SNPsSusceptibilityMutationsMillion single nucleotide poAlleleSingleVariantsLociDeterminantsVariationsGenomicPredispositionGenotypesLocusAtrial fibrillationGenotypeC677TMetabolismTraitsVariationPopulationsMarkersMultifactorialMutationInheritanceGSTM1PhenotypesPromoter regionRestrictionGenes associatedEvolutionaryLineagesEncodesPatientsAnalysesDiseaseStudiesInvestigateClinical relevanceAbstractAssociationEnzymesVitaminPrevalentIsolatesOccursDiversityPatternsDifferencesDiseasesProteinsOvarianRiskInteractionRecurrenceProgressionDisordersAssociationsIndividuallyTraitMolecular
SNPs25
- The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). (routledge.com)
- Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. (routledge.com)
- Single nucleotide polymorphisms (SNPs) in the Gγ-globin gene promoter in BCL11A regions and HBS1L-MYB intergenic polymorphism (HMIP) are thought to be associated with Hb F levels. (scirp.org)
- What are single nucleotide polymorphisms (SNPs)? (medlineplus.gov)
- Single nucleotide polymorphisms, frequently called SNPs (pronounced "snips"), are the most common type of genetic variation among people. (medlineplus.gov)
- SNPs can also be used to track the inheritance of disease-associated genetic variants within families. (medlineplus.gov)
- An audio definition of SNPs is available from the National Human Genome Research Institute's Talking Glossary of Genetic Terms. (medlineplus.gov)
- How scientists locate SNPs in the genome is explained by the University of Utah Genetic Science Learning Center. (medlineplus.gov)
- As a living information and communications system, the genome encodes patterns in single nucleotide polymorphisms (SNPs) reflecting human adaptation that optimizes population survival in differing environments. (scirp.org)
- We assert that the stability of whole genome adaptation is reflected in the frequencies of maintained diversity in these common variants (SNPs) for a population in its environment. (scirp.org)
- SNPs are probably the most important category of genetic changes influencing common diseases. (snpedia.com)
- And in terms of common diseases, 9 of the top 10 leading causes of death have a genetic component and thus most likely one or more SNPs influence your risk. (snpedia.com)
- The emphasis in SNPedia is on SNPs that have significant medical consequences, are common, are reproducible (or found in meta-analyses or studies of at least 500 patients), and/or have other historic or medical significance. (snpedia.com)
- We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). (medsci.org)
- Single nucleotide polymorphisms (SNPs) denote the single nucleotide variations occurring at specific sites in the genome with substantial frequency within the population [ 1 , 9 , 10 ]. (medsci.org)
- That project looked at nearly 10 million single nucleotide polymorphisms (SNPs). (bigthink.com)
- The involvement of single-nucleotide polymorphisms (SNPs) in the TLR genes in infectious pathogenicity, including toxoplasmic retinochoroiditis, points at a possible involvement of TLR alterations in immunity against T. gondii . (springer.com)
- Single nucleotide polymorphisms (SNPs) in the promoter region of FAS and FASLG may alter their transcriptional activity. (duke.edu)
- Four tagged single-nucleotide polymorphisms (SNPs) of HMGB1 were detected by a TaqMan-based real-time polymerase chain reaction (PCR) in patients. (jcancer.org)
- I ca. 100 områder i det humane genom er der identificeret single nucleotide polymorphisms (SNPs), som enkeltvis korrelerer med en - ofte - let øget risiko for udvikling af koronarsygdom. (ugeskriftet.dk)
- Five tag‐single nucleotide polymorphisms (SNPs) of GOLGB1 (rs1169, rs7153, rs9968051, rs9819530, and rs6794341), which capture the majority of alleles spanning within gene, were genotyped in a case-control study with 270 patients with NSCPO and 284 unrelated healthy controls. (deepdyve.com)
- If you are reading a news story where it says, for example, scientists find the genetic contributors to diabetes or some other condition or trait, you're probably reading about SNPS. (genome.gov)
- With enough people in our study, we can use the SNPs as markers to see that certain areas of the genome appear to be the same in people who have diabetes, and that tells us where we should look in more detail for a genetic cause. (genome.gov)
- Among these subjects, 29 VDR single nucleotide polymorphisms (SNPs) were selected and genotyped, and plasma vitamin D concentrations were measured. (nih.gov)
