• In the Bernthsen acridine synthesis, diphenylamine is condensed with carboxylic acids in the presence of zinc chloride. (wikipedia.org)
  • Other older methods for the organic synthesis of acridines include condensing diphenylamine with chloroform in the presence of aluminium chloride, by passing the vapours of orthoaminodiphenylmethane over heated litharge, by heating salicylaldehyde with aniline and zinc chloride or by distilling acridone (9-position a carbonyl group) over zinc dust. (wikipedia.org)
  • In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. (researchgate.net)
  • These transformations tolerated a broad range of the nucleophilic reagents thus allowing the synthesis of a wide variety of hetero- and carbocyclic compounds including the derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, and isoxazole as well as their heterofused derivatives. (researchgate.net)
  • Heterocyclic compounds - Nomenclature & classification Synthesis, reactions & medicinal uses of following compounds/derivatives Pyrrole, Furan, & Thiophene Relative aromaticity & reactivity of Pyrrole, Furan, & Thiophene. (medipdf.in)
  • Essentiality of pyridine Synthesis and medicinal use that include Pyrimidine, Purine, azepines, and their derivatives. (medipdf.in)
  • In this study, the researcher at Kaohsiung Medical University developed synthesis of acridines and diaryl ketones under acid promoted intramolecular decarbonylative coupling of unstrained ketone. (kmu.edu.tw)
  • To overcome this drawback, in this study, the scientist Prof. Jeh-Jeng Wang and co-workers found that metal free acid promoted intramolecular decarbonylative of unstrained ketones for the synthesis of acridine derivatives. (kmu.edu.tw)
  • This study was published online in Organic Letters on 19 th February 2020 as a research communication entitled "Acid-Promoted Intramolecular Decarbonylative Coupling Reactions of Unstrained Ketones: A Modular Approach to Synthesis of Acridines and Diaryl Ketones" and is available online at https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.0c00304 . (kmu.edu.tw)
  • The lead author of entitled "Acid-Promoted Intramolecular Decarbonylative Coupling Reactions of Unstrained Ketones: A Modular Approach to Synthesis of Acridines and Diaryl Ketones" Ganesh Kumar Dhandabani, Chia-Ling Shih, and corresponding author include Dr. Jeh-Jeng Wang (Professor, Kaohsiung Medical University, Department of Medicinal and Applied Chemistry). (kmu.edu.tw)
  • In this thesis, the synthesis of 3,6-diisocyanate acridine, thiourea derivative and bisguanidine are presented. (ktf-split.hr)
  • Boron nitride nanomaterial based solid acid catalyst is an efficient and reusable sulfonic acid catalyst for the one-pot synthesis of 9-(2-(4-ethylpiperazin-1-yl)quinolin-3-yl)-3,3-dimethyl-3,4,9,10-tetrahydroacridin-1(2H)-one derivatives under microwave irradiation conditionsvia. (iaamonline.org)
  • A nanocrystalline titania-based sulfonic acid material was prepared, characterized and used as an effective, efficient and re-usable catalyst for the synthesis of 2-amino-4-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-6-phenyl-4H-pyran-3-carbonitriles and 2-amino-4-(2-(4-methylpiperazin-1-yl)quinolin-3-yl)-6-(pyridin-4-yl)-4H-pyran-3-carbonitrile derivatives under solvent-free conditions. (iaamonline.org)
  • The present invention relates generally to the synthesis of fluorescent compounds that are analogues of cyanine dyes. (justia.com)
  • The Project Gutenberg eBook of Synthesis of 2-methyl-4-selenoquinazolone 2-phenylbenzoselenazole, and Its Derivatives, by Y -Gwan Chen, M. A. (gutenberg.org)
  • The Project Gutenberg EBook of Synthesis of 2-methyl-4-selenoquinazolone, 2-phenylbenzoselenazole, and its derivatives, by Y -Gwan Chen This eBook is for the use of anyone anywhere in the United States and most other parts of the world at no cost and with almost no restrictions whatsoever. (gutenberg.org)
  • A three-step synthesis of the title compounds starting from 4,4'-dibenzyloxy-2,2',6,6'-tetramethoxybiphenyl (V) has been accomplished and the proposed structure of 6,6"-binaringenin for succedaneaflavanone is confirmed. (heterocycles.jp)
  • A series of compounds containing heterocyclic cores and gem -difluorocycloalkyl substituents was obtained under conditions of the parallel synthesis (i.e., simultaneous performance of reaction procedures, treatment of the reaction mixture, and product isolation for a number of similar transformations) using the reductive amination - the "Nitrogen deletion" reaction sequence. (edu.ua)
  • The synthesis of the target compounds commenced from heteroaromatic aldehydes and the corresponding gem -difluorocycloalkyl or ( gem -difluorocycloalkyl)methyl amines and included the NaBH 3 CN-mediated reductive amination and "Nitrogen deletion" upon the action of Levin's anomeric amide. (edu.ua)
  • Like the related molecules pyridine and quinoline, acridine is mildly basic. (wikipedia.org)
