Commonly heart failure thus myocardial gene expression. Medical search. Frequent questions

Schisandra chinensis is a commonly used traditional Chinese medicine, which has been widely used in the treatment of acute myocardial infarction in China. (frontiersin.org)
Cardiovascular disease, including atherosclerosis, myocardial infarction, heart failure and stroke, is the leading cause of morbidity and mortality in developed nations. (frontiersin.org)
These changes in turn can lead to the development of left ventricular hypertrophy (LVH), coronary artery disease (CAD), various conduction system diseases, and systolic and diastolic dysfunction of the myocardium, complications that manifest clinically as angina or myocardial infarction, cardiac arrhythmias (especially atrial fibrillation), and congestive heart failure (CHF). (medscape.com)
Formally known as "beta-adrenergic blocking agents," beta blockers came to prominence in the 1960s, when deaths from myocardial infarction (MI), the clinical term for heart attack , were very common. (medicalxpress.com)
Muscular damage to the heart sustained during infarction may cause the organ to be less effective in pumping blood to the rest of the body, a condition that can eventually lead to heart failure and death. (medicalxpress.com)
Both treatments provide comparable results and similar long-term benefits, including improved function in the left ventricle, an area often damaged during heart attack, as well as reduced infarction size and improved vessel function," said Gerdes, who has studied the cardiovascular benefits and effects of thyroid hormone treatment for more than a decade. (medicalxpress.com)
Kuo Zhang et al, Comparison of therapeutic triiodothyronine versus metoprolol in treatment of myocardial infarction in rats, Thyroid (2018). (medicalxpress.com)
Rapid and correct diagnosis of acute myocardial infarction (AMI) plays a crucial role in saving patients' life. (hindawi.com)
Acute myocardial infarction (AMI) is one of the leading causes for death worldwide, and it is the single largest cause of death in the United States, responsible for 1 out of every 6 deaths [ 1 , 2 ]. (hindawi.com)
However it causes unwanted side effects, and may induce myocardial infarction [ 4 ]. (walshmedicalmedia.com)
Acute myocardial infarction (AMI) is the most serious manifestation of coronary artery disease. (springeropen.com)
Cardiovascular illnesses are the leading cause of death worldwide, accounting for almost 33% of all deaths, with acute myocardial infarction (AMI) being a major contributor [ 53 ]. (springeropen.com)
Despite substantial declines in mortality following myocardial infarction (MI), subsequent left ventricular remodeling (LVRm) remains a significant long-term complication. (researchgate.net)
a composite of myocardial infarction, stroke, new acute decompensated heart failure, venous thromboembolism, ventricular or atrial arrhythmia, pericardial effusion, or aborted cardiac arrest) among consecutively hospitalized adults with COVID-19, using multivariable binary logistic regression analysis. (stanford.edu)
Hypertension affects approximately 75 million adults in the United States and is a major risk factor for stroke, myocardial infarction, vascular disease, and chronic kidney disease. (medscape.com)

Through the network analysis, reduction of cardiac preload and myocardial contractility was shown to be the major effect of Schisandra components, which was further experimentally validated. (frontiersin.org)
In addition, the expression of NCOR2 and NFAT in myocyte were experimentally confirmed to be associated with Schisandra in the treatment of AMI, which may be responsible for the preservation effect of myocardial contractility. (frontiersin.org)
Another approach involves delivering genes that regulate myocardial contractility, aiming to improve the heart's pumping ability. (aliyuncs.com)
This syndrome has occasionally been accompanied by impaired myocardial contractility and episodic hypotension . (rxlist.com)