- Common genetic mutations called Single nucleotide polymorphisms, or SNPs, have been implicated in changing the placebo response in clinical trials. (mentalfloss.com)
Susceptibility12
- Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. (routledge.com)
- The purpose of this case-control research is to determine if GABRG2 polymorphisms contribute to IGE susceptibility and antiepileptic drug resistance in Pakistani population. (hindawi.com)
- So far, the studies which explore the relationship between the E2F1 polymorphisms and ovarian cancer susceptibility are rare. (hindawi.com)
- The fact that genetic factors account for about 60% of the overall susceptibility to RA highlights the importance of research into genetic aberrations of this disease [ 3 , 6 - 8 ]. (medsci.org)
- Furthermore, we found that HMGB1 rs1360485 polymorphisms seemed to be related to susceptibility to developing poorly differentiated cancer linked to tobacco consumption in EGFR mutant patients. (jcancer.org)
- Our results suggest that common polymorphisms of GOLGB1 are not associated NSCPO susceptibility in the Brazilian population. (deepdyve.com)
- The report covers research from the authors' laboratories on the structure and regulation of UDP-glucuronosyltransferase (UGT) genes, glucuronidation of xenobiotics and endobiotics, the toxicological relevance of UGTs, the role of UGT polymorphisms in cancer susceptibility, and gene therapy for UGT deficiencies. (aspetjournals.org)
- Genome-wide association studies have identified more than 100 genetic loci for SLE susceptibility across populations, with most of the genetic risk shared across borders and ethnicities. (medscape.com)
- The increased cases of neurodevelopmental disorders in children, together with their increased susceptibility to OP neurotoxicity cannot be explained by genetic factors alone but could be related to gene-environment interactions. (cdc.gov)
- Carcinogenesis is a multistep process and individual risk to development of cancer depends not only on environmental factors or extrinsic exposure to carcinogens but also on genetic susceptibility of an individual. (bvsalud.org)
- Factors that influence the tobacco exposed individuals developing a malignancy may thus include a combination of total tobacco exposure and genetic susceptibility of the individual 12 . (bvsalud.org)
- Polymorphic genotypes of these enzymes may serve as genetic biomarkers for susceptibility to certain malignancies and therefore may help predict individual cancer risk 8 . (bvsalud.org)
Mutations10
- Genetic polymorphism is a term used somewhat differently by geneticists and molecular biologists to describe certain mutations in the genotype, such as single nucleotide polymorphisms that may not always correspond to a phenotype, but always corresponds to a branch in the genetic tree. (wikipedia.org)
- Rare variations are not classified as polymorphisms, and mutations by themselves do not constitute polymorphisms. (wikipedia.org)
- The criterion is that the frequency of the least common morph is too high simply to be the result of new mutations or, as a rough guide, that it is greater than 1% (though that is far higher than any normal mutation rate for a single allele). (wikipedia.org)
- Mutations in ion channel genes have been identified as a common cause of IGE. (hindawi.com)
- Recently, multiple mutations in gamma 2 subunit of GABA receptors are discovered in two families which furnished the genetic evidence for possible role of GABA receptor system in epileptogenesis. (hindawi.com)
- Darbar D. Genetics of atrial fibrillation: Rare mutations, common polymorphisms, and clinical relevance. (nature.com)
- The aim of this study was to explore potential associations between genetic polymorphisms of HMGB1 and EGFR mutations in a cohort that included 280 patients with NSCLC, some of whom were smokers and others who never smoked. (jcancer.org)
- Some of the recently discovered genetic risk factors, such as factor V Leiden and prothrombin G20210A mutations, are quite common in the population. (intechopen.com)
- Led by Kathryn Hall of Harvard Medical School, a group of scientists reviewed previous research for evidence of a genetic variation in the placebo effect by looking for correlations between certain genetic mutations and the strength of a person's placebo response. (mentalfloss.com)