  • Acridine is a photobase which has a ground state pKa of 5.1, similar to that of pyridine, and an excited state pKa of 10.6. (wikipedia.org)
  • Seven compounds show good activity against single cell line whereas, compounds having a pyridine scaffold showed significant anti‐proliferative activity. (researchgate.net)
  • In the fused ring system of the title compound, C 32 H 37 NO 4 , the central di-hydro-pyridine ring adopts a flattened boat conformation, the mean and maximum deviations of the di-hydro-pyridine ring being 0.1429 (2) and 0.2621 (2) Å, respectively. (iucr.org)
  • at one time acridine dyes were popular, but they are now relegated to niche applications, such as with acridine orange. (wikipedia.org)
  • Several dyes and drugs feature the acridine skeleton. (wikipedia.org)
  • At one time acridine dyes were commercially significant, but they are now uncommon because they are not lightfast. (wikipedia.org)
  • Acridine dyes are prepared by condensation of 1,3-diaminobenzene derivatives. (wikipedia.org)
  • Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention. (justia.com)
  • Fluorescent dyes with aromatic amino or guanidine groups, such as propidium iodide (PI), diaminophenylindole (DAPI), acridine orange (AO), and Hoechst dyes, interact with nucleotides to emit fluorescence. (dojindo.com)
  • The present review covers all synthetic methods based on isocyanide-based multicomponent reactions for the preparation of polysubstituted pyrroles as the parent cores of many essential drugs, biologically active compounds, and compounds with wide application in materials science. (dntb.gov.ua)
  • Acridine and its derivatives can be prepared by many synthetic processes. (wikipedia.org)
  • Therefore, several researchers are pursuing efforts to create new synthetic routes for acridine derivatives. (kmu.edu.tw)
  • The developed protocol allowed for the preparation of a 12-member compound library (67 % synthetic efficiency). (edu.ua)
  • In this review we summarize the current state of the art in detailing the three main categories of quadruplex-binding macrocycles described so far (telomestatin-like polyheteroarenes, porphyrins and derivatives, polyammonium cyclophanes), and in addressing both synthetic issues and biological aspects. (hindawi.com)
  • Abstract: Sulfonamide compounds, also known as sulfa drugs, are a significant class of synthetic bacteriostatic antimicrobials and were the primary source of therapy against bacterial infections before the introduction of penicillin in 1941. (dntb.gov.ua)
  • This structure is further coupled with a phenyl pyrimidine derivative, making it a compound of significant interest in the field of organic electronics. (noctiluca.eu)
  • Stereoisomerism & Optical isomerism - optical activity, enantiomers, Di-stereoisomerism, Meso compound elements that exhibit symmetry, and the achiral molecules DL nomenclature system for optical isomers. (medipdf.in)
  • The basis for these compounds are acridine, guanidine and thiourea molecules. (ktf-split.hr)
  • These biological nanopores have been designed to protect the interior of the bacterial cell from leakage of toxic compounds while selectively allowing the entry of the molecules needed for cell growth and function. (ibecbarcelona.eu)
  • These compounds are neutral molecules that pass through cell membranes and covalently conjugate with cell proteins. (dojindo.com)
  • Acridines are an important class of heteroaromatic compounds that have versatile biological properties, such as antimalarial, anticancer and antileukaemia. (kmu.edu.tw)
  • Previously, it was demonstrated that these aptamers can selectively deliver anticancer ligands," Dr. Cruz said, such as acridine orange derivatives, and showed improved selectivity towards cancer cell lines. (utexas.edu)
  • c) Selenium, in the nucleus of cyclic compounds, has been shown to be instrumental for a positive coloration at least equal to the -NH- or -S- groupings. (gutenberg.org)
  • A heterocyclic compound or ring structure is a cyclic compound that has atoms of at least two different elements as members of its ring(s). (alchetron.com)
  • Values for the negative logarithm of the acid dissociation constant, pKa, of the conjugated acid of amines, diamines and cyclic organic nitrogen compounds, shown together with the molecular structure of the acids. (engineeringtoolbox.com)
  • With the higher larger carboxylic acids, the derivatives substituted at the meso carbon atom are generated. (wikipedia.org)
  • See also boiling and melting point of different kinds of organic compounds , boiling and melting point of organic nitrogen compounds , pKa of phenols, alcohols and carboxylic acids and pKa of inorganic acids and bases , as well as acid and base pH indicators and Acid-base properties of aqueous solutions of salts with ions from both acids and bases . (engineeringtoolbox.com)
  • Compound 7d NPs exhibited the best inhibition against Topo I and Topo II enzymes with IC50 of 0.042 and 1.172 µM, respectively. (bvsalud.org)
