Complex antigens cd. Medical search. Frequent questions

Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen. (bdbiosciences.com)
Analysis of the CAMPATH-1H binding site reveals that in contrast to most antibodies CDR L3 plays a dominant role in antigen binding. (ox.ac.uk)
Furthermore CDR H3, which is essential for effective antigen recognition in most antibodies, participates in only two main-chain interactions in CAMPATH-1H. (ox.ac.uk)
In an effort to assess the risk of B. pseudomallei infection to service personnel in Australia, 341 paired samples, representing pre- and post-deployment samples of Marines who trained in Australia, were analyzed for antibodies against B. pseudomallei antigens. (health.mil)
The cellular response is mainly a lymphocyte-mediated reaction, whereas the humoral response includes production of antibodies against the antigen by the plasma cells. (medscape.com)
Immunoglobulins (Igs), the term is sometimes used interchangeably with "antibodies," are glycoprotein molecules produced by B lymphocytes and plasma cells in response to an immunogen or after recognition of specific epitopes on the antigen. (medscape.com)
The antibodies then specifically bind to only those particular antigens. (medscape.com)
Antibodies can bind to the different antigens causing agglutination and precipitation of the antigens leading to neutralization of the antigen effect. (medscape.com)
They can also stimulate the destruction of antigen by cells like macrophages, neutrophils, and eosinophils by covering the surface of the antigen by the Fc portion of the antibodies in a process known as "opsonization. (medscape.com)
Platelet factor 4 binds to bacteria, inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia. (trillium.de)
11. Amiral J, Bridey F, Wolf M, Boyer-Neumann C, Fressinaud E, Vissac AM, Peynaud-Debayle E, Dreyfus M, Meyer D. Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. (trillium.de)
The surface of the plate will become coated with the antibodies that recognize and bind precisely to the antigen in the sample. (cd-elisakit.com)
Indirect ELISA has a number of advantages over other techniques for detecting antibodies, including its adaptability and agility to detect a variety of antigens and antibodies. (cd-elisakit.com)
A specific and accurate technology, indirect ELISA relies on the precise binding of antibodies to antigens and uses enzymes to generate a detectable signal. (cd-elisakit.com)
Indirect ELISA is a great instrument that can be customized to detect a wide variety of antigens and antibodies and is frequently used in biological research and clinical diagnostics, despite its drawbacks. (cd-elisakit.com)

CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). (biolegend.com)
The antigen recognized by the CD3 antibody is noncovalently associated with either α/β or γ/δ TCR (70 to 90 kDa). (bdbiosciences.com)
Description: The 17A2 monoclonal antibody reacts with the mouse CD3 complex. (thermofisher.com)
1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen. (ox.ac.uk)
Variable region constitutes the antibody binding region of the molecule to the different antigens as it consists of about 110 amino acids that vary widely among the different antibody molecules. (medscape.com)
Antigen-antibody complexes were detected using horseradish peroxidase-conjugated secondary antibody and Super Signal West Pico chemiluminescent substrate (Pierce). (nostradamus2018.com)
An affinity-purified rabbit polyclonal C-Stop antibody raised against the final 12 residues of PAM was used to analyze sf-CD levels (15). (nostradamus2018.com)
PF4-HIT antibody (KKO) complexes activate broad innate immune and inflammatory responses. (trillium.de)
The idea of specific antigen-antibody binding forms the basis of indirect ELISA. (cd-elisakit.com)
A solid surface, usually a microtiter plate, is immobilized with an antigen-a molecule that can elicit an immune response-and then blocked to stop non-specific antibody binding. (cd-elisakit.com)
An antigen-antibody-secondary antibody-enzyme complex is created when this secondary antibody identifies and binds to the primary antibody. (cd-elisakit.com)
As a result, indirect ELISA is a sensitive and precise technique that can detect low antibody concentrations and tell apart closely similar antigens. (cd-elisakit.com)
This is a classic type II reaction in the Gell and Coombs classification of antigen-antibody reactions. (medscape.com)

Leucocyte Typing IV: White Cell Differentiation Antigens. (bdbiosciences.com)

Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
Summary of T-cell studies performed during the Second International Workshop and Conference on Human Leukocyte Differentiation Antigens. (bdbiosciences.com)
Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation. (bdbiosciences.com)
Bernard A, Boumsell L, Hill C. Joint report of the first international workshop on human leucocyte differentiation antigens by the investigators of the participating laboratories: T2 protocol. (bdbiosciences.com)

CD molecules are leucocyte antigens on cell surfaces. (wikipedia.org)
histocom-patibility complex (MHC) molecules plus interleukin (IL)-7. (123dok.net)
Antigens are the molecules that are recognized and stimulate the cells of immune system. (medscape.com)

Murine MC are divided into three subsets based on surface expression of lymphocyte antigen 6 complex, locus C (Ly6C) ( 3 , 4 ). (frontiersin.org)

Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)
Efficient recognition of foreign pathogens by T cells requires adhesive interactions between T cells and other cell types, such as endothelial cells and antigen-presenting cells (APCs), and with components of the extracellular matrix. (scielo.br)
discuss the role of integrins in T cell- mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs. (scielo.br)

They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein. (bvsalud.org)

Clevers H, Alarcón B, Wileman T, Terhorst C. The T cell receptor/CD3 complex: a dynamic protein ensemble. (bdbiosciences.com)
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. (cdantigens.com)
Creative BioMart is a leading provider of recombinant protein products and protein expression-related services with the commitment to harnessing the advancements in protein expression and purification technology to give its customers access to robust, efficient, and reliable solutions for most complex biology questions. (woodtv.com)
It recognises the CD52 antigen which is a small glycosylphosphatidylinositol(GPI)-anchored protein expressed on lymphocytes and mediates cell depletion. (ox.ac.uk)

In this study, we have used tetrameric major histocompatibility complex-peptide complexes to directly visualize antigen-specific cluster of differentration (CD)8+ T cells during the primary immune response to Epstein-Barr virus (EBV) infection in humans. (ox.ac.uk)

The different receptor complexes may be linked to ligand-specific cellular responses initiated by CD14. (unideb.hu)

CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex. (biolegend.com)
TCR signal transduction, T cell activation and antigen recognition. (biolegend.com)
CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. (exbio.cz)
It is expressed on cytolytic T cells and functions in conjunction with the T cell receptor in the recognition of MHC-I/peptide complexes. (rndsystems.com)

Mouse γ 1 (IgG 1 ) recognizes a keyhole limpet hemocyanin (KLH) antigen not expressed on human cells. (bdbiosciences.com)
The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkynje cells in the cerebellum. (exbio.cz)
8. Coccia MA, Brams P. High titer, prostate specific antigen-specific human IgG production by hu-PBL-SCID mice immunized with antigen-mouse IgG2a complex-pulsed autologous dendritic cells. (southernbiotech.com)
The authors also argue that memory B and T cell responses are long-lived in the absence of antigen, but they are modulated and influenced by other infections and that memory B and T cells can either provide protective immunity or contribute to immunopathology on infection with homologous or heterologous viruses. (scielo.br)
Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo. (ox.ac.uk)
We show that massive expansion of activated, antigen-specific T cells occurs during the primary response to this virus. (ox.ac.uk)
The majority of the antigen-specific cells had an activated/memory phenotype, with expression of human histocompatibility leukocyte antigen (HLA) DR, CD38, and CD45RO, downregulation of CD62 leukocyte (CD62L), and low levels of expression of CD45RA. (ox.ac.uk)
After recovery from AIM, the frequency of antigen-specific T cells fell in most donors studied, although populations of antigen-specific cells continued to be easily detectable for at least 3 yr. (ox.ac.uk)
Although PAM sf-CD is unstable in AtT-20 corticotroph tumor cells, it is readily detected in primary rat anterior pituitary cells. (nostradamus2018.com)
sf-CD is produced by primary rat anterior pituitary cells in response to secretogogue, suggesting that sf-CD acts as a signaling molecule relaying information about secretion from the secretory granule to the nucleus. (nostradamus2018.com)
Immunoprecipitation and Mass Spectrometry Myc-TMD-CD cells or wild type AtT-20 cells were grown in 15 confluent 150-mm dishes each and treated with lactacystin for 5 h in complete serum-free medium containing 0.02 mg/ml bovine serum albumin. (nostradamus2018.com)
The CD1 family: serving lipid antigens to T cells since the Mesozoic era. (hcdm.org)
CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. (hcdm.org)
CD1a, as other members of the CD1 family, is involved in the immune response by presenting self and non-self lipid and glycolipid antigens to T cells. (hcdm.org)
Immunofluorescence study showed replication of SARS-CoV in the cells derived from throat wash, demonstrating the possibility of developing a convenient antigen detection assay. (cdc.gov)

