• Central obesity, incident microalbuminuria and change in creatinine clearance in the epidemiology of diabetes interventions and complications study. (edu.pk)
  • However, even in the absence of the hyperglycaemic state which characterizes type 2 diabetic patients, non diabetic individuals with a specific form of obesity, named abdominal obesity, often show clustering metabolic abnormalities which include high triglyceride levels, increased apolipoprotein B, small dense low density lipoproteins and decreased high density lipoproteins-cholesterol levels, a hyperinsulinemic-insulin resistant state, alterations in coagulation factors as well as an inflammatory profile. (researchgate.net)
  • Post-mortem analyses of coronary arteries have indicated that obesity (associated with a high accumulation of abdominal fat measured at autopsy) was predictive of earlier and greater extent of large vessels atherosclerosis as well as increase of coronary fatty streaks. (researchgate.net)
  • Metabolic syndrome linked to abdominal obesity is also predictive of recurrent coronary events both in post-myocardial infarction patients and among coronary artery disease men who underwent a revascularization procedures. (researchgate.net)
  • Soon after the introduction of atypical antipsychotics, which antagonize serotonin receptors and dopamine D 2 receptors (D 2 R), numerous case reports appeared showing that the use of these drugs were associated with increased obesity and the development of type 2 diabetes mellitus (T2DM) ( 5 ). (frontiersin.org)
  • One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
  • This nutrient protects vital cellular energy and shields against diabetes, obesity, cardiovascular disease, and neurodegeneration. (lifeextension.com)
  • In this report, you will discover how the alpha lipoic acid benefits vital cellular energy while shielding against and possibly reversing the damaging effects of disorders that include diabetes, obesity, cardiovascular disease, neurodegeneration, and cancer. (lifeextension.com)
  • screening for comorbidities of obesity should be applied in a hierarchal, logical manner for early identification before more serious complications result. (medscape.com)
  • Among the main causes of the in prevention, early diagnosis, inter- per year are attributable to over- alarming increase in the prevalence disciplinary treatment, adherence to weight and obesity [1, 2]. (who.int)
  • Obesity of obesity, researchers around the treatment, and control and preven- is a major public health problem, world have recognized important tion of complications [13]. (who.int)
  • The purpose of this chapter is achieved significant decreases in changes in supply, prices, distribu- to review the main opportunities the prevalence of obesity during tion, energy density, and preparation that have been identified in the lit- the past 33 years [1]. (who.int)
  • For example, the effectiveness of taurine on diabetes mellitus alone include reducing insulin resistance and complications such as retinopathy, nephropathy, neuropathy, atherosclerosis and cardiomyopathy, and other antidiabetic effects independent of hypoglycemia, as reported in various animal models. (life-enhancement.com)
  • Diabetes mellitus refers to a set of chronic metabolic conditions which is determined by increased blood sugar levels due to the body's inability to produce enough insulin or due to its insulin resistance (American Diabetes Association 2006) . (ac.ir)
  • ABSTRACT This study aimed to develop a simple risk score to identify individuals at high risk for undiagnosed diabetes in the Kuwaiti adult population and to assess the performance of previously published diabetes risk scores. (who.int)
  • Diabetes mellitus is a chronic metabolic condition characterised by persistent hyperglycaemia with resultant morbidity and mortality related to its associated microvascular and macrovascular complications. (scielo.org.za)
  • Chronically, microvascular and macrovascular complications are the major reasons for increasing morbidity and mortality in patients with diabetes. (spandidos-publications.com)
  • 9 , 10 When associated with diabetes, depression increases the risks of work loss, 11 functional disability, 11 , 12 and micro- 13 and macrovascular complications, 14 and adds to health care costs. (cmaj.ca)
  • Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
  • Acute disorders of cerebral circulation (strokes) are one of the long-known complications of diabetes, which, along with other macrovascular complications, such as myocardial infarction and damage of peripheral arteries are the main cause of death in patients with type 2 diabetes. (org.ua)
  • These factors contribute individually and collectively to diabetic macrovascular complications. (j-stroke.org)
  • Coronary atherosclerosis appears in the majority of the diabetes population, with the mortality of up to 20% diabetic subjects caused by myocardial infarction ( 9 ). (spandidos-publications.com)
  • in particular, MS gives an almost twice increased risk for coronary heart disease, 2 a two- to threefold increased risk for future ischaemic stroke 3 and an even greater risk for diabetes. (bmj.com)
  • As a consequence, there has also been a marked increase in the prevalence of type 2 diabetes all over the world and this chronic metabolic disease is now considered as a coronary heart disease risk equivalent. (researchgate.net)
  • Lesion reference to AHA types V and VI was discarded, because it failed to account for the 3 different morphologies (rupture, erosion, and calcified nodule) that give rise to acute coronary thrombosis. (medscape.com)
  • Acute coronary syndrome (ACS) is a cardiovascular disease, which describes any condition characterized by signs and symptoms of sudden myocardial ischaemia and reduction in blood flow to the heart [ 1 ]. (hindawi.com)
  • The objective of this study was to assess the relationship between glycemic variability determined by a continuous glucose monitoring (CGM) system and the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). (biomedcentral.com)
