Complex lectins c type. Medical search. Frequent questions

Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis. (wikipedia.org)
We have previously shown that hemocyanins are internalized by APCs through receptor-mediated endocytosis with proteins that contain C-type lectin domains, such as mannose receptor (MR). However, the contribution of other innate immune receptors to the proinflammatory signaling pathway triggered by hemocyanins is unknown. (exeter.ac.uk)
Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
Researchers analyzed the samples for compounds binding to lectins , natural plant proteins with an affinity for carbohydrates. (technewslit.com)
In this case, the team focused on glycans , a type of carbohydrate in proteins that ranges from simple to complex in structure. (technewslit.com)
Lectins are a diverse group of proteins, both in terms of structure and activity. (embl.de)
When examined from the viewpoint of the bound sugar, the structural information accumulated so far on lectins and other proteins that are specific to galactose and glucose (or mannose), provides suggestive evidence for distinct ligand-dependent distribution of hydrogen-bond partners in the combining site. (embl.de)
Lectins are glycan binding proteins and each lectin will only bind to particular glycans. (bmgrp.com)
All proteins have a type of sugar-coat - small, complicated sugar molecules that reside on a protein's surface. (scienceblog.com)
Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
LincRNAs potentially function in many different ways, including cotranscriptional regulation, bridging proteins to chromatin, and scaffolding of nuclear and cytoplasmic complexes [11]. (antiviralbiologic.com)
Over the past several years, we have engineered a range of proteins with new functions, including protein-protein interactions that are specific enough to control complex biological processes in mammalian cells (Kapp*, Liu* et al. (ucsf.edu)
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. (lookformedical.com)
Lectins are proteins of non-immunological origin with the ability to bind to carbohydrates reversibly. (bvsalud.org)
The complement system consists of a complex network of several plasma proteins that interact with each other and cell surface proteins. (medscape.com)
C3b binds to other complement proteins on the cell membrane to finally form the membrane attach complex (MAC), which ultimately leads to opening pores in the cell membrane and promoting cell lysis. (medscape.com)

The endosomal Toll-like receptors (TLRs) TLR7 and TLR9 are required for pDCs, as well as other cell types, to sense viral nucleic acids, but the mechanism by which signaling through these shared receptors results in the prodigious production of type I IFN by pDCs is not understood. (nih.gov)
In the Brown Group, we are interested in a superfamily of receptors called C-type lectin receptors (CLRs). (exeter.ac.uk)
Together with B cell lymphoma (Bcl)10 and the paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein (Malt)1, Card9 links spleen-tyrosine kinase (Syk)-coupled C-type lectin receptors to inflammatory responses. (nih.gov)
A second research project Wen currently works on is to study the role of C-type lectin receptors in neuroinflammation. (duke.edu)
The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1. (medscape.com)

The emergence of functional studies on animal lectins during the 1990s has provided the appropriate framework to better understand their roles in cell death. (nature.com)

A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. (wikipedia.org)
classified C-type lectins into 7 subgroups (I to VII) based on the order of the various protein domains in each protein. (wikipedia.org)
Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. (musc.edu)
Caspase recruitment domain-containing protein (Card)9 is a nonredundant adapter protein that functions in the innate immune system in the assembly of multifunctional signaling complexes. (nih.gov)
The Gal/GalNAc lectin is an adhesion protein complex which sustains tissue invasion by E. histolytica. (pasteur.fr)
Genes upregulated in the fiber cells were enriched for proteosome complexes, unfolded protein responses, phosphatase activity, and ubiquitin binding. (antiviralbiologic.com)

Lectin array technology is based on the lectin-glycan affinity ( 6 ), which is not suitable for glycoproteomic analysis. (frontiersin.org)
The principle of glycan structure profiling analysis using LecChip™ is based on the lectin to glycan binding affinity. (bmgrp.com)
Fortunately, evanescent-field fluorescence excitation allows for generation of lectin-glycan affinity data from unwashed samples by taking advantage of the higher signal strength of specifically bound glycans. (bmgrp.com)
Thus, peptides derived from HLA-A*0201 were purified by wheat germ agglutinin (WGA) lectin affinity chromatography as previously described. (ox.ac.uk)

