Components nuclear proteins. Medical search. Frequent questions

Moreover, the ultrastructural localization of both 125- and 160-kDa proteins was investigated by electron microscope immunocytochemistry with gold-conjugated secondary antibodies. (nih.gov)
Phosphorylation-resistant site mutations in PIF7 result in increased nuclear localization and shade-induced gene expression, and consequently augment hypocotyl elongation. (elifesciences.org)
Blocking the interaction between PIF7 and 14-3-3 proteins or reducing the expression of 14-3-3 proteins accelerates shade-induced nuclear localization and de-phosphorylation of PIF7, and enhances the shade phenotype. (elifesciences.org)
These studies have revealed that 14-3-3 proteins can interact with the phosphorylated forms of their client proteins in response to certain signals, and that this binding finalizes the signaling event by enabling a change in the subcellular localization, protein stability or intrinsic enzymatic activity of the client, or by promoting an association between the client and other proteins. (elifesciences.org)
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. (cipsm.de)
Selinexor induced IκB nuclear localization as a single agent, and the effect was enhanced by stabilization of IκB when pretreated with the proteasome inhibitor carfilzomib. (aacrjournals.org)
In this study, we show that selinexor induces nuclear localization of IκB. (aacrjournals.org)
XPO1, the main nuclear export protein, transports cargo proteins containing nuclear localization signals out of the nucleus ( 1-3 ). (aacrjournals.org)
Projection of a HeLa cell expressing a YFP-SC35 fusion protein that localizes to nuclear speckles and in a diffuse nuclear localization. (cellimagelibrary.org)
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
One such mechanism may be defective nuclear import of TDP-43 protein, as a disruption of its nuclear localization signal leads to mislocalization and aggregation of TDP-43 in the cytoplasm. (crick.ac.uk)

NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. (hmdb.ca)
An autoimmune response to nuclear and cytoplasmic autoantigens is detected in about 60-80% of patients with polymyositis and dermatomyositis. (medscape.com)
ProteinExt ® Mammalian Nuclear and Cytoplasmic Protein Extraction Kit provides a fast and efficient method to extract nuclear and cytoplasmic proteins from mammalian cells and tissues. (transgenbiotech.com)
In order to explore the factors that regulate the nuclear import of TDP-43, we used a small interfering RNA library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopherin-beta1 and cellular apoptosis susceptibility protein resulted in marked cytoplasmic accumulation of TDP-43. (crick.ac.uk)
U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies. (ox.ac.uk)
The responding samples to H4, displayed increased expression of myeloid markers, a clear decrease in the nuclear-cytoplasmic ratio and the potential of re-activation of the monocytic transcriptional program reducing leukemia propagation in vivo. (lu.se)

8, 2020 Like wrenches made of Legos, SWI/SNF chromatin remodeling complexes tighten or loosen DNA in our cells to control how genes are turned on and made into proteins. (sciencedaily.com)
A common feature, particularly evident for 125- and 160-kDa proteins, was their absence from cap-shaped chromatin marginations, whereas they were present in the areas of remaining decondensed chromatin. (nih.gov)
These results show that, in addition to the well-known chromatin changes, nuclear organization undergoes other rearrangements during the apoptotic process. (nih.gov)
Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. (nih.gov)
One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
DSB sites are preferentially located within chromatin loops, while several proteins that are required for DSB formation (Rec114, Mei4, and Mer2) localize on the chromosome axis (Blat et al. (springer.com)
Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. (bvsalud.org)
The NE tethers large chromatin domains through interaction with the nuclear lamina and other associated proteins. (bvsalud.org)
Here, we show that HGPS-related lamina defects trigger an altered 3D telomere organization with increased contact sites between telomeres and the nuclear lamina, and an altered telomeric chromatin state. (bvsalud.org)
They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)
The first suggests that disruption of the inner nuclear membrane and the nuclear lamina causes disorganization of nuclear chromatin and gene expression, while the second proposes that the mechanical strength of the cell nucleus is disrupted when the nuclear lamina is weakened leading to structural and signaling defects in mechanically stressed tissue such as muscle and heart. (medscape.com)

