AntibodiesPresentationProteinsCellsParticular antigenHistiocytic neoplasmsCluster of differentiatSpecific antigensMelanomaMajor histocoDiagnosisReceptorMoleculeTumorsProstateInfectionsImmune complexesHistocompatibilityLymphocytesProteinMonoclonalMyeloidFlow cytometryLeukocyteOvarianRenalCancerCellProteasomeSyntheticImmunohistochemicalTissueSerumSurvivalVasculitis
Antibodies7
- These antibodies bind to the circulating antigen and create immune complexes, which then deposit within vessels, activating complement and inducing inflammatory mediators. (medscape.com)
- however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)
- Analysis of the CAMPATH-1H binding site reveals that in contrast to most antibodies CDR L3 plays a dominant role in antigen binding. (ox.ac.uk)
- Furthermore CDR H3, which is essential for effective antigen recognition in most antibodies, participates in only two main-chain interactions in CAMPATH-1H. (ox.ac.uk)
- Such chronic injury is usually mediated by anti-human leukocyte antigen antibodies. (medscape.com)
- Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
- In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
Presentation5
- In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. (novusbio.com)
- The MTDH-SND1 complex reduces tumor antigen presentation and inhibits T cell infiltration and activation by binding to and destabilizing Tap1/2 messenger RNAs, which encode key components of the antigen-presentation machinery. (princeton.edu)
- In our body, the function of T cells and B Cells is to recognize specific non-self antigens, during a process known as antigen presentation. (wellnessadvantage.com)
- Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells. (ox.ac.uk)
- Intracellular antigens must be processed before presentation to CD8 + T cells by major histocompatibility complex (MHC) class I molecules. (johnshopkins.edu)
Proteins6
- For immunization with such antigens, proteins should be less suitable than peptides, which do not require proteasome digestion in dendritic cells. (ox.ac.uk)
- A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins. (ox.ac.uk)
- Major histocompatibility complex class I-restricted T-cell epitopes can be generated from these proteins by the proteasome after retrotranslocation into the cytosol. (ox.ac.uk)
- The processing of this epitope depends on the proteasome and the transporter associated with antigen processing and shows a novel pathway of class I processing that relies on the failure of ER-targeted proteins to reach their target compartment. (ox.ac.uk)
- These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
- We were also able to define immunogenic membrane proteins from lung (squamous and adenoCa) as well as prostate neoplasms. (jcancer.org)
Cells22
- HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
- CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). (wikipedia.org)
- The antigen is found bound to the membranes of all mature T-cells, and in virtually no other cell type, although it does appear to be present in small amounts in Purkinje cells. (wikipedia.org)
- The emergence of chimeric antigen receptor T cells (CARTs) has revolutionized the treatment of B-cell neoplasms in the last few years. (ebmt.org)
- Antigen-antibody complexes induce ia+ suppressor inducer cells that in" by S V. Rao, J A. Frelinger et al. (jax.org)
- Antigen-antibody complexes induce ia+ suppressor inducer cells that initiate suppression of macrophages. (jax.org)
- RCAS1 (Receptor-binding Cancer Antigen expressed on SiSo cells) is a protein that is expressed in different types of cancer and seems to be involved in the process of the tumour cells' escape from the immune system surveillance (immunoescape). (esmo.org)
- Following activation, B cells and T cells leave a lasting legacy of the antigens they have encountered, in the form of memory cells. (wellnessadvantage.com)
- We show that dendritic cells also carry immunoproteasomes and fail to present this antigen. (ox.ac.uk)
- Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. (loinc.org)
- This is the first example of a tumor-specific antigen exclusively presented by tumor cells expressing the immunoproteasome. (ox.ac.uk)
- Recent data suggest that ICAM-3 expression can be induced on endothelial cells in lymphoid neoplasms as shown for Hodgkin's and non-Hodgkin's disease. (biovendor.com)
- The blood group system particular to primates that denotes the presence or absence of A,B, and O antigens on erythrocytes (red blood cells). (anthropogeny.org)
- A glycoprotein formed by immune cells ( B-cells ) that specifically recognize certain molecules ( antigens ) to neutralize pathogens such as bacteria and viruses . (anthropogeny.org)
