Components complex mixtures. Medical search. Frequent questions

My research is focussed upon the characterization of complex mixtures using ultrahigh resolution mass spectrometry. (warwick.ac.uk)
Through the molecular characterization of complex mixtures, containing tens of thousands of components, profiles can be established for individual samples, serving as fingerprints. (warwick.ac.uk)

Could implementing a mixture assessment factor improve the regulatory assessment of combination effects of chemicals? (gu.se)
Will a mixture assessment factor improve the regulatory assessment of combination effects of chemicals? (gu.se)
More than 200 participants joined the FRAM zoominar where Prof. Thomas Backhaus presented the result of a project with the Swedish Chemicals Agency about a possible implementation of an additional safety factor considering mixtures in the regulatory assessment of combination effects of chemicals. (gu.se)
Hazardous chemicals do not occur as isolated entities in an otherwise pristine environment but form complex multi-component mixtures, which can easily comprise dozens of chemicals. (gu.se)
The Mixture Assessment Factor (MAF, also termed Mixture Allocation Factor) has been suggested as a pragmatic tool to account for the risks from a mixture already during the risk and safety assessment of individual chemicals. (gu.se)
Currently, she is the project leader for polycyclic aromatic compounds, which are being used as a case study to evaluate the joint action of chemicals with component-based approaches (e.g., dose addition models). (nih.gov)
They have been widely used for the analysis of complex mixtures and purification of chemicals, biochemicals, and pharmaceuticals. (aiche.org)
Commercial flavorings used in the flavoring manufacturing and food production industries are often complex mixtures of flavoring chemicals, many of which are volatile, meaning that they evaporate into the air from their liquid or solid form. (cdc.gov)
Even though flavorings exposures often involve multiple chemicals, diacetyl may serve as a marker or surrogate for mixed exposures to some hazardous flavorings, as it has been an ingredient in butter flavorings mixtures where disease has been observed. (cdc.gov)
it's instead a complex mixture of different-but-related chemicals that started out as dead plants and animals. (smithsonianmag.com)

All the venomous species have a venom gland that synthesizes, stores and secretes a complex mixture of biological molecules including proteins. (nature.com)
It is often a complex mixture that includes proteins, enzymes and baker's additives, which could include sweeteners, coloring, flavoring and other ingredients. (constantcontact.com)
The enzymatic activity of bromelain is primarily attributed to its proteolytic components, which break down proteins into smaller peptides and amino acids. (bcr.org)

The text concludes with new goodness-of-fit methods for assessing parametric models and a discussion of two-level variance component models and finite mixtures. (routledge.com)
This paper tries to improve the finite mixture model and introduces the asymmetric gaussian mixture model into it. (techscience.com)

Opportunities and limitations for untargeted mass spectrometry metabolomics to identify biologically active constituents in complex natural product mixtures. (uib.no)
The fermentation mixture furthermore contains small quantities of complex constituents that can contribute to the flavour of the product even if they are present only in parts per million. (britannica.com)
Reaction products synthesised from constituents of the starting components (expected oligomers) could not be eluted from GC even after derivatisation, indicating that standard GC-MS screening would miss most potential migrants. (who.int)

You can combine components from any manufacturer, analyze and control in detail agent distribution, parts needed, storage options, overpressure vents. (vds.de)
The method applies Bayesian probabilistic model to analyze scattering data from mixtures of oligomeric species, allows for a modeling large structural ensembles, can be used to assess uncertainty of all parameters and minimizes over-fitting. (lu.se)

Assessing potential associations between exposures to complex mixtures and health outcomes may be complicated by a lack of knowledge of causal components of the mixture, highly correlated mixture components, potential synergistic effects of mixture components, and difficulties in measurement. (unc.edu)
We extend recently proposed nonparametric Bayes shrinkage priors for model selection to investigations of complex mixtures by developing a formal hierarchical modeling framework to allow different degrees of shrinkage for main effects and interactions and to handle truncation of exposures at a limit of detection. (unc.edu)

Serving customers through two premier brands, Thermo Scientific and Fisher Scientific, we help solve analytical challenges from routine testing to complex research and discovery. (bionity.com)

therefore, in general, there was no known appreciable health risks from inhalation of these components at the time of this evaluation. (cdc.gov)
Inhalation of butter flavoring chemical mixtures, including diacetyl, has been associated with severe obstructive lung disease popularly know as "popcorn lung. (cdc.gov)

Mineral oil and polyalphaolefin hydraulic fluids are mixtures that have oil in them and will burn. (cdc.gov)
If spilled on soil, some of the ingredients in the hydraulic fluids mixture may stay on the top, while others may sink into the groundwater. (cdc.gov)
Mineral oil and polyalphaolefm hydraulic fluids are mixtures that have oil in them and will burn. (cdc.gov)
The complex flow characteristics of gases or 2-phase mixtures make hydraulic calculations enormously complex. (vds.de)