Uncontrolled and prolonged elevation of BP can lead to a variety of changes in the myocardial structure, coronary vasculature, and conduction system of the heart. (medscape.com)
Thus, hypertensive heart disease is a term applied generally to heart diseases, such as LVH (seen in the images below), coronary artery disease, cardiac arrhythmias, and CHF, that are caused by the direct or indirect effects of elevated BP. (medscape.com)
For patient education information, see the Heart Health Center , Diabetes Center and the Cholesterol Center , as well as High Blood Pressure , High Cholesterol , Chest Pain , Coronary Heart Disease , and Heart Attack . (medscape.com)
Life-threatening disorders like coronary heart disease, cerebrovascular, peripheral arterial, rheumatic heart, congenital heart diseases, deep-vein thrombosis, and pulmonary embolism are caused due to impairment of heart and blood vessels, and they are collectively known as cardiovascular diseases (CVDs). (walshmedicalmedia.com)
Statins are the most effective drugs in the treatment of lowering low-density lipoproteins and coronary heart disease. (walshmedicalmedia.com)
It is distinct from structural cardiac disorders such as coronary artery disease, valvular disorders, and congenital heart disorders. (msdmanuals.com)
The most common cause of mortality worldwide is cerebrovascular disease (CVD), which includes coronary heart disease (CHD), congestive heart failure, CVD and stroke, peripheral artery diseases, carotid artery diseases, and aortoiliac disease. (medscape.com)
Such as high blood pressure, coronary heart disease, valvular heart disease, congenital heart disease and cardiomyopathy, ect[5]. (researchsquare.com)
These models, however, don't medical development, diastolic dysfunction could result in di- progress to more advanced renal illness seen in people astolic heart failure, which is finest described because the presence which is characterised by a lack of glomerular п¬Ѓltration, of scientific indicators and symptoms of coronary heart failure within the pres- overt proteinuria, and superior structural lesions (22, sixty one). (ehd.org)
Do you have coronary heart disease or are you healthy and would like to participate in research? (nih.gov)
This study is comparing how well two types of magnetic resonance imaging (MRI) scanners can detect different types of heart diseases, such as coronary heart disease, heart failure, congenital heart disease, and heart valve disease. (nih.gov)
This study aims to improve magnetic resonance imaging (MRI) methods to detect coronary heart disease. (nih.gov)
Healthy people and people who have coronary heart disease will have MRI scans while resting and after taking a medicine that temporarily makes your heart work harder. (nih.gov)
To participate in this study, you must be at least 18 years old and either healthy or diagnosed with coronary heart disease. (nih.gov)
Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)

Myocardial injury induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reportedly related to disease severity and mortality, attracting attention to exploring relevant pathogenic mechanisms. (biomedcentral.com)
The heart may be not circumscribed ready to euthanasia performed by a region blood that is the acute left failure regurgitation. (worldclassbows.com)
About 25% of patients with APL treated with VESANOID (tretinoin) have experienced a syndrome called the retinoic acid-APL ( RA -APL) syndrome characterized by fever, dyspnea , acute respiratory distress, weight gain, radiographic pulmonary infiltrates, pleural and pericardial effusions, edema, and hepatic, renal, and multi- organ failure . (rxlist.com)
Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)

Pathophysiology is the cascade of changes caused in a person by a disease process, in this instance, congestive heart failure. (ceufast.com)
Young people with less mPOA, and levels of this function or congestive heart treatment fibers" applicable to this article. (sideload.com)
We will improve whether RGS4 fails present form in a other failure cancer in Professor to congestive coliphages. (seabaygame.com)
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Anteroposterior x-ray from a 28-year old woman who presented with congestive heart failure secondary to her chronic hypertension, or high blood pressure. (medscape.com)
The enlarged cardiac silhouette on this image is due to congestive heart failure due to the effects of chronic high blood pressure on the left ventricle. (medscape.com)

Overall, pioglitazone reduced the composite outcome of stroke, MI, or hospitalized heart failure in the IRIS trial. (libsyn.com)
Most groups, including the JNC, the American Diabetes Associate (ADA), and the American Heart Association/American Stroke Association (AHA/ASA) recommend lifestyle modification as the first step in managing hypertension. (medscape.com)

Background: Physiological cardiac hypertrophy occurs commonly in response to exercise and can protect against pathological stress. (researchgate.net)
Myocardial hypertrophy occurs in many cardiovascular diseases. (researchsquare.com)

METHODS AND RESULTS: Human iPSC-derived engineered heart tissue was exposed to C18:1AC. (bvsalud.org)
During MI, increased adrenaline raises pressure in the arteries and increases heart rate to compensate for the sudden loss of contractile tissue. (medicalxpress.com)
In the last few years, the dysregulation of tissue expression levels of miRNAs has been directly linked to cardiac disease. (hindawi.com)
Heart failure commonly begins with an insult to the cardiac tissue such as occurs in an ischemic heart attack where blood flow to the heart muscle itself is blocked or drastically reduced. (ceufast.com)
Histopathological examination of heart tissue was performed. (springeropen.com)
During an AMI, the first ischemic insult initiates a cascade of unanticipated biochemical and metabolic changes inside the heart tissue. (springeropen.com)
By enhancing blood supply to the damaged heart tissue, these therapeutic genes can potentially improve cardiac function and reduce symptoms such as shortness of breath and fatigue. (aliyuncs.com)
Downregulated adipose tissue expression of browning genes with increased environmental temperatures. (medscape.com)
The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)
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In today's paper, first author Dr Valiente-Alandi, corresponding author Dr Blaxall from University of Cincinnati College of Medicine and Heart Institute, and their colleagues hypothesized that interfering with fibronectin polymerization, or its genetic ablation and fibroblasts, would attenuate myocardial fibrosis and improve cardiac function following ischemia reperfusion injury. (libsyn.com)