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al. (nih.gov)
The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells. (nih.gov)

Endogenous lectins and glycans are critical signals in the resolution of cell death. (nature.com)
Although lectins were already known because of their ability to agglutinate red blood cells, 3 the involvement of lectins and glycans in PCD had not been elucidated. (nature.com)
Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
The Cy3 molecules attached to glycans that have successfully bound to lectins will fluoresce and the total LecChip™ fluorescence pattern can be captured with the scanner. (bmgrp.com)
If a washing process is applied to the LecChip™ to remove non-lectin binding redundant glycoproteins, many of the specifically bound glycans are also lost. (bmgrp.com)
By contrast, Cy3-tagged glycans that interact with the lectins located on the LecChip™ are contained in the stronger part of the evanescent field and are effectively excited. (bmgrp.com)
We have applied the lectin Amaranthin, having a nominal specificity for Galβ1,3GalNAcR and Neu5Ac2,3Galβ1,3GalNAcα-R, and a monoclonal antibody raised against Galβ1,3GalNAcαR to examine the distribution of these simple O-glycans in adult rat kidney. (uzh.ch)
2019) 'Sequence-to-structure dependence of isolated IgG Fc complex biantennary N-glycans: a molecular dynamics study' . (maynoothuniversity.ie)

Card9 complexes are engaged upon fungal, bacterial, or viral recognition, and they are essential for host protection. (nih.gov)

occurs by three pathways: the classical pathway, the lectin pathway, and the alternative pathway (or properdin system). (britannica.com)
Activation of the complement system occurs through the classical (CP), lectin (LP), or alternative (AP) pathways. (jrheum.org)
The classical, lectin, and alternative pathways converge into a final common pathway when C3 convertase (C3 con) cleaves C3 into C3a and C3b. (msdmanuals.com)

8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
The complement system is activated via 3 different mechanisms: (1) the classical pathway, which is activated by antibody-antigen complexes, (2) the alternative pathway, which is activated by microbial cell surfaces in the absence of antibodies, and (3) the lectin pathway, which is activated by mannose residues on microbes. (medscape.com)

Disruption of the Gal/GalNAc lectin function in engineered parasites (HGL-2 trophozoites) changed the pathophysiology of hamster liver abscess formation. (pasteur.fr)
These data highlight the key role of the Gal/GalNAc lectin in initiation of E. histolytica hepatic infection. (pasteur.fr)

This domain, which is known as the C-type lectin domain (CTL) or as the carbohydrate-recognition domain (CRD), consists of about 110 to 130 residues. (embl.de)
Using the gal-3 inhibitor GB0139 (TD139) and gal-3C we found that the gal-3-induced inhibitory effect on ROS production was dependent on the carbohydrate recognition domain of the lectin. (lu.se)

Furthermore, differential binding was observed also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA. (researchgate.net)

A different type of signal activates each pathway. (britannica.com)

Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses toward type 1 T helper (Th1) polarization. (exeter.ac.uk)
Lectin-glycan interactions are known to be relatively weak compared to antigen-antibody and biotin-avidin interactions. (bmgrp.com)
After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)
CR2 associates with CD19 forming a CR2-CD19 complex when stimulated by C3d-bearing antigen engaging CR2. (medscape.com)

We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
Lectin-carbohydrate interactions: different folds, common recognition principles. (embl.de)
The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)

Zoom lens fibers cell differentiation is certainly an extremely coordinated process regarding specific adjustments in gene appearance between two different cell types. (antiviralbiologic.com)
Sequenced genomes were classified using the seven-gene multilocus sequence typing (MLST) scheme and a core genome (cg)MLST scheme was used to determine phylogeny. (cdc.gov)

