LysosomesProteasome Endopeptidase ComplexEndosomesProteolysisLysosome-Associated Membrane GlycoproteinsUbiquitinEndocytosisAutophagyPhagosomesBiodegradation, EnvironmentalUbiquitinationAcid PhosphataseCell LineCathepsin DProtein TransportMolecular Sequence DataUbiquitin-Protein LigasesCysteine EndopeptidasesAmino Acid SequenceLysosomal-Associated Membrane Protein 2Cells, CulturedCathepsinsKineticsMicroscopy, ElectronVacuolesUbiquitinsMutationMultienzyme ComplexesChloroquineEndoplasmic ReticulumBiological TransportEndoplasmic Reticulum-Associated DegradationProtein BindingHydrogen-Ion ConcentrationHydrolysisProtein Processing, Post-TranslationalLiverSubcellular FractionsHeLa CellsGolgi ApparatusFibroblastsPeptide HydrolasesCell MembraneCell FractionationProteinsModels, Biologicalbeta-N-AcetylhexosaminidasesOrganellesMembrane ProteinsCathepsin Brab GTP-Binding ProteinsChediak-Higashi SyndromeMicroscopy, FluorescenceSignal TransductionHydrolasesReceptor, IGF Type 2Cell CompartmentationCysteine Proteinase InhibitorsGlucuronidaseTime FactorsProtein Structure, TertiaryEndopeptidasesIntracellular MembranesCarrier ProteinsCytoplasmLysosomal Storage DiseasesAmmonium ChlorideRecombinant Fusion ProteinsMacrophagesProtease InhibitorsProteasome InhibitorsRNA, MessengerMannosephosphatesOrganoidsMucolipidosesPhosphorylationEndosomal Sorting Complexes Required for TransportCell Line, TumorMultivesicular BodiesCricetinaeHEK293 CellsRNA StabilityAsialoglycoproteinsBlotting, WesternBase SequenceMicroscopy, ConfocalAndrostenesVesicular Transport ProteinsCathepsin LCytosolF-Box ProteinsRNA InterferenceSubstrate SpecificityAcetylglucosaminidaseElectrophoresis, Polyacrylamide GelDown-RegulationHexosaminidasesProtein StabilityRNA, Small InterferingRecombinant Proteins