The downstream regulator of PI3K/Akt is hypoxia-inducible factor-1α (HIF-1α) which is a master regulator of gene expression in hypoxia, and it has the ability to influence cellular adaptive responses to hypoxia or ischemia. (springeropen.com)
Cell survival during ischemia/reperfusion is governed by HIF-1α-dependent genes such as heme oxygenase-1, inducible nitric oxide synthase, cyclooxygnease-2, and vascular endothelial growth factor. (springeropen.com)
Inhibiting fibronectin matrix deposition by pUR4 treatment or by deleting fibronectin gene expression in cardiac fibroblasts confirmed cardioprotection against ischemia reperfusion-induced injury by attenuating at first left ventricular remodeling and cardiac fibrosis, thus preserving cardiac function. (libsyn.com)

Traditional Chinese medicine (TCM) is a commonly used therapeutic strategy for the treatment of AMI in China. (frontiersin.org)
Accordingly, over the last few years the use of PDE 5 inhibitors has been expanded to the therapeutic management of some cardiovascular disorders, including heart failure (HF). (ecrjournal.com)
In summary, interfering with fibronectin polymerization may be a new therapeutic strategy for treating cardiac fibrosis and heart failure. (libsyn.com)
Expression of LTBP2 was elevated and specifically localized in the fibrotic regions of the myocardium after injury in mice and in human heart failure, suggesting that it may be a potential therapeutic target. (libsyn.com)
Importance Mortality is high among patients heart failure (HF) who are receiving treatment, and therefore identifying new pathways rooted in preclinical cardiac remodeling phenotypes may afford novel biomarkers and therapeutic avenues. (researchgate.net)
One particularly influential approach in this regard is the use of adenoviral vectors, which hold great potential for unlocking the therapeutic benefits of gene therapy. (aliyuncs.com)
Adenoviruses are DNA viruses that can be genetically modified to deliver therapeutic genes into target cells, offering a means to correct or replace defective genes responsible for disease pathogenesis. (aliyuncs.com)

In addition to expression changes in tissues, more recent studies have indicated that miRNAs are detectable in serum, plasma, urine, and other body fluids in a highly stable form that is protected from endogenous RNase activity [ 4 ]. (hindawi.com)
The A 3 isoform is located in tissues having cardiac or smooth muscle constituents, such as the heart, bladder, prostate, urethra, penis, uterus and skeletal muscle. (ecrjournal.com)
Even though all cells of a multicellular organism have the same set of genes, cells in various tissues produce different sets of proteins. (americascupmagazine.com)
Therefore, a global transcriptome analysis on A. mongolicus tissues was performed to identify the genes essential for the metabolism and to profile their expression patterns in greater details. (biomedcentral.com)
For triterpene saponin biosynthesis, we found the genes in MVA and non-MVA pathways were differentially expressed among three examined tissues, indicating the parallel but compartmentally separated biosynthesis pathways of IPP and DMAPP in A. mongolicus . (biomedcentral.com)
By harnessing these viral vectors' ability to efficiently infect both dividing and non-dividing cells, scientists can introduce specific genes into diseased tissues and initiate targeted cellular responses aimed at restoring normal physiological functions. (aliyuncs.com)
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Pulmonary arterial hypertension is a group of diseases, probably with a genetic predisposition and possibly an environmental trigger, leading to elevated pulmonary arterial tree resistance, right heart failure, and a generally poor prognosis. (cardiologyonline.com)

RNA sequencing revealed that cardiac fibroblasts from each strain exhibited unique gene expression changes in response to isoproterenol. (libsyn.com)
The authors further identified LTBP2 as a commonly upregulated gene after isoproterenol treatment. (libsyn.com)

Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)
These muscle abnormalities underlie the characteristic features of EOMFC, including skeletal muscle weakness and a form of heart disease called dilated cardiomyopathy. (medlineplus.gov)
Many TTN gene variants have been found to cause familial dilated cardiomyopathy, a condition that weakens and enlarges the heart, preventing it from pumping blood efficiently. (medlineplus.gov)
Signs and symptoms of familial dilated cardiomyopathy typically begin in mid-adulthood and result in heart failure. (medlineplus.gov)
TTN gene variants account for approximately one-quarter of all cases of familial dilated cardiomyopathy. (medlineplus.gov)
If we allow this to continue, the results may lead to ventricular remodeling, decompensation of cardiac function and dilated cardiomyopathy, heart failure and even sudden cardiac death[7] Therefore, preventing the occurrence and development of cardiac hypertrophy is very important. (researchsquare.com)

however, perinatal infection with parvovirus can result in a myocarditis with resultant myocardial damage, heart failure, and sudden death in young puppies as well. (vin.com)
Objective: Myocarditis is an important cause of heart failure. (cardiologyonline.com)

miRNAs are endogenous, small (~22 nucleotides), single-stranded, noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to the 3′ untranslated regions (UTRs) of their target mRNAs [ 10 ]. (hindawi.com)

These genetic changes occur near the end of the TTN gene and lead to the production of an abnormally short version of the titin protein. (medlineplus.gov)

Ramalin of the invention is a compound derived from natural material, has no toxicity or side effects, and inhibits the expression of inducible nitric oxide synthase (iNOS) in the transcription stage to significantly inhibit the production of nitric oxide (NO) that is a key mediator of inflammatory responses. (justia.com)

The clinical investigators will use new MRI methods to look at healthy people and people who have heart problems. (nih.gov)
Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)

In contrast to protein interaction networks, enriched gene ontology (GO) terms of AMI related genes were used to construct a gene ontology interaction (GOI) network, which can be used to simulate the functional interactions between differential expressed genes of disease. (frontiersin.org)
Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. (wikipedia.org)
β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
Proteomics may be used to study which proteins are expressed under various conditions within a single cell type or to compare protein expression patterns between different organisms. (americascupmagazine.com)
Despite limited understanding on mechanisms, disruption of protein turnover is widely implicated in diverse pathologies from heart failure to neurodegenerations. (nature.com)
We report here a large dataset of protein turnover dynamics in the heart of six common genetic strains of mice, acquired under both normal and hypertrophic conditions. (nature.com)
The dataset contains over 1.92 million data points in protein isotope labeling kinetics, culminating as the in vivo turnover rates of 3,228 cardiac proteins and the expression levels of 8,064 proteins. (nature.com)
The TTN gene provides instructions for making a very large protein called titin. (medlineplus.gov)
This protein plays an important role in skeletal muscles, which the body uses for movement, and in heart (cardiac) muscle. (medlineplus.gov)
It is unclear how TTN gene variants cause centronuclear myopathy, but it is likely that a shortage of normal titin protein leads to dysfunction of the sarcomere. (medlineplus.gov)
Type 2 DM (DM2) is milder and involves a CCTG repeat expansion mutation of the cellular nucleic acid binding protein gene CNBP (previously known as ZFN9) on chromosome 3q21.3. (msdmanuals.com)
decrease the expression of β-MHC, ANF, Ang II, AT 1 R, c-fos and c-myc mRNA and the protein levels of PLC, IP 3 , AngII and AT 1 R in left ventricular myocardium, in addition, the content of Ca 2+ also decrease. (researchsquare.com)
AT 1 R is a member of the 7-fold transmembrane G-protein-coupled receptor (GPCR) family[12,13], mainly exists in the myocardial membrane and can mediate cardiac hypertrophy induced by pressure overload and mechanical stimulation after activation [14]. (researchsquare.com)
Based on recent studies, endosomal dependence can compensate for S protein priming to mediate SARS-CoV-2 infection of CMs, damage the contractile function of CMs, trigger electrical dysfunction, and tip the balance of the renin-angiotensin-aldosterone system to exert a myocardial injury effect. (biomedcentral.com)
4 ] quantified the proximity between disease genes and drug targets based on a protein interaction network to discover new indications for 900 U.S. Food and Drug Administration-approved drugs. (e-enm.org)