- Although SLE is generally a complex genetic illness, there are several examples of mutations that can produce a monogenetic form of the illness. (medscape.com)
Million single nucleotide po1
- In these studies, upwards of a million single-nucleotide polymorphisms are typed in each individual. (medscape.com)
Allele1
- The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease. (who.int)
Single15
- Sickle cell disease is an inherited genetic disorder, resulting from homozygous and compound heterozygote mutation in the β globin gene as a single base-pair point mutation (GAG to GTG) results in the substitution of glutamic acid (hydrophilic) to Valine (hydrophobic) in the 6th position of the β-chain of hemoglobin resulting in hemoglobin S formation [7]. (scirp.org)
- A novel approach to estimating genetic variability is in silico mining for single nucleotide polymorphisms (SNP). (usp.br)
- Is the Subject Area "Single nucleotide polymorphisms" applicable to this article? (plos.org)
- In a population sample of 316 U.K. clinical isolates, silent single nucleotide polymorphisms (sSNPs) resolve an unambiguous phylogeny and provide a unifying framework for epidemiologic, population, and evolutionary analyses. (cdc.gov)
- This exact same single nucleotide polymorphism (SNP) was previously identified to be associated with increased height. (bmj.com)
- In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. (uni-koeln.de)
- Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-alpha and ribavirin for 24-72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. (uni-koeln.de)
- To determine whether genetic variations of IGF modify pancreatic cancer risk, we compared the frequency of six single nucleotide polymorphisms of IGF1 and IGF2 in a large-scale case control study. (aacrjournals.org)
- Single nucleotide polymorphisms were investigated using the TaqMan method in 892 patients with pancreatic ductal adenocarcinoma and 783 healthy controls who were recruited from The University of Texas M. D. Anderson Cancer Center from 2000 to 2007. (aacrjournals.org)
- Genome-wide association studies that link phenotypes to thousands of single nucleotide polymorphism markers are nowadays common practice for such analyses. (nih.gov)
- A single nucleotide polymorphism (abbreviated SNP, pronounced snip) is a genomic variant at a single base position in the DNA. (genome.gov)
- Single nucleotide polymorphism, or SNP. (genome.gov)
- Thanks to the Human Genome Project, we have found that these single letter changes in our genetic code are placed all across our genomes. (genome.gov)
- [ 80 ] For example, presence of the MRE11A single-nucleotide polymorphism rs1805363 has been associated with worse cancer-specific survival after radiation therapy, with a gene-dosage effect observed, but not after cystectomy. (medscape.com)
- We have investigated 11 paired diagnostic and relapse samples with single nucleotide polymorphism array and mutation analyses of FLT3, KRAS, NRAS and PTPN11 in order to identify changes associated with relapse and to ascertain the genetic evolution patterns. (lu.se)
Variants8
- Furthermore, our approach provides insights for new discoveries on the biology of common variants. (scirp.org)
- Olesen M, Nielsen M, Haunsø S, Svendsen J. Atrial fibrillation: The role of common and rare genetic variants. (nature.com)
- Studying twins allows for researchers to examine the entirety of genetic influence, including how genes interact with one another, how rare variants influence a person, and how the interplay between genes and the environment takes place. (bigthink.com)
- This metric only looks at common gene variants. (bigthink.com)
- 74 genetic variants associated with educational aptitude were identified in this study. (bigthink.com)
- Genetic variants in golgin subfamily B member 1 (GOLGB1), a gene that is essential for normal murine palatogenesis, were analyzed in this study to establish its potential association with NSCPO risk in the Brazilian population. (deepdyve.com)
- Here, using a tag SNP approach, we comprehensively evaluated the role of common genetic variants in VDR and their interaction with plasma vitamin D levels in relation to colorectal cancer risk in Japanese populations. (nih.gov)
- Pharmacogenetic studies have been also performed in order to evaluate the role of host genetic variants in the prediction of recurrence risk and response to adjuvant treatment with FLs and OXA. (frontiersin.org)
Loci4