- They exist in pentameric form (IgM), dimeric form (IgA) or single form (IgG, IgE, IgD), which consist of Y-shaped units that each have two antigen-binding pockets on one side and a region recognized by immune cells on the opposite. (anthropogeny.org)
- BCRs also control B-cell activation by biochemical signaling and by physical acquisition of antigens from immune synapses with antigen-presenting cells. (anthropogeny.org)
- Additionally, B-cells present antigens and secrete cytokines . (anthropogeny.org)
- Further insights on the roles of CD8 + specificities and TCR avidity of naturally arising tumor-specific T cells, where both high and low avidity T cells recognizing the same peptide-major histocompatibility complex (pMHC) coexist in the same tumor, are crucial for understanding T cell exhaustion and resistance to PD-1 immunotherapy. (bmj.com)
- Inhibitors of components of B cell receptor signalling are being pursued as novel therapeutics for lymphoid neoplasms, e.g. polatuzumab vedotin is an investigational antibody-drug conjugate targeting a toxic payload to CD79B +ve cells in various hematological malignancies. (guidetoimmunopharmacology.org)
- Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
- These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
- The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)
Particular antigen1
- Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen. (roche.com)
Histiocytic neoplasms2
- True histiocytic neoplasms are similarly positive. (novusbio.com)
- AACT antibody reacts with histiocytes and histiocytic neoplasms. (neobiotechnologies.com)
Cluster of differentiat1
- CD3 (cluster of differentiation CD3), is an antigen that is part of the T cell receptor (TCR) complex on a mature T lymphocyte. (esmo.org)
Specific antigens2
- The tips of the "Y" can recognize specific antigens and lead to a successful immune response, while the bottom of the "y" regulates immune cell responses. (anthropogeny.org)
- Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
Melanoma1
Major histoco1
- Immunohistochemical and immunoelectron study of major histocompatibility complex class-II antigen in canine cutaneous histiocytoma: its relation to tumor regression. (illumina.com)
Diagnosis5
- The most frequent application is the diagnosis of neoplasms of the female breast . (lookformedical.com)
- Diagnosis of this neoplasm is usually incidental (85% are asymptomatic when diagnosed) when the patient has a CBC and/or peripheral blood smear . (cancer.gov)
- Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. (neobiotechnologies.com)
- Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. (roche.com)
- Female canine mammary neoplasms (CMNs) are defined as a heterogeneous group of diseases of complex classification, diagnosis, and prognosis. (scielo.br)
Receptor3
- The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. (lookformedical.com)
- Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type II as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis. (ox.ac.uk)
- CD79B is a component of the multimeric B cell antigen receptor (along with CD79A and a membrane-bound antibody that acts as the antigen recognition moiety). (guidetoimmunopharmacology.org)
Molecule3
- Following small-molecule compound C26-A6 treatment to disrupt the MTDH-SND1 complex, we showed enhanced immune surveillance and sensitivity to anti-programmed cell death protein 1 therapy in preclinical models of metastatic breast cancer, in support of this combination therapy as a viable approach to increase immune-checkpoint blockade therapy responses in metastatic breast cancer. (princeton.edu)
- Intercellular Adhesion Molecule-3 (ICAM-3) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). (biovendor.com)
- Using a recombinant vaccinia virus (Vac) to transiently express the K d molecule, we studied the antigen processing efficiency of 26 different human tumor lines. (johnshopkins.edu)
Tumors2
- Our findings suggest that downregulation of antigen processing may be one of the strategies used by tumors to escape immune surveillance. (johnshopkins.edu)
- We report here that Ptch +/- mice develop primordial follicular neoplasms resembling human trichoblastomas, and that exposure to ultraviolet radiation or ionizing radiation results in an increase in the number and size of these tumors and a shift in their histologic features so that they more closely resemble human basal cell carcinoma. (nature.com)
Prostate3
- 2001. Value of prostate specific antigen α1-antichymotrypsin complex for the detection of prostate cancer in patients with a PSA level of 4.1-10.0 ng/mL: comparison with PSA-related parameters. (neobiotechnologies.com)
