisms susceptible to low concentrations of penicillin G. (medscape.com)
  • Improved knowledge of factors affecting the levels and distribution of oxygen within a tumor is needed. (lu.se)
  • Peak tissue concentrations occurred at or before 4 hours after administration. (cdc.gov)
  • The kinetics of distribution and elimination appeared to be the same in female and pregnant animals. (europa.eu)
  • Tracer techniques and quantitative autoradiographic and tissue counting models for measurement of metabolic rates were combined with positron computed tomography (PCT) and (F-18)2-fluoro-2-deoxy-D-glucose (FDG) for the measurement of local cerebral metabolic rate for glucose (LCMRGlc) in humans. (nih.gov)
  • The value of needle-core biopsy specimens for measurement of metal concentrations is questionable. (avma.org)
  • Skeletal muscle tissue (SKM) may be damaged due to mechanical, metabolic, and exertional causes. (degruyter.com)
  • After 10 minutes, cerebral blood FDG activity levels were found to be a minor fraction of tissue activity. (nih.gov)
  • DNeasy Blood & Tissue Kits are intended for molecular biology applications. (qiagen.com)
  • DNeasy Blood & Tissue Kits provide fast, easy silica-based DNA extraction without phenol or chloroform in convenient spin-column and 96-well-plate formats. (qiagen.com)
  • Extracting DNA using the DNeasy Blood & Tissue Kit can be automated on the QIAcube Connect . (qiagen.com)
  • DNeasy Blood & Tissue standard protocols can also be executed using the TRACKMAN Connected system, paired with PIPETMAN M Connected pipettes, both from Gilson. (qiagen.com)
  • The TRACKMAN Connected system guides researchers through the DNeasy Blood & Tissue protocols while automatically adjusting the Bluetooth-enabled PIPETMAN M Connected pipette settings. (qiagen.com)
  • In partnership with My Green Lab, we've also assessed the environmental impact of the DNeasy Blood & Tissue Kit (250). (qiagen.com)
  • For an eco-friendlier alternative to this kit, see our QIAwave DNA Blood & Tissue Kit . (qiagen.com)
  • Later, on the blood concentration shows a trend to come back slowly to the initial values. (europa.eu)
  • The brain tissue/plasma ratio of 0.025 suggested minimal AlbudAb blood-brain barrier penetration. (nih.gov)
  • The entry rate of a drug into a tissue depends on the rate of blood flow to the tissue, tissue mass, and partition characteristics between blood and tissue. (msdmanuals.com)
  • Distribution equilibrium (when entry and exit rates are the same) between blood and tissue is reached more rapidly in richly vascularized areas, unless diffusion across cell membranes is the rate-limiting step. (msdmanuals.com)
  • Vessel reduction combined with increased blood pO(2) caused the distribution to widen due to a lack of vessels. (lu.se)
  • Protein bound drug contribute to the free drug concentration in the central compartment. (pharmacology2000.com)
  • Some drugs distribute mostly into fat, others remain in extracellular fluid, and others are bound extensively to specific tissues. (msdmanuals.com)
  • In vivo studies suggest that the concentration in phagocytes may contribute to drug distribution to inflamed tissues. (medscape.com)
  • The distribution of 14C-test substance was studied in female and 14.5-day-pregnant mice by whole-body autoradiography after administrating 6.5-6.7 mg test substance/kg bw (11-14 uCi/mouse) by oral intubation. (europa.eu)
  • The extent of drug distribution into tissues depends on the degree of plasma protein and tissue binding. (msdmanuals.com)
  • A high performance liquid chromatography assay was used to measure melphalan concentrations. (ox.ac.uk)
  • Whether this causes or contributes to debilitating disease over a normal lifespan depends on the type and concentration of the particles. (usgs.gov)
  • Changes were mainly observed in cells exposed to artificial ascites containing higher cytokine concentrations than patient-derived ascites. (bvsalud.org)
  • Regarding the body fat topography, most showed higher concentration of fat in the thigh, and smaller deposits in the biceps region. (bvsalud.org)
  • No differences were found in the frequency distribution of genotypes among the study groups. (hindawi.com)
  • Specifically, we compared population-level differences in (1) investment from mothers (egg mass, embryo retention and thyroid yolk hormone concentration), (2) embryo energy expenditure during development, and (3) embryo energy allocation from yolk towards tissue. (lu.se)
  • It has good tissue penetration but does not enter the cerebrospinal fluid. (medscape.com)
  • Efficacy of foliar application of calcium products on tomatoes as defined by penetration depth of and concentration within fruit tissues. (sun.ac.za)