The surface of the living cells is decorated by a complex layer of glycosylated molecules that store relevant biological information. (nature.com)
Common mechanisms of recognition, engulfment, and degradation of the different types of cargo are assumed, but very little is known about the shared and specific molecules involved in the phagocytosis of each target by microglia. (frontiersin.org)
Previously, using synthetic glycopeptides carrying a natural cytosolic type of monosaccharide O-beta-linked N-acetylglucosamine (GlcNAc) glycosylation of serine residues, we have shown that glycopeptides act as suitable substrates for TAP-mediated transport into the endoplasmic reticulum (ER), and that they bind efficiently to class I major histocompatibility complex (MHC) molecules and can elicit glycopeptide-specific cytotoxic T-lymphocyte (CTL) responses in mice. (ox.ac.uk)

Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
Lectins can be found in many organisms and are involved in a multitude of cellular processes that depend on specific recognition of complex carbohydrates. (embl.de)
Structural basis of lectin-carbohydrate recognition. (embl.de)
Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. (embl.de)

In mammals, complex glycosphingolipids can carry hundreds of sugar chains as polar head groups, and this structural diversity and complexity is thought to be closely related to their multiple biological functions. (go.jp)
However, recent studies indicated that these structural modifications of complex sphingolipids are important for many cellular functions. (go.jp)
This review focuses on the physiological importance of each detailed structure and the structural diversity of complex sphingolipids in S. cerevisiae and the other yeasts. (go.jp)

Lectin microarrays using LecChip™ allows the highly sensitive analysis of carbohydrates in various sample types (purified and crude samples, e.g. cell/tissue extracts, living cells, virus particles, cell culture supernatants, serum, urine). (bmgrp.com)

8] Deficiency of CD18 on phagocytic cells causes LAD type 1 (see Table 2). (medscape.com)

Three CD11 alpha chains and a common CD18 beta chain form heterodimer transmembrane complexes (CD11a/CD18, CD11b/CD18, CD11c/CD18). (medscape.com)

Cy3 labeled glycoproteins are applied to the LecChip™ surface which then bind to specific lectins on the chip. (bmgrp.com)

Mass spectrometry and lectin arrays are common technologies publicly adopted in glycosylation analysis. (frontiersin.org)

Intracellular lectins and glycan-modifying enzymes mediate autophagy and control host immunity and inflammation. (nature.com)
Triggering of apoptosis in both host cell types most likely has a central role in modulating inflammation, a major landmark in hepatic amoebiasis. (pasteur.fr)

How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)
The two recognized types of immunity are innate and adaptive. (medscape.com)
What are the types of immunity? (medlineplus.gov)

In the budding yeast Saccharomyces cerevisiae , the complex sphingolipids have five types of ceramide differing in hydroxylation status, and three types of polar head group containing inositol phosphate and mannose, and thus S. cerevisiae complex sphingolipids can be classified into 15 subtypes in total. (go.jp)
MBL = mannose-binding lectin. (msdmanuals.com)
5] C1q is a member of the collectin family, which also includes surfactant A, surfactant D, and mannose-binding lectin (MBL). (medscape.com)

miR-125a reduced expression of C-type lectin domain family 5, member a ( Clec5a ), which is involved in myeloid differentiation. (jci.org)

Most cell types, including unicellular organisms, have the capacity to phagocytose. (frontiersin.org)
However, they have a different origin and are a unique macrophage cell type in the adult organism. (frontiersin.org)
By histochemistry glycosyltransferases and their products can be localized to specific cell types in organs of complex cellular composition. (uzh.ch)
To your knowledge, this is actually the initial study determining the appearance of 254 lengthy intergenic non-coding RNAs (lincRNAs) within the zoom lens, which 86 lincRNAs shown differential expression between your two cell types. (antiviralbiologic.com)
The mammalian zoom lens comprises of just two cell types: epithelial cells, which comprise a monolayer of cells that series the anterior hemisphere from the zoom lens, and fibers cells, which will make up the rest from the zoom lens mass. (antiviralbiologic.com)
Osei P, Northcote-Smith J, Fang J, Singh K, Ortu F, Suntharalingam K . The Bulk Breast Cancer Cell and Breast Cancer Stem Cell Activity of Bi-nuclear Copper(II)-Phenanthroline Complexes. (le.ac.uk)
Complement is consumed in neoplastic disorders (eg, B-cell lymphoma) or immune complex disorders. (msdmanuals.com)
Managing sickle cell anemia in children is complex. (cdc.gov)
Rather, its genotoxic effects are limited to indirect clastogenicity occurring in select cell types, and only when high dose and time thresholds are exceeded. (cdc.gov)
Kim also described the self-regenerating nature of a unique cell type Sanals in the system and these cells are now confirmed to be a type of stem cells. (who.int)