- The main goal of the first project is to understand the role of natural and sexual selection in the evolution and maintenance of genetic variation at loci coding for melanin-based colour traits by combining disciplines of behavioural ecology, genetics and population genetics. (unil.ch)
- Thus, we selected three widely-studied polymorphism loci (rs3213172, rs3213173, and rs3213176) to find a novel marker for the risk prediction of ovarian cancer. (hindawi.com)
- Using a population-based approach that analyzes multiple loci around the chromosome, we demonstrate that neutral genetic variation in genes associated with antimicrobial drug resistance has sufficient variation to construct a robust phylogenetic tree for M. tuberculosis . (cdc.gov)
- The application of genomic prediction models that take into account the effects of all individual loci may greatly enhance the elucidation of the genetic architecture of quantitative traits in plants. (nih.gov)
Determinants6
- Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. (routledge.com)
- Human complex metabolic traits are in part regulated by genetic determinants. (lu.se)
- We applied exome sequencing as a basis for finding genetic determinants of metabolic traits and show the existence of low-frequency and common coding polymorphisms with impact on common metabolic traits. (lu.se)
- article{56523986-819a-47dd-8322-bd05ce5e7b7d, abstract = {{Human complex metabolic traits are in part regulated by genetic determinants. (lu.se)
- However, further work is needed to dissect the additional monogenic and polygenic determinants for patients without a genetic explanation for their AF despite the presence of specific genetic indicators such as young age of onset and/or positive family history. (nature.com)
- According to King's College researchers, genetic determinants had more to do with academic achievement than "grit," or any other personality trait. (bigthink.com)
Variations5
- But at certain locations there are differences - these variations are called polymorphisms. (snpedia.com)
- These are the most common genetic variations people have. (bigthink.com)
- Researchers concluded that genetic variations accounted for different levels of academic achievement among children. (bigthink.com)
- Overall, the findings of this study provide only limited support for an association between common genetic variations in VDR and colorectal cancer risk in the Japanese population. (nih.gov)
- Therefore variations in the expression of these genes due to heritable genetic polymorphisms might modulate the process of carcinogenesis by altering the exposure levels of tobacco derived carcinogens. (bvsalud.org)
Genomic2
Predisposition4
- Idiopathic generalized epilepsy is the most common category of epilepsy with nonfocal mechanism of onset and no external cause or no cause beyond genetic predisposition according to the current definition [ 4 ]. (hindawi.com)
- Genetic predisposition, clinical risk factor burden, and lifetime risk of atrial fibrillation. (nature.com)
- And would those who had a genetic predisposition toward lower achievement receive more resources or less? (bigthink.com)
- Coletta, Ricardo D. 2018-01-01 00:00:00 Nonsyndromic oral clefts are common congenital birth defects that exhibit variable prevalence around the world, often influenced by population‐dependent genetic predisposition. (deepdyve.com)
Genotypes3
- The kalemic systems in those breeds were characterized by a polymorphism of middle level due to the existence of the two phenotypes and of three genotypes. (academicjournals.org)
- Therefore, the aims of this study were to sequence the -Phs and FRO1 genes, to assess SNP frequencies in coding and non-coding regions of both genes, and to assess the possible use of these polymorphisms for investigating the genetic diversity of 31 cultivated genotypes of common bean and one of P. lunatus. (usp.br)
- Do the placental barrier, parasite genotype and Toll-like receptor polymorphisms contribute to the course of primary infection with various Toxoplasma gondii genotypes in pregnant women? (springer.com)
Locus2
- In goats belonging to the different breeds and sub breed, the genetic polymorphism at the determinant locus of blood potassium was revealed by flame spectrophotometer method. (academicjournals.org)
- Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion. (cdc.gov)
Atrial fibrillation2
Genotype3
- The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