  • In situ selenium nanoparticles (SeNPs) for some derivatives were synthesised.Cytotoxicity, Topo I and Topo II inhibitory assays, and DNA intercalation abilities were evaluated.Compound 7d NPs showed the best Topo I and Topo II inhibition.Cell cycle arrest, apoptosis induction, and molecular docking studies were performed. (bvsalud.org)
  • 5'-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis. (shengsci.com)
  • Moreover, Kennard-Stone sampling of the actives were applied to select 30 diverse compounds for further molecular docking studies in order to gain structural insights on the origin of AChE inhibition. (peerj.com)
  • A novel family of 4-aminoacridine derivatives was obtained by linking this heteroaromatic core to different trans-cinnamic acids. (ibecbarcelona.eu)
  • Furthermore, the newly-synthesised compounds was used for molecular docking in Hsp90 protein studies. (iaamonline.org)
  • Molecular aspects of monooxygenases and bioactivation of toxic compounds. (cdc.gov)
  • DMQA is an organic compound characterized by its unique molecular structure, which comprises two 9,9-dimethyl-9,10-dihydroacridine units substituted to a benzene ring. (noctiluca.eu)
  • When Chinese hamster ovary cells expressing the human SP receptor were photolabeled with this compound and analyzed with the use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography, several radioactive bands were observed, including a major band centered at molecular mass 80 kDa, the expected value for the SP receptor expressed in Chinese hamster ovary cells. (shengsci.com)
  • Molecular docking revealed that compounds 13 , 5 and 28 exhibited the lowest binding energies of −12.2, −12.0 and −12.0 kcal/mol, respectively, against human AChE, which is modulated by hydrogen bonding, π - π stacking and hydrophobic interaction inside the binding pocket. (peerj.com)
  • Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. (wikipedia.org)
  • Acridine displays the reactions expected of an unsaturated N-heterocycle. (wikipedia.org)
  • Likewise, the compounds with two benzene rings fused to the central heterocycle are carbazole, acridine, and dibenzoazepine. (alchetron.com)
  • All newly synthesized compounds were screened for anti‐proliferative activity against different human tumor cell lines. (researchgate.net)
  • All the derivatives are characterized by TLC and spectral analysis 1H NMR, 13 C NMR, IR, MASS. All the synthesized compounds were screened as in vitro anti-cancer, and anti-bacterial activity. (jyoungpharm.org)
  • It is an organic compound that is used as a flavoring agent in the food industry. (askanydifference.com)
  • The 5-membered ring compounds containing two heteroatoms, at least one of which is nitrogen, are collectively called the azoles. (alchetron.com)
  • The hypothetical compound with six nitrogen heteroatoms would be hexazine. (alchetron.com)
  • The review is summarized and systematized the published data on the multicomponent reactions of ethyl trifluoroacetoacetate, carbonyl compounds (aldehydes and ketones), and nucleophilic reagents. (researchgate.net)
  • 1990. Significance of exposure to benzene and other toxic compounds through environmental tobacco smoke. (cdc.gov)
  • Visualization of a cell with fluorescent compounds provides a wide variety of information for the analysis of cell functions. (dojindo.com)
  • Various activities and structures of a cell can be targeted for staining with fluorescent compounds (Fig. 1). (dojindo.com)
  • The carbon 9-position of acridine is activated for addition reactions. (wikipedia.org)
  • Fusion of two benzene rings gives rise to a third large family of compounds, respectively the acridine, dibenzothiophene, carbazole, and dibenzofuran. (alchetron.com)
  • Therefore, the study of heterocyclic chemistry focuses especially on unsaturated derivatives, and the preponderance of work and applications involves unstrained 5- and 6-membered rings. (alchetron.com)
  • In the search for life elsewhere in the solar system, we have some expectations about what life might look like: It will likely involve carbon chemistry, and a spatial segregation of organic compounds in a way that simple chemical processes would not permit. (nationalacademies.org)
  • Visible-light microscopes can be used to obtain some information about the chemistry of nonfluorescing compounds at a spatial resolution of 200 to 1000 nm. (nationalacademies.org)
  • The crystal structures of acridinedione derivatives are expected to provide useful information on the mol-ecular conformation, which has a direct relationship to biological activity. (iucr.org)
  • 1936: Treibs isolates chlorophyl derivatives from crude oil, explaining the biological origin of petroleum. (alchetron.com)
  • When formic acid is the carboxylic acid, the reaction yields the parent acridine. (wikipedia.org)
  • Reaction with potassium cyanide gives the 9-cyano-9,10-dehydro derivative. (wikipedia.org)
  • Mechanism of addition-fragmentation reaction of thiocarbonyls compounds in free radical polymerization. (univ-lyon1.fr)