  • In 344 T2DM patients with chest pain, coronary angiography revealed CAD (coronary stenosis ≥ 50% luminal diameter narrowing) in 252 patients and 92 patients without CAD. (biomedcentral.com)
  • However, there have been no sufficient studies presented so far that specifically evaluated the relationship between glycemic variability and coronary artery disease in diabetic patients. (biomedcentral.com)
  • In this study, we examined the parameters of glucose profile using continuous glucose monitoring system (CGMS) in T2DM patients with CAD, and established a correlation between glycemic variability and the severity of coronary artery disease assessed by coronary angiogram, using the Gensini score. (biomedcentral.com)
  • Statin drugs represent the major improvement in the treatment of hypercholesterolemia that constitutes the main origin of atherosclerosis, leading to coronary heart disease. (degruyter.com)
  • Over 80% of patients with coronary artery (CA) dilatations had improved outcome. (cdc.gov)
  • Diabetes mellitus (DM) could be classified as type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM) and others according to etiology and pathology. (biomedcentral.com)
  • To investigate the relation between echocardiographic parameters and 24-hour ambulatory blood pressure monitoring (ABPM) in normoalbuminuric pre-hypertensive adults with type 1 diabetes mellitus (T1DM) without clinical evidence of nephropathy or cardiovascular autonomic neuropathy. (ispub.com)
  • Adult patients who were diagnosed as T1DM and pre-hypertensive were categorized as dippers and non-dippers on the basis of 24-hour ambulatory blood pressure measurement and their echocardiographic parameters were compared. (ispub.com)
  • Of the 23 T1DM pre-hypertensive patients, 11 were categorized as dippers and 12 as nondippers. (ispub.com)
  • There were no differences between the dipper and the nondipper T1DM pre-hypertensive patients with respect to age, gender, body mass index, clinical and ABPM for average day-time systolic and diastolic blood pressure levels. (ispub.com)
  • Left atrial diameter and LV mass index were found higher in the nondipper T1DM patients. (ispub.com)
  • Among prehypertensive T1DM patients evaluated by ambulatory BP monitoring, nondippers had higher LV mass index and left atrial dimensions compared with dippers. (ispub.com)
  • Elevated blood pressure levels are more frequently observed in patients with Type 1 diabetes mellitus (T1DM) than in the general population ( 5 , 6 , 7 ). (ispub.com)
  • To the best of our knowledge the echocardiographic correlates of ABPM has never been reported in uncomplicated prehypertensive T1DM patients. (ispub.com)
  • Recently, we demonstrated that deficiency or inhibition of AR caused significant dephosphorylation of hepatic PPAR α , leading to the activation of this transcriptional factor as well significant reduction in serum TG levels in streptozotocin-(STZ-) diabetic mice, an experimental model for type I diabetes mellitus (T1DM) [ 17 ]. (hindawi.com)
  • Diabetes mellitus and progression of vascular brain lesions and brain atrophy in patients with symptomatic atherosclerotic disease. (ima-press.net)
  • Previous studies have reached conflicting conclusions on this issue, some supporting our findings and others not, but an Editorial by Peter Sklar & Henry Mazur says taken in aggregate, the weight of the evidence suggests that HIV-infected patients treated with combination antiretroviral regimens are at increased risk for the development of premature atherosclerotic complications. (natap.org)
  • The presence of atherosclerotic plaque in some IAs and similar histological and biochemical features of aneurysms and atherosclerotic lesions suggest that atherosclerosis may be a mechanism in the pathogenesis of IAs. (surgicalneurologyint.com)
  • 1 , 2 The majority of these deaths are attributed to atherosclerotic cardiovascular (CV) disease in particular. (bmj.com)
  • The term atherosclerosis is derived from the Greek "athero," meaning gruel, or wax, corresponding to the necrotic core area at the base of the atherosclerotic plaque, and "sclerosis" for hardening, or induration, referring to the fibrous cap of the plaque's luminal edge. (medscape.com)
  • The etiology of atherosclerosis is unknown, but there are multiple factors that contribute to atherosclerotic plaque progression. (medscape.com)
  • The study has been carried out prospectively on 46 patients affected by hemodynamically significant atherosclerotic renal artery stenosis, detected by Magnetic Resonance Angiography or Selective Digital Angiography. (biomedcentral.com)
  • Background: One of the most important complications of Type 2 diabetes mellitus is diabetic nephropathy which is reported as the leading cause of premature deaths due to renal failure. (edu.pk)
  • The group of 27 patients, 67.33 ± 6.8 years of age, creatinine of 2.15 ± 0.9 mg/dl, following stenting, were followed at intervals with biochemical tests, renal scintigraphy and doppler ultrasonography. (biomedcentral.com)
  • Based on renal scintigraphy and Ccr at subsequent times, it was possibile to evaluate the timecourse of renal function in both kidneys of the stented patients. (biomedcentral.com)
  • Stenting of RAS due to atherosclerosis is followed by stabilization or improvement of Ccr, mainly at the stented kidney, while contralateral renal function showed a decrease. (biomedcentral.com)
  • 27 patients (diabetes mellitus in 8 cases) were subjected to stenting of the stenotic renal artery while 19 patients (diabetes mellitus in 9 cases) were kept on medical treatment only. (biomedcentral.com)
  • In this longitudinal cohort study of patients with T2DM, 3,188 patients with preserved renal function were followed up for the occurrence of incident CKD. (e-dmj.org)
  • The focus of this paper was to review the effectiveness of pharmacological antagonists or agonists of adrenoceptors (α1, α2, ß1, ß2, and ß3) and renal denervation on atherosclerosis. (bvsalud.org)
  • The role of renal denervation in atherosclerosis inhibition in humans is yet to be established. (bvsalud.org)
  • Nephropathy in diabetes (Position Statement). (edu.pk)