- The CT genotype of E2F1 gene rs3213172 polymorphism is associated with an increased risk of ovarian cancer, and E2F1 gene rs3213172 polymorphism may be a novel marker for the risk prediction of ovarian cancer. (hindawi.com)
- To disentangle the genetic architecture of such traits, natural variation within species can be explored by studying genotype-phenotype relationships. (nih.gov)
C677T1
- We also investigated the potential effect of the C677T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) to the sUA level in different dementia types. (mdpi.com)
Metabolism4
- Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
- Polymorphisms in other genes, some of which have not been identified, have a smaller effect on warfarin metabolism. (medlineplus.gov)
- Several CYP2C9 gene polymorphisms decrease the activity of the CYP2C9 enzyme and slow the body's metabolism of warfarin. (medlineplus.gov)
- Six common polymorphisms in vitamin D metabolism genes were genotyped. (medscape.com)
Traits4
- Diversity analysis in common bean (Phaseolus vulgaris L.), based on morphological traits and molecular markers, has revealed the existence of two major gene pools, the Mesoamerican and Andean pools, which differ in several features, including the grain morphology and physiology. (usp.br)
- Based on our study, coding polymorphisms with MAF above 1% do not seem to have particularly high effect sizes on the measured metabolic traits. (lu.se)
- This project is original, since the interest in melanin-based colour traits and genetic colour polymorphism has recently grown. (unil.ch)
- Furthermore, we recently proposed a new genetic mechanism to explain why melanin-based colour traits are frequently associated with several individual attributes. (unil.ch)
Variation11
- it is related to biodiversity, genetic variation, and adaptation. (wikipedia.org)
- Polymorphism does not cover characteristics showing continuous variation (such as weight), though this has a heritable component. (wikipedia.org)
- Polymorphism deals with forms in which the variation is discrete (discontinuous) or strongly bimodal or polymodal. (wikipedia.org)
- The significance of geographical variation is that it may lead to allopatric speciation, whereas true polymorphism takes place in panmictic populations. (wikipedia.org)
- Once the statistical distribution of variation reaches homeostasis in a given environment, a human population can be described in terms of the maintained order and patterns of polymorphisms in the whole genome. (scirp.org)
- 6 The aim of our study was to prove that common genetic variation in the DOT1L gene is important in hip OA at this level of confidence. (bmj.com)
- The common polymorphisms of the gene ABCG2 coding the efflux transporter BCRP and the gene SLCO1B1 coding the influx transporter OATP1B1 are associated with the interindividual variation in the effectiveness and tolerability of the cholesterol-lowering statins. (helsinki.fi)
- I have a background as a systematist and perform genetic and experimental research on the evolution of wild plants, with special emphasis on natural selection, ecotypic variation, floral diversification and the evolutionary effects of inbreeding. (lu.se)
- In the past years, I have been involved in several studies on genetic erosion - the loss of genetic variation resulting from genetic drift in small, fragmented populations. (lu.se)
- Data from artificially bottlenecked populations of Nigella degenii and wild populations of Brassica cretica show that genetic drift causes idiosyncratic, trait-specific changes in the genetic variation rather than a consistent, proportional decline in all measures of variation. (lu.se)
- Our results also indicate that the structuring of quantitative genetic variation can be relatively insensitive to landscape fragmentation, at least over the timescales considered by most conservation biologists. (lu.se)
Populations3
- Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. (routledge.com)
- To provide greater confidence when inferring genetic effects of small population size, we have extended our analyses to experimental systems or natural populations with a known history of fragmentation. (lu.se)
- Little is known about how genetic and nongenetic factors modify responses of vitamin D supplementation in nonwhite populations. (medscape.com)
Markers3
- GNP-5285 ] - Insert Walnut genetic resources, phenotyping, SSR markers data from BRC (ODS). (inra.fr)