  • The ability of compound 7d NPs to arrest the cell cycle and induce apoptosis was investigated. (bvsalud.org)
  • In situ selenium nanoparticles (SeNPs) for some derivatives were synthesised. (bvsalud.org)
  • Attempt was made to study organic selenium compounds of the heterocyclic series in reference to those properties leading to tinctorial and pharmaceutical possibilities. (gutenberg.org)
  • a) Organic selenium compounds were reviewed and their properties examined critically with those of allied compounds. (gutenberg.org)
  • The literature was reviewed and classified with reference to the properties under consideration, and new selenium organic compounds were prepared and studied which it is hoped may throw some additional light upon the problem. (gutenberg.org)
  • No attempt has ever been made to compile a bibliography of selenium organic compounds. (gutenberg.org)
  • In the perusal of the organic records of the metal, distributed over the span of a century, there are indications of the value of selenium compounds for pharmaceutical and tinctorial uses. (gutenberg.org)
  • a) Compounds newly made have been shown to exhibit a distinct tinctorial value in comparison with their analogues. (gutenberg.org)
  • Among the series of compound 9h, 9i, 10h, 10i exhibit more potent against two cancer cell lines MCF7, A549. (jyoungpharm.org)
  • Chrysaniline was synthesized by O. Fischer and G. Koerner by condensing o-nitrobenzaldehyde with aniline, the resulting o-nitro-p-diaminotriphenylmethane being reduced to the corresponding o-amino compound, which on oxidation yields chrysaniline. (wikipedia.org)
  • With heterocycles containing five atoms, the unsaturated compounds are frequently more stable because of aromaticity. (alchetron.com)
  • Acridine is separated from coal tar by extracting with dilute sulfuric acid. (wikipedia.org)
  • Acridine is easily oxidized by peroxymonosulfuric acid to the acridine amine oxide. (wikipedia.org)
  • Acridine orange (3,6-dimethylaminoacridine) is a nucleic acid-selective metachromatic stain useful for cell cycle determination. (wikipedia.org)
  • Glucosamine usually exists in microbial, animal derived polysaccharides and bound polysaccharides in the form of N-neneneba acetyl derivatives (such as chitin) or N-nenenebb sulfate and N-acetyl-3-O-lactate ether (cell wall acid). (chemenu.com)
  • Acetone is a breakdown product of a chemical compound. (askanydifference.com)
  • Several reviews (2) of its compounds, including references, have been published, besides the resumes in the chemical dictionaries. (gutenberg.org)
  • Quantum chemical calculations for the frontier mol-ecular orbitals were undertake to determine the chemical reactivity of the title compound. (iucr.org)
  • Physical properties and chemical reactivity of alternant hydrocarbons and related compounds. (cas.cz)
  • Site-moiety mapping of compounds from the diversity set revealed three binding anchors encompassing both hydrogen bonding and van der Waals interaction. (peerj.com)
  • With 5-heteroatoms, the compound may be considered inorganic rather than heterocyclic. (alchetron.com)
  • Acridine and related derivatives (such as amsacrine) bind to DNA and RNA due to their abilities to intercalate. (wikipedia.org)
  • 1963) Tables of Spectrophotometric Absorption Data of Compounds Used for the Colorimetric Determination of Elements. (photochemcad.com)
  • The anti‐proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. (researchgate.net)
  • Compound 5 showed high antiproliferative activity against several human tumor cell lines. (researchgate.net)
  • Many acridines, such as proflavine, also have antiseptic properties. (wikipedia.org)
  • Derivatives of 1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide are promising chemicals to search and develop drugs with the pharmacological properties required. (edu.ua)
  • An azido derivative of [3H2](2S, 3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl) methyl)-1-azabicyclo[2.2.2]octon-3-amine (CP-96,345), a potent nonpeptide antagonist of the substance P (SP) (neurokinin-1) receptor, was synthesized and shown to have an affinity for the human SP receptor similar to that of the parent compound, CP-96,345. (shengsci.com)
  • The targets and the SeNP derivatives were examined for their cytotoxicity towards five cancer cell lines. (bvsalud.org)
  • Succinimidyl ester compounds can also be used to improve retention of the fluorescent derivative within the cell. (dojindo.com)
  • CFSE is also an ester compound that passes through viable cell membranes. (dojindo.com)
  • Acridines are substituted derivatives of the parent ring. (wikipedia.org)
  • As a class of coordination compound repeated by metal or metal clusters as SBUs (second building units) and organic linkers, the cavity ranged between that of Zeolite and mesoporous silica 3 . (ukessays.com)
  • In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed. (anti-agingfirewalls.com)