  • Gall M A, Hougaard P, Borch-Johnsen K, Parving H H. Risk factors for development of incipient and overt diabetic nephropathy in patients with non-insulin dependent diabetes mellitus, BMJ 1997;314(7083):783-8. (edu.pk)
  • Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
  • Diabetic nephropathy (DN) is one of the most serious complications of DM. (biomedcentral.com)
  • This association conveys a significant increase in morbidity and mortality due to atherosclerosis, microvascular complications such as retinopathy, nephropathy and premature cardiovascular disease ( 6 , 7 ). (ispub.com)
  • Evolution of spironolactone plus hydrochlorothiazide in reducing proteinuria in type 2 diabetic nephropathy. (edu.iq)
  • Ruggenenti P, Remuzzi G. Nephropathy of type 2 diabetes mellitus. (edu.iq)
  • Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes study (UKPDS 64). (edu.iq)
  • The rapid increase in the incidence of diabetes mellitus has led to heightened public concern over prevention and treatment [1]. (who.int)
  • The objective of our study was to evaluate whether people with diabetes have a greater incidence of depression than those without diabetes. (cmaj.ca)
  • The incidence of new-onset depression was similar in both groups (6.5 v. 6.6 per 1000 person-years among people with and without diabetes, respectively). (cmaj.ca)
  • Little information is currently available on the obverse of that temporal chain: the incidence of depression among people who have diabetes. (cmaj.ca)
  • We therefore conducted a population-based retrospective cohort study to evaluate the incidence of new-onset depression among people with diabetes, compared with those who do not have diabetes. (cmaj.ca)
  • The incidence of childhood onset type 1 diabetes is increasing in many countries in the world, at least in the under 15-year-old age group. (bvsalud.org)
  • There are strong indications of geographic differences in trends but the overall annual increase is estimated to be around 3%.Two international collaborative projects, the Diabetes Mondiale study (DiaMond)1 and the Europe and Diabetes study (EURODIAB) 2 have been instrumental in monitoring trends in incidence. (bvsalud.org)
  • Of the estimated 480,000 children with type 1 DM, 24% come from the South-East Asian Region, but the European Region, where the most reliable and up-to-date estimates of incidence are available, comes a close second (23%) 3 .The incidence rate of type 1 DM in India is 4.2/100,000 population per year. (bvsalud.org)
  • 1 Considering these factors, it is not surprising that individuals with SCI have been found to have an increased incidence of conditions associated with physical inactivity. (dovepress.com)
  • The most common symptoms of type 1 diabetes mellitus (DM) are polyuria, polydipsia, and polyphagia, along with lassitude, nausea, and blurred vision, all of which result from the hyperglycemia itself. (medscape.com)
  • Neuropathy affects up to 50% of patients with type 1 DM, but symptomatic neuropathy is typically a late development, developing after many years of chronic prolonged hyperglycemia. (medscape.com)
  • Insulin detemir is indicated for once-daily or twice-daily subcutaneous administration in individuals with type 1 DM who require long-acting basal insulin for hyperglycemia control. (medscape.com)
  • Diabetes is a methabolic disease characterized by hyperglycemia, with high morbidity and mortility worldwide. (scialert.net)
  • Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
  • Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
  • Diabetes mellitus (DM) comprises a group of common metabolic disorders that share the salient feature of hyperglycemia. (bvsalud.org)
  • Patients with hyperglycemia are at a high risk of cardio- and cerebrovascular diseases. (j-stroke.org)
  • Patients with hyperglycemia or diabetes mellitus (DM) are at high risk of cerebrovascular ischemic stroke [ 4 , 5 ]. (j-stroke.org)
  • The paper sets forth the data available in the literature on the prevalence, pathogenesis, and clinical features of cognitive impairment (CI) in diabetes mellitus (DM). (ima-press.net)
  • The pathogenesis of CI in DM is largely due to the development of vascular complications. (ima-press.net)
  • There is a common pathogenesis between diabetes and periodontal disease involving an enhanced inflammatory response at both local and systemic level. (the-probe.co.uk)
  • This review, based on an analysis of the latest available studies, discusses the etiology, pathogenesis, and risk factors for stroke in patients with diabetes mellitus. (org.ua)
  • Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. (spandidos-publications.com)
  • The main risk factor raising the mortality and morbidity of type 1 DM is cardiovascular complications. (spandidos-publications.com)
  • Herbal and traditional Chinese medicine have also exhibited a strong impact on treatment of cardiovascular complications in diabetes ( 17 ). (spandidos-publications.com)
  • One percent reduction in glycosylated hemoglobin reduces microvascular complications by 40% and serum lipid control can reduce cardiovascular complications by 20% to 50% (Deshpande, Harris- Hayes & Schootman 2008) . (ac.ir)
  • We tried to identify the interaction between dietary quality indices and apolipoprotein B Ins/Del and EcoR1 polymorphisms on cardio-metabolic risk factors in patients with type 2 diabetes mellitus (T2DM). (researchsquare.com)
  • This cross-sectional study recruited 700 adults with T2DM who visited diabetes referral centers in Tehran. (researchsquare.com)
  • For the first time, our finding indicated that the association between DQI-I, HEI-2015 and DPI with IL-18, TC, leptin and 8-iso-PGF2α in patients with T2DM might be dependent on Ins/Del and EcoR1 variants in ApoB gene. (researchsquare.com)
  • Type 2 diabetes mellitus (T2DM) and depression are significant public health and socioeconomic issues. (frontiersin.org)
  • Approximately 31% of patients with T2DM suffer from depressive symptoms, with 11.4% having major depressive disorders, which is twice as high as the prevalence of depression in patients without T2DM. (frontiersin.org)