We anticipate these data will aid in understanding key mitochondrial and metabolic pathways in heart diseases, and further serve as a reference for methodology development in dynamics studies in multiple organ systems. (nature.com)
Leonurine (Leo) is commonly used for cardiovascular and cerebrovascular diseases. (researchsquare.com)
Myocardial hypertrophy is one of the important causes of death of patients caused by cardiovascular diseases and an independent risk factor for the morbidity and mortality of cardiovascular diseases [1-3]. (researchsquare.com)
The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
From a physiological and pathophysiological point of view, the conformational states of the sodium channel during heart function constitute a significant aspect for the diagnosis and treatment of heart diseases. (bvsalud.org)

Heart cells (myocytes) die as a result of necrosis from this traumatic insult. (ceufast.com)
In this instance, affected heart cells begin to structurally enlarge and stretch out of shape in an attempt to strengthen the weakened heart. (ceufast.com)
Scientists compare gene expression patterns between infected and uninfected host cells, gaining important information about the cellular responses to infectious disease. (americascupmagazine.com)
For example, adenoviral vectors can be used to introduce genes encoding calcium-handling proteins involved in excitation-contraction coupling, which is essential for proper contraction and relaxation of cardiac muscle cells. (aliyuncs.com)
techniques are cells of DNA, and most hearts are the heart for depending a teenage growth. (seabaygame.com)
heart: A treatment did only by 2+ development institutions, now cells, to organize the heart or understanding of active hormones of the number. (worldclassbows.com)

This helps the heart keep up with the body's demands for oxygenated blood. (ceufast.com)
Growth structure, biofilm, decline in pH, extracellular polysaccharide, expression levels of virulence-related body's genes, multilocus series keying in (MLST) and also phylogenetic bushes have been looked at of these about three web sites.Results. (bcl-2inhibitors.com)

Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP). (wikipedia.org)
Using an integrated platform of metabolic labeling, high-resolution mass spectrometry and computational analysis, we report here a comprehensive dataset of the in vivo half-life of 3,228 and the expression of 8,064 cardiac proteins, quantified under healthy and hypertrophic conditions across six mouse genetic strains commonly employed in biomedical research. (nature.com)
Autosomal Dominant Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)
The validation of newer approaches based on microRNA targeting and gene therapy strategies, as well as the discovery of novel pathophysiological mechanisms and targets through genetic technology, may lead to the development of additional novel AF therapies. (nature.com)
Background Family history reflects the complex interplay of genetic susceptibility and shared environmental exposures and is an important risk factor for obesity, diabetes, and heart and blood conditions (ODHB). (cdc.gov)

Cellular losses further weaken the heart and cause an intricate process known as heart remodeling to occur. (ceufast.com)

The etiology of hypertensive heart disease is a complex interplay of various hemodynamic, structural, neuroendocrine, cellular, and molecular factors. (medscape.com)
A recent and developing proteomic analysis relies on identifying proteins called biomarkers, whose expression is affected by the disease process. (americascupmagazine.com)
Variants in the TTN gene have been identified in people with early-onset myopathy with fatal cardiomyopathy (EOMFC), an inherited disease that affects both skeletal and cardiac muscle. (medlineplus.gov)
Several variants in the TTN gene have been found to cause hereditary myopathy with early respiratory failure (HMERF), an inherited disease that affects muscles used for movement (skeletal muscles) and muscles that are needed for breathing (respiratory muscles). (medlineplus.gov)
Among organ-related symptoms, hepatomegaly is seen in more than 95% of patients and can be accompanied by signs of chronic liver disease, such as abdominal pain and cutaneous stigmata of liver disease (palmar erythema, spider angioma, or jaundice), and liver failure (ascites or encephalopathy). (medscape.com)
This vision is becoming increasingly plausible with the advent of gene therapy, a promising field that aims to manipulate an individual's genes to prevent or treat disease. (aliyuncs.com)
As a critical function of the system, Angiotensin II (Ang II) plays a key role in heart disease[9]. (researchsquare.com)
Myocardial injury induced by SARS-CoV-2 was reportedly attributable to disease severity and mortality. (biomedcentral.com)
Tackling Inflammation to Fight Age-Related Ailments - NYT, 12/23/19 - 'Specialists in the biology of aging have identified a rarely recognized yet universal condition that is a major contributor to a wide range of common health-robbing ailments, from heart disease, diabetes and cancer to arthritis, depression and Alzheimer's disease. (qualitycounts.com)
Project End delta-1 reperfusion:( associated from Applicant's sequence): disease in usually abdominal( LV) -A( current) by either LV insulin color or effective agent is treated found as cardiac failure for Pituitary request Microbe( CHF). (seabaygame.com)
Aortic stenosis (AS) is the most common valvular heart disease among Western populations and severe AS has an estimated prevalence of 3-4% among people older than 75 years of age. (cardiologyonline.com)
Taking N-acetyl cysteine by mouth seems to reduce homocysteine levels, a possible risk factor for heart disease. (medlineplus.gov)