Confocal micrograph showing the expression of different fluorescent proteins in the stem of a thale cress seedling (Arabidopsis thaliana) used to study in vivo gene expression. (cellimagelibrary.org)

Here, we show that shade light induces the de-phosphorylation and nuclear accumulation of PIF7. (elifesciences.org)
These studies demonstrate a phosphorylation-dependent translocation of PIF7 when plants are in shade and a novel mechanism involving 14-3-3 proteins, mediated by the retention of PIF7 in the cytoplasm that suppresses the shade response. (elifesciences.org)
Nuclear protein peptidyl-prolyl isomerase Pin1-mediated prolyl isomerization can be an essential and novel regulatory mechanism for protein phosphorylation. (bioskinrevive.com)
Recombinant Pin1 Protein in Vitro Peptide and Phosphorylation Mapping. (bioskinrevive.com)
Pin1 proteins had been made in bacterias and in vitro phosphorylation of Ceftobiprole medocaril Pin1 protein was completed by purified recombinant MLK3 from baculovirus as referred to (29). (bioskinrevive.com)
By combinatorial screening using H4 and molecules with defined targets, we demonstrated that H4 induces differentiation by the activation of protein kinase C (PKC) signaling pathway, and in line with this, activates PKC phosphorylation and translocation of PKC to the cell membrane. (lu.se)

mixed-lineage kinase 3 (MLK3) a MAP3K family member phosphorylates Pin1 on a Ser138 site to increase its catalytic activity and nuclear translocation. (bioskinrevive.com)
see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. elegans ), and WNT (see Wnt signaling ), as well as the functions of the SynMuv and mediator proteins (see Transcriptional regulation ). (wormbook.org)

The 14-3-3 proteins are highly conserved in all eukaryotes. (elifesciences.org)
The lamin family of proteins make up the matrix and are highly conserved in evolution. (nih.gov)

The research, performed by Vivien Nagy, a visiting graduate student, André Hoelz, a research associate, and colleagues in Rockefeller University's Laboratory of Cell Biology, uncovered the molecular structure of three interacting proteins that form the centerpiece of the Nup84 complex - an important structural component of the nuclear pore complex. (sciencedaily.com)

This gene encodes a B type nuclear lamin. (nih.gov)
During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. (nih.gov)
Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3. (nih.gov)
This gene provides instructions for making the lamin B1 protein. (medlineplus.gov)
Additionally, an increase in the amount of lamin B1 leads to a hardening of the nuclear envelope. (medlineplus.gov)
This complex includes nuclear membrane integral and associated proteins including emerin, lamin A/C, SUN1, SUN2, nesprin-1, and nesprin-2 that are proposed to form a mechanical link between the nucleoskeleton and cytoskeleton. (medscape.com)

This study examined the roles of hormone-dependent transcription factors (Nuclear Receptors), in accessory gland development, function and male fertility of a genetically tractable insect model, Drosophila melanogaster. (sdbonline.org)
Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway. (ox.ac.uk)
Using Drosophila oogenesis as a model system, we show that mutations in smn cause abnormal nuclear organization in nurse cells and oocytes. (ox.ac.uk)

This selectivity helps protect the DNA and is the job of machines that stud the envelope of the nucleus, called nuclear pore complexes. (sciencedaily.com)
Jan. 31, 2022 The nucleus is guarded by a highly secure door, the so-called nuclear pore, that controls the transport of substances from the cytoplasm to the cell nucleus and back. (sciencedaily.com)
The cyclin D1 proteins primarily remains unpredictable until phospho-Pin1 in the nucleus isomerizes cyclin D1 to a well balanced conformation. (bioskinrevive.com)
This stabilization and retention of IκB in the nucleus resulted in inhibition of NFκB and transcriptional suppression of the critical antiapoptotic protein, survivin. (aacrjournals.org)
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. (prosci-inc.com)
NUP50 is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import.The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. (prosci-inc.com)
Nuclear lamina is a fundamental structure of the cell nucleus and regulates a wide range of molecular pathways. (bvsalud.org)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Firstly, smn germline clones phenocopy mutations for two P body components, Cup and Ovarian tumour (Otu). (ox.ac.uk)
When the same Lmna mutations are induced in mice genetically deficient in the LINC complex protein SUN1, life is extended to more than one year. (bvsalud.org)
In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)
EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
New mutations have been found in the synaptic nuclear envelope protein 1 ( SYNE1 ) gene and in the synaptic nuclear envelope protein 2 ( SYNE2 ) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
Lastly, mutations in the transmembrane protein 43 (TMEM43), also termed LUMA, which binds to emerin and SUN2, has also been reported to cause an EDMD phenotype in a few families. (medscape.com)
Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)