  • This study evaluated the impact of increased PIPAC intraperitoneal pressure on the distribution and cell penetration of doxorubicin in a sheep model. (bvsalud.org)
  • Phenytoin prevents the electrical spread of a focus of irritable tissue from entering normal tissue. (medscape.com)
  • means that to understand drug distributions we must understand transporter distributions. (biorxiv.org)
  • Perland and Fredriksson, 2017 ) or the pharmaceutical drug substrates of these transporters, and one clue to this may be to understand their differential tissue distribution. (biorxiv.org)
  • The energy for drug release is derived from the concentration gradient existing between a saturated solution of drug in the system and the much lower concentration prevailing in the skin. (nih.gov)
  • Clonidine flows in the direction of the lower concentration at a constant rate, limited by the rate‑controlling membrane, so long as a saturated solution is maintained in the drug reservoir. (nih.gov)
  • The optimal drug concentration or target concentration may be thought of as a balance between adverse and beneficial drug effects. (pharmacology2000.com)
  • The disposition and tissue distribution of angiopeptin, a long-acting octapeptide analogue of somatostatin, were studied in rats following single iv and sc administration of the drug. (aspetjournals.org)
  • After equilibrium, drug concentrations in tissues and in extracellular fluids are reflected by the plasma concentration. (msdmanuals.com)
  • For poorly perfused tissues (eg, muscle, fat), distribution is very slow, especially if the tissue has a high affinity for the drug. (msdmanuals.com)
  • Volume of distribution has nothing to do with the actual volume of the body or its fluid compartments but rather involves the distribution of the drug within the body. (msdmanuals.com)
  • These in situ results were compared with those using conventional sodium hypochlorite tissue digestion and particle filtration. (usgs.gov)
  • Results showed that n CeO 2 at both concentrations did not impact gas exchange in leaves at any growth stage, while n ZnO at 800 mg/kg reduced net photosynthesis by 12%, stomatal conductance by 15%, and relative chlorophyll content by 10% at day 20. (acs.org)
  • The results also suggest that it is possible to distinguish between diffusion-limited and anemic hypoxia from the characteristics of the pO(2) distribution. (lu.se)
  • thus, plasma concentration is low and volume of distribution is high. (msdmanuals.com)
  • In summary, demographic variables and past consumption of locally produced foods were found to be the most important predictors of PCB concentrations in residents living in the vicinity of a former PCB manufacturing facility. (cdc.gov)
  • A 51% decrease in D(99), from 123 to 60 Gy, was found between the lowest and highest pO(2) concentrations. (lu.se)
  • Objective -To determine the comparative virulence of 5 isolates of bovine viral diarrhea virus (BVDV) type II by inoculating 6- to 9-month-old beef calves with isolates originating from the tissues of cattle affected with naturally occurring, transient, acute, nonfatal infections or naturally occurring, peracute, fatal infections. (avma.org)
  • The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
  • Clinical severity scores were assigned on the basis of tissue metal concentrations. (avma.org)
  • Gas exchange was monitored every 10 days, and at harvest, bioaccumulation of Ce and Zn in tissues was determined by ICP-OES/MS. The effects of NPs exposure on nutrient concentration and distribution in ears were also evaluated by ICP-OES and μ-XRF. (acs.org)
  • In the ideal case, drugs would be applied at exactly the therapeutic concentration and would precisely target desired cells or tissues. (europa.eu)
  • There was no retention in any fetal tissue. (europa.eu)
  • Comparison of mean immunoglobulin levels between the periodontosis and periodontitis groups revealed a statistically significant increase p less than 0.05 for IgG in the granulation tissue from the periodontosis group. (dtic.mil)
  • In 2 cases there was significant regional toxicity in the treated limb, but this was not related to the levels of melphalan measured in the tissues of the limb. (ox.ac.uk)
  • Procedure -The study used BVDV isolates 17011, 713, and 5521 that originated from fetuses aborted from cows with transient, nonfatal, acute BVDV infections and isolates 23025 and 17583 that originated from the tissues of cattle with peracute, fatal BVDV infections. (avma.org)
  • We developed and tested a protocol for in situ characterization of the types and distribution of inorganic particles in biopsied lung tissue from three human groups using field emission scanning electron microscopy (FE-SEM) combined with energy dispersive spectroscopy (EDS). (usgs.gov)