• Synthesis
  • Turovska B. Synthesis of indolizines and their di(tetra)hydroderivatives by intramolecular cyclization of delta-oxoalkylpyridinium compounds and by [3+cycloaddition. (osi.lv)
  • The first part of this dissertation deals with employing the use of multi-component coupling reactions (MCC) for the synthesis of large diverse compound libraries. (wits.ac.za)
  • firstly the Groebke-Blackburn reaction for the synthesis of imidazo[1,2-a]pyridines and secondly a reaction developed by Poigny and co-workers for the synthesis of 3-amino-1-cyano-indolizines. (wits.ac.za)
  • We thus turned our attention to the synthesis of the 3-amino-1-cyano-indolizines, which proved to be very difficult. (wits.ac.za)
  • In an attempt to determine whether similar methodology could be used for the synthesis of pyranonaphthoquinone containing compounds an unexpected and novel reaction was discovered. (wits.ac.za)
  • Balaban also developed new synthesis of oxazoles by AlCl3 catalyzed substitution of aromatic compounds with azlactones, followed by dehidratation. (wikipedia.org)
  • Another experimental research direction involves the synthesis of chelate compounds having boron as the central atom. (wikipedia.org)
  • S )-Allylproline methyl ester 5 is an important building block for the total synthesis of the fungal metabolites (-)-stephacidin A, (+)-stephacidin B, and (+)-notoamide B, quaternary indolizines and indolizidinones ( Figure 1 ), and we turned our attention toward an alternative synthetic route for ( S )- 5 , figured out through key intermediate ( S )- 9 , and features the Stevens sigmatropic rearrangement co-catalyzed by ionic liquids ( Scheme 1 ). (scielo.br)
  • aromatic
  • Clear distinctions can be made based on three attributes: oxidation, the involvement of light, and the incorporation of molecular oxygen into the products: Sensitizers (denoted "Sens") are compounds, such as fluorescein dyes, methylene blue, and polycyclic aromatic hydrocarbons, which are able to absorb electromagnetic radiation (usually in the visible range of the spectrum) and eventually transfer that energy to molecular oxygen or the substrate of photooxygenation process. (wikipedia.org)
  • novel
  • We thus chose to test our synthesised compound library against the HIV enzyme, reverse transcriptase (RT) in the hopes of identifying a potential novel non-nucleoside reverse transcriptase inhibitor (NNRTI). (wits.ac.za)
  • reaction
  • reported on one such reaction in which an azo compound is lysed via photolysis to form the diradical hydrocarbon and then trapped in a stepwise fashion by molecular oxygen: In type II reactions, the 3Sens* transfers its energy directly with 3O2 via a radiation-less transition to create 1O2. (wikipedia.org)
  • active
  • Estrone derivatives, particularly those bearing a spiranic 2-aminooxazoline scaffold were found to be the most active compounds, with GI50 values ranging from the low micromolar to the submicromolar level (0.34-1.5 μM). (deepdyve.com)
  • title
  • In title compound, C 16 H 15 N 3 O 2 , the 1,2,4-triazolo[1,5- a ]pyridine ring system is almost planar (r.m.s. deviation = 0.0068 Å) and forms a dihedral angle of 61.4 (3)° with the phenyl ring. (iucr.org)
  • In title compound (Fig. 1) the the [1,2,riazolo[1,5- a ]pyridine ring system is almost planar, as indicated by its r.m.s. deviation of 0.0068 Å and by the dihedral angle of 0.9 (3)° between the pyridine and triazole rings. (iucr.org)
  • group
  • The γ-carboxamide of Boc-L-Gln was dehydrated to a nitrile group and the resulting compound is selectively methylated providing N-Boc-2-methylamino-4-cyanobutyric acid. (infona.pl)