Cytoplasmic expression of the CD3 antigen as a diagnostic marker for immature T-cell malignancies. (bdbiosciences.com)
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. (exbio.cz)

Herb-partitioned moxibustion may inhibit excessively activated autophagy and modulate the expression of immune-related factors by regulating the LKB1-mTOR-PI3KC signal transduction networks, thereby alleviating intestinal inflammation in CD rats. (hindawi.com)
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. (abcam.co.jp)

These findings may provide insight into the mechanisms by which the BCR, and other such multimeric receptor complexes, initiate both apoptotic and proliferative responses to antigen. (nih.gov)

Serum and fecal biomarkers were evaluated for association with the Mayo Clinic endoscopy score in UC patients and with ICO alone or ICO-CTE in CD patients. (nih.gov)
In CD, we found that use of the ICO-CTE increased specificity of known biomarkers. (nih.gov)

Therefore, we developed a novel system in which we could form and then aggregate dimers, representative of partial receptor complexes, which contained either Ig alpha alone, Ig beta alone, or the two chains together and then examine their ability to induce apoptosis in the immature B-cell line, WEHI-231. (nih.gov)

Epitopes are a component of the antigen that are recognized by the immune system and determine whether the cellular or the humoral arm of the immune system shall be activated against that particular antigen. (medscape.com)
Recent medical research indicates that a large number of gluten epitopes, may be implicated in the development of Gluten-Reactivity, CD and other associated conditions. (renuehealth.com)
The measurement of IgA and IgG against multiple gluten epitopes in blood can have important implications in the accurate diagnosis and design of therapy for Gluten-Reactive and CD patients. (renuehealth.com)

Cobbold SP, Hale G, Waldmann H. Non-lineage, LFA-1 family, and leucocyte common antigens: new and previously defined clusters. (bdbiosciences.com)

LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. (nih.gov)

To investigate the mechanism of action of herb-partitioned moxibustion on CD from the perspective of autophagy and immunity. (hindawi.com)
The interactions of genetic susceptibility, immunity, and environmental factors are important in the pathogenesis of CD. (hindawi.com)
BACKGROUND: Although cell mediated immunity is primarily thought to mediate the pathogenesis of sarcoidosis, the presence of immunoglobulins, immune complexes and complement suggests that processes of humoral immunity may contribute to immunopathology in sarcoid lesions. (ox.ac.uk)

Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. (nih.gov)
PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum. (harvard.edu)

This complex is composed of at least six proteins that range in molecular weight from 20 to 30 kdaltons (kDa). (bdbiosciences.com)
sf-CD levels are also modulated by the phosphorylation status of the cytosolic domain and by the ability of the cytosolic domain to interact with cytosolic proteins. (nostradamus2018.com)
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders (such as viruses and bacteria). (medlineplus.gov)

In its never-ending effort to fully understand the immune system's complexity, the finely complex and multidisciplinary discipline of immunology has given rise to a myriad of tools and approaches that are employed to research its various elements. (cd-elisakit.com)

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (nih.gov)

Combinations of fecal calprotectin and serum MMP9 for UC, and combinations of fecal calprotectin, serum MMP9, and serum interleukin-22 in CD, demonstrated the strongest association with imaging/endoscopy-defined inflammation. (nih.gov)

The third National Health and Nutrition Examination Survey (NHANES III), conducted from 1988 through 1994, was the seventh in a series of these surveys based on a complex, multi-stage sample plan. (cdc.gov)

We present the 1.9 A structure of the CAMPATH-1H Fab complexed [corrected] with an analogue of the antigenic determinant of CD52. (ox.ac.uk)
5. Brandt S, Krauel K, Jaax M, Renné T, Helm CA, Hammerschmidt S, Delcea M, Greinacher A. Polyphosphates form antigenic complexes with platelet factor 4 (PF4) and enhance PF4-binding to bacteria. (trillium.de)