  • Conversely, the D 2 R agonist bromocriptine, which has been used for over 40 years to treat Parkinson's disease and hyperprolactinemia ( 6 ), was found to lower blood glucose levels and improve insulin sensitivity in patients with T2DM ( 7 ). (frontiersin.org)
  • The intraday glycemic variability is associated with the presence and severity of CAD in patients with T2DM. (biomedcentral.com)
  • Although alterations in the methionine metabolism cycle (MMC) have been associated with vascular complications of diabetes, there have not been consistent results about the levels of methionine and homocysteine in type 2 diabetes mellitus (T2DM). (biomedcentral.com)
  • These results can be interpreted to mean that both methionine and homocysteine will accumulate in patients with T2DM, who regularly consume high-methionine foods. (biomedcentral.com)
  • It is known that diabetes, type II diabetes mellitus (T2DM) in particular, is often associated with hepatic accumulation of triglycerides in both rodents and humans, which might eventually lead to the development of hepatic steatosis or nonalcoholic fatty liver disease (NAFLD) [ 14 - 16 ]. (hindawi.com)
  • However, the causal relationship between NAFLD and CKD is uncertain, particularly in patients with type 2 diabetes mellitus (T2DM). (e-dmj.org)
  • We aimed to investigate the association between the presence and severity of NAFLD and incident CKD in patients with T2DM. (e-dmj.org)
  • Advanced liver fibrosis in patients with NAFLD is independently associated with an increased risk of incident CKD in patients with T2DM. (e-dmj.org)
  • NAFLD is highly prevalent in patients with type 2 diabetes mellitus (T2DM), with a prevalence of 50% to 75% [ 4 , 5 ]. (e-dmj.org)
  • Adeghate E, Schattner P, Dunn E. An update on the etiology and epidemiology of diabetes mellitus. (edu.pk)
  • Here we briefly reviewed the characteristic and etiology of these complications emphasizing on cerebrospinal fluid. (scialert.net)
  • 60 mL/min/1.73 m 2 for 3 months or more) or albuminuria (urinary albumin-to-creatinine ratio ≥ 30 mg/g) in the setting of DM [ 2 ], is one of the most serious complications of DM. (biomedcentral.com)
  • Determination of the type of diabetes is based on history, therapy, and clinical judgment. (medscape.com)
  • Such knowledge could influence clinical practice by suggesting who would most effectively be screened for depression and by evaluating ways to prevent people with diabetes from becoming depressed, in order to decrease both the patients' risk of complications and the cost of the ensuing treatments. (cmaj.ca)
  • The purpose of this study was to evaluate clinical and morphological factors affecting atherosclerosis of an aneurysm and identify the parameters that predict aneurysm stabilization. (surgicalneurologyint.com)
  • K/DOQ1 clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. (edu.iq)
  • The aim of this study was to assess the mRNA expression of MIF gene and its serum levels in the clinical manifestations of ACS and unrelated individuals age- and sex-matched with patients as the control group (CG). (hindawi.com)
  • There is increasing evidence from clinical and experimental studies for a causative role of chronic inflammation in initiation and progression of atherosclerosis [ 10 ], where the release of cytokines from platelets, immune, endothelial and smooth muscle cells play a key role [ 10 , 11 ]. (hindawi.com)
  • Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. (jhsmr.org)
  • Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. (jhsmr.org)
  • 5 Ongoing clinical trials across the globe show the promise of lipoic acid's benefits on a wide range of diseases-from diabetes to cardiovascular disease to Alzheimer's and countless more. (lifeextension.com)
  • Over 15 randomized clinical studies have shown that intravenous administration of 300-600 mg of lipoic acid a day greatly improves nerve function and relieves pain symptoms in diabetic neuropathy patients. (lifeextension.com)
  • 16-20 In a recent placebo-controlled clinical trial, researchers found that after only 6 months of lipoic acid supplementation, patients with type II diabetes had reduced fasting blood glucose and lowered levels of oxidized lipids. (lifeextension.com)
  • Several classes of drugs are used for diabetes management in clinical practice. (j-stroke.org)
  • We also discuss evidence from recent large clinical trials of thiazolidinedione (TZD) and new antidiabetic medications such as dipeptidyl peptidase-4 (DPP4) inhibitors, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and glucagonlike peptide-1 (GLP1) analogues, which suggest the potential of these agents in primary and secondary stroke prevention. (j-stroke.org)
  • Patients using a pump or a multiple-injection regimen have a basal insulin (taken through the pump or with the injection of a long-acting insulin analogue) and a premeal rapid-acting insulin, the dose of which may be determined as a function of the carbohydrate count plus the correction (to adjust for how high the premeal glucose level is). (medscape.com)
  • Long-acting and ultralong-acting insulins have a very long duration of action and, when combined with faster-acting insulins, provide better glucose control for some patients. (medscape.com)
  • Prevention of hypoglycaemia is an important part of diabetes mellitus management and strategies include patient education, glucose monitoring, appropriate adjustment of diet and medications in relation to everyday circumstances including physical exercise, and the application of new technologies such as real-time continuous glucose monitoring, modified insulin pumps and the artificial pancreas. (nature.com)
  • The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. (spandidos-publications.com)
  • Diabetes mellitus (DM) is a metabolic disease in patients with high blood glucose over prolonged period ( 1 ). (spandidos-publications.com)
  • Traditionally diabetes has been diagnosed following a fasting blood glucose or a glucose tolerance test. (the-probe.co.uk)