The role of SUN3 in the ER is reinforced by the identification of a protein interaction between SUN3 and the ER membrane-bound transcription factor maMYB. (brookes.ac.uk)
Signaling components affected by metals include growth factor receptors, G-proteins, MAP kinases, and nuclear transcription factors. (cdc.gov)
Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
The extracted proteins are suitable for a variety of downstream applications, including SDS-PAGE, Western blot, ELISA, enzyme-activity assays, immunoprecipitation and transcription factor activity analysis. (transgenbiotech.com)
Previous studies have indicated that KIN17 is involved in global genome repair, DNA replication, transcription and regulation of the cell cycle as part of a multi-protein complex. (spandidos-publications.com)
PRDM9 is a member of the PRDM family of transcription regulators, but unlike other family members, it contains a Krüppel-associated box (KRAB)-related domain that is predicted to be a potential protein interaction domain. (springer.com)
In this study, we set out to find a novel molecular marker of RCC by using hepatocyte nuclear factor 4A (HNF4A), a transcription factor implicated in RCC progression and malignancy, as a blueprint. (lu.se)
Through transcriptomic analyses, we show that the nuclear factor I A (NFIA)-driven transcription network is active in primary RCC and that higher levels of NFIA confer a survival benefit. (lu.se)

Mid-SUN proteins are a neglected family of conserved type III membrane proteins of ancient origin with representatives in plants, animals and fungi. (brookes.ac.uk)

My research focuses on the nuclear envelope in plants. (brookes.ac.uk)
In eukaryotic cells the genetic material is surrounded by a membrane system called the nuclear envelope (NE). (brookes.ac.uk)
Previous higher plant studies have associated them with functions at the nuclear envelope and the endoplasmic reticulum (ER). (brookes.ac.uk)
The Nuclear Envelope is a hallmark of eukaryotic cells. (brookes.ac.uk)
This Frontiers Research Topic aims to highlight recent advances made to examine the role of the nuclear envelope (NE) as the "key border" in plants. (brookes.ac.uk)
A key player in this spatial scattering of chromosomes is the nuclear envelope (NE). (bvsalud.org)

These gatekeepers have proved largely inscrutable to researchers over the years, despite their conspicuously large size (they are made of 30 different proteins, or nucleoporins), but bit by bit, scientists are learning how these machines work. (sciencedaily.com)

NLRP3/cryopyrin is a member of the NOD-like receptor (NLR) protein family that plays a pivotal role in the inflammatory response against pathogens and cellular damage. (nature.com)
Moreover, modulation of the proteins involved in cellular metal homeostasis may help in the regulation of metabolism, adaptability to a diverse range of environmental conditions, and biofortification. (frontiersin.org)
Here, we review progress in the understanding of different subcellular metal transport components in plants and discuss the prospects of regulating cellular metabolism and strategies to develop biofortified crop plants. (frontiersin.org)
Analysis of the expression of chosen nuclear import factors in post-mortem brain samples from patients with TDP-43 positive frontotemporal lobar degeneration, and spinal cord samples from patients with amyotrophic lateral sclerosis, revealed a considerable reduction in expression of cellular apoptosis susceptibility protein in frontotemporal lobar degeneration. (crick.ac.uk)
We propose that cellular apoptosis susceptibility protein associated defective nuclear transport may play a mechanistic role in the pathogenesis of the TDP-43 positive frontotemporal lobar degeneration. (crick.ac.uk)
Although patients may differ in their clinical manifestations, patients do share a propensity to develop autoantibodies directed against nucleic acids and associated nuclear and cellular proteins. (cdc.gov)

