• The product has similar indications in the United States but is also approved there for use in men with metastatic castration-resistant prostate cancer (mCRPC) that harbors deleterious BRCA mutations (germline and/or somatic). (medscape.com)
  • ERLEADA ® (apalutamide) is an androgen receptor inhibitor indicated for the treatment of patients with non-metastatic castration-resistant prostate cancer (nmCRPC) and for the treatment of patients with metastatic castration-sensitive prostate cancer (mCSPC). (crohnscolitisprofessional.org)
  • They're not only metastatic castration-resistant, they're 1 step further. (onclive.com)
  • The castration complex is a concept developed by Sigmund Freud, first presented in 1908, initially as part of his theorisation of the transition in early childhood development from the polymorphous perversity of infantile sexuality to the 'infantile genital organisation' which forms the basis for adult sexuality. (wikipedia.org)
  • Freud argued that the castration complex is closely linked to the Oedipus Complex, especially with its prohibitive and normative function. (wikipedia.org)
  • In his later work Freud includes the castration complex in the category of primal phantasies that are universal in their derivation from the incest taboo, the necessary founding condition for all human social and cultural formations. (wikipedia.org)
  • Oedipus complex is a psychosexual theory first developed by neurologist Sigmund Freud in 1899. (psychcentral.com)
  • While Freud used the Oedipus complex to describe his theory in both male and female children, it was later suggested that it was specific to male children. (psychcentral.com)
  • Their many books include translations of Nasio's Five Lessons on the Psychoanalytic Theory of Jacques Lacan and The Book of Love and Pain: Thinking at the Limit with Freud and Lacan , both also published by SUNY Press. (sunypress.edu)
  • For Sigmund Freud, anxiety was nothing more than the expression of libidinal conflicts, especially the Oedipal complex/fear of castration. (columbia.edu)
  • Causes[edit] Freud argued that the Madonna-whore complex is caused by oedipal castration fears which arise when a man experiences the affection he once felt for his mother with women he now sexually desires. (pearltrees.com)
  • In his essay, Some character-types met with in psycho-analytic work, Freud (1958) uses Shakespeare's Richard III as the model for his analysis of personality problems of people with disabilities. (dsq-sds.org)
  • Freud was born in Frieberg, Moravia in 1856, but when he was four years old his family moved to Vienna, where Freud was to live and work until the last year of his life. (crystalinks.com)
  • In 1885-86 Freud spent the greater part of a year in Paris, where he was deeply impressed by the work of the French neurologist Jean Charcot, who was at that time using hypnotism to treat hysteria and other abnormal mental conditions. (crystalinks.com)
  • Sigmund Freud (1856-1939) is commonly referred to as 'the father of psychoanalysis' and his work has been tremendously influential in the popular imagination, popularizing such notions as the unconscious, defense mechanisms, Freudian slips and dream symbolism, while also making a long-lasting impact on fields as diverse as literature, film, Marxist and feminist theories, literary criticism, philosophy and psychology. (psychologistanywhereanytime.com)
  • 4. In her most important work of the Viennese period (Freud, A. 1936), one case can be considered autobiographical, a self-analysis of the woman she had then become, in other words a woman who found a way of sublimating her infantile and adolescent conflicts. (symbiosisonlinepublishing.com)
  • The Oedipus Complex is perhaps the psychoanalytic model Freud is most widely known for after his elaboration of the unconscious. (mscp.org.au)
  • Guided by the theoretical domains framework (TDF), urologists and patients from facilities with the highest and lowest castration rates across the VA will be interviewed to identify key preferences and de-implementation barriers for reducing castration as prostate cancer treatment. (biomedcentral.com)
  • The investigators will conduct national surveys of urologists to prioritize key barriers identified in Aim 1 for stopping incident castration as localized prostate cancer treatment using a DCE experiment design. (biomedcentral.com)
  • Aim 3: To pilot two tailored de-implementation strategies to reduce castration as localized prostate cancer treatment. (biomedcentral.com)
  • In prostate cells, prior to androgen binding, AR is inactively bound to a foldosome of chaperone proteins within the cytoplasm, including HSP90, preventing nuclear localization while maintaining ligand access [ 7 , 8 ]. (oncotarget.com)
  • Level of resistance to androgen deprivation treatments and increased androgen receptor (AR) activity are major drivers of castration resistant prostate malignancy (CRPC). (biobender.com)