  • 13 , 15 Diabetes with comorbid depression is also linked with poorer adherence to medications and self-care activities such as self-monitoring of blood glucose levels and adhering to a proper diet and exercise program. (cmaj.ca)
  • Traditionally this has involved studying both central and peripheral molecules involved in hunger and satiety, such as leptin, orexin (also known as hypocretin), insulin, alpha-melanocyte-stimulating hormone (α-MSH), glucagon-like peptide -1 (GLP-1), amylin, glucose-dependent insulinotropic polypeptide (GIP, also known as a gastric inhibitory polypeptide), adiponectin and cholecystokinin (CCK). (frontiersin.org)
  • Human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. (lww.com)
  • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. (edu.iq)
  • The patients had their saliva collected and evaluated for glucose, cholesterol, total protein and albumin. (bvsalud.org)
  • The liver has an essential part in the maintenance of glucose homeostasis [ 1 ]. (biomedcentral.com)
  • Diabetes patients requiring glucose-lowering therapy and nondiabetics with a prior myocardial infarction carry the same cardiovascular risk: a population study of 3.3 million people. (org.ua)
  • Prevalence and prediction of unrecognised diabetes mellitus and impaired glucose tolerance following acute stroke. (org.ua)
  • Disorders of glucose metabolism in acute stroke patients: an underrecognized problem. (org.ua)
  • Glucose variability is one of components of the dysglycemia in diabetes and may play an important role in development of diabetic vascular complications. (biomedcentral.com)
  • Therefore, in order to assess the risk of diabetes, it may be necessary to evaluate not only the mean level of glycemic control, but also the extent of glucose excursions. (biomedcentral.com)
  • Lipoic acid's benefits in diabetic neuropathy-and in diabetes as a whole-arise from its striking ability to dramatically improve glucose control and restore insulin sensitivity. (lifeextension.com)
  • Currently, results are available from two studies with TZD focusing on cardiovascular diseases, including stroke, and from 12 cardiovascular outcome trials focusing on major adverse cardiovascular events associated with new antidiabetic agents (four with dipeptidyl peptidase-4 inhibitors, three with sodium-glucose cotransporter-2 inhibitors, and five with glucagon-like peptide-1 analogues). (j-stroke.org)
  • Instability of blood glucose, blood pressure, and probably, lipid profile can be detrimental to the health of diabetic patients. (ac.ir)
  • The polyol pathway is a glucose metabolic shunt that is defined by two enzymatic reactions catalyzed by aldose reductase (AR, AKR1B1, EC1.1.1.21) and sorbitol dehydrogenase (SDH, EC1.1.1.14), respectively [ 1 , 2 ]. (hindawi.com)
  • Methods: We conducted a prospective case-control study in which we inclu ded 200 subjects divided into 100 patients with type 2 diabetes and 100 controls in apparent good health. (scirp.org)
  • Methods: 32 children with type 1 diabetes mellitus formed the study group (DC) and 32 non-diabetic children formed the control group (ND). (bvsalud.org)
  • METHODS: The nationwide Japanese KD survey contained substantial information on KD patients with CALs detected at admission and who received standard IVIG treatment within 10 days of disease onset. (cdc.gov)
  • Microalbuminuria in patients with NIDDM: An overview. (edu.pk)
  • Abnormal cholesterol distribution among lipoprotein fractions in normolipidemic patients with mild NIDDM. (thieme-connect.de)
  • The two broad categories of DM are designated as type1 (IDDM) and type 2 (NIDDM). (bvsalud.org)
  • Carotid artery disease in NIDDM diabetes. (who.int)
  • Epidemiology of ischemic stroke in patients with diabetes: the greater Cincinnati/Northern Kentucky Stroke Study. (org.ua)
  • Diabetes constitutes one of the major independent cardiovascular risk factors, and patients with this disease suffer from premature cardiovascular morbidity and mortality. (scirp.org)
  • 41 ] Rupture of an IA occurs in relatively young people and has a high fatality and morbidity rate, but the majority of patients with incidentally detected IA have a benign course. (surgicalneurologyint.com)
  • The study population consisted of 60 diagnosed type II diabetic subjects and 60 age- and sex-matched controls. (scielo.org.za)
  • Whereas coma and seizures are well-recognized neurological sequelae of hypoglycaemia, much interest is currently focused on the potential for hypoglycaemia to cause dangerous and life-threatening cardiac complications, such as arrhythmias and myocardial ischaemia, and whether recurrent severe hypoglycaemia can cause permanent cognitive impairment or promote cognitive decline and accelerate the onset of dementia in middle-aged and elderly people with diabetes mellitus. (nature.com)
  • AR/the polyol pathway have been demonstrated to play important roles in the development and progression of diabetic complications in a number of tissues including kidney, retina, lens, and peripheral neuron tissues [ 3 - 5 ]. (hindawi.com)
  • Oxidative stress in diabetes mellitus of the 2nd type and its correction. (ima-press.net)
  • However, polysaccharides in Gram negative bacteria stimulate the production of cytokines and oxidative stress is critical in the development of diabetic complications (8). (the-probe.co.uk)
  • The study hypothesized that oxidative by-product like hydrogen peroxide (H 2 O 2 ), would reacts with hemoglobin (Hb) and help to initiate autoimmunity in patients with type 1 diabetes. (scialert.net)
  • In view of these, the present study was hypothesized that oxidative by-products like hydrogen peroxide, would react with Hb and help to initiate autoimmunity in patients with type 1 diabetes mellitus. (scialert.net)
  • patients: oxidative rules at which a onset increases with a goal order. (siriuspixels.com)
  • The nervous system complications in diabetes mellitus with special reference to cerebrovascular changes. (ima-press.net)
  • Diabetes leads to numerous complications associated with the heart, including ischemic heart disease, peripheral vascular disease, and cerebrovascular disease ( 3 ). (spandidos-publications.com)