- The samples were also genotyped for 40 biallelic polymorphic markers to characterize the genetic ancestry. (deepdyve.com)
- Our aim was to integrate our previously reported clinical-genetic prognostic score with new immunogenetic markers of 5-year disease-free survival (DFS) to evaluate the recurrence risk stratification before fluoropyrimidine (FL)-based adjuvant therapy. (frontiersin.org)
Multifactorial2
- 1 Although OA is multifactorial, it is known to have significant genetic contribution and a number of studies have attempted to dissect such contribution (see 2 for review). (bmj.com)
- Venous thrombosis is a multifactorial disease frequently related to the interaction of genetic and environmental risk factors. (intechopen.com)
Mutation3
- Generelt giver kendskab til genotypen ved de monogenetiske sygdomme for nuværende dog minimal viden om prognosen, og selv blandt slægtninge i familier med en velkarakteriseret mutation varierer penetransen og ekspressiviteten betydeligt [10]. (ugeskriftet.dk)
- Environmental carcinogens and certain other endogenous factor (genetic alteration and mutation) interacting in a complex manner can give rise to development of cancer. (bvsalud.org)
- Mutation in the cellular machinery controlling growth or differentiation is an example of the type of genetic change that occurs in initiation 5 . (bvsalud.org)
Inheritance4
- To qualify as a polymorphism, some kind of balance must exist between morphs underpinned by inheritance. (wikipedia.org)
- Autosomal dominant is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
- Autosomal recessive is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
- The risk of developing SLE is at least in part genetic, but it is a complex genetic illness with no clear mendelian pattern of inheritance. (medscape.com)
GSTM15
- To investigate whether genetic polymorphisms of glutathione S-transferases ( GSTM1 , GSTT1 , and GSTO2 ) in relation to the work place contribute to the development of cataract. (molvis.org)
- This finding suggests that the polymorphisms of GSTM1 and GSTO2 and also work place may act additively for developing cataract. (molvis.org)
- This non systematic review summarizes current data available on the role of environment gene interaction in form of GSTM1 null polymorphism and oral carcinogenesis. (bvsalud.org)
- Relevant data was selected in order to summarize the studies conducted on GSTM1 null polymorphism and oral cancer. (bvsalud.org)
- Relationship between GSTM1 null polymorphism in oral cancer needs to be established to confirm the role of environment gene interaction in oral carcinogenesis. (bvsalud.org)
Phenotypes4
- In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species. (wikipedia.org)
- Balanced polymorphism refers to the maintenance of different phenotypes in population. (wikipedia.org)
- 1% with common metabolic phenotypes. (lu.se)
- 1%. In stage 2 we identified 51 potential associations with one or more of eight metabolic phenotypes covered by 45 unique polymorphisms. (lu.se)
Promoter region1
Restriction2
- For this purpose, we genotyped exon2, exon5 ( C540T and C588T ), exon7 ( T813C ), exon8 ( K289M ), and exon9 of GABRG2 gene by restriction fragment length polymorphism and Sanger's sequencing in 87 drug-responsive idiopathic generalized epilepsy patients, 55 drug-resistant epilepsy patients, and 83 healthy controls. (hindawi.com)
- Restriction fragment length polymorphism (RFLP) and sequencing results indicated only C588T polymorphism in the studied subjects. (hindawi.com)
Genes associated1
- Additionally, people who have more than one polymorphism in a gene or polymorphisms in multiple genes associated with warfarin sensitivity have a lower tolerance for the drug's effect or take even longer to clear the drug from their body. (medlineplus.gov)
Evolutionary2
- According to the theory of evolution, polymorphism results from evolutionary processes, as does any aspect of a species. (wikipedia.org)
- The evolution of small, selfing flowers from large, animal-pollinated flowers is one of the most common evolutionary trends in the plant kingdom. (lu.se)
Lineages1
- Although much attention has focused on the selective advantage of self-pollination, there have been few attempts to explore the selective and genetic mechanisms underlying the floral reduction so prevalent in selfing lineages. (lu.se)
Encodes1
- The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human diseases. (medsci.org)
