Commonly rats wistar. Medical search. Frequent questions

Whereas there were no significant differences between the female and male rats in response to either dose of olanzapine administration, an injection of 0.4 mg/kg risperidone significantly suppressed avoidance more in female rats than in male rats. (lu.se)
In conclusion, we show that there are sex-specific differences as well as similarities between female and male rats in the CAR test and novel APDs should be tested on female and male rats in the future. (lu.se)
This study examined the therapeutic potential of daidzein and the underlying mechanisms against AKI induced by glycerol in male rats. (bvsalud.org)
Wistar strain male rats, aged 45 weeks old, were given either control or astaxanthin feed at a low level of 0.004 per cent of their daily feed for one year. (newhope.com)
Histopathological examination of the testes and ductus deferens in male rats, and ovaries and uterus of female rats (caspase-3 and -9 immunoreactivity) was performed. (gazi.edu.tr)

Other common strains are the Sprague Dawley, Fischer 344, Holtzman albino strains, Long-Evans, and Lister black hooded rats. (wikipedia.org)
A lot of Universities and institutions are now into bioscience and most of them doesn't know where to get Sprague Dawley rats. (philippinetambayan.com)

Objective: To know the effect of oral administered in various dosage of acetaminophen on histological appearance from proximal tubules of Wistar Rats kidney. (undip.ac.id)
Result: The administered of Acetaminophen altering the histological appearance of Wistar rats proximal tubules of kidney which are albuminosa degeneration. (undip.ac.id)
Conclusion: There were differences of histopathology appearance from proximal tubules of Wistar Rats kidney between untreated group and acetaminophen treated group. (undip.ac.id)
There were also differences histopathology appearance from proximal tubules of Wistar Rats kidney between various dosages of acetaminophen treated group, and proximal tubules cell injury was rising along with the rise of acetaminophen dosage. (undip.ac.id)

Materials and methods: Forty rats were assigned to four groups at random (ten animals per group). (bvsalud.org)
Methods- The present study made use of 300 Wistar rats randomly allocated into controls and rats receiving a 16-week high-fat, high-caloric diet (HCD). (sun.ac.za)
Methods: The study was implemented on 64 Wistar albino rats (20 days old). (gazi.edu.tr)
Methods for extraction of sterigmatocystin have been commonly based on a mixture of acetonitrile and 4% aqueous potassium chloride. (wikipedia.org)
Methods: Fifty-four female rats were first divided equally into two groups: ovariectomized (Ovx) and simulated ovariectomy (Sham). (bvsalud.org)

A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). (lookformedical.com)
The possible mechanisms by which the isolated compound produced its effect on the cardiovascular system were explored using the anaesthetized normotensive rat model.Fractionation of the organic extracts of the leaves led to the isolation of a novel diterpene,(13S)-9 , 13 -epoxylabda-6 (19),15(14)diol dilactone (EDD) whose structure was elucidated using infra red (IR), nuclear magnetic resonance (NMR), mass spectroscopy(MS), and X-ray diffraction analysis. (uwc.ac.za)

While less commonly used for research than laboratory mice, rats have served as an important animal model for research in psychology and biomedical science. (wikipedia.org)
Inbred strains are also available, but are not as commonly used as inbred mice. (wikipedia.org)
This was the first in a series of developments that have begun to make rats tractable as genetic research subjects, although they still lag behind mice, which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. (wikipedia.org)
Many investigators who wish to trace observations on behavior and physiology to underlying genes regard aspects of these in rats as more relevant to humans and easier to observe than in mice, giving impetus to the development of genetic research techniques applicable to rats. (wikipedia.org)
[4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)
Intraperitoneal (i.p.) injection is the most frequently used method for implementing parenteral therapies in rats and mice. (uludag.edu.tr)
For that reason, we have developed a method for identifying the location of the caecum in rats and mice and thus revealed the most reliable location for i.p. injection in these animals. (uludag.edu.tr)
Two hundred Wistar albino rats and 100 BALB/c mice were used. (uludag.edu.tr)
In both rats and mice, the caecum was most commonly located on the animal's left side. (uludag.edu.tr)
citation needed] Chronic symptoms include induction of hepatomas in rats, pulmonary tumours in mice, renal lesions and alterations in the liver and kidneys of African Green monkeys. (wikipedia.org)

