Complex cytogenetics1989ChromosomeChromosomesBoneInvolvesGeneticInvestigationsTractChromosomalLaboratory testsTissuesCancerAnalysisStudiesExposureClinicalDiagnosisFISHAnemiaBloodPatientsTherapyFluorescence in situ hybriFlow cytometryMolecular geneticsMyelomaImmunohistochemistryMutationsFlt3ChromosomesMalignanciesBiomarkersLeukemiaMethodsHumanDiseaseStudyTreatmentDevelopment
Complex cytogenetics2
- ATLL in the Caribbean population presents more often as the acute and lymphomatous subtypes, is associated with complex cytogenetics, and has a high rate of CNS involvement. (oncotarget.com)
- In few newly diagnosed CML cases, complex cytogenetics variants of the Philadelphia (Ph) chromosome can be observed with the involvement of a third chromosome other than chromosome 9 & chromosome 22. (who.int)
19891
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Chromosome2
- Molecular cytogenetics combines two disciplines, molecular biology and cytogenetics, and involves the analysis of chromosome structure to help distinguish normal and cancer-causing cells. (wikipedia.org)
- The chromosome numbers of Musa × paradisiaca L. is 3n = 33 (x = 11), metacentric, submetacentric and acrocentric chromosome are commonly observed. (tci-thaijo.org)
Chromosomes2
- Human cytogenetics began in 1956 when it was discovered that normal human cells contain 46 chromosomes. (wikipedia.org)
- Cytogenetics is the microscopic study and analysis of chromosomes within the nucleus. (psychesystems.com)
Bone1
- It will be reported once the predefined number of survival events has been reported in patients who develop a seizure while taking XTANDI and of engaging in any activity where sudden loss of pregnancy when administered to a hematologist for further investigations including bone marrow analysis and blood sample for cytogenetics. (hpprinterrepairsnj.com)
Involves1
- It also commonly involves the usage of dyes, most frequently the previously mentioned Giemsa dye. (psychesystems.com)
Genetic5
- Cytogenetics is a useful tool in identifying and treating genetic diseases early on. (psychesystems.com)
- Here are some of the techniques and methodology between cytogenetics and genetic diseases. (psychesystems.com)
- Amniocentesis is the most commonly used invasive method for prenatal diagnosis of genetic disorders. (ogscience.org)
- METHODS: We retrospectively analyzed 785 cases of midtrimester prenatal genetic amniocentesis which were performed in the cytogenetics laboratory using in situ coverslip culture at Dong-A University Hospital from January 1995 to March 2003. (ogscience.org)
- Some of the commonly seen problems are rooted in genetic study and with the right investigation can be identified and diagnosed at the prenatal stage. (fetalandgynaeimaging.com)
Investigations1
- Cytogenetics investigations for confirmation of CML revealed 46,XY, t(7;9;22)(q11.2;q34;q11.2) in 100% metaphases counted. (who.int)
Tract1
- 35% involve the head and neck, most commonly in the sinonasal tract. (mayocliniclabs.com)
Chromosomal1
- How about the fact that it is the most commonly occurring chromosomal condition? (cram.com)
Laboratory tests1
- Clinical-laboratory analyzes are commonly known as laboratory tests. (hickeysolution.com)
Tissues1
- It commonly originates in the tissues in which the cells are regularly replaced by mitosis. (sciencetechstudy.com)
Cancer32
- Today, the study of molecular cytogenetics can be useful in diagnosing and treating various malignancies such as hematological malignancies, brain tumors, and other precursors of cancer. (wikipedia.org)
- Somatic copy number aberrations (CNAs) occur commonly in human cancer and evaluation of their characteristic patterns may be used as a diagnostic tool, especially in soft tissue sarcomas [ 3 ]. (biomedcentral.com)
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- These mouse probes are commonly used when developing model systems for studies in the field of genetics, mutagenesis, developmental cancer biology and also as human surrogates for studying the effects of genotoxic agents. (diagnostictechnology.com.au)
Analysis1
- This is the first analysis to describe ATLL pathological features, cytogenetics, and response to standard therapy and transplantation in the Caribbean cohort. (oncotarget.com)
Studies2
- However, to reach accurate diagnosis and subclassification, the utilizing of flow cytometry, to confirm monoclonality, and other ancillary studies such immunocytochemistry, cytogenetics and molecular studies is needed. (cytojournal.com)
