• built in drug dosing calculatio
  • Davis's Drug Guide for Nurses - now with over 760 Integrated Calculators - combines the most comprehensive, up-to-date and practical drug resource with built in drug dosing calculation tools for most weight or body surface area based dosing. (bio-medicine.org)
  • DrDrugs®: Drug Guide for Physicians - now with over 760 Integrated Calculators - combines the most comprehensive, up-to-date and practical drug resource with built in drug dosing calculation tools for most weight or body surface area based dosing. (bio-medicine.org)
  • Now, in addition to providing the most comprehensive, up-to-date and practical drug information, DrDrugs includes over 800 built in drug dosing calculation tools . (skyscape.com)
  • dose
  • Simply review a drug, calculate the dose and administer all in a single step without needing to switch to a separate drug dosing program. (skyscape.com)
  • Plus new integrated dosing calculators - Now, with over 800 built in weight-based drug dosing calculation tools, simply review a drug, calculate the dose and administer all in a single step, without needing to switch to a separate drug dosing program. (skyscape.com)
  • Collectively, these findings suggest that the D2 receptor is not necessary for cocaine self-administration, but this receptor subtype is involved in mechanisms that limit rates of high-dose cocaine self-administration. (jneurosci.org)
  • The rationale for development of liposomal formulations is primarily that of improving the safety profile of the drug, which may permit dose intensification and/or an increase in the cumulative dose that may be administered, resulting in enhanced efficacy. (clinicaltrials.gov)
  • LEM will be given to patients with advanced solid tumors to determine the dose of drug these patients can tolerate. (clinicaltrials.gov)
  • At least three patients will be studied at each dose level and at least three patients will complete one 21-day course before any patient is enrolled at the next dose level. (clinicaltrials.gov)
  • The preclinical stages are also necessary to determine approximate dose ranges and proper drug formulations (i.e., tablet, injection etc…) This is also the stage in which the drug candidate may be first tested in laboratory animals prior to moving to the phase one trials. (wikipedia.org)
  • placebo
  • After the administration of the vaccine or placebo, the researchers collect data on antibody production, on health outcomes (such as illness due to the targeted infection or to another infection). (wikipedia.org)
  • 2016
  • https://www.gpo.gov/fdsys/pkg/FR-2016-12-14/pdf/2016-29941.pdf Code of Federal Regulations, 2012-04-01 The first 8 items in the temporary section of the schedule shown on the DEA website are not included here because they are duplicates of entries in the tables above. (wikipedia.org)
  • In August 2016 the DEA reaffirmed its position and refused to remove Schedule I classification. (wikipedia.org)
  • For follicular lymphoma, the FDA awarded copanlisib orphan drug status in February 2015 and fast track designation in February 2016. (wikipedia.org)
  • patients
  • Approximately 100 patients will be needed to complete collection of 26 weeks of safety data, and approximately 50 patients will be needed to complete collection of 52 weeks of safety data. (businesswire.com)
  • Copanlisib (trade name Aliqopa, AL-ih-KO-pah, codenamed BAY 80-6946), is a drug which is approved by US FDA for the treatment of adult patients experiencing relapsed follicular lymphoma who have received at least two prior systemic therapies. (wikipedia.org)
  • 1970s
  • In the 1970s, recreational drug users discovered that combining pentazocine with tripelennamine (a first-generation ethylenediamine antihistamine most commonly dispensed under the brand names Pelamine and Pyribenzamine) produced a euphoric sensation. (wikipedia.org)
  • treaties
  • this quote needs a citation] Rufus King notes that this stratagem was similar to that used by Harry Anslinger when he consolidated the previous anti-drug treaties into the Single Convention and took the opportunity to add new provisions that otherwise might have been unpalatable to the international community. (wikipedia.org)
  • statutory
  • While not specifically related to clinical trials, the Council also recommended that FDA "make full use of accelerated approval for all drugs meeting the statutory standard of addressing an unmet need for a serious or lifethreatening disease, and demonstrating an impact on a clinical endpoint other than survival or irreversible morbidity, or on a surrogate endpoint, likely to predict clinical benefit. (wikipedia.org)
  • Jon Gettman, former director of the National Organization for the Reform of Marijuana Laws, has argued that cannabis does not fit each of the three statutory criteria for Schedule I. Gettman believes that "high potential for abuse" means that a drug has a potential for abuse similar to that of heroin or cocaine. (wikipedia.org)
  • reactions
  • Recent scientific advances have helped to use transgenic animals as a part of vaccine preclinical protocol in hopes to more accurately determine drug reactions in humans. (wikipedia.org)
  • Phase two will consist of more healthy volunteers in the vaccine target population (~100s of people) to determine reactions in a more diverse set of humans and test different schedules. (wikipedia.org)
  • Abuse
  • It was passed by the 91st United States Congress as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 and signed into law by President Richard Nixon. (wikipedia.org)
  • cannabis
  • The US government, on the other hand, maintains that cannabis is dangerous enough to merit Schedule I status. (wikipedia.org)
  • Subsequently, medical cannabis advocacy group Americans for Safe Access filed an appeal, Americans for Safe Access v. Drug Enforcement Administration in January 2012 with the District of Columbia Circuit, which was heard on 16 October 2012 and denied on 22 January 2013. (wikipedia.org)
  • In 1970, Congress placed cannabis into Schedule I on the advice of Assistant Secretary of Health Roger O. Egeberg. (wikipedia.org)
  • anti-cannabis organizations Groups fighting against cannabis legalization, or apologizing for harm caused by drug prohibition, including: D.A.R.E., Partnership at Drugfree.org, and SAM. (wikipedia.org)
