Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers. (wikipedia.org)
The aim of this study was to contrast the pharmacokinetics and pharmacodynamics of remifentanil and alfentanil in healthy, adult male volunteers. (silverchair.com)
Ten volunteers received infusions of remifentanil and alfentanil on separate study sessions using a randomized, open-label crossover design. (silverchair.com)
Pharmacodynamically, the drugs are similar in terms of the time required for equilibration between blood and the effect-site concentrations, as evidenced by a T(12)k(e0) for remifentanil of 0.75 min [corrected] and 0.96 min for alfentanil. (silverchair.com)
However, remifentanil is 19 times more potent than alfentanil, with an effective concentration for 50% maximal effect of 19.9 ng x ml(-1) versus 375.9 ng x ml(-1) for alfentanil. (silverchair.com)
Compared to alfentanil, the high clearance of remifentanil, combined with its small steady-state distribution volume, results in a rapid decline in blood concentration after termination of an infusion. (silverchair.com)
Analgesic1
In comparative studies, trefentanil was slightly more potent and shorter acting than alfentanil as an analgesic, but induced significantly more severe respiratory depression. (fubinaca.com)
Trefentanil has very similar effects to alfentanil, much like those of fentanyl itself but more potent and shorter lasting. (fubinaca.com)
The risk of respiratory depression is especially high with potent fentanyl analogues such as alfentanil and trefentanil , and these drugs pose a significant risk of death if used outside of a hospital setting with appropriate artificial breathing apparatus available. (fubinaca.com)
Methods1
Alfentanil clearance was determined by noncompartmental methods and by a three-compartment model with both pooled population and two-stage analysis. (asahq.org)
Clearance2
Alfentanil clearance was used as a metabolic probe for P450 3A4 activity. (asahq.org)
There was no significant difference in any measure of alfentanil clearance. (asahq.org)
Plasma2
With the exception of remifentanil's nearly 20-times greater potency (30-times if alfentanil partitioning between whole blood and plasma is considered), the drugs are pharmacodynamically similar. (silverchair.com)
Alfentanil (20 micrograms/kg bolus) was administered to nine nonsmoking, nonpregnant female volunteers (age, 26 +/- 5 yr) with normal menstrual cycles on three separate occasions during the same menstrual cycle: days 2 (menstrual phase), 13 (estrogen peak), and 21 (progesterone peak). (asahq.org)
Pharmacokinetics2
Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers. (wikipedia.org)
The authors discuss the pharmacodynamics and pharmacokinetics of fentanyl, sufentanil, and alfentanil and compare them with other opioids. (nih.gov)
A total of 204 patients scheduled for day surgery of cold knife cervical conization received either remimazolam-alfentanil anesthesia (remimazolam group) or propofol-alfentanil anesthesia (propofol group). (bvsalud.org)
The occurrence of hypotension, bradycardia, hypoxemia and the degree of body movement were secondary outcomes, as well as the moment at which consciousness was lost, the interval between the end of anesthesia and the operating room's release of the patient, and the overall dosage of alfentanil administered during the procedure. (bvsalud.org)
Conclusion: In patients who underwent cold knife cervical conization, remimazolam-alfentanil anesthesia was associated with a reduced incidence of intraoperative cardiopulmonary adverse events compared with propofol-alfentanil anesthesia. (bvsalud.org)
A Comparative Study of Emergence Agitation between Sevoflurane and Desflurane Anesthesia in Children. (ekja.org)
Morphine2
Heart rate, arterial blood pressures, respiratory rate, body temperature, and central nervous system excitement were compared before and after epidural administration of morphine (0.1 mg/kg), butorphanol (0.08 mg/kg), alfentanil (0.02 mg/kg), tramadol (1.0 mg/kg), the k-opioid agonist U50488H (0.08 mg/kg), or sterile water using an incomplete Latin square crossover design in five conscious adult horses. (equine-behaviour.de)
05) reductions in respiratory rate were detected after epidural administration of morphine, alfentanil, U50488H, and sterile water. (equine-behaviour.de)
Propofol3
The objective of this study was to compare the safety and efficacy profiles of the remimazolam and propofol when combined with alfentanil for sedation during ERCP procedures. (bvsalud.org)
INTERVENTIONS: Patients scheduled for ERCP were randomly assigned to be sedated with either a combination of remimazolam-alfentanil or propofol-alfentanil. (bvsalud.org)
CONCLUSION: During elective ERCP, patients administered with remimazolam showed fewer respiratory depression events under deep sedation with hemodynamic advantages over propofol when administered in combination with alfentanil. (bvsalud.org)
Intravenous2
A 0.5-1.0 mg bolus of intravenous alfentanil was given (Rapifen, AstraZeneca, UK), if the patient felt pain during the operation. (medscape.com)
We therefore, planned this comparative study to evaluate and compare the efficacy of intravenous magnesium sulphate (30 mg/kg) versus sublingual nitroglycerine spray (0.4 mg/spray) in attenuating the presser response to Laryngoscopy and Tracheal Intubation. (ijclinicaltrials.com)
Combination1
Effects of a Combination of Nicardipine and Alfentanil on Hemodynamic Response after Endotracheal Intubation. (ekja.org)
Adult1
This was a comparative prospective trial of 317 adult patients with inguinal hernia. (medscape.com)
Analysis1
14. Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. (nih.gov)
Significant1
No significant differences were observed in the overall alfentanil dosages administered, bradycardia, bodily movement, or time to losing consciousness between the two groups. (bvsalud.org)