Laboratory rats or lab rats are strains of the subspecies Rattus norvegicus domestica which are bred and kept for scientific research. (wikipedia.org)
In 18th-century Europe, wild brown rats (Rattus norvegicus) ran rampant and this infestation fueled the industry of rat-catching. (wikipedia.org)
Rattus norvegicus , Wistar Rat, Rj:WI (IOPS HAN). (eurotoxpath.org)

Conclusion: Collectively, the present study confirmed the potential benefits of MT in downregulating the increased hepatic alpha-fetoprotein expression and in restoring pancreatic ß-cells in a streptozotocin-induced diabetic rat model, suggesting its promising role in the treatment of diabetes. (bvsalud.org)

Over the next 30 years, rats were used for several more experiments and eventually the laboratory rat became the first animal domesticated for purely scientific reasons. (wikipedia.org)
As there is evidence that the hooded rat was known as the "Japanese rat" in the early 20th century, Kuramoto concluded that one or more Japanese hooded rats might have been brought to Europe or the Americas and an albino rat that emerged as a product of the breeding of these hooded rats was the common ancestor of all the albino laboratory rats in use today. (wikipedia.org)
Laboratory rats are frequently subject to dissection or microdialysis to study internal effects on organs and the brain, such as for cancer or pharmacological research. (wikipedia.org)
Laboratory rats not sacrificed may be euthanized or, in some cases, become pets. (wikipedia.org)
In October 2003, researchers succeeded in cloning two laboratory rats by nuclear transfer. (wikipedia.org)
The Wistar strain is a well-known laboratory model with sufficient historical data. (europa.eu)
Rats, Inbred WF are a strain of laboratory rats that are commonly used in medical research due to their consistent genetic makeup and susceptibility to various diseases. (lookformedical.com)
Caecum location in laboratory rats and m. (uludag.edu.tr)
Since chemical-induced immune dysfunction has been associated with increased cancers and/ or infectious diseases in laboratory animals, the potential immunotoxicity of alachlor was studied with a multiple immunoassay model in 9-week old male F344/N rats. (cdc.gov)
Irrespective of the actual and their embryotoxic alkoxyacetic acid metabolites in rat and number of laboratory animals required for REACH, the man. (cdc.gov)
Because it is expected that more in vivo dose-response curves for developmental toxicity of than 20% of the laboratory animals needed for REACH will be the parent glycol ethers in rat and man. (cdc.gov)

Genetic analysis of 117 albino rat strains collected from all parts of the world carried out by a team led by Takashi Kuramoto at Kyoto University in 2012 showed that the albinos descended from hooded rats and all the albinos descended from a single ancestor. (wikipedia.org)
Scientists have bred many strains or "lines" of rats specifically for experimentation. (wikipedia.org)
It has been demonstrated that some strains of Bacillus coagulans can survive extremes of heat, acidity of the stomach and bile acids, to which commonly consumed probiotics are susceptible. (newhope.com)

Objective: This study was conducted to assess the influence of MT on diabetes-related hepatic injuries and to determine how ß-cells of the pancreas in diabetic rats respond to MT administration. (bvsalud.org)
This study aims to study the effect of aqueous extract of L. inermis leaves in acute ethanol induced hepatic damage in adult Wistar rats. (projectreserve.com)
1975. [Effect of methyl parathion or zineb administration on the activity of some hepatic enzymes in rats]. (cdc.gov)
Skin and hepatic tumours are induced in rats by dermal application. (wikipedia.org)