Knowledge gaps, suitable MAF sizes as well as the general pros and cons of applying the MAF for regulatory mixture risk assessment was also discussed. (gu.se)
She is particularly interested in developing and refining methods for evaluating the toxicity of mixtures to inform risk assessment. (nih.gov)

This presentation discusses the use of new FTIR mixture searching software and simple ATR sample analysis for rapid screening of seized drugs with a focus on using infrared mixture search data to confidently support GC/MS results for more effective expert testimony. (thermofisher.com)
Although simple substances can be identified easily using well-known classical methods such as Fourier-transform infrared spectroscopy (FTIR), analysis becomes more challenging when dealing with complex mixtures. (bioprocessintl.com)

Each differs in detailed composition, but all consist of a mixture of waxes, solvent, and dyes. (wikipedia.org)
Mucus is a complex mixture of components, and keeping the composition right is important," Lieleg said. (upi.com)
2 A strict chemical definition of agar is not presently possible as it is prepared from a number of different red algae, or mixtures thereof, and its composition varies. (fao.org)
At a given temperature and pressure, vapours over a boiling mixture have a composition that is a function of the vapour pressures of the components of the mixture. (britannica.com)

Rider serves as co-chair with Danielle Carlin, Ph.D., of the NIEHS Combined Exposure/Mixtures working group, which aims to advance mixtures research throughout the Institute. (nih.gov)
In addition, laboratory studies document that diacetyl has toxic properties as a single component that parallel the effects of exposure to a butter flavoring mixture. (cdc.gov)

DE is a complex mixture of particulates and gases. (cdc.gov)

Necessary are precise flow measurements for all components and also an exact replica of the system in a simulation. (vds.de)

A mass spectrometer and method of mass spectrometry are disclosed wherein two separate samples are mass analysed and then the relative intensity, concentration or expression level of one or more components, molecules or analytes in a first sample is quantitated relative to the intensity, concentration or expression level of one or more components, molecules or analytes in a second sample. (gc.ca)
2. A method as claimed in claim 1, further comprising providing a plurality of further samples each comprising a mixture of components, molecules or analytes. (gc.ca)

The gaussian mixture model is the most common one. (techscience.com)
The existing image denoising methods usually assume that each component of the natural image is subject to the gaussian mixture model (GMM). (techscience.com)
It is well known that most natural images are complex and their distribution is not entirely gaussian. (techscience.com)
Since the asymmetric gaussian mixture model can simulate the asymmetric distribution on the basis of the gaussian mixture model, it is more consistent with the natural image data, so the denoising effect of the natural complex image is better. (techscience.com)
We carried out image denoising experiments under different noise scales and types, and found that the asymmetric gaussian mixture model has better denoising effect and performance. (techscience.com)
K. Jin and S. Wang, "Image denoising based on the asymmetric gaussian mixture model," Journal on Internet of Things , vol. 2, no.1, pp. 1-11, 2020. (techscience.com)

Specifically, we introduce a set of latent Dirichlet processes as sources of component models (atoms), and for each data set, we construct a nonparametric mixture model by combining sub-sampled versions of the latent DPs. (neurips.cc)

Diacetyl is a prominent chemical ingredient in butter flavorings and is a component of the vapors coming from these and other flavorings. (cdc.gov)
It's certainly brighter than the SmN, but all of the scent components are very balanced, and no single ingredient dominates. (badgerandblade.com)

Empirical data clearly show that the risk of such mixtures exceeds the risk of each mixture component, which is also recognized in policy documents such as the new European chemical strategy for sustainability that was published by the EU Commission in 2020. (gu.se)
In December 2020, FRAM hosted a seminar about what does this strategy meant for chemical mixtures. (gu.se)

Individual components could be observed as protonated molecular ions [M+Na] + and/or as their K + adducts in positive mode. (degruyter.com)
The gaseous components primarily include oxides of carbon, nitrogen, and sulfur, as well as some low molecular weight hydrocarbons. (cdc.gov)
A-TEEM™ Molecular Fingerprinting is a new optical technique that is ideal for comprehensive component analysis in a variety of QC/QA applications, particularly, pharmaceuticals. (horiba.com)
By enabling both time resolution and structural detail Time-Resolved Small Angle X-ray/Neutron Scattering (TR-SAXS/TR-SANS) is uniquely suited to interrogate complex self-assembly reactions and to provide a molecular understanding of self-assembly pathways. (lu.se)