- It further discusses the use of actual tests and how to intepret the results for diagnosis with special importance given to Cytogenetics and FISH (Fluorescence In Situ Hybridization) studies. (fetalandgynaeimaging.com)
Exposure1
- It's important to note that 77% [n = 150] of this patient population would have been ineligible for participation in the KarMMA-1 trial, most commonly due to prior exposure to BCMA-targeted therapy, organ dysfunctions like renal insufficiency, poor performance status, and cytopenias. (cancernetwork.com)
Clinical1
- Dietz's research into the origins of Marfan syndrome led to clinical trials, which he directed, of a treatment using a commonly available medication, and his work may lead to a blood test to detect aortas that are at risk for rupture. (genomeweb.com)
Diagnosis1
- While MDS are most commonly found in older patients (median age at diagnosis, 71 years), MDS can be diagnosed at any age, including childhood. (dermatologyadvisor.com)
FISH1
- FISH is a commonly used diagnostic tool in cytogenetics. (psychesystems.com)
Anemia1
- Patients with low-risk MDS (eg, refractory anemia with normal cytogenetics findings) generally do not develop AML, whereas patients with high-risk MDS (eg, refractory anemia with excess blasts-type 2) frequently do. (medscape.com)
Blood1
- Most commonly, biomarkers of exposures to stable compounds, such as metals, comprise measurements of the metal concentrations in appropriate samples, such as blood, serum or urine. (iloencyclopaedia.org)
Patients1
- Clinically, patients commonly suffer from frequent upper respiratory infections. (immunodeficiencysearch.com)
Therapy1
- Again, several regimens are commonly used for consolidation therapy, including the European LeukemiaNet regimen, the European APL regimen, and the PETHEMA regimen. (medscape.com)
Fluorescence in situ hybri5
- Fluorescence in situ hybridization (FISH) is becoming increasingly used to detect chromosomal changes in cancer cytogenetics. (nih.gov)
- Myeloma patients with high-risk disease, commonly defined as the presence of high-risk cytogenetics or fluorescence in situ hybridization (FISH) findings such as 13q deletion by conventional cytogenetics, t(4;14), t(14;16), or del(17p), have much shorter PFS with inferior survival. (nih.gov)
- It is commonly used for various cytogenetic applications, including karyotyping, fluorescence in situ hybridization (FISH), and chromosome analysis. (capricorn-scientific.com)
- Prior studies have employed a variety of methods, including targeted sequencing using cancer-related gene panels, whole-exome sequencing, fluorescence in situ hybridization, conventional cytogenetics, and immunohistochemistry (IHC), to evaluate the molecular changes in varied sample size of MAS cases ( 8 , 9 , 14 - 17 ). (frontiersin.org)
- Microscopy , cytogenetics, immunophenotyping, flow cytometry , fluorescence in situ hybridization (FISH), polymerase chain reaction (PCR), and gene expression profiling are all used to diagnose hematologic malignancies. (marketdataforecast.com)
Flow cytometry1
- Special tests include immunohistochemistry (e.g. sudan black stain - now rarely considered adequate for such a serious diagnosis), immuno phenotyping by flow cytometry - current confirmatory test, and cytogenetics (by karyotyping, FISH, PCR as required), and others. (shyamhemoncclinic.com)
Molecular genetics3
- Analysis of the genome currently incorporates three different laboratory disciplines: cytogenetics, molecular genetics and biochemical genetics, so depending on the clinical question, genetic results may be given for a specific gene or at a whole genome level. (europa.eu)
- As in other areas of medical genetics, advances in molecular genetics have contributed many new insights in the field of cytogenetics. (basicmedicalkey.com)
- Emphasis is given to the recent contributions of molecular genetics to cytogenetics. (basicmedicalkey.com)
Myeloma2
- Commonly, myeloma genetics tests like cytogenetics tests (FISH), gene expression profiling (GEP) and International Myeloma Staging Systems have all been used because higher risk genetic features have been identified. (healthtree.org)
- Myeloma commonly follows a multiply relapsing and remitting course with patients requiring successive lines of multi-drug therapy over increasing number of years. (hsanz.org.au)
Immunohistochemistry1
- The pathologist commonly use a technique called immunohistochemistry to learn about the tumor cells. (sarcomahelp.org)
