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Viral Nonstructural ProteinsAntigensAntigens, BacterialAntigens, SurfaceAntigens, NeoplasmAntigens, ViralAntigens, CDMolecular Sequence DataAntigens, CD8Cell LineAntigens, CD3Amino Acid SequenceVirus ReplicationMinute virus of miceAntibodies, MonoclonalEpitopesRNA, ViralT-LymphocytesViral ProteinsAntigens, ProtozoanAntigens, CD34HepacivirusDengue VirusAntigens, CD38Mice, Inbred BALB CBase SequenceAntigens, CD40Enzyme-Linked Immunosorbent AssayAntigens, CD19CD4-Positive T-LymphocytesImmunoglobulin GLymphocyte ActivationSindbis VirusHLA AntigensAntigens, Polyomavirus TransformingImmunizationPolyproteinsAntigens, FungalCross ReactionsRNA HelicasesAntigens, CD20Antigens, CD28Antibodies, BacterialH-2 AntigensAntigens, CD1Antibodies, ViralAntibody FormationCD40 LigandB-LymphocytesAntigens, DifferentiationParvovirusAntigens, HelminthAntigens, CD14RepliconAntigens, CD7OvalbuminAntigens, CD44Antigens, CD2Genome, ViralRecombinant ProteinsFlow CytometryHistocompatibility Antigens Class IIImmune SystemAntibody SpecificityVero CellsImmune ToleranceImmune SeraAntigens, CD80Cells, CulturedCercopithecus aethiopsAntigens, CD5Receptors, Antigen, T-CellHLA-DR AntigensRNA ReplicaseViral Core ProteinsMice, Inbred C57BLCarcinoembryonic AntigenCD4-CD8 RatioFoot-and-Mouth Disease VirusAntigens, Viral, TumorRotavirusAntigens, CD56SpleenEncephalitis Virus, JapaneseAntigens, Differentiation, MyelomonocyticSemliki forest virusAntigens, CD45Molecular WeightFluorescent Antibody TechniqueAntigens, CD86Membrane GlycoproteinsCD8-Positive T-LymphocytesRecombinant Fusion ProteinsDendritic CellsAntigens, CD53Histocompatibility AntigensDensovirusAntigens, CD24Orthoreovirus, AvianViral Structural Proteins
DomainEnvelope proteinsHepatitisProteasesViralReceptorGenomeVirusHighly
Domain2
  • domain 3 (residues 175-191) is highly hydrophobic and acts as a signal sequence for E1 envelope protein. (wikipedia.org)
  • Crystal structure of the N-terminal domain of the effector protein SidI of Legionella pneumophila reveals a glucosyl transferase domain. (resist-cluster.de)
Envelope proteins4
  • Both envelope proteins (E1 and E2) are highly glycosylated and important in cell entry. (wikipedia.org)
  • The thus replicated HCV genomic RNA is packaged by the Core protein and envelope proteins (E1 protein and E2 protein), which are structural proteins, so that new viral particles are formed. (justia.com)
  • HCV envelope proteins are considered to play a key role in the binding of HCV to cell surfaces. (justia.com)
  • Thus, research has been conducted for preparation of antibodies against envelope proteins in blood serum samples of HCV patients. (justia.com)
Hepatitis1
Proteases1
  • The large pre-protein is later cleaved by cellular and viral proteases into the 10 smaller proteins that allow viral replication within the host cell, or assemble into the mature viral particles. (wikipedia.org)
Viral5
  • This is why on publicly available databases, such as the European Bioinformatics Institute, the viral proteome only consists of 2 proteins. (wikipedia.org)
  • citation needed] At the 5′ and 3′ ends of the RNA are the untranslated regions (UTR), that are not translated into proteins but are important to translation and replication of the viral RNA. (wikipedia.org)
  • The mature nonstructural proteins (NS2 to NS5B) generation relies on the activity of viral proteinases. (wikipedia.org)
  • NS1 (p7) protein is dispensable for viral genome replication but plays a critical role in virus morphogenesis. (wikipedia.org)
  • Epidemiological studies in humans and experimental studies in animal have shown that viral infections can induce or protect from autoimmunopathologies depending on several factors including genetic background, host-elicited immune responses, type of virus strain, viral load, and the onset time of infection. (mdpi.com)
Receptor3
  • It prevents CD81 from latching onto its respective receptor on the virus. (wikipedia.org)
  • E1 serves as the fusogenic subunit and E2 acts as the receptor binding protein. (wikipedia.org)
  • First, HCV binds to a specific protein (virus receptor) on the cell surface and is incorporated by endocytosis into the host cell. (justia.com)
Genome2
  • citation needed] The proteins of this virus are arranged along the genome in the following order: N terminal-core-envelope (E1)-E2-p7-nonstructural protein 2 (NS2)-NS3-NS4A-NS4B-NS5A-NS5B-C terminal. (wikipedia.org)
  • The HCV genome encodes a precursor protein that is converted into 10 types of virus protein (i.e. (justia.com)
Virus3
  • HVR1 helps E2 shield the virus from the immune system. (wikipedia.org)
  • The virus is taken up by dendritic cells, which, after antigen processing, presents it to T cells, leading to immune activation and release of a cascade of cytokines that are believed to mediate the systemic effects of plasma leakage and circulatory insufficiency. (who.int)
  • After each virus protein has been generated by processing, the HCV genomic RNA is replicated by RNA polymerase, which is one of the generated virus proteins. (justia.com)
Highly1
  • domain 3 (residues 175-191) is highly hydrophobic and acts as a signal sequence for E1 envelope protein. (wikipedia.org)