Patients8
- Patients are initially counseled on the basis of their age and genetic and family history. (medscape.com)
- Study the HBS1L-MYB (rs4895441 and rs9376090) genetic polymorphisms in Egyptian patients with β -thalassemia major and sickle cell disease and its relation to Hb F and severity of the disease. (scirp.org)
- In sickle cell disease patients, Genetic polymorphisms in HBS1L-MYB (rs9376090 & rs4895441) affect the level of Hb F which could improve the prognosis of these patients. (scirp.org)
- Whole genome sequencing (WGS) performed at CDC on isolates from 15 patients* confirmed that the recent isolates did not share common strains or plasmids with the 2012 outbreak. (cdc.gov)
- Patients were genotyped for a panel of 192 tagging polymorphisms in 34 immune-related genes. (frontiersin.org)
- The integration of IFNG -rs1861494 in our previous clinical genetic multiparametric score of DFS improved the patients' risk stratification (Log-rank P = 0.0026 in the pooled population). (frontiersin.org)
- Patients with resistant tumors would be offered upfront cystectomy, while those with chemoradiation-sensitive tumors would be offered bladder-preserving therapy, with regimens selected on the basis of genetic analysis. (medscape.com)
- are not very common (albuminuria and/or retinopathy develop in 6 to 10% of patients). (msdmanuals.com)
Analyses1
- Results from field surveys, genetic analyses, stress-manipulation experiments and comparative studies of population structure indicate that several selection pressures, operating at both vegetative and reproductive stages, contribute to the maintenance of these pollen-color dimorphisms. (lu.se)
Disease6
- This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. (routledge.com)
- Also, a significant association was detected between polymorphisms and disease severity. (scirp.org)
- Huntington's disease is an example of an autosomal dominant genetic disorder. (genome.gov)
- If we want to identify genetic contributors to a common complex disease like diabetes, we can group together thousands of people who have diabetes and compare their SNP patterns to thousands of people who do not have diabetes. (genome.gov)
- Alzheimer disease (AD) is the most common progressive degenerative form of dementia, strongly associated with advancing age. (medscape.com)
- Alzheimer's disease (AD) is the most common cause of dementia. (lu.se)
Studies3
- Genetic association data for rs12982744 and hip OA were derived from the Translational Research in Europe Applied Technologies for OsteoArthritis (TREAT-OA) consortium and combined with data from the UK (arcOGEN consortium), Estonia (Estonian Genome Center of the University of Tartu) and other studies (Nottingham, GOAL). (bmj.com)
- Recent studies have shown that transporters can mediate drug-drug interactions, and transporter genes are subject to genetic polymorphism which may affect pharmacokinetic parameters of a drug, such as absorption, distribution, and excretion. (helsinki.fi)
- Few studies have been performed with nonsyndromic cleft palate only (NSCPO), limiting the knowledge of the genetic risk factors related to this type of oral cleft. (deepdyve.com)
Investigate1
- The in vitro method developed in this study remains in the research team as a tool to investigate the polymorphisms of the SLCO1B1-gene, the inhibition of the transporter and possible drug interactions. (helsinki.fi)
Clinical relevance1
- Problems arise with interpretation in many new polymorphisms without significant clinical relevance. (intechopen.com)
Abstract1
Association5
- The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. (uni-koeln.de)
- Insulin-like growth factors (IGF) have been associated with risk of common human cancers, but the association between IGFs and pancreatic cancer risk is unclear. (aacrjournals.org)
- Association of Common Genetic Polymorphisms with Melanoma Patient IL-12p40 Blood Levels, Risk, and Outcomes. (duke.edu)
- Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. (nih.gov)
- [ 7 , 8 ] The recognition that DS is associated with trisomy 21 helped in understanding the genetic basis of this association. (medscape.com)
Enzymes2
- Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. (routledge.com)
- Genetic polymorphism occurs in several genes that code drug metabolizing enzymes or drug transporters. (helsinki.fi)
Vitamin1