  • Taken together this work identifies the MLL complex as a critical co-activator of AR and a potential restorative target in advanced prostate malignancy. (biobender.com)
  • between AR menin and the MLL complex in advanced prostate malignancy. (biobender.com)
  • Furthermore the MLL complex is required for AR-mediated gene manifestation and can become targeted with small molecule TPT-260 (Dihydrochloride) menin-MLL inhibitors suggesting that treatments in development for MLL fusion-positive leukemia's may have energy for castrate-resistant prostate malignancy. (biobender.com)
  • RESULTS AR interacts with the MLL complex Using co-immunoprecipitation (co-IP) assays in the AR-dependent prostate malignancy cell collection VCaP we previously reported that AR interacts with proteins of the MLL complex26. (biobender.com)
  • Next we co-immunoprecipitated endogenous ASH2L menin and AR from VCaP and another AR-dependent prostate malignancy cell collection LNCaP to confirm an association between AR and MLL complex proteins. (biobender.com)
  • It is anticipated that these new classes of anti-AR drugs will provide an additional arsenal to treat castration-resistant prostate cancer. (tech-strategy.org)
  • Prostate cancer, like other cancers, is an extremely complex process. (medscape.com)
  • However, the PCPT results also provided information that has not received adequate exposure and debate in the medical literature: Of the almost 19,000 men included in this randomized trial, 5 men died from prostate cancer in the finasteride and in the placebo arm, but 1123 men in total died. (medscape.com)
  • Analysis of a cancer registry in the United States, which included men with prostate cancer, showed that patient-clinician information engagement leads to increased consumption of fruits and vegetables by cancer patients. (medscape.com)
  • Carl Jung, a former pupil and colleague of Freud's, proposed the use of "Electra complex" to describe a female child experiencing Oedipus complex. (psychcentral.com)
  • According to Freud's theory, it's typical for symptoms of Oedipus complex to vary between children. (psychcentral.com)
  • Many studies published through the 1950's in the medical and psychiatric literature reinforced Freud's conclusions by citing common personality problems of disabled people including their hostility, bitterness, and vindictiveness (O'Brien, 2001). (dsq-sds.org)
  • While many of Freud's ideas have fallen out of favor or been modified by other analysts, and modern advances in the field of psychology have shown flaws in some of his theories, his work remains influential in clinical approaches, and in the humanities and social sciences. (crystalinks.com)
  • Notwithstanding the multiple manifestations of psychoanalysis as it exists today, it can in almost all fundamental respects be traced directly back to Freud's original work. (crystalinks.com)
  • Further, Freud's innovative treatment of human actions, dreams, and indeed of cultural artifacts as invariably possessing implicit symbolic significance has proven to be extraordinarily fecund, and has had massive implications for a wide variety of fields, including anthropology, semiotics, and artistic creativity and appreciation in addition to psychology. (crystalinks.com)
  • The development of the psychoanalysis of adolescence began with Freud's founding work on the "Transformations of Puberty" (1905). (symbiosisonlinepublishing.com)
  • Freud's foundational concepts of castration, primary femininity, infantile sexuality, when understood as indeterminately expressed elements of subjectivity, all speak to an anti-humanist and anti-deterministic Freudian subject. (mscp.org.au)
  • How can we reconcile the Leonardo Da Vinci essay that proposes a lifelong open bisexual Oedipus complex with Freud's later essay on its dissolution? (mscp.org.au)
  • If the 'researches of childhood' are part of the imaginary life of children and vital to castration, does this give childhood development primacy within Freud's thought? (mscp.org.au)
  • By so proceeding, it is possible to say that the main example of the discipline created by Freud's revolutionary research is the Oedipus complex, the child at the mother's bed grappling with conflicts that could potentially bring about neuroses, which are related to the administration of sexual drives in triangular relationships. (bvsalud.org)
  • Nasio makes the provocative claim that the entirety of the psychoanalytical corpus, all of its concepts, including repression, sublimation, the theory of the drives, desire, as well as the phantasm of the phallus and castration anxiety, revolves around the idea that the child desires the parents. (sunypress.edu)