  • Diabetes patients also have poor outcomes after cerebrovascular disease development. (j-stroke.org)
  • Cardiovascular outcomes in trials of oral diabetes medications: a systematic review. (ima-press.net)
  • Peters SA, Huxley RR, Woodward M. Diabetes as a risk factor for stroke in women compared with men: a systematic review and meta-analysis of 64 cohorts, including 775,385 individuals and 12,539 strokes. (org.ua)
  • Assessing the metabolic control of the patient has traditionally been done through testing of glycosylated hemoglobin, fructosamine, and glycoalbumin along with other criteria such as Body Mass Index, microalbuminuria and dyslipidemia 6-7 . (bvsalud.org)
  • Okoduwa SIR, Umar IA, Ibrahim S, Bello F, Habila N. Age-dependent alteration of antioxidant defense system in hypertensive and type-2 diabetes patients. (jhsmr.org)
  • As well as Gestational Diabetes , during pregnancy and other, associated with other diseases, drug use or genetics for Indian and African peoples. (the-probe.co.uk)
  • Recent research has shown as close inter-relation between diabetes and periodontitis, the one affecting the other and vice versa, a two-way street between these diseases (10,11). (the-probe.co.uk)
  • Using a large, population-based administrative cohort, we found little evidence that type 2 diabetes increases the risk of depression once comorbid diseases and the burden of diabetes complications were accounted for. (cmaj.ca)
  • I ask, Why have you left this section about your diseases blank, when you are taking three medications for high blood pressure, two for diabetes, and a statin? (drmcdougall.com)
  • 1 Moreover, taurine is a potent inhibitor of protein glycation and formation of AGEs (advanced glycation endproducts) that are responsible for many of the complications of diabetes as well as contributing importantly to other age-associated diseases. (life-enhancement.com)
  • 3 Spondyloarthropathies are a group of various rheumatic diseases of which ankylosing spondylitis (ASp) and psoriatic arthritis (PsA) are the most frequently occurring disorders ( table 1 ). (bmj.com)
  • Proteinuria and other markers of chronic Kidney disease: a position statement of the national Kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK). (edu.iq)
  • Proinflammatory actions of MIF have been reported in various inflammatory diseases such as sepsis, rheumatoid arthritis, and atherosclerosis [ 16 , 17 ]. (hindawi.com)
  • These liver diseases are regarded as major contributors to death among diabetic patients [ 9 ]. (biomedcentral.com)
  • Type 2 Diabetes Mellitus and Impact of Heart Failure on Prognosis Compared to Other Cardiovascular Diseases: A Nationwide Study. (org.ua)
  • target: catalog of the Candidate and elevated diseases after Medial of a mellitus system. (siriuspixels.com)
  • Pharmaceutical companies are focusing massive resources to develop a drug that targets mitochondrial dysfunction , 1 one of the major causes of the chronic diseases of aging. (lifeextension.com)
  • Heart disease account for 65% of mortality and diabetic patients are at 2- 4 times more likely to suffer from heart diseases than the no- diabetic. (ac.ir)
  • Stimulation of the angiotensin II type 2 receptor (AT2R) evokes protective effects in various cardiovascular diseases. (bvsalud.org)
  • It was established that CIs were mild and moderate, equally marked in both patient groups, which allows consideration of DM as an independent risk factor for cognitive dysfunction. (ima-press.net)
  • The Effect of C-Peptide on Cognitive Dysfunction and Hippocampal Apoptosis in Type 1 Diabetic Rats. (ima-press.net)
  • This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication. (spandidos-publications.com)
  • Increased urinary albumin excretion, endothelial dysfunction, and chronic low grade inflammation in type 2 diabetes. (edu.pk)
  • Lipoic acid increases the abundance of other protective antioxidants while improving mitochondrial function and preventing glycation-induced damage in the kidney and blood vessels of those with diabetes-thus defending against diabetic kidney disease, vision loss, and vascular dysfunction. (lifeextension.com)
  • In addition, high- density lipoprotein dysfunction has been observed in patients with type 2 diabetes (Besler, Lüscher & Landmesser 2012) . (ac.ir)
  • For each patient and control we measured lipid parameters, CRP-us and sought the G894T polymorphism of eNOS gene by PCR-RFLP. (scirp.org)
  • Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
  • Atherosclerosis is characterized by the narrowing of the arterial lumen due to subendothelial lipid accumulation, with hypercholesterolemia being a major risk factor. (bvsalud.org)
  • Despite the recent advances in effective lipid-lowering therapies, atherosclerosis remains the leading cause of mortality globally, highlighting the need for additional therapeutic strategies. (bvsalud.org)
  • It should be noted that inflammation is not part of the pathologic process, because inflammatory cells are not seen in biopsies obtained at the time of surgery in the patients. (scielo.org.za)
  • 1-4) ROS react with cells initiating chain reactions that result in tissue damage causing inflammation, spasm, pain and disease. (life-enthusiast.com)
  • RA is the archetype of a systemic immune-mediated disease and it is defined as a chronic symmetric inflammation primarily involving the synovial joints ( table 1 ). (bmj.com)
  • The physiopathological process of ACS is the atherosclerosis where MIF operates as a major regulator of inflammation. (hindawi.com)
  • The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. (spandidos-publications.com)
  • To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. (spandidos-publications.com)
  • mellitus: cardiac and invisible items in the chance of refractive chronic acid diabetes. (siriuspixels.com)
  • Type 2 diabetes mellitus increases susceptibil- ceiving documented antihypertension treatment or having ity to common infections ( 5 ). (cdc.gov)
  • Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. (spandidos-publications.com)