Thus, in order to research the multi-mechanism complex system in TCM, network pharmacology has been commonly used in recent years to predict the major target proteins or signal pathways of TCM. (frontiersin.org)
Cardiac glutathione peroxidase (GSH-px), malondialdehyde (MDA), hypoxia-inducible factor 1 alpha (HIF-1α), autophagy proteins (P62 & LC3IIB) and gene expression of PI3K, Akt, FOXO-1, and eNOS were assessed. (springeropen.com)

Another electrical property is conductivity, which is characterized by a conduction and activation process, where the action potential, by the all-or-nothing law, travels throughout the heart. (bvsalud.org)

According to the Framingham Study, hypertension accounts for about one quarter of heart failure cases. (medscape.com)
[ 1 ] In the elderly population, as many as 68% of heart failure cases are attributed to hypertension. (medscape.com)
[ 2 ] Community-based studies have demonstrated that hypertension may contribute to the development of heart failure in as many as 50-60% of patients. (medscape.com)
In patients with hypertension, the risk of heart failure is increased by two-fold in men and by three-fold in women. (medscape.com)
Valsartan is an angiotensin receptor blocker, and used to treat hypertension and heart failure . (walshmedicalmedia.com)

To illustrate this potential, consider the hypothetical case study of John, a 45-year-old patient suffering from chronic heart failure due to impaired cardiac function. (aliyuncs.com)
Specifically, it will delve into their potential applications in treating chronic heart failure and the challenges that need to be addressed for successful implementation. (aliyuncs.com)
Adenoviral vectors have shown promise in gene therapy for chronic heart failure by targeting key cellular mechanisms involved in the progression of this condition. (aliyuncs.com)

Regulation of gene expression by the thyroid hormone receptor. (ebmconsult.com)
Receptor gene expression best steroids for cutting fat that in the absence of ligand the inactive conformation is preferred. (sideload.com)
In addition, it inhibits the activation of the inflammatory mediator NF-κB, inhibits p38 MAPK, ERK1/2 and JNK signaling pathways, and inhibits the expression of the LPS receptor TLR4, suggesting that Ramalin has an excellent anti-inflammatory effect. (justia.com)
Small Indels in the Androgen Receptor Gene: Phenotype Implications and Mechanisms of Mutagenesis. (medscape.com)

theβ-myosin heavy chain(β-MHC)and atrial natriuretic factor (ANF), which are recognized as a marker of cardiac hypertrophy, were determined by Real-time quantitative PCR (qRT-PCR), then another gene phospholipase C (PLC), inositol triphosphate (IP 3 ), which associated with RAS were determined by Western blot(WB). (researchsquare.com)
This study is looking at how well oral anticoagulation medicines work to prevent complications, such as blood clots and heart attack, for patients who experience post-operative atrial fibrillation (POAF). (nih.gov)
Prevention of atrial fibrillation: report from a National Heart, Lung, and Blood Institute workshop. (nature.com)
The heart is constituted by three types of muscle: atrial, ventricular, and specialized excitatory and conducting fibers. (bvsalud.org)
HN - 2008 BX - Lateral Sinus MH - Atrial Septum UI - D054087 MN - A07.541.459.249 MS - The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart. (bvsalud.org)

Since the effects on myocardial oxygen consumption determinants were found to be less relevant than expected, 1 they were not considered to have a real advantage over commonly used nitrates. (ecrjournal.com)
We have previously proposed several pathogenic mechanisms explaining the association of COVID-19 with myocardial injury, including SARS-CoV-2 host cell invasion, myocardial oxygen supply/demand imbalance, abnormal coagulation, and excessive immune reaction [ 11 ]. (biomedcentral.com)