The results showed that rat received both dosage regimens of M. loriformis ethanolic extract demonstrated no mortality when administered orally for 30 consecutive days. (tci-thaijo.org)
P1 is rats being given Acetaminophen orally ½ x 2400mg/ KgW. (undip.ac.id)
P2 is rats being given Acetaminophen orally 2400mg/KgW. (undip.ac.id)
P3 is rats being given Acetaminophen orally 2 x 2400 mg/KgW. (undip.ac.id)
Three days before exposure, rats were given PWE orally and treatment continued for 2 more days. (blogspot.com)

The results indicated dose-related effects of methanolic extract on paw edema, hyperalgesia and serum IL-6 level reduction in rats. (jcimjournal.com)
Action of phytochemicals of this extract on various systems like CNS, Gastrointestinal were analysed in adult rats. (annalsofrscb.ro)
Ethanolic extract of A.calamus can be considered as appetite stimulant in immature rats. (annalsofrscb.ro)
The other two groups of rats were given M. loriformis ethanolic extract at dosages of 0.1 and 1 g/kg/day. (tci-thaijo.org)
The doses of the extract of Feretia apodanthera administered the rats through the oral route were 100, 200, and 400 mg/kg. (alexjvs.com)
The current study was carried out to determine the effect of methanolic leaf extract of Costus pictus D Don on the pancreas of diabetic-induced albino Wistar rats. (eurjanat.com)
The mitigating effect of Ananas comosus (pineapple juice) extract on an aluminum-induced testicular toxicity in male Wistar rats was examined in this study. (springeropen.com)

The Wistar Kyoto (WKy) rat is resistant to mammary carcinomas induced with 7,12-dimethybenz[a]anthracene (DMBA), whereas the Wistar Furth (WF) strain is susceptible. (mcw.edu)

Local communities and herbalists commonly used it in the management of diabetes mellitus type 2 with limited information on its effectiveness. (academicjournals.org)
In Group IV (DM + MT), following the induction of diabetes, rats received MT (the same as in Group III). (bvsalud.org)
Diabetes was induced in male Wistar rats (n = 10/group) using streptozotocin (20 mg/kg sc) daily for 3 days. (scirp.org)
Sixty male Wistar rats divided into four groups were studied: control (C), control treated with D-alpha-tocopherol (C + T), diabetic (D), and diabetic treated with D-alpha-tocopherol (D + T). Treatment with D-alpha-tocopherol (40 mg/kg every other day, ip) was started three days after diabetes induction with streptozotocin (60 mg/kg, ip). (scielo.org)
These results suggest that D-alpha-tocopherol is able to protect rats, at least in part, from the harmful effects of diabetes on renal function. (scielo.org)
Mulawarmanti, Dian : Periodontitis is one of oral complication that commonly found in patients with Diabetes Mellitus. (hangtuah.ac.id)

Wistar rats are commonly used in subchronic and chronic inhalation toxicity studies. (europa.eu)
Furthermore, the results of the acute and 90-day subchronic oral toxicity studies in rats resulted in the conclusion of a NOAEL greater than 1,000mg/kg per day. (newhope.com)

TLR-4 expression has been observed in the meninges, choroid plexus, and circumventricular organs of the adult rat brain [ 2 ]. (biomedcentral.com)

The 10-day LD50 in Wistar rats is 166 mg/kg in males, 120 mg/kg in females, and 60-65 mg/kg for ip. (wikipedia.org)

Only 1 ml corn oil was given by gavage to the rats in Group I. A diazinon dose of 335 mg/kg was given by gavage to the rats in Group II. (ejgm.org)

The acute dermal toxicity of the read-across substance Biofert Plusz was studied in male and female Wistar rats using a Limit test according to OECD Guideline 402. (europa.eu)
Five male and 5 female rats received dermal application to the clipped skin of 7.12 mL/kg bw undiluted Biofert Plusz corresponding to 2000 mg/kg bw (related to dry mass). (europa.eu)
2000. Placental transfer and pharmacokinetics of a single dermal dose of [14C] methyl parathion in rats. (cdc.gov)