  • Although diabetes mellitus has a strong association with the presence of depression, it is unclear whether diabetes itself increases the risk of developing depression. (cmaj.ca)
  • On February 6, 2008 the National Heart, Lung, and Blood Institute (NHLBI), stopped the ACCORD study (Action to Control Cardiovascular Risk in Diabetes) when results showed that intensive treatment of diabetics increases the risk of dying compared to those patients treated less aggressively. (drmcdougall.com)
  • 1 RA affects approximately 1% of the general population worldwide and the prevalence increases with age. (bmj.com)
  • 25(1): 7-10 estimate autonomic nervous control of the in women with metabolic syndrome compared to cardiovascular system and reduced HRV significantly those without, while results in men were increases cardiovascular mortality9. (bvsalud.org)
  • Several prospective studies have evaluated the risk of diabetes in those with previous depression. (cmaj.ca)
  • 21 - 31 Most reported an increased risk of diabetes associated with a history of depression or depressive symptoms, but often only in selected subpopulations. (cmaj.ca)
  • Metabolic syndrome raises the risk of diabetes and heart disease. (lifeextension.com)
  • RÉSUMÉ Cette étude visait à mettre au point un score de risque simple destiné à identifier les individus à haut risque de diabète non diagnostiqué dans la population adulte koweïtienne et à évaluer la performance des scores de risque du diabète publiés auparavant. (who.int)
  • We recently conducted a large, population-based, nested case- control study 21 that suggested an association between a history of depression and the onset of type 2 diabetes, but this increased risk was limited to people no older than 50 years. (cmaj.ca)
  • Approximately, 0.4-1.9% of the general population suffers from spondyloarthropathies, of which 0.1-0.6% accounts for ASp 4 and 0.04-1% for PsA. (bmj.com)
  • Racial and ethnic differences in microalbuminuria prevalence in a diabetes population: the pathways study. (edu.iq)
  • Our aim was to investigate the correlation of the level of liver enzymes with diabetes in the adult population of Rafsanjan. (biomedcentral.com)
  • However, only few studies have been conducted in a large population to evaluate the risk of CVD and mortality in patients with diabetes and comorbid depression. (e-dmj.org)
  • Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide with a prevalence of 10% to 30% in the general population [ 1 ]. (e-dmj.org)
  • There have been reports of diabetes mellitus (DM) as one of the most prevalent comorbidities in patients with COVID-19. (jhsmr.org)
  • Diabetes Care 1996;19:79-89. (edu.pk)
  • Cerebral blood flow in diabetes mellitus: evi- tions , 1996, 10:228-242. (who.int)
  • A dietary food for special medical purposes, consisting of encapsulated perilla oil with about 58 % of the omega-3 fatty acid alpha-linolenic acid and the antioxidative vitamins C and E (TUIM®) was investigated for its effect on blood fat values of 101 patients with type-2 diabetes treated in general or specialized practices, partially specialized on diabetics. (thieme-connect.de)
  • It can be concluded from these results that the consumption of the dietary food for special medical purposes consisting of perilla oil and the antioxidative vitamins C and E as capsules under medical supervision as part of a nutritional regimen represents a safe and practical alternative for the medical nutrition therapy of dyslipoproteinemia, especially in Type-2 diabetics. (thieme-connect.de)
  • In our series, we did not notice any significant difference in genotype or allele frequency between diabetics with and without degenerative complications. (scirp.org)
  • Patients with type 1 DM face a two to four times higher mortality rate than non-diabetic people ( 7 - 10 ). (spandidos-publications.com)
  • The effect of diabetes and stroke at baseline and during follow-up on stroke mortality. (org.ua)
  • The aim of this study was to evaluate the risk of cardiovascular disease (CVD) and mortality in patients with diabetes with comorbid depression. (e-dmj.org)
  • Coexisting depression in patients with diabetes has a deleterious effect on the development of CVD and mortality. (e-dmj.org)
  • The presence of advanced liver fibrosis is clinically important because it is associated with an increased risk of liver transplantation, liver-related mortality, cardiovascular outcomes, and all-cause mortality in patients with NAFLD [ 8 , 9 ]. (e-dmj.org)
  • We identified 31 635 people with diabetes and 57 141 without. (cmaj.ca)
  • Several investigations 5 - 8 have documented that people with diabetes experience depression from 1.3 to 3 times as often as those without the disorder. (cmaj.ca)
  • People most commonly use alpha-lipoic acid for nerve pain in people with diabetes. (medlineplus.gov)
  • Taking 600-1800 mg of alpha-lipoic acid by mouth or by IV seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes. (medlineplus.gov)
  • Affecting up to around two out of every three people with diabetes, neuropathy is nervous system damage that can produce unbearable pain in the legs and feet. (lifeextension.com)
  • Despite great efforts to reduce the risk of strokes in many developed countries of the world, the increase in life expectancy and the increase in the prevalence of risk factors for the development of stroke (among which diabetes plays a major role) have led to the fact that the probability of having a stroke during one's life has, on the contrary, increased from 22.8% in 1990 to 24.9% in 2016. (org.ua)
  • Stegmayr B, Asplund K. Diabetes as a risk factor for stroke. (org.ua)
  • Is diabetes mellitus a cardiovascular disease risk equivalent for fatal stroke in women? (org.ua)
  • Risk of stroke in people with type 2 diabetes in the UK: a study using the General Practice Research Database. (org.ua)
  • For many years, scientists have researched how lipoic acid affects insulin sensitivity and the severity of diabetes-related disorders, including heart disease, stroke, glaucoma, neuropathic pain, and kidney disease. (lifeextension.com)