  • Although androgen deprivation therapy (ADT) is initially effective, the unconfined disease inevitably overcomes the androgen blockade and recurs as lethal castration-resistant PCa (CRPC) [ 6 ]. (oncotarget.com)
  • Modern mental health care professionals now often use the phrase "Oedipal complex" when referring to children of either sex. (psychcentral.com)
  • The structure and consequences of the castration complex are different in the boy and in the girl, terminating the Oedipus Complex for the boy, initiating it for the girl. (wikipedia.org)
  • Oedipus Complex: What Is It and How Is It Addressed? (psychcentral.com)
  • Oedipus complex takes its name from Greek mythology to describe a psychological theory involving how children view their parents. (psychcentral.com)
  • This experience is the main characteristic of a theory of psychology known as Oedipus complex. (psychcentral.com)
  • But when the fixation becomes persistent, Oedipus complex may affect a person into adulthood. (psychcentral.com)
  • What is Oedipus complex? (psychcentral.com)
  • The name "Oedipus complex" comes from the character Oedipus in Greek mythology, who - without realizing his parental ties - kills his father and then marries his mother. (psychcentral.com)
  • Like Oedipus complex, Electra complex also takes its name from Greek mythology. (psychcentral.com)
  • However, it's important to note that experiencing conflict with your mom or dad doesn't necessarily indicate Oedipus complex. (psychcentral.com)
  • You may not be able to see obvious signs of Oedipus complex. (psychcentral.com)
  • First English translation of Nasio's groundbreaking work on the Oedipus complex. (sunypress.edu)
  • In this long-awaited book, Juan-David Nasio, one of France's leading Lacanian psychoanalysts, argues that the Oedipus complex represents the core of psychoanalysis as well as the fundamental constitution of the human being. (sunypress.edu)
  • Included in Oedipus is a fascinating interview with Nasio, which was conducted by the translators for this book. (sunypress.edu)
  • Nasio advances the argument that the Oedipus complex remains at the center of psychoanalysis-indeed, that without it there can be no psychoanalysis. (sunypress.edu)
  • Nasio has written a splendid, erudite, and concise volume on what is arguably the central concept in psychoanalysis-the Oedipus complex … A welcome addition to and clarification of the significant body of work on sexual identity, this volume will be valuable across the social sciences and humanities, and appreciated for its clarity, concision, and relevance … Highly recommended. (sunypress.edu)
  • Its methodology is centered on the interpretation of the transference material in the light of the Oedipus complex and regressions to the fixation points. (bvsalud.org)
  • The regulation of AR activity involves a cascade of complex interactions ENOblock (AP-III-a4) with numerous chaperones co-factors and co-regulatory proteins leading ultimately to direct binding of AR dimers to ENOblock (AP-III-a4) specific DNA androgen response elements within the promoter and enhancers of androgen-regulated genes. (tech-strategy.org)
  • This course is designed to be accessible to new comers to psychoanalysis and will explain key terms like castration, perversion, etc. in understandable ways that everybody can get to grips with. (mscp.org.au)
  • This entails a legacy of castration anxiety for the boy and penis envy for the girl. (wikipedia.org)
  • For the boy, anatomical difference (the possession of a penis), induces castration anxiety as a result of an assumed paternal threat made in response to his sexual activities. (wikipedia.org)
  • The present work seeks to explain the process by which anxiety was transformed from a trope of nineteenth-century existential theology into the medicalized conception we have today. (columbia.edu)
  • Chapter four examines examines the work of the German-Jewish neurologist Kurt Goldstein, whose 1935 work The Organism drew extensively on Heidegger and Binswanger to develop a fully realized medical account of anxiety. (columbia.edu)
  • The final two chapters of my dissertation explain how the medical conception of anxiety proliferated across multiple disciplines in postwar America, including theology, literature, and psychotherapy. (columbia.edu)
  • In order to begin our approach to this difficult context linking personal life, psychoanalysis, and theoretical elaborations in a complex web of ramifications, we will consider the following points: 1. (symbiosisonlinepublishing.com)
  • Full clinical examination under a general anaesthetic, including an assessment of dental health, age and weight. (monkeyworld.org)
  • Assessing the value of a clinical approach orientated around the question of the object lack in the contemporary clinic, the book comprises 16 chapters which follow the development of a range of concepts elaborated by Lacan in these seminars, including sustained engagement with his critique of object relations theory. (routledge.com)