Results were verified in vivo on a subcutaneous C6 glioblastoma model in Wistar rats. (oncotarget.com)
The in vivo pharmacokinetic study was carried out in Wistar rats. (ijpsonline.com)
response curves for rat were found to be in concordance with the 2004), in vitro and in silico alternatives for developmental embryotoxic dose levels measured in reported in vivo rat studies. (cdc.gov)

Thirty male Wistar rats were randomly divided into three treatment groups. (tci-thaijo.org)
Thirty (30) female rats were equally divided into five (5) groups (I-V). Group I which served as negative control received distilled water (2 ml) for 8 days. (projectreserve.com)

HBOT for 3 days and longer in diabetic rats reduced hyperglycemia to control levels. (scirp.org)

All but one of the testicular tumors occurred in the rats from a single supplier. (wikipedia.org)

Study assessed the hypoglycemic effect of C. schweinfurthii aqueous and total crude leaf and pulp extracts on blood glucose levels in Wistar albino rats. (academicjournals.org)
In view of this and on account of the interleukin (IL)-6's role in inflammation and pain induction, this study investigated the effects of Achillea santolina extracts on inflammation which was induced by complete Freund's adjuvant (CFA) in male Wistar rats. (jcimjournal.com)
Inflammatory symptoms such as hyperalgesia and paw edema in CFA-injected rats' paw were measured by radiant heat and plethysmometer during different stages of study respectively. (jcimjournal.com)
In this study, we investigated whether sex-specific differences could be observed in response to the commonly prescribed APDs olanzapine and risperidone using the conditioned avoidance response (CAR) test. (lu.se)
Hence the study was undertaken with the aim, to assess the effects of early exposure of A.calamus on behavioural development of wistar rat off springs. (annalsofrscb.ro)
Method : This experimental study used Post Test Only Control Group Design, with 24 male Wistar rats divided into 4 groups, with age of 4,5-6 months and weight of 200-300 gram. (undip.ac.id)
In the present study, we have investigated the molecular and microscopic basis of cognitive impairment induced by alcohol and/or Atorvastatin (ATOR) administration to male Wistar albino rats and explored the possible protective effect of acetylsalicylic acid (ASA). (uky.edu)
This study was aimed at the isolation and identification of a cardio-active compound from L. leonurus, a plant commonly used in traditional medicines in South Africa for the treatment of hypertension and other cardiac problems. (uwc.ac.za)
In this study, we aimed to investigate the hormonal and histopathological effects of 4-chlorophenoxy acetic acid (4-CPA), a commonly used plant growth regulator, on the gonadal functions of rats. (gazi.edu.tr)
The objective of the present study was to determine if treatment of diabetic rats with D-alpha-tocopherol could prevent the changes in glomerular and tubular function commonly observed in this disease. (scielo.org)
The treatment of the animals in this study adhered to commonly accepted ethics guidelines. (biomedcentral.com)
Groups of rats [9-12 per group) were injected (ip) on days -1, 6 and 13 of the 14-day multiple-assay study. (cdc.gov)
Doses used in this study were 25%, 50% and 75% of the acute (4-hr) LD100 dose of 5 mg/kg reported for Wistar rats receiving single ip injections (in propylene glycol). (cdc.gov)
The present study further ana- lyzed behavioral correlates of two novel breeding lines of rats, Carioca high-and low-conditioned freez- ing (CHF and CLF), based on defensive freezing responses to contextual cues previously associated with electric footshock. (bvsalud.org)
Such differences in emotionality responses in the 10th generation of selected rats further indicate a possible use of this model to study correlations between trait anxiety and defen- sive reactions. (bvsalud.org)