Cleavage by -secretase generates a soluble fragment of the cytosolic domain (sf-CD) that is known to localize to the nucleus. (nostradamus2018.com)

Current testing for Gluten-Reactivity and Celiac disease (CD) includes serum IgG and IgA against gliadin and tissue transglutaminase-2 (tTG2). (renuehealth.com)
CD or gluten- sensitive enteropathy, is only one aspect of a range of possible manifestations of reactivity to gluten. (renuehealth.com)

This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence. (hindawi.com)
In recent years, increasing evidence has shown that autophagy-related genetic susceptibility is also closely related to the pathogenesis of CD [ 4 , 5 ]. (hindawi.com)
They may also influence the pathogenesis of the disorder by presenting antigen(s) and forming immune complexes at sites of disease activity. (ox.ac.uk)

Crohn's disease (CD) is a complex, chronic, nonspecific inflammatory bowel disease (IBD). (hindawi.com)
Ulcerative colitis (UC) is one of the idiopathic forms of inflammatory bowel disease (IBD), sharing this designation with Crohn disease (CD). (medscape.com)
It is believed that the 2 idiopathic forms of inflammatory bowel disease (IBD), ulcerative colitis and Crohn disease (CD), develop secondary to complex interactions among genetic predispositions, environmental risk factors, and the immune system. (medscape.com)

Research performed in-house confirms that different Gluten-Reactive and CD patients recognize an array of gluten antigens. (renuehealth.com)

One theory proposes that ulcerative colitis occurs as a direct result of an aberrant immune response to "gut luminal antigen" in a genetically susceptible host. (medscape.com)
CD), wheat allergy (WA), and non-celiac tion and the immune response it presents gluten sensitivity (NCGS)2. (bvsalud.org)

The EMBARK study evaluated disease activity in patients with ulcerative colitis (UC) and CD, and used endoscopy with or without cross-sectional imaging for biomarker discovery. (nih.gov)

C3 cleavage may result in formation of the membrane attack complex (MAC), the cytotoxic component of the complement system. (msdmanuals.com)

T cell activation by lipopeptide antigens. (hcdm.org)

However, Ig alpha, Ig beta, and most of the other receptor chains that contain ITAMs, including CD3 epsilon, CD3 gamma, TCR zeta, and Fc epsilon Rl gamma, are found as components of multimeric and heterogeneous complexes. (nih.gov)
CD3 recognizes the epsilon chain of the CD3 antigen/T-cell antigen receptor (TCR) complex. (bdbiosciences.com)
CD3 subunits gamma, delta and epsilon are required for proper assembly, trafficking and surface expression of the TCR complex. (thermofisher.com)

The response of a B cell to antigen is dependent on the surface expression of a clonotypic B-cell receptor complex (BCR) consisting of membrane-bound Ig and disulfide-linked heterodimers of Ig alpha/beta. (nih.gov)
PAM isoform expression, which is tissue-specific and developmentally regulated, affects the efficiency with which sf-CD is produced. (nostradamus2018.com)

Goodpasture syndrome (ie, anti-GBM disease) is an uncommon disorder of complex pathogeneses. (medscape.com)

The body's immune system can react adaptively against the antigen via 2 pathways: cellular or humoral. (medscape.com)

In Crohn's disease (CD), clinical symptoms correspond poorly to inflammatory disease activity. (nih.gov)

Anatomy29

Organisms11

Diseases4

Chemicals and Drugs154

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes32

Disciplines and Occupations1

Information Science3

Health Care3

Antibodies15

Antibody13

White Cell Differentiation Antigens1

Differentiation4

Molecules3

Lymphocyte antigen1

APCs4

Receptors1

Protein4

Humans1

CD141

Recognition4

Cells15

Cytoplasmic2

Signal transduction2

Responses1

Biomarkers2

Receptor complexes1

Epitopes3

Leucocyte1

Leukocyte1

Immunity3

Human2

Proteins3

Immunology1

Histocompatibility1

Inflammation1

19881

Antigenic2

Soluble1

Reactivity2

Pathogenesis3

Inflammatory bowel d3

Recognize1

Immune response2

Ulcerative colitis1

Cytotoxic1

Activation1

Epsilon3

Expression2

Disorder1

Body's1

Crohn's1