  • The chapters build to provide an invaluable resource to interpret and evaluate Lacan's early teaching, and to find in his early concepts a fresh utility and scope for both clinical work and psychoanalytic research and enquiry. (routledge.com)
  • At last, a scholarly examination of Lacan's Seminars IV and V by practitioners who know how to read Lacan and show us the intimate link between conceptual developments and clinical work. (routledge.com)
  • A long chapter of the work is devoted to adolescence, probably the most complete essay on the topic at that time: it is the first clinical and theoretical study of what was later called, particularly in France and in Anglo-Saxon countries, the 'adolescent process', a generic term whose relevance is still questioned today (André, J. Chabert C, 2010). (symbiosisonlinepublishing.com)
  • The strong sex difference in tuberculosis prevalence is explained by a complex interplay of factors relating to behavioral and environmental risks, access to healthcare, and clinical manifestations. (cdc.gov)
  • Future research should include trials commencing preconception and provide results disaggregated by a priori defined participant characteristics including social and environmental factors, clinical traits, and other novel risk factors to predict GDM prevention through interventions. (cdc.gov)
  • Commonly proposed reasons behind this phenomenon include differences in how men and women seek and access TB care, how social roles affect contact with persons harboring Mycobacterium tuberculosis infection, and how certain male-dominated occupations (e.g., mining) can increase the risk for TB ( 4 ). (cdc.gov)
  • Accordingly the girl's castration complex effects the redirection of her libidinal desires toward the father and away from the mother, whom she resents for depriving her of the penis, and the concomitant displacement of the clitoris by the vagina as the leading erogenous zone. (wikipedia.org)
  • Its basic epistemological values are those belonging to the natural sciences, including causal explanations, and the main practical value is the elimination of the suffering that follows from conflicting internal pulses of the libidinal type. (bvsalud.org)
  • We found that AR associates with the MLL histone methyltransferase complex through a direct connection with menin. (biobender.com)
  • BACKGROUND The histone methyltransferase (HMT) family includes histone lysine methyltransferases (HKMTs) and histone/protein arginine methyltransferases (PRMTs). (cancerindex.org)
  • Outcomes will include acceptability, feasibility, and scalability in preparation for an effectiveness trial comparing these two widely varying de-implementation strategies. (biomedcentral.com)
  • As the treatment of genitourinary cancers becomes more complex, we continue to work with urologists and their teams to improve outcomes for patients across the continuum of disease," said Craig Tendler , M.D., Vice President, Late Development and Global Medical Affairs, Janssen Research & Development, LLC. (crohnscolitisprofessional.org)
  • Taylor suggests that his attitude was far more complex, involving feminine identification. (blogspot.com)
  • As the name suggests , field castration involves gelding a horse or pony outside of a hospital environment. (mareandfoal.org)
  • Previous work suggests that motor bias (the preferred use of one limb over the other) can potentially be used as an indicator of emotional reactivity and welfare risk. (mdpi.com)
  • The author makes the point on page 85 that America has elevated capital above humans-capital votes in America, humans do not, in the one place where it really matters: the crafting of legislation that transfers wealth from the individual working poor to the privilege elite that own the military-industrial-prison complex. (phibetaiota.net)
  • Unfortunately with the inevitable progression of the cancer to castration resistance many of these drugs become ineffective. (tech-strategy.org)
  • This is a complex process that can happen in different ways, but a common way involves misuse of important transcription factors-like AR-which are then able to alter cell behavior. (helix.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Feminists such as I expect to despise the work due to its clear and vicious misogyny. (blogspot.com)
  • Regarding children with or without disabilities, 2) State University of Campinas to despise equity is a gesture similar to castration. (bvsalud.org)
  • Subjects touched on only lightly by Taylor include the artist's admitted alcoholism, his childhood in Germany during the First World War, his being labelled as degenerate by the Nazis, his emigration, the death of his wife, and others. (blogspot.com)
  • Up to and including the phallic stage of this development the penis and clitoris are the leading erogenous zones. (wikipedia.org)