Get precise analysis of complex mixtures with A-TEEM: The spectroscopic tool for speed, sensitivity, and low detection limits. (horiba.com)

The determination of the partition coefficient is not applicable for complex mixtures (UVCB-substance). (europa.eu)
For example, the first successful separation of a substance from a complex mixture is an overwhelming moment. (basf.com)

A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)

These images show distribution of individual chemical components, polymorphs and phases, and variation in crystallinity. (horiba.com)
Often the actual spectrum is quite complex, so comprehensive Raman spectral libraries can be searched to find a match, and thus provide a chemical identification. (horiba.com)
False color images can be created based on the Raman spectrum - these show the distribution of individual chemical components, and variation in other effects such as phase, polymorphism, stress/strain, and crystallinity. (horiba.com)
His curiosity led him to pursue a doctorate in chromatography, a chemical analysis method used to separate and precisely determine the individual components of mixtures of substances. (basf.com)
They may contain a number of chemical components, each with individual chemical properties - and any variation in which ingredients can affect cell culture processes and biological products being manufactured. (bioprocessintl.com)
Many biological processes depend on chemical reactions that are localized in space and time and therefore require catalytic components that self-organize. (lifeboat.com)

Pair interactions between different species in this more complex model drove an instability that spread throughout the three-species system, causing the catalysts to clump together. (lifeboat.com)

This presentation will introduce the fundamental principles of SMB, the methods and tools developed at Purdue to overcome the major barriers, and the applications of the tools in developing a tandem SMB for insulin purification from a ternary mixture. (aiche.org)

The aim is to reduce the need for dedicated and data-demanding scenario-specific mixture risk assessments. (gu.se)
I am mainly working with i) instrumental characterization/profiling of complex multicomponent systems (body fluids and tissue) and development of data-analytical methods and algorithms for resolution, exploration, pattern recognition, discrimination and classification of such systems, and, ii) applications of such methods to solve multifaceted problems of medical and pharmaceutical origin. (uib.no)
Master and PhD projects are provided within the areas of new algortihms and methods for profiling and data analysis of complex systems, and, application of such methods to solve medical and pharmaceutical problems. (uib.no)
Mixture distributions are often used to model complex data. (neurips.cc)
In this paper, we develop a new method that jointly estimates mixture models over multiple data sets by exploiting the statistical dependencies between them. (neurips.cc)
However, the analysis of such data is complicated because scattering arises from a mixture of many components, the information content in each spectrum is limited and there is no framework for simultaneous analysis of data from different data sources. (lu.se)

In vitro testing of the whole mixture for genotoxicity is expected to fail because of the required sensitivity and the glycidyl functions probably wrongly resulting in positive tests. (who.int)

By separating individual components, we generate valuable information about their properties and interactions. (basf.com)
Mixtures of such active catalysts generate complex reaction networks, and the process by which self-organization emerges in these networks presents a puzzle. (lifeboat.com)

Organic matter (OM)is comprised of a complex mixture of substrates, which are difficult to fully characterize. (lu.se)

As mentioned above, a fermentation mixture primarily contains water and ethyl alcohol and distillation involves increasing the percentage of ethyl alcohol in the mixture. (britannica.com)
It is important to retain those components that make a positive contribution to the product and to remove those that are unwanted, primarily some organic aldehydes, acids, esters, and higher alcohols. (britannica.com)

In the FRAM seminar from July 1, our Director Prof. Thomas Backhaus presented an overview of the current ongoing discussion in regulatory policy and science and then presented an algorithm on how the MAF can be estimated from the risk profile of a mixture. (gu.se)

DeMixT uses probabilistic modeling to infer proportions of stromal and cancer-cell components from a set of input samples, comprising both tumor and normal-tissue samples 8 . (nature.com)
These are distinguished from DRUG COMBINATIONS which have only a few components in definite proportions. (reference.md)
However, to satisfy the regulatory requirements, components of the complex mixture need to be identified at lower proportions than those accessible. (who.int)

Ever since I first got involved with chromatography - the separation of a mixture of substances - in my second semester, I knew: this is what I want to do. (basf.com)
A model-based approach is used to develop reversed-phase chromatography (RPC) processes for purifying lispro human proinsulin (lispro-HPI) from a complex multi-component mixture with ~70% impurities and unknown components. (aiche.org)

This is largely due to the ambiguous results it can provide when analyzing seized drugs that are mixtures. (thermofisher.com)

Protein complexes, which are formed as a result of these interactions, consist of two or more components that associate along specific pathways - protein association pathways. (lu.se)

The instrument is suited for trace analysis of important pollutants such as polyaromatic hydrocarbons, creosotes, and polychlorinated biphenyls in complex mixtures. (epa.gov)

