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  • unlikely
  • Their data indicated that it was unlikely that picrotoxin acted simply as a voltage-gated channel blocker, although it did reduce the frequency of channel openings. (wikipedia.org)
  • However, given the short half-life of the compound, significant impairment of daytime performance is unlikely if zaleplon is administered at bedtime or shortly after retiring for the evening. (biopsychiatry.com)
  • surprisingly
  • Not surprisingly these compounds' efficacies were accompanied by the normalization of long-term potentiation in the dentate gyrus one month after the end of treatment, further suggesting persistent drug-mediated improvements in learning and memory. (wikipedia.org)
  • fruit
  • Picrotoxin occurs naturally in the fruit of the Anamirta cocculus, a climbing plant from India and other parts of Southeast Asia. (wikipedia.org)
  • found
  • Under kinetically controlled conditions, this process generally results in exo cyclization and forms bridged ring systems like those found in picrotoxin. (wikipedia.org)
  • shown
  • This compound has been shown to increase noradrenaline levels and turnover in the hypothalamus. (adooq.com)
  • properties
  • These novel compounds were designed to exhibit the beneficial properties of THC without the accompanying psychotropic effects, which limit its therapeutic utility. (allindianpatents.com)
  • similar
  • Sesquiterpenes such as picrotoxin and diterpenes such as clerodane diterpene are also present, while the triterpenes are scarce and where present are similar to oleanane. (wikipedia.org)
  • Several
  • Several classes of compounds can modulate the pentylenetetrazol discriminative stimulus including 5-HT1A, 5-HT3, NMDA, glycine, and L-type calcium channel ligands. (wikipedia.org)
  • Picrotoxin has also been used as a starting material in several synthetic processes, including the creation of dl-picrotoxadiene, which retains certain features of the picrotoxin skeleton. (wikipedia.org)
  • present
  • Following a talk at MUG '99 meeting at which the concept of a Virtual Chemical Stores/Stockroom was introduced, Daylight agreed to explore the possibility of producing a commercial product that would allow the information, present in electronic compound catalogues, to be made available in consistent format to end-users. (daylight.com)
  • Sources
  • The major sources of data are still the compound vendors, in particular those providing compounds for screening. (daylight.com)
  • However as the concept is not limited to commercially available compounds, other sources, such as the World Drug Index, or the NCI database would benefit from this approach. (daylight.com)
  • active
  • Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active inigredient the stereospecific (+) enantiomer, having (3S, 4S) configuration of ?6 tetrahydrocannabinol type compounds. (allindianpatents.com)
  • Said pharmaceutical compositions comprise as their active ingredient the stereospecific (+) enantiomers, having (3S, 4S) configuration, of ?6-tetrahydrocannabinol (THC) type compounds of general formula (I), as defined hereinbelow. (allindianpatents.com)
  • data
  • The original concept was to build a large single Thor database, however the data model allows alternatives such as Virtual Databases , in which the constituent databases are not merged, or using the Oracle cartridge retaining the compound hierarchy by judicious use of tables. (daylight.com)
  • amplitude
  • Pharmacological induction of hippocampal hyperexcitability in vitro transformed the abundant but relatively weak CA3-HMC connections to very large amplitude spontaneous bursts of compound EPSCs (cEPSCs) in young mice (∼P20) and, to a lesser degree, in adult mice (∼P70). (eneuro.org)
  • several
  • it has where to buy xanax online with mastercard been shown by harnack cheap sibutramine 15mg in australia that several centralnervous stimulants, including picrotoxin, cause a fall in the temperaturein this way. (oromiamedia.org)
  • Additionally, several syntheses have been proposed for picrotoxinin and picrotin, the two molecules that make up picrotoxin. (wikipedia.org)
  • Picrotoxin has also been used as a starting material in several synthetic processes, including the creation of dl-picrotoxadiene, which retains certain features of the picrotoxin skeleton. (wikipedia.org)
  • Several classes of compounds can modulate the pentylenetetrazol discriminative stimulus including 5-HT1A, 5-HT3, NMDA, glycine, and L-type calcium channel ligands. (wikipedia.org)
  • present
  • Black seed (also known as nigella seeds) is a member of the buttercup family and its seeds are dark, thin, and crescent shaped with approximately 100 nutritional chemical constituents present (new nutritional compounds are still being identified). (znaturalfoods.com)