- Supplemented 2000 IU/d vitamin D 3 raised 25(OH)D and 25(OH)D Bio but was unable to correct deficiency in 25% of Chinese participants, which might be partially attributed to the effect of genetic modification. (medscape.com)
Prevalent2
- Idiopathic generalized epilepsy (IGE) is the most prevalent type of epilepsy with genetic origin. (hindawi.com)
- The polymorphic genes have subtle effect on cancer risk at individual level but may have a large population impact because the relevant polymorphism may be highly prevalent in a population. (bvsalud.org)
Isolates1
- Klebsiella pneumoniae carbapenemase (KPC) is the most common carbapenemase seen in the United States, but isolates with the New Delhi metallo-β-lactamase (NDM) are emerging. (cdc.gov)
Occurs2
- 126 The most common example is sexual dimorphism, which occurs in many organisms. (wikipedia.org)
- While it is unclear how many of these events are due to warfarin sensitivity, the most common sign is excessive internal bleeding, which often occurs when individuals with warfarin sensitivity are given too much of the medication. (medlineplus.gov)
Diversity1
- Recursion relations for mean pairwise coalescent times are used to obtain simple approximate expressions for diversity and divergence statistics for an inversion polymorphism at equilibrium under recombination and drift, and for the approach to equilibrium following the sweep of an inversion to a stable intermediate frequency. (ed.ac.uk)
Patterns1
- The effects of an inversion polymorphism on patterns of linkage disequilibrium are also examined. (ed.ac.uk)
Differences1
- Some of these genetic differences, however, have proven to be very important in the study of human health. (medlineplus.gov)
Diseases2
- Genetic factors levels vary significantly in the general pop- contribute significantly to the development ulation and are influenced by environmental of these diseases. (who.int)
- Which genes are commonly associated with genetic diseases? (cshlpress.com)
Proteins2
- Investigating the role of cell membrane proteins has increased over the last decade, as drugdrug interactions and genetic polymorphisms have been found to cause changes in drug pharmacokinetics and dynamics. (helsinki.fi)
- Certain VKORC1 gene polymorphisms decrease the amount of functional VKORC1 enzyme available to help activate clotting proteins. (medlineplus.gov)
Ovarian4
- The present study is aimed at exploring whether rs3213172, rs3213173, and rs3213176 polymorphisms of the E2F1 gene confer risk for ovarian cancer. (hindawi.com)
- E2F1 gene rs3213173 and rs3213176 polymorphisms confer no risk to ovarian cancer risk. (hindawi.com)
- The early symptoms of ovarian cancer are insidious, and the most common clinical symptoms are abdominal pain, abdominal distension, and urgency of urination. (hindawi.com)
- The present study is to explore whether E2F1 gene polymorphisms confer risk for ovarian cancer. (hindawi.com)
Risk1
- Our findings showed that C588T polymorphism of GABRG2 is a risk variant for IGE in Pakistani population. (hindawi.com)
Interaction1
- In other words, the scoring system examines interaction between genes, and estimates the difference between genetic influences and common variance. (bigthink.com)
Recurrence1
- Bladder cancer is a common urologic cancer that has the highest recurrence rate of any malignancy. (medscape.com)
Progression1
- oxidation modification of the genetic material may also participate in the progression of benign to malignant neoplasms. (bvsalud.org)
Disorders2
- Many genetic disorders can be detected early in pregnancy using various noninvasive and invasive techniques. (medscape.com)
- Molecular genetic methods were implemented into the screening examinations for thrombophilic disorders in the 1990's along with the first discoveries of coagulation inhibitors (AT, protein C and protein S). The discovery of the molecular cause of activated protein C (APC) resistance by Bertina in 1994 greatly expanded their utilization. (intechopen.com)
Associations2
Individually1
- We are just beginning to learn which of the 30 million or so possible polymorphisms influence health, either individually or in sets. (snpedia.com)
Trait1
- Put simply, polymorphism is when there are two or more possibilities of a trait on a gene. (wikipedia.org)
Molecular2
- The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)
- Now, a study published in the journal Molecular Psychiatry is helping to quantify genetic influence. (bigthink.com)