• activation
  • Background and Purpose- Pharmacological modulation of complement activation recently has been postulated as a therapeutic target in the treatment of neurological injury. (ahajournals.org)
  • 4 Within minutes of vascular occlusion, multiple inflammatory events ensue, including activation of the complement cascade, 5 which can contribute directly to neuronal cell death. (ahajournals.org)
  • In a preliminary study of 35 patients undergoing CABG surgery, administration of pexelizumab reduced total complement activity, soluble C5b-9 formation, and leukocyte activation. (ahajournals.org)
  • Factor B, factor D, and properdin (factor P) are specific components of the alternative pathway of complement activation. (asmscience.org)
  • The complement activation is tightly regulated by membrane-bound and fluid-phase regulatory components to avoid runaway activation of the enzymatic cascade that could lead to excess host tissue damage, inflammation, and depletion of complement components. (asmscience.org)
  • Activation of the alternative pathway is tightly controlled by membrane associated complement regulatory components and the competition of the main fluid phase antagonists factor B and factor H for binding C3b or hydrolsed C3. (asmscience.org)