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. (nih.gov)

Recently, intracellular microbial sensors have also been identified, including NOD-like receptors and the helicase-domain-containing antiviral proteins RIG-I and MDA5. (nature.com)

Kar2p is localized to the luminal (i.e., noncytoplasmic) face of the ER membrane, yet nuclear fusion must initiate from the cytosolic side of the outer nuclear membrane or the ER membrane with which it is contiguous. (rupress.org)
There is both genetic and biochemical evidence that Kar2p interacts with Sec63p, an ER membrane protein containing both luminal and cytosolic domains that is involved in protein translocation across the membrane. (rupress.org)

Breast cancers HeLa and Pin1 MEF cells had been cultured as referred to previously (13 28 Pin1 constructs had been manufactured in pGEX and pEGFP vectors as well as the deletion mutants of MLK3 had been built in pEBG vector ( SI Components and Strategies ). (bioskinrevive.com)
Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T follicular helper (Tfh) or T helper 17 (Th17) cells. (cipsm.de)
Using a newly developed human neuronal cell model, derived from patient-induced pluripotent stem cells, we find that 2-aminobenzamide histone deacetylase (HDAC) inhibitors increase FXN mRNA levels and frataxin protein in FRDA neuronal cells. (frontiersin.org)
Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. (prosci-inc.com)
We have determined a role for a nuclear protein, called p63, in maintaining placental stem cells ('cytotrophoblast') in their stem cell state. (ca.gov)
Germline and mitotic clonal analysis reveals that both nurse cells and oocytes require SMN to maintain normal organization of nuclear compartments including chromosomes, nucleoli, Cajal bodies and histone locus bodies. (ox.ac.uk)
We will address how repurposing of biological and synthetic components can be used to create artificial cells for development in areas such as fuel production, drug delivery and environmental remediation. (royalsociety.org)

Researchers have also shown that one member of the three-protein structure interacts promiscuously with two nucleoporins as do other proteins in the nuclear pore, supporting a model of a flexible complex that can rearrange itself into different formations. (sciencedaily.com)
PIF7 interacts with 14-3-3 proteins. (elifesciences.org)
We also show that CXXC1 interacts with IHO1, an essential component of the meiotic double-strand break (DSB) machinery. (springer.com)
In S. cerevisiae , this interaction is at least in part provided by Spp1 that directly interacts with both methylated H3K4 near DSB sites and the axis-localized protein Mer2 (Acquaviva et al. (springer.com)

They also describe competing interactions within the Nup84 complex and discuss the possibility of binding promiscuity as a common feature in the nuclear pore complex. (sciencedaily.com)
These findings suggest that more than one assemblage of its elements may be necessary for the function of the nuclear pore complex - to import and export macromolecules including ribosomes and messenger RNA. (sciencedaily.com)
Now that we realize that promiscuity may be a major factor in the nuclear pore complex - that the nucleoporins have different ways of interacting with each other - the complex is no longer just a three-dimensional jigsaw puzzle," Hoelz says. (sciencedaily.com)

Upon activation of MLK3 by known agonists ceramide and TNFα (27) or various other unidentified agonists MLK3 could phosphorylate Pin1 in the S138 site (Fig. S7) and promote its nuclear translocation. (bioskinrevive.com)
sec61 and sec62 mutant alleles that cause similar or more severe protein translocation defects show no karyogamy defects. (rupress.org)
Taken together, these results suggest a direct role for Sec63p, Sec71p, and Sec72p in nuclear membrane fusion and argue against the alternative interpretation that the karyogamy defects result as an indirect consequence of the impaired membrane translocation of another component(s) required for the process. (rupress.org)

