Combines capillary gas chromatography mass spectrometry. Medical search. Frequent questions

While it can be measured using various analytical techniques, capillary electrophoresis (CE) is widely used for this purpose. (uwaterloo.ca)
The readily reproducible methods range from gas and liquid chromatography coupled to mass spectrometry detection and other classic detectors, to capillary electrophoresis and immunochemical or radioimmunoassay methods. (nhbs.com)
Analysis of the by-products by the me- thod of capillary electrophoresis revealed single, two-and tribasic carboxylic acids, while the gas chromatography-mass spectrometry analysis confirmed the presence of aldehydes, alcohols, esters, and nitrogen-containing heteroatomic compounds besides carboxylic acids. (gubkin.ru)
Here, capillary electrophoresis (CE) coupled to electrospray ionization mass spectrometry (ESI-MS) is implemented to analyze complex mixtures of InsPs and PP-InsPs with high sensitivity. (biomed.news)
Capillary electrophoresis is an analytical method featured by high resolution capability, combining advantages of electrophoretic separation with a possibility of automated analysis and easy quantitative calculation characteristic of high-performance liquid chromatography. (itcras.ru)
Capillary electrophoresis is a quantitative analytical method usable to determine compositions of complicated biological mixes while analyzing environmental objects, foods, medications, etc. (itcras.ru)
Technologies used in physical forensics include liquid chromatography-mass spectrometry (LC-MS) for explosives and fiber analysis, gas chromatography-mass spectrometry (GC-MS) for explosives, scanning electron microscopy, capillary electrophoresis (CE), ion mobility spectrometry (IMS), laser-induced breakdown spectroscopy (LIBS) for glass, and advanced computational methods. (worldwidelearn.com)
Recent advances in experimental techniques like liquid chromatography coupled with mass spectrometry (LC-MS), gas chromatography coupled with mass spectrometry (GC-MS) and capillary electrophoresis coupled with mass spectrometry (CE-MS), allow for the generation of high-throughput metabolomics data. (biomedcentral.com)

Quantification of glyphosate and other organophosphorus compounds in human urine via ion chromatography isotope dilution tandem mass spectrometry. (cdc.gov)

Several techniques exist to perform BSS on Ion Mobility Spectrometry, being Simple-to-use interactive self-modeling mixture analysis (SIMPLISMA) and Multivariate Curve Resolution (MCR) the most commonly used. (ibecbarcelona.eu)
For the first time, BSS techniques are used to deconvolve samples of the gas chromatography - ion mobility spectrometry tandem. (ibecbarcelona.eu)
This is typical of diverse instrumental techniques such as Gas Chromatography-Mass Spectrometry (GC-MS) or Gas Chromatography-Ion Mobility Spectrometry (GC-IMS). (ibecbarcelona.eu)

This study aimed to characterize the chemical profiles of these different species of Curcumae Radix, and develop a method for rapid discrimination of these species by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOFMS) combined with multivariate statistical analysis. (biomedcentral.com)
For these reasons, we systematically compared the chemical content of Korean red ginseng and Chinese red ginseng with a sample profiling strategy combining UltraPerformance LC (Waters Corporation, Milford, Massachusetts), orthogonal acceleration time-of-flight mass