• Self, DW & Stein, L 1992, ' The D 1 agonists SKF 82958 and SKF 77434 are self-administered by rats ', Brain Research , vol. 582, no. 2, pp. 349-352. (elsevierpure.com)
  • 6-Br-APB is a synthetic compound that acts as a selective D1 agonist, with the (R)-enantiomer being a potent full agonist, while the (S) enantiomer retains its D1 selectivity but is a weak partial agonist. (wikipedia.org)
  • The reported failure of the prototypical (but partial) D 1 agonist SKF 38393 to support self-administration behavior contradicts hypotheses of D 1 -mediated reinforcement. (elsevierpure.com)
  • It is suggested that these properties, rather than partial D 1 agonist efficacy, explain the failure of SKF 38393 to act as a reinforcer. (elsevierpure.com)
  • During substitution tests, no dose of any compound [apomorphine, Ly 171555, lisuride, LSD, amphetamine, cocaine, (-) 3-PPP, or SKF 82526] mimicked SKF 38393, the effects of which were blocked by the D1 antagonist Sch 23390 but not by haloperidol. (utmb.edu)
  • both compounds produce inverted U-shaped dose-response curves. (elsevierpure.com)
  • Synthesis and separation of diastereomeric N-(1-phenylethyl)amides of inherently chiral hydroxydibenzoyloxy-calix[4]arene acetic acids (2022) Chirality, 34(11),pp.1466-1471.https://www.scopus.com/inward/record.uri?eid=2-s2.0 85136719766&doi=10.1002%2fchir.23503&partnerID=40&md5=21fd40d69ba3d6b5c9bc10e56bcd406. (org.ua)
  • Clinically, when GMP-level plasminogen was administered to 6 AD patients for 1-2 weeks, their average scores on the Minimum Mental State Examination (MMSE), which is a standard scoring system used to measure the memory loss and cognitive deficits, were extremely significantly improved by 4.2 +/- 2.23 points, e.g., an average increase from 15.5 +/- 8.22 before treatment to 19.7 +/- 7.09 after treatment. (inra.fr)
  • The external validation cohort was recruited from the CAPEC trial (n = 1379), which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine, Risperidone, and Aripiprazole groups. (inra.fr)
  • 3 Department of Pharmacology, School of Pharmacy, Nantong University. (nih.gov)
  • We prospectively analyzed 12-lead electrocardiograms from 21 patients admitted for hypertensive emergencies (average blood pressure, 222 +/- 4/140 +/- 3 mm Hg). (nih.gov)
  • Additionally, our findings that ex vivo treatment of bone marrow cells with the Y2 antagonist did not affect osteoblast and osteoclast formation suggests the inhibitor is not affecting these cells directly, and suggests a central role for compound action in this system. (bvsalud.org)
  • Interestingly, this compound has no psychedelic or empathogenic action. (qualiacomputing.com)
  • Controversy exists, however, over the precise location and role of the D(3) subtype of DA receptor. (nih.gov)
  • 1 Department of Internal Medicine, University of Chicago, Ill. (nih.gov)
  • 1 Department of Pharmacy, The Second Affiliated Hospital of Nantong University. (nih.gov)
  • C-terminal telopeptide 1 (CTX-1), a blood biomarker of bone resorption, was decreased in treated animals. (bvsalud.org)
  • As a general overview, some examples of the possible benefits of drug combinations include: (1) Enhanced euphoria, e.g. see speedball which is massively euphoric but also very dangerous, (2) reduced psychological discomfort (e.g. anxiolytics with psychedelics), (3) uniquely interesting effects, e.g. (qualiacomputing.com)