Mutations3
- Biallelic CEBPA mutations and FMS-like tyrosine kinase receptor 3 (FLT3) length mutations are frequently identified in human acute myeloid leukemia (AML) with normal cytogenetics. (ox.ac.uk)
- We have generated an AML mouse model using knockin mouse strains to study cooperation of an internal tandem duplication (ITD) mutation in the Flt3 gene with commonly observed CCAAT/enhancer binding protein alpha (C/EBPα) mutations. (ox.ac.uk)
- Seventy-three percent of patients had intermediate-risk cytogenetics, 88% had tumors that harbored FLT3 -ITD mutations, 20% had undergone prior HSCT and 82% had received up-front intensive chemotherapy. (onclive.com)
Flt31
- the most commonly affected genes are NPM1 , FLT3 , DNMT3A , CEBPA , IDH1 , and IDH2 . (medlineplus.gov)
Chromosomes3
- Human cytogenetics began in 1956 when it was discovered that normal human cells contain 46 chromosomes. (wikipedia.org)
- Since trisomy of C-group chromosomes is commonly observed in leukemia, BT-induced aneuploidy may be involved in benzene-induced leukemia. (nih.gov)
- One of the fundamental techniques in cytogenetics is karyotyping , which involves the analysis and classification of chromosomes based on their size, shape, and banding patterns. (capricorn-scientific.com)
Malignancies3
- Today, the study of molecular cytogenetics can be useful in diagnosing and treating various malignancies such as hematological malignancies, brain tumors, and other precursors of cancer. (wikipedia.org)
- It is well known that leukemias are haematopoietic malignancies characterized by biological diversity, varied cytogenetics, different immunophenotype profiles, and diverse outcome. (hindawi.com)
- In addition, aside from hematologic malignancies, Holmlin said that Bionano's technology could have clinical applications within the broader cytogenetics market, which includes other cancers and some inherited diseases that are caused by large structural variants. (genomeweb.com)
Biomarkers2
- Most commonly, biomarkers of exposures to stable compounds, such as metals, comprise measurements of the metal concentrations in appropriate samples, such as blood, serum or urine. (iloencyclopaedia.org)
- Primary CNS lymphoma commonly expresses immune response biomarkers. (cdc.gov)
Leukemia1
- INDUCTION for all subtypes of AML, except M3, is essentially same, with a combination commonly known as 3+7 i.e. 3 days of Daunorubicin and 7 days of Ara-C. M3 or APL (acute promyelocytic leukemia) has some important differences in initial therapy and various regimens exist. (shyamhemoncclinic.com)
Methods1
- The companies will develop tests around a handful of specific but undisclosed indications within the hematology oncology space, with the objective of demonstrating that Bionano's technology is "a more efficient, scalable, and powerful tool for looking at structural variants that are relevant for cancer in a diagnostic setting" than the fluorescent in situ hybridization and karyotyping methods commonly used today, Bionano CEO Erik Holmlin said. (genomeweb.com)
Human1
- Somatic copy number aberrations (CNAs) occur commonly in human cancer and evaluation of their characteristic patterns may be used as a diagnostic tool, especially in soft tissue sarcomas [ 3 ]. (biomedcentral.com)
Disease2
- The disease starts most commonly in the legs or arms, but it can appear in any part of the body. (sarcomahelp.org)
- In an interdisciplinary fashion, research programs investigate plant breeding methodologies - commonly involving biotechnologies such as molecular marker mapping, quantitative trait locus analysis, and marker-assisted selection - cytogenetics, quantitative and population genetics, physiological and statistical genetics, disease and insect resistance, and improving the nutritional value of crops. (colostate.edu)
Study1
- PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study group. (mjhid.org)
Treatment2
- However, the most important information for treatment plan and prognosis both come from cytogenetics. (shyamhemoncclinic.com)
- In addition, commonly used drugs such as hydroxychloroquine have seen a significant surge in demand for COVID-19 treatment. (marketdataforecast.com)
Development1
- Subsequent development of histiocytic sarcoma and follicular lymphoma: cytogenetics and next-generation sequencing analyses provide evidence for transdifferentiation of early common lymphoid precursor-a case report and review of literature. (cdc.gov)