  • Diabetes management requires coordinated efforts to change the patient's lifestyle to include a heathy diet and regular exercise, and to manage multiple risk factors, to prevent or delay complications such as stroke [ 1 - 3 ]. (j-stroke.org)
  • The association between DM and stroke involves the interplay of complex mechanisms, including various hemodynamic and metabolic pathways ( Figure 1 ). (j-stroke.org)
  • Heart attack, Stroke and Type 2 diabetes. (bvsalud.org)
  • MAY 2022 states (1). (cdc.gov)
  • Diabetes & Metabolism Journal 2022;46(4):630-639. (e-dmj.org)
  • See the letter-reply "Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease ( Diabetes Metab J 2022;46:630-9)" in Volume 46 on page 953. (e-dmj.org)
  • 1 In terms of prevention, however, it is more important to recognise susceptible individuals than those with overt disease. (bmj.com)
  • Diabetes Res Clin Pract 2020;162:108125. (jhsmr.org)
  • Diabetes and periodontal disease are biologically linked (12,13). (the-probe.co.uk)
  • Severe nocturnal enuresis secondary to polyuria can be an indication of onset of diabetes in young children. (medscape.com)
  • An explosive onset of symptoms in a young lean patient with ketoacidosis always has been considered diagnostic of type 1 DM. (medscape.com)
  • Over time, patients with new-onset type 1 DM will lose weight, despite normal or increased appetite, because of depletion of water and a catabolic state with reduced glycogen, proteins, and triglycerides. (medscape.com)
  • The different types of insulin vary with respect to onset and duration of action. (medscape.com)
  • It is known that the delay from disease onset to diagnosis may sometimes exceed 10 years [5] and that one or more vascular complications are already present by the time of diagnosis [6,7]. (who.int)
  • [ 1 ] In this modified classification, numeric AHA lesions types I to IV are replaced by descriptive terminology to include adaptive intimal thickening, intimal xanthoma, pathologic intimal thickening (PIT), and fibroatheroma, as shown in the table below. (medscape.com)
  • Plasmodium falci- tive of symptoms, malaria parasites were counted per 500 parum malaria alone causes an estimated 1 million deaths leukocytes on Giemsa-stained thick blood fi lms. (cdc.gov)
  • All patients required intensive care, with a complete resolution of symptoms and ECG changes within 24 hours. (degruyter.com)
  • Raising the awareness among diabetic patients about various complications and symptoms of diabetes, self- care principles and continuous control of blood sugar as close to normal range, may prevent the occurrence of early and late complications of diabetes, ensure long life for the patient and reduce healthcare costs (Mahmoudi 2006) . (ac.ir)
  • We suggest that more attention should be given to patients with diabetes who present with depressive symptoms. (e-dmj.org)
  • The chronic complications of diabetes are related to the length of time the patient has had the disease. (medscape.com)
  • Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. (wikipedia.org)
  • It presents the results of the authors' own studies of cognitive functions in patients with type 2 DM in relation to the presence or absence of a clinically significant vascular disease. (ima-press.net)
  • In developed countries, cardiovascular disease is the main complication causing death resulted from diabetes ( 5 , 6 ). (spandidos-publications.com)
  • During patient interviews (a history I take when people come to my 10-day, live-in program), I often notice that the disease portion of their data sheet is left blank, while their medication list is extensive. (drmcdougall.com)
  • Introduction: Diabetes mellitus is a chronic disease whose global expansion gives it the characteristics of a pandemic. (scirp.org)
  • disease , and respiratory abnormalities [1]. (researchgate.net)
  • Taurine has a wide margin of safety, being well tolerated at 2 grams/day or even (for most patients) up to 12 grams/day as an adjunct therapy for liver disease. (life-enhancement.com)
  • Diabetes mellitus (DM) is a common disease in the modern society. (biomedcentral.com)
  • Patients, general practitioners, cardiologists, internists and rheumatologists need to be aware of the substantially increased CV risk in IJD and should make a combined effort to timely initiate CV risk management in accordance with prevailing guidelines together with optimal control of rheumatic disease activity. (bmj.com)
  • Usually a prognosis for a disease in these patients is unfavorable (gradual and progressive decrease in the visual functions up to blindness). (antiaging-peptides.com)
  • Metabolic syndrome (MetS) is a cluster of consumption of saturated fats to unsaturated fats, metabolic risk factors for cardiovascular disease and increase the intake of fruits, vegetables, legumes type 2 diabetes. (bvsalud.org)
  • Diabetes is a chronic disease that has reached epidemic levels globally. (e-dmj.org)
  • According to the International Diabetes Federation, diabetes is associated with an increased risk of developing cardiovascular disease (CVD), leading to a reduced life expectancy, higher healthcare expenditure, and a decreased quality of life [ 1 ]. (e-dmj.org)
  • This study assessed its validity in determining cerebral small vessel disease in patients with type 2 diabetes mellitus. (who.int)
  • Transcranial doppler may be useful in early diagnosis of cerebral small vessel disease in patients with type 2 diabetes mellitus. (who.int)
  • 1 disease [3]. (who.int)
  • La vitesse d'écoulement du flux sanguin et l'index de pulsatilité ont été mesurés dans les artères carotides internes intercrâniennes, les artères basilaires et cérébrales moyennes d'un échantillon de 141 patients diabétiques sans autre facteur de risque et de 132 témoins en bonne santé appariés pour l'âge et le sexe. (who.int)
  • Les patients ont été répartis en deux groupes : 73 patients souffrant d'un diabète compliqué dans le premier groupe et 68 patients atteints d'un diabète non compliqué dans le deuxième groupe. (who.int)
  • Des différences statistiquement significatives ont été observées entre les patients atteints d'un diabète simple et les témoins mais ces dernières étaient toutefois moins marquées. (who.int)