Rats were exposed to a gamma radiation dose of 8 Gy from a Cesium-137 source in order to inflict intestinal mucositis. (blogspot.com)
Therefore, predicted dose-response curves for rat could be used to of animal use. (cdc.gov)
PBK model allows the prediction of dose-response curves for implantation rat whole-embryo culture test, the rat limb bud human developmental toxicity. (cdc.gov)

The acute oral toxicity L-threonine mother liquor was studied in a test according to OECD Guideline 401 with male and female Hsd/Win:WU rats. (europa.eu)
Evaluation of acute immunotoxicity of alachlor in male F344/N rats. (cdc.gov)

Twenty-one male Wistar albino rats, (weighing 180-200 g) were randomly divided into three equal groups. (ejgm.org)

Rat off springs were divided into two groups. (annalsofrscb.ro)
Results: Although hormone levels were similar between the groups, rats that received 4-CPA showed significantly higher degrees of apoptosis compared to the control group (p (gazi.edu.tr)
Four groups of male Wistar rats received dry and powdered L. edodes reconstituted in water for 30 days: control (water only), L. edodes 100 mg/kg, L. edodes 400 mg/kg, and L. edodes 800 mg/kg. (fapesp.br)
A significant decrease in hemoglobin concentration was found in the 400 and 800 mg/kg/day L. edodes groups, and leukopenia occurred in rats that consumed L. edodes 800 mg/kg/day compared with the control group. (fapesp.br)
Net acid excretion, evaluated in 9- and 18-month-old rats, was stimulated in the fish oil group when compared both to control and to the other two LD groups. (scielo.org)
Fifteen male wistar rats are divided into three groups. (hangtuah.ac.id)
However, compared to water-fed rats, the PA, WPC, and PA+WPC groups exhibited greater MPS responses with no differences existing between conditions. (biomedcentral.com)

The parameters were compared with diabetic and normal rats. (eurjanat.com)

We aimed to determine the efficacy of HBOT in wound healing and organ preservation in a diabetic rat model. (scirp.org)
In summary, our findings show the efficacy of HBOT in this diabetic rat model. (scirp.org)

Zaringhalam J, Manaheji H, Mghsoodi N, Farokhi B, Mirzaiee V . Spinal mu-opioid receptor expression and hyperalgesia with dexamethasone in chronic adjuvant- induced arthritis in rats. (jcimjournal.com)
We examined the effects of chronic administration of diets containing 5% lipid-enriched diet (LD, w/w) on renal function of rats at different ages. (scielo.org)
Aim: To investigate the effects of estrogen deficiency associated with chronic alcohol consumption on the mandibular condyle in rats. (bvsalud.org)

The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. (mcw.edu)

During the 2-3 weeks prior exposure start, all rats will be trained to the 6-hour restraint in nose-only tubes. (europa.eu)

To this end we tested the effect of 1.25 and 2.5 mg/kg olanzapine and 0.25 and 0.4 mg/kg risperidone using female and male Wistar rats in the CAR test. (lu.se)
In addition, we found that the estrous cycle of the female rats did not have a significant effect on the avoidance response. (lu.se)
2000 mg/kg bw (related to dry mass) was determined in male and female Wistar rats. (europa.eu)
Male and female rats from the 10th generation were used to assess anxiety-like reactions in the elevated plus maze (EPM), depressive-like behavior in the forced swim test (FST), and aversive memory in the contextual fear conditioning paradigm. (bvsalud.org)

Rats bearing mutant genes which are phenotypically expressed in the animals. (lookformedical.com)

Rats who received daidzein displayed markedly lower interleukin-1ß (IL-1ß), tumor nuclear factor-α (TNF-α), myleoperoxidase (MPO), and nuclear factor kappa B (NF-κB) levels together with higher interleukin-10 (IL-10) related to the model group. (bvsalud.org)