  • If you know anything about Alan Turing - anything at all, including, say, what you might have gleaned from reading Neal Stephenson's excellent doorstop of a novel Cryptonomicon - The Imitation Game is unlikely to surprise you. (eugeneweekly.com)
  • During WW II, Turing built a machine that cracked the vital Nazi code called Enigma, and much of The Imitation Game focuses on Turing and a small staff as they work frantically to decipher a code that changes every day. (eugeneweekly.com)
  • The moral quandary this poses is given a too-neat movie treatment that tidily encapsulates the movie's overall weakness: Everything difficult or complex is oversimplified, smoothed out, burnished to a golden, Oscar-like hue - including Alan Turing, and the ugliness that awaited him. (eugeneweekly.com)
  • Some years after the war, when his work was still secret, Turing was prosecuted for being gay. (eugeneweekly.com)
  • The paper was the birth of what are now called Turing machines, symbol manipulating devices that can be adapted to simulate the logic of any algorithm, no matter how complex. (cctvcamerapros.com)
  • The most frequently described behaviors include compulsive gambling, compulsive sexual behavior, compulsive shopping and binge-eating or compulsive eating. (rxisk.org)
  • This work identifies a new mechanism for ligand-induced AR-HSP90 dissociation and AR activation. (oncotarget.com)
  • Taylor's remarkable book helps to elucidate the wedding of attraction and repulsion in Bellmer's work by drawing on psychoanalytic theory, while questioning the artist's own psychoanalytically informed interpretation of his art. (blogspot.com)
  • No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. (mdpi.com)
  • Nevertheless, even these viewers are won over in the presence of the art works themselves - at least to the extent of admitting its theoretical and aesthetic interest. (blogspot.com)
  • The MLL-HMT complex consists of highly conserved core proteins including MLL ASH2L RbBP5 and WDR5 which are essential for the enzymatic activity of the complex13-15. (biobender.com)
  • To further study the nature of this connection we fractionated VCaP cell nuclear extracts by size-exclusion chromatography and measured the presence of AR and MLL complex proteins by immunoblot analysis. (biobender.com)
  • Subsequent immunoprecipitation with AR ASH2L and menin antibodies followed by immunoblot analysis for AR and MLL complex proteins shown their association (Fig. 1b c). (biobender.com)
  • in both instances MLL complex proteins co-immunoprecipitated with AR (Supplementary Fig. 1a b). (biobender.com)
  • Work in this thesis provides further evidence that PDE4D7 and DHX9 proteins are novel interactors in PC. (gla.ac.uk)
  • Of course, this is a simplification-in the real world, the process is more complex and may include many proteins. (helix.com)
  • This is an elegant essay, possibly the best single individual work I have read within the 475+ non-fiction books on national security and global issues including the future of America. (phibetaiota.net)
  • The trauma induced by the child's discovery of anatomical difference between the sexes (presence or absence of the penis) gives rise to the fantasy of female emasculation or castration. (wikipedia.org)
  • Once the castration complex is initiated with the child's discovery and puzzlement over the anatomical difference between the sexes (presence or absence of the penis), it makes the assumption that this difference is due to the female's penis having been cut off or mutilated. (wikipedia.org)
  • However, until now, the absence of intercommunity attacks - including killings - in communities that live in open, mosaic environments has supported hypotheses of reduced resource competition in drier habitats, and informed referential models of early hominin social dynamics in a similar habitat. (bvsalud.org)
  • The design of small molecule inhibitors targeting these specific AR domains is only now being realized and is the culmination of decades of work including crystallographic and biochemistry approaches to map the shape and accessibility of the AR surfaces and cavities. (tech-strategy.org)
  • Mixed-lineage leukemia (MLL) a homolog of trithorax (trxG) is definitely a component of a large Collection-1-like histone methyl transferase (HMT) complex that possesses an inherent histone 3 lysine 4 (H3K4) methyl transferase activity12. (biobender.com)
  • Therefore, it is intended to foster reflection on health promotion in children with disabilities, awakening the urge of working professionals and those receiving training to extend professional commitment and recognize its importance. (bvsalud.org)
  • Juan-David Nasio is a psychoanalyst who lives and works in Paris and was the first psychoanalyst to be inducted into the prestigious French Legion of Honor. (sunypress.edu)