It was found that the peptides derived from HLA-A*0201 which had been retained by the O-GlcNAc-binding lectin WGA did indeed carry a HLA-A*0201 binding motif. (ox.ac.uk)
Furthermore, using an enzymatic labeling procedure we present evidence that the HLA-A*0201-derived peptides which bind to the WGA lectin are glycosylated with terminal GlcNAc residues. (ox.ac.uk)

In the lab, Blixt and his PhD student, Kowa Chen, tested a plant lectin and and a monoclonal antibody. (scienceblog.com)

The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)

The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)

The low penetration of HGL-2 trophozoites into hepatic tissue was shown to be associated with weak attraction of neutrophils and macrophages to the infiltrated areas and absence of pro-inflammatory tumour necrosis factor, in contrast to wild type or control vector infections. (pasteur.fr)
Upon proteolytic activation, an enzymatic cascade is propagated, resulting in recruitment of inflammatory cells, amplification of their phagocytic capacity, and formation of membrane attack complexes that promote lysis of microbes. (medscape.com)

NGL viewer: web-based molecular graphics for large complexes. (icr.ac.uk)

[Harrison RA, Oliver J, Hasson SS (2003) Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species. (answering-christianity.com)
The lectin from D. violacea (DVL) already has its activity described as anti-candida in some species. (bvsalud.org)
One such process is the production of reactive oxygen species (ROS) by the neutrophil enzyme complex NADPH-oxidase, which can be assembled and active either extracellularly or intracellularly in phagosomes (during phagocytosis) and/or granules (in absence of phagocytosis). (lu.se)

In addition, a decreased C4 level along with a low level or dysfunctional C1 esterase inhibitor confirms the diagnosis of hereditary angioedema types I and II. (medscape.com)

In graduate school, he studied biological marco-complexes such as ribosomes and amyloids. (duke.edu)

The C-type designation is from their requirement for calcium for binding. (wikipedia.org)

Type 3 occurs more frequently in females. (msdmanuals.com)

Your immune system is a complex network of cells, tissues, and organs. (medlineplus.gov)

One phenovariant, which we named feeble, showed abrogation of both TLR-induced type I IFN and proinflammatory cytokine production by pDCs, while leaving TLR responses intact in other cells. (nih.gov)

C-Type+Lectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Drickamer K (October 1999). (wikipedia.org)

Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)

Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)

This review describes the protecting-group-free syntheses by our group and others of glyco-monomers and -polymers, and reviews the results of binding assays using our glycopolymers with lectins and influenza viruses. (go.jp)
In contrast, addition of hydroxyl groups to the ceramide moiety in complex sphingolipids and extension of the polar head group are non-essential for growth. (go.jp)
A set of blood types of two or more alleles makes up a blood group system. (dvm360.com)

Lectin purified human class I MHC-derived peptides: evidence for presentation of glycopeptides in vivo. (ox.ac.uk)

Anatomy1

Organisms19

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes11

Disciplines and Occupations2

Technology, Industry, Agriculture4

Information Science3

Proteins17

Receptors7

Animal lectins1

Protein6

Affinity4

Receptor2

Glycans8

Fungal1

Pathways3

Complement system2

GALNAC2

Carbohydrate-recognition domain2

Endogenous1

Pathway1

Antigen4

Interactions3

Gene2

Molecules3

Recognition4

Structural3

Carbohydrates1

Deficiency1

Transmembrane1

Glycoproteins1

Glycosylation1

Inflammation2

Immunity3

Mannose3

Domain1

Cell10

GlcNAc2

Monoclonal1

Adhesion1

Adaptive1

Inflammatory2

Molecular1

Species3

Hereditary1

Biological1

Calcium1

Occurs1

Tissues1

Responses1

MeSH1

Membrane1

Neutrophil1

Group3

Human1