- Here, we show that an HLA-A(*)0201-restricted epitope from prostate stem cell antigen contains the cleavage site of the ER signal peptidase. (ox.ac.uk)
- As processing of prostate stem cell antigen by signal peptidase occurs immediately after co-translational insertion, the epitope must be processed from polypeptides that have never reached the ER. (ox.ac.uk)
Infections2
- [ 1 ] In this form of vasculitis, circulating antigens in the body (produced by factors such as medications, infections, and neoplasms) induce antibody formation. (medscape.com)
- Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
Immune complexes1
- Henoch-Schönlein purpura (HSP), a small-vessel vasculitis characterized by deposition of immunoglobulin A (IgA) immune complexes, reportedly has an incidence of 14 cases per million people per year. (medscape.com)
Histocompatibility1
Lymphocytes3
- Tumor infiltrating lymphocytes (TILs) have been correlated with patients' survival in several neoplasms. (esmo.org)
- By stimulating human lymphocytes with an autologous renal carcinoma, we obtained CTL recognizing an antigen derived from a novel, ubiquitous protein. (ox.ac.uk)
- It recognises the CD52 antigen which is a small glycosylphosphatidylinositol(GPI)-anchored protein expressed on lymphocytes and mediates cell depletion. (ox.ac.uk)
Protein2
- Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. (roche.com)
- The identification of putative prognostic factors in canine mammary neoplasms (CMNs) has been focused on tissue-specific biomarkers, but the serum biomarkers, including cancer antigen 15-3 (CA 15-3), c-reactive protein (CRP), and lactate dehydrogenase (LDH) have been demonstrated to display clinical application in cases of CMNs. (scielo.br)
Monoclonal2
- This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
- Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffinembedded tissue sections. (roche.com)
Myeloid3
- The antigen remains present in almost all T-cell lymphomas and leukaemias, and can therefore be used to distinguish them from superficially similar B-cell and myeloid neoplasms. (wikipedia.org)
- 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
- Chronic myeloid leukemia ( CML ), BCR-ABL1-positive, is a myeloproliferative neoplasm (MPN) in which granulocyte s are the major proliferative component. (cancer.gov)
Flow cytometry1
- Cytologic material undergoes complex evaluation applying immunohistochemistry flow cytometry and digital image analyses. (gov.pl)
Leukocyte1
- LFA-1, an alpha-beta complex, is a member of the leukocyte integrin family which mediate lymphocyte adhesion. (biovendor.com)
Ovarian1
Renal1
Cancer3
- Through genetic and pharmacological targeting of the MTDH-SND1 interaction, we reveal a key role for this complex in suppressing antitumor T cell responses in breast cancer. (princeton.edu)
- Di Gioia D, Blankenburg I, Nagel D, Heinemann V, Stieber P. Tumor markers in the early detection of tumor recurrence in breast cancer patients: CA 125, CYFRA 21-1, HER2 shed antigen, LDH and CRP in combination with CEA and CA 15-3. (scielo.br)
- The major neoplasm worldwide is oral cancer. (bvsalud.org)
Cell2
- The pro-thymocytes differentiate into common thymocytes, and then into medullary thymocytes, and it is at this latter stage that CD3 antigen begins to migrate to the cell membrane. (wikipedia.org)
- BCRs allow the B-cell to bind to a specific antigen , against which it will initiate an antibody response. (anthropogeny.org)
Proteasome1
- Potential therapeutic applications of these findings include enhancing antigen processing at the level of the transcription of MHC-encoded proteasome and transporter genes. (johnshopkins.edu)
Synthetic1
- 1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen. (ox.ac.uk)
Immunohistochemical1
- In general, immunohistochemical staining allows the visualization of antigens via the sequential application of a specific antibody (primary antibody) to the antigen, a secondary antibody (link antibody) to the primary antibody, an enzyme complex and a chromogenic substrate with interposed washing steps. (roche.com)
Tissue1
- Ability of neoplasms to infiltrate and actively destroy surrounding tissue. (lookformedical.com)
Serum1
- This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
Survival1
- RESULTS: Minichromosome maintenance complex component 2 (MCM2) and cyclin A were significantly associated with overall survival. (ox.ac.uk)
Vasculitis1
- Hypersensitivity vasculitis is thought to be mediated by immune complex deposition. (medscape.com)