  • After neutering, or what some people call castration, it can take a few weeks to see any changes. (thedailytail.com)
  • Even the act of augmenting antibodies every two months with the vaccines will continue to give people a false hope of immunity, as the health of their T-cell response, macrophage response, complex microbiome, mucous membranes, nutrient absorption , cellular energy cycles and innate surveillance immune molecules are ignored. (pandemic.news)
  • Desk III Pathway Analyses from the Organizations between Prepregnancy BMI and Genome-Wide CpG Methylation Assessed from Cable Bloodstream in the Boston Delivery Cohort: Stratified by Gender It ought to be observed that although every one of the research topics had been Dark kids to limit the confounder results from hidden people stratification we included specific ancestry quotes from 141 ancestry-informative markers (Goals) [Liu et al. (tech-strategy.org)
  • In these works, the female figure is deformed, dismembered and threatened in ominous situations. (blogspot.com)
  • Female reproductive problems are usually related to complex cycling rhythms gone wrong. (encyclopedia.com)
  • DHX9 is an RNA/DNA helicase that is involved in multiple cellular processes, including transcription and maintaining genome stability. (gla.ac.uk)
  • This also caused his special clearance to be revoked so he was unable to continue his cryptographic work. (cctvcamerapros.com)
  • The castration of Christianity will continue as more blind followers are misled and enslaved by a mentality of fear and control. (pandemic.news)
  • Health professionals are the lifeblood of the health system"(President M Robinson), yet our junior doctors (NCHD-trainees) continue to report that responses for improving their working conditions have had "little tangible change or impact on their day-to-day working lives and training experience? (hrb.ie)
  • Taylor went on to note that some of Vanderbilt's "financial folks" looked at how much each transgender patient could bring into the hospital and found that, just looking at "top surgery" (not even including "bottom surgery"), each transgender patient would be extremely profitable. (shemalelisting.com)
  • Rescue situations involving unhandled equines are often complex, having vets with the skills to carry out procedures in the field is increasingly important. (mareandfoal.org)
  • We also have a state-of-the-art surgical suite at our hospital so that we can perform larger and more complex procedures. (fhvet.com)
  • Madonna-whore complex In sexual politics the view of women as either Madonnas or whores limits women's sexual expression, offering two mutually exclusive ways to construct a sexual identity. (pearltrees.com)
  • It has this in common with The Theory of Everything , which provided no insight into Stephen Hawking's work. (eugeneweekly.com)
  • For Physical Education professionals, as well as those of other fields of knowledge who share our daily work routine, it is appropriate to separate the making of thinking, the practice of theory. (bvsalud.org)
  • In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. (cancerindex.org)
  • To assist in the diagnosis and treatment of our apes' ailments, Monkey World has a fully equipped hospital complex on site. (monkeyworld.org)
  • We conducted a nested, case-control study within this TB prevalence survey to assess the contribution of various factors that might have contributed to that ratio, including access to health care, exposure, socioeconomic status (SES), and possible biological factors. (cdc.gov)
  • Mechanistically, ARD1 forms a ternary complex with AR and HSP90 in vitro and in vivo . (oncotarget.com)
  • Considering that many PKA substrates are found in complex with PDEs, DHX9 was found to be a PKA substrate in vitro. (gla.ac.uk)
  • Our analysis included 1,319 participants, of whom 250 were case-patients. (cdc.gov)
  • Any keeper who is ill does not work with the animals. (monkeyworld.org)
  • Jay's list of proposed article titles for Neurotica 's first issue included 'The New Look is the Anxious Look', 'The Castration Complex in Animals' and 'Can You Slap Your Mother? (spiked-online.com)
  • In a major upgradation exercise, the renovation of the Memorial commenced in mid-July and the complex was ready within three months for inauguration on the 59th anniversary of the battle. (pragativadi.com)
  • His first major work was On Computable Numbers, with an Application to the Entscheidungs problem, completed in 1936. (cctvcamerapros.com)
  • and the German past, when Hitler and Goering pulled off a gradual castration of free voice and vote with incremental steps, all done gradually, incrementally, inconspicuously, until suddenly a state of totalitarian rule existed. (phibetaiota.net)
  • In: Tani G, included and have a voice. (bvsalud.org)