The reproductive function of rats was studied at the Institute for Experimental Biology at the University of California, Berkeley by Herbert McLean Evans and Joseph A. Long. (wikipedia.org)
Mignini F, Sabbatini M, D'Andrea V, Cavallotti C (2010) Intrinsic innervation and dopaminergic markers after experimental denervation in rat thymus. (eurotoxpath.org)
Despite the functional properties of L. edodes, the doses commonly reported in experimental studies arc much higher than those actually consumed. (fapesp.br)

The rat is commonly used species for toxicological studies in accordance with international recommendations. (europa.eu)

Wistar rats) [155], failed to influence food intake during a 1 h ad libitum feeding period, moderate to high doses of CBD (4.4 mg·kg −1 , i.p. [58]. (researchgate.net)

In subsequent experiments, P5 rats were randomly assigned to TLR-3 specific agonist, poly I:C, or saline treated group. (biomedcentral.com)

on the other hand, in thyroparathyroidectomized rats (TPTX model), a significant decrease in renal acid excretion, glomerular filtration rate (GFR) and renal plasma flow (RPF) was detected. (scielo.org)

2.5 h post-feeding rats were injected with 5.44 mg puromycin diHCl for MPS assessment via SUnSET and 3 hours post-feeding rats were euthanized and mixed gastrocnemius muscles were removed for immunoblotting analyses. (biomedcentral.com)

Most are derived from the albino Wistar rat, which is still widely used. (wikipedia.org)
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. (lookformedical.com)

We have shown that preconditioning by lipopolysaccharide (LPS) will result in 90% reduction in ischemic brain damage in P7 rats. (biomedcentral.com)

In Group III, rats received 10 mg/kg/day of intraperitoneal melatonin (IP MT) intraperitoneally over a period of 4 weeks. (bvsalud.org)

Identification of low-penetrance alleles that occur commonly in populations may benefit from unbiased genome-wide screening. (mcw.edu)

At the end of the treatment peroid, rats were anesthesized. (tci-thaijo.org)
Pre-treatment with poly I:C downregulated NF-κB and upregulated IRF3 expression in P5 rat ischemic brains. (biomedcentral.com)
Pre-treatment with poly I:C did not offer neuroprotection in P7 rat brains. (biomedcentral.com)
Rizatriptan benzoate is a selective 5-Hydroxytryptamine (5-HT) 1B/1D receptor agonist which is commonly prescribed for treatment of migraine. (ijpsonline.com)

Conclusion: 4-CPA induced apoptosis in the gonads of rats without concurrent changes in plasma hormone levels. (gazi.edu.tr)

Both group rats off springs were observed for weight gain, ear and eye opening time. (annalsofrscb.ro)
Each group consisted of ten rats. (tci-thaijo.org)
In addition to diazinon, a 20% lipid solution (3 ml/kg) was administered via tail vein to the rats in Group III. (ejgm.org)

The analysis of gaze behaviour is nowadays commonly employed to help with the diagnosis and exclusion of differential neurological conditions as well as to help researchers better understand cognition in the early stages of life. (helsinki.fi)
However, nowadays it also commonly used in the cases of suicide attempt. (undip.ac.id)

Feretia apodanthera is a shrub with twisting branches commonly used in folklore medicine to manage erectile dysfunction and to treat stomach upset. (alexjvs.com)

Pancreatic β-cell damage was negligible in rats treated with HBOT for 5 days and longer while diabetic nephropathy was diminished in animals treated for 10 days. (scirp.org)
The body weight of the animals was within the range commonly recorded for this strain and age. (europa.eu)

The most commonly used organic phosphorus compounds are diazinon, malathion, and parathion. (ejgm.org)

The Mcs7 region on rat chromosome 10 (RNO10) is orthologous to human 17q, a common site of genetic aberrations in breast cancer. (mcw.edu)

This paper will review recent scientific studies conducted on these commonly used aphrodisiacs, and determine whether the results support or refute their use for human sexual enhancement. (researchgate.net)
The hypoglycaemic studies were done in normal and glucose-challenged rats. (alexjvs.com)

Anatomy6

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