  • Early anti-cannabis propaganda includes the 1936 drug exploitation film Reefer Madness. (wikipedia.org)
  • compounds
  • 1 ). In the sections that follow, we briefly describe key aspects of the Agents Developmental Pathway that present particular challenges or require improvement in design or implementation, so as to improve the efficiency of bringing new compounds to the clinic as drugs for human testing. (aacrjournals.org)
  • successfully
  • Operator Testing and Mentoring - New operators must successfully complete a written test before being permitted to purchase insurance. (wikipedia.org)
  • New operators must successfully complete mentoring under the guidance of an experienced operator during their first rail excursion. (wikipedia.org)
  • Insomnia
  • Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the New Drug Application (NDA) for suvorexant, the company's investigational insomnia medicine, has been accepted for standard. (thestreet.com)
  • Officials
  • After health-care professionals and drug-enforcement officials became aware of this scenario, the mu-opioid-antagonist naloxone was added to oral preparations containing pentazocine to prevent perceived "misuse" via injection, and the reported incidence of its recreational use has declined precipitously since. (wikipedia.org)
  • herbal
  • As traditional medical treatment revolves around drug therapy, traditional Chinese medicine herbal remedies are the most common alternative treatment for tetanus. (encyclopedia.com)
  • cocaine
  • However, it has been difficult to differentiate the roles of the D2-like receptor subtypes in the behavioral effects of cocaine because of the relatively low selectivity of drugs for D2, D3, and D4 receptors in vivo . (jneurosci.org)
  • First, we evaluated cocaine self-administration behavior, and related effects of nonselective D2-like drugs, in mutant mice that lack the D2 receptor but express D3 and D4 receptors. (jneurosci.org)
  • In wild-type mice, pretreatment with the D2-like antagonist eticlopride increased rates of self-administration of high doses of cocaine, and the D2-like agonist quinelorane served as a positive reinforcer when substituted for cocaine. (jneurosci.org)
  • Next, we compared the effects of novel antagonists selective for different D2 receptor subtypes on cocaine self-administration behavior in outbred rats. (jneurosci.org)
  • In rats, a D2 selective antagonist increased rates of self-administration of high doses of cocaine and also combinations of cocaine and the D2-like agonist quinelorane, whereas D3/D4 antagonists were ineffective. (jneurosci.org)
  • Our results also suggest that D3 and D4 receptors do not play major roles in the modulation of cocaine self-administration by D2-like drugs. (jneurosci.org)
  • Thus, several lines of evidence suggest a prominent role for dopamine receptors in cocaine self-administration behavior. (jneurosci.org)
  • Phase
  • In 2012, the President's Council of Advisors on Science and Technology (PCAST) recommended that FDA "run pilot projects to explore adaptive approval mechanisms to generate evidence across the lifecycle of a drug from the premarket through the postmarket phase. (wikipedia.org)
  • petition
  • The petition was ultimately denied after 22 years of court challenges, but a pill form of cannabis's psychoactive ingredient, THC, was rescheduled in 1985 to allow prescription under schedule II. (wikipedia.org)
  • safety
  • Federal Railroad Administration Liaison - NARCOA maintains an ongoing dialogue with the Federal Railroad Administration (FRA) on safety and regulatory issues affecting the hobby. (wikipedia.org)
  • The purpose of screening the receiving parties of finished goods is to exude "due diligence" and "reasonable care" when completing transactions with foreign entities, ensuring the safety and intention of the products and importers. (wikipedia.org)
  • To assess the safety of the drug, data from 168 adults with follicular lymphoma and other hematologic malignancies treated with copanlisib were evaluated. (wikipedia.org)
  • Data for safety and efficacy of copanlisib are described in a consumer-friendly way in the FDA Drug Trial Snapshot. (wikipedia.org)
  • Treatment
  • Despite the increasing number of pregnant women being prescribed metformin for treatment of diabetes or PCOS and the recognition that physiological changes occurring during pregnancy may affect metformin disposition, data on the PK of the drug during gestation are limited. (aspetjournals.org)
  • It eliminated mandatory minimum sentences and provided support for drug treatment and research. (wikipedia.org)
  • Copanlisib was granted orphan drug status for the treatment of splenic, nodal and extranodal subtypes of marginal zone lymphoma. (wikipedia.org)
  • trade
  • The nation first outlawed addictive drugs in the early 1900s and the International Opium Convention helped lead international agreements regulating trade. (wikipedia.org)
  • data
  • Adapting the design as results arrive adds to the complexity of design, monitoring, drug supply, data capture and randomization. (wikipedia.org)
  • high
  • A vaccine candidate drug is first identified through preclinical evaluations that could involve high throughput screening and selecting the proper antigen to invoke an immune response. (wikipedia.org)
  • include
  • Traditional opponents to U.S. investment policy such as Public Citizen decried the 2012 Model BIT, criticizing the Obama Administration for failing to include strong enough labor and environment protections and for preserving the ability of US and foreign businesses to initiate "investor-state" arbitrations. (hoganlovells.com)
  • It will for example include a new calendar and further improvements of the mobile template. (wikipedia.org)
  • Company
  • Pentazocine was developed by the Sterling Drug Company, Sterling-Winthrop Research Institute, of Rensselaer, New York. (wikipedia.org)
  • example
  • For example, the first subgroup could complete the entire regimen before the second subgroup starts or the second can begin before the first ends as long as SAEs were not detected. (wikipedia.org)
  • adults
  • but recently there have been reports of teens and adults in the UK abusing this drug, known as "tombstones" to the abusers. (wikipedia.org)