• activation
  • Background and Purpose- Pharmacological modulation of complement activation recently has been postulated as a therapeutic target in the treatment of neurological injury. (ahajournals.org)
  • 4 Within minutes of vascular occlusion, multiple inflammatory events ensue, including activation of the complement cascade, 5 which can contribute directly to neuronal cell death. (ahajournals.org)
  • In a preliminary study of 35 patients undergoing CABG surgery, administration of pexelizumab reduced total complement activity, soluble C5b-9 formation, and leukocyte activation. (ahajournals.org)