• Nevertheless, the structure of intact apo-form leptin and the structural transition leptin undergoes upon receptor binding are not fully understood yet. (bvsalud.org)
  • The convention for a polypeptide is to list its constituent amino acid residues as they occur from the amino terminus to the carboxylic acid terminus. (wikipedia.org)
  • The amino acid residues are always joined by peptide bonds. (wikipedia.org)
  • Protein sequence can be determined by Edman degradation, in which the N-terminal residues are hydrolyzed from the chain one at a time, derivatized, and then identified. (wikipedia.org)
  • A. cDNA encoding the biosynthetic precursor of AcT-2 was successfully cloned from a skin secretion-derived cDNA library by means of RACE PCR and this contained an open-reading frame consisting of 62 amino acid residues with a single AcT-2 encoding sequence located towards the C-terminus. (hindawi.com)
  • The peptide was initially identified during smooth muscle pharmacological screening of skin secretion HPLC fractions and the unique primary structure-GMRPPWF-NH 2 -was established by both Edman degradation and electrospray MS/MS fragmentation sequencing. (hindawi.com)
  • Their combined efforts resulted in the unravelling of the molecular structures and biological actions of several thousands of such molecules representing many classes of biochemical, studies on which have served to reveal many novel regulatory systems and potential drug targets in mammalian systems [ 1 - 4 ]. (hindawi.com)
  • Many biopolymers spontaneously fold into characteristic compact shapes (see also "protein folding" as well as secondary structure and tertiary structure), which determine their biological functions and depend in a complicated way on their primary structures. (wikipedia.org)
  • A major defining difference between biopolymers and synthetic polymers can be found in their structures. (wikipedia.org)
  • In contrast, most synthetic polymers have much simpler and more random (or stochastic) structures. (wikipedia.org)
  • Biopolymers often have a well-defined structure, though this is not a defining characteristic (example: lignocellulose): The exact chemical composition and the sequence in which these units are arranged is called the primary structure, in the case of proteins. (wikipedia.org)
  • Such a sequence is called the primary structure of the biopolymer. (wikipedia.org)
  • We previously demonstrated that microvesicles can functionally deliver plasmid DNA to cells and showed that plasmid size and sequence, in part, determine the delivery efficiency. (regenerativemedicine.net)