SMB, however, has not been widely used for multi-component separation. (aiche.org)
A second barrier is the lack of SMB equipment for multi-component separation. (aiche.org)

A rate model with the reversed-phase modulator isotherm was developed and verified to describe the adsorption behavior of each component at different loading, linear velocities and gradient shapes. (aiche.org)
Each mixture model may acquire atoms from different latent DPs, while each atom may be shared by multiple mixtures. (neurips.cc)
We show that an increasing use of more complex model gives a gradual increase of predictive performance. (lu.se)

Snake venom-secreted phospholipase A2 (svPLA2) enzymes, both catalytically active and inactive, are a central component in envenoming. (bvsalud.org)

The determination of the water solubility according to EU Method A.6 and OECD Guideline 105 was not successful due to the fact that L-threonine mother liquor has a complex compostion with individual water solubilities of the separate components. (europa.eu)
Inside, the samples are split into their individual components. (basf.com)

And now with this new compliance package, A-TEEM is a spectroscopic solution that can be used to identify low level components in complex mixtures or identify contaminants and out of spec product and offers end-to-end coverage for a GMP environment. (horiba.com)

The aim of this report was to provide an overview of the recent scientific information on the need for an additional mixture assessment factor (MAF), in order to account for combination/mixture effects during the evaluation of risks for humans and the environment. (gu.se)

With mixtures, relative peak intensities provide information about the relative concentration of the components, while absolute peak intensities can be used for absolute concentration information. (horiba.com)

The [5 + 2] cycloaddition is one of the most efficient ways to access seven-membered rings since the two-carbon components (alkenes, alkynes, or allenes) are readily available. (degruyter.com)
Vinylcyclopropane (VCP) as the five-carbon component for [5 + 2] cycloadditions. (degruyter.com)
Buried deep in the earth and placed under heat and pressure for millions of years, their bodies break down and the hydrogen and carbon rearrange into the components of oil. (smithsonianmag.com)

She is also leading an effort to inform the safety evaluation of complex mixtures. (nih.gov)
A description of the instrumental components is given and an evaluation of the instrument using anthracene and several oil samples is provided to illustrate the usefulness of the instrument. (epa.gov)

Toward this goal, she is using botanical dietary supplements, such as Ginkgo biloba extract, to develop methods for determining sufficient similarity of complex mixtures. (nih.gov)

Various polymers, typically acrylates, are the next major component, conferring gloss and holding the dyes in suspension. (wikipedia.org)
Typically, low-melting paraffin wax is melted, followed by the higher melting waxes, and finally the colorant-stearate mixture. (wikipedia.org)

Separation of the steroidal components of I-tiam-hong (Nervilia purpurea SCHLECHTER and Nervilia aragona GAUD) and Cordyceps sinensis (BEAK. (go.jp)

Straight-forward mass characterization of the complex mixtures could be achieved. (degruyter.com)

Interaction Metabolomics to Discover Synergists in Natural Product Mixtures. (uib.no)

The first stop for your procurement process: discover innovative products for lab and process that make your everyday life easier and solve even complex challenges. (bionity.com)

Poland) Control of complex combustior processes. (cia.gov)

Fig. 1 - Microspec's ability to extrude advanced medical tubing with complex shapes and many lumens makes it possible to accomplish more in a single device. (medicaldesignbriefs.com)

At the These samples would be pooled and processed by using outset, researchers wanted to determine whether viruses as available technology to isolate virus particles en masse, a class differed in a systematic way from all other small recover viral nucleic acids, produce amplified shotgun particles in nature. (cdc.gov)

The treatments are presented in order from the easiest to implement to the more complex and difficult. (dot.gov)

When the sedimentation coefficients of libraries, carry out shotgun sequencing of the mixture of then-known viruses were plotted against their isopycnic viral genomes, and reconstruct these genomes in silico banding densities, nearly all viruses fell into an otherwise with the techniques originally developed to sequence the essentially vacant area in the center of the plot, surround- entire human genome from random fragments. (cdc.gov)

Editor's Note: Microspec's advanced 28 lumen tubing was spotlighted in an article in the March issue of Medical Design Briefs, www.medicaldesignbriefs.com/component/content/article/1105-mdb/features/21704 . (medicaldesignbriefs.com)

A major barrier is the lack of efficient methods and tools to design SMB that can recover a product with high purity and high yield from a mixture of three or more components. (aiche.org)
At the same time, marine virologists have devel- oped efficient methods for concentrating, amplifying, and sequencing complex viral mixtures obtained from the ocean. (cdc.gov)

Anatomy6

Organisms4

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Psychiatry and Psychology1

Phenomena and Processes29

Disciplines and Occupations4

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Characterization of complex2

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