Rationale: Pathological hypertrophy commonly leads to heart failure (HF) and loss of cardiomyocytes, while physiological hypertrophy protects the heart and enhances cardiomyogenesis. (researchgate.net)
Loss of cardiomyocytes is a major cause of heart failure, and while the adult heart has a limited capacity for cardiomyogenesis, little is known about what regulates this ability or whether it can be effectively harnessed. (researchgate.net)
Limited by insufficient evidence, myocardial injury caused by direct viral invasion of cardiomyocytes (CMs) is not fully understood. (biomedcentral.com)
However, the relevant pathogenetic mechanisms of myocardial injury caused by direct viral invasion of cardiomyocytes have not been fully elucidated. (biomedcentral.com)

I am very interested in making gene therapies through viral vectors (AAV, lentivirus, adenovirus) available, affordable, and reliable. (researchgate.net)

Long noncoding-RNAs (lncRNAs) are critical regulators of cardiac development as well as pathological hypertrophy and heart failure (HF). (researchgate.net)

Several variants (also known as mutations) in the TTN gene have been found to cause centronuclear myopathy, a condition that is characterized by muscle weakness (myopathy) in the skeletal muscles. (medlineplus.gov)
The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous dominant trait that causes reduced visual clarity and sometimes blindness. (thermofisher.com)

At the end of that period, thyroid hormone proved to be as good, if not better, than metoprolol at improving heart function and reversing expression of detrimental genes linked to heart failure , providing all the benefits of the beta blocker plus some additional benefits unique to thyroid hormones, such as improved expression of genes related to better contraction and relaxation of the heart. (medicalxpress.com)
In patients with thyrotoxicosis (thyroid storm), or symptomatic hyperthyroidism, there is an excess of thyroid hormone (T4 & T3) production and secretion that may result in increases in heart rate, tremors and nervousness. (ebmconsult.com)
Biochemical basis of thyroid hormone action in the heart. (ebmconsult.com)

This strategy holds promise for restoring normal contractile function and preventing further deterioration of heart function. (aliyuncs.com)
What do we are topically chronic ebook theoretische plasmaphysik eine and responsible heart function? (worldclassbows.com)

However, plakoglobin is a very weak transactivator when bound to DNA - this is probably caused by the divergence of their C-terminal sequences (plakoglobin appears to lack the transactivator motifs, and thus inhibits the Wnt pathway target genes instead of activating them). (wikipedia.org)

In the hemodynamic model of heart failure which provides the standard of care and treatment, there are many causes of congestion and myocardial failure. (ceufast.com)

Gross specimen of the heart with concentric left ventricular hypertrophy. (medscape.com)

For the construction of a "component-gene ontology" network of Schisandra in the treatment of AMI, the HPLC-Q-TOF-MS was used to analyze the Schisandra extract. (frontiersin.org)
While beta blockers have been viewed as the gold standard in MI treatment for years, a significant population at risk for heart failure is unable to tolerate these drugs. (medicalxpress.com)
In recent years, the field of regenerative biomedicine has witnessed a paradigm shift with the emergence of gene therapy as a promising treatment modality. (aliyuncs.com)
In conclusion, adenoviral vectors hold immense potential for revolutionizing regenerative biomedicine and offering new treatment options for chronic conditions such as heart failure. (aliyuncs.com)
The American Headache Society released a list of 5 commonly performed tests or procedures that are not always necessary in the treatment of migraine and headache, as part of the American Board of Internal Medicine (ABIM) Foundation's Choosing Wisely campaign. (medscape.com)

Heart relaxation also stands out as an active process, dependent on the energetic output and on specific ion and enzymatic actions, with the role of sodium channel being outstanding in the functional process. (bvsalud.org)

Anatomy19

Organisms8

Diseases42

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment69

Phenomena and Processes56

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science6

Health Care29

Geographicals1

Infarction15

Contractility4

Coronary15

Acute4

Congestive7

Stroke2

Hypertrophy occurs2

Tissue10

Improve cardiac function1

Ischemia3

Therapeutic7

Tissues7

Abstract1

Prognosis1

Isoproterenol2

Dilated cardiomyopathy6

Myocarditis2

Regulate1

Abnormally1

Inducible nitric oxide sy1

Clinical2

Protein17

Diseases5

Cells6

Body's2

Genetic5

Remodeling1

Disease12

Proteins2

Conduction1

Hypertension5

Chronic Heart F3

Receptor4

Atrial5

Oxygen2

Cardiomyocytes4

Viral vectors1

RNAs1

Mutations2

Thyroid3

Function2

Inhibits1

Hemodynamic1

Ventricular1

Treatment5

Relaxation1