OPA1 mediates mitochondrial fusion in cooperation with mitofusins 1 and 2 and participates in cristae remodeling by the oligomerization of two L-OPA1 and one S-OPA1, which then interact with other protein complexes to alter cristae structure. (wikipedia.org)
The SUN1 miniprotein disrupts binding between the endogenous LINC complex SUN and KASH domains, displacing the cardiomyocyte KASH complexes from the nuclear periphery, resulting in at least a fivefold extension in lifespan. (bvsalud.org)

Previous work in this area has been on modeling the assembly structure of the type III secretion system and prediction of the high-resolution structures of homo-oligomeric proteins using limited experimental data from Nuclear Magnetic Resonance (NMR) in order to speed up the process of structure determination. (lu.se)
Molecular mobility in keratin-rich materials monitored by nuclear magnetic resonance: A tool for the evaluation of structure-giving properties. (lu.se)
Molecular dynamics simulations and solid-state nuclear magnetic resonance spectroscopy measurements of C-H bond order parameters and effective correlation times in a POPC-GM3 bilayer. (lu.se)
METHODS: In this single center study conducted from October 2018-2019, lipid constituents from lipoprotein subclasses were quantified by targeted nuclear magnetic resonance spectroscopy. (cdc.gov)

The results highlight the importance of mid-SUNs as functional components of the ER and outer nuclear membrane. (brookes.ac.uk)

This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, and small, round mitochondria. (wikipedia.org)
Insect hormones such as ecdysteroids and juvenoids play a key role in accessory gland development and protein synthesis but little is known about underlying molecular players and their mechanism of action. (sdbonline.org)
For protein synthesis, it seems that the low hormone that stimulates specific nuclear. (afip.org)

I'm using cell and molecular biology techniques, biochemistry as well as microscopy to characterise the plant SUN proteins. (brookes.ac.uk)
Such a model would provide an unprecedented view of the molecular architecture of T3SS by visualizing the placement of its componentswithin the assembly as well as interactions between these components. (lu.se)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)

Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. (wikipedia.org)
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. (wikipedia.org)
It is a component of the mitochondrial network. (wikipedia.org)
The OPA1 protein localizes to the inner mitochondrial membrane, where it regulates mitochondrial fusion and cristae structure. (wikipedia.org)
Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1β release. (nature.com)
TTC triplet in the first intron of the FXN gene, encoding the essential mitochondrial protein frataxin. (frontiersin.org)
TTC triplet repeat expansion in an intron of the nuclear FXN gene, which encodes the essential mitochondrial protein frataxin ( 1 ). (frontiersin.org)

Disruption of the genes encoding other Sec63p-associated proteins (Sec71p and Sec72p) also results in karyogamy defects. (rupress.org)

Many biological processes are controlled by large multi-component protein assemblies, the size and complexity of which typically precludes the determination of their high-resolution structures. (lu.se)
Our goal is to use high-resolution structural modeling techniques guided by constraints taken from lower resolution experimental data to generate structural models of important biological protein assemblies for which high resolution structural determination is unfeasible. (lu.se)

Combination treatment has proven effective for patients with acute promyelocytic leukemia, exemplifying the importance of therapy targeting multiple components of oncogenic regulation for a successful outcome. (lu.se)

Phosphorylated Pin1 protein had been digested with trypsin and peptides had been examined by 2D electrophoresis as referred to (30) ( SI Components and Strategies ). (bioskinrevive.com)
Phosphorylated Pin1 S138 peptides had been used to create Pin1 pS138 antibody in rabbit ( SI Components and Strategies ). (bioskinrevive.com)

While the antibody to the nucleolar isoform of DNA topoisomerase II gave a fluorescent pattern that was well-maintained until the late phases of apoptosis, the other three nuclear antigens showed marked modifications in their distribution. (nih.gov)
The mobility of a fluorescent protein fusion can be assessed using a technique known as fluorescence recovery after photobleaching (FRAP). (microscopyu.com)
Fluorescent protein fusions are the tags of choice for use in FRAP because they can be bleached without detectable damage to the cell. (microscopyu.com)
Section from rat brain cortex showing a subset of fluorescent-protein expressing neurons and microglia. (cellimagelibrary.org)
Z-stack from rat brain cortex showing a subset of fluorescent-protein expressing neurons and microglia. (cellimagelibrary.org)

This study identifies a non-canonical EcR-corepressor complex with the potential for a direct regulation of ATP-dependent nucleosome remodelling by a nuclear hormone receptor. (sdbonline.org)

In addition, we identified proteins that interact with the KRAB domain of PRDM9 in yeast two-hybrid assay screens, particularly CXXC1, a member of the COMPASS complex. (springer.com)

HP1 is a structural component of heterochromatin. (cipsm.de)

In addition to low-resolution models of the intact T3SS core from cryo-electron microscopy, several high-resolution structures of monomeric T3SS components have been determined. (lu.se)

NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. (hmdb.ca)

KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. (spandidos-publications.com)

SMN is critical for small nuclear ribonucleoprotein (snRNP) assembly. (ox.ac.uk)

Male accessory gland is the major source of proteinaceous secretions, collectively called as seminal proteins (or accessory gland proteins), which upon transfer, manipulate the physiology and behavior of mated females. (sdbonline.org)
In conjunction with membrane expansion, mass spectrometry of oligodendrocyte surface proteins revealed that VAMP2/3 incorporates axon-myelin adhesion proteins that are collectively required to form nodes of Ranvier. (stanford.edu)

What pathways are this gene/protein implicaed in? (cancerindex.org)
The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (bvsalud.org)

In glutathione S-transferase pull-down assays, TDP-43 bound to karyopherin-alphas, thereby confirming the classical nuclear import pathway for the import of TDP-43. (crick.ac.uk)
Taken together, our results suggest that SMN is required for the functional integrity of the U body-P body pathway, which in turn is important for maintaining proper nuclear architecture. (ox.ac.uk)

It does so by forming a multiprotein signaling complex, the NLRP3 inflammasome, with apoptosis-associated speck-like protein containing CARD (ASC) and caspase-1 1 . (nature.com)
ER membrane protein complex required for nuclear fusion. (rupress.org)
We propose that an ER/nuclear membrane protein complex composed of Sec63p, Sec71p, and Sec72p plays a central role in mediating nuclear membrane fusion and requires ER luminally associated Kar2p for its function. (rupress.org)
Chromobox homolog 2 (Cbx2), also known as CDCA6 and M33, is an approximately 56 kDa protein component of the nuclear polycomb repressive complex 1 (PRC1). (rndsystems.com)

In this study we focused our attention on the behavior of four nuclear matrix proteins during the various stages of apoptosis in the HL-60 cell line exposed to the DNA topoisomerase I inhibitor, camptothecin. (nih.gov)

These specific aspects are reviewed in this article, with separate attention being paid to small organic molecules and protein therapeutics. (snmjournals.org)
Although microdosing has been associated predominantly with small organic molecules and site-specific labeling, there is growing interest in applying the concept to protein therapeutics and in using some of the exclusive properties of proteins for nuclear imaging purposes. (snmjournals.org)
This article discusses the consequences of the facilitated regulations, the impact of performing studies at very low pharmacologic concentrations, and the differences in regulation and pharmacology between smaller (organic) molecules and larger (protein biologic) molecules. (snmjournals.org)

Anatomy26

Organisms12

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes74

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care1

Localization11

Cytoplasmic6

Chromatin11

Arabidopsis1

Phosphorylation6

Kinase2

Highly conserved2

Interacting proteins that form1

Lamin6

Drosophila4

Nucleus7

Mutations8

Transcription8

Membrane proteins1

Envelope6

Different proteins1

Cellular6

Inner nuclear membrane1

Receptors1

Cytosolic2

Cells7

Interacts4

Pore3

Translocation3

Complexes2

Magnetic Resonance4

Outer nuclear membrane1

Synthesis3

Molecular3

Mitochondrial7

Genes1

Biological2

Promyelocytic leukemia1

Peptides2

Fluorescent5

Remodelling by a nu1

Interact1

Heterochromatin1

Electron1

Homo1

Cell cycle1

Ribonucleoprotein1

Collectively2

Pathways2

Pathway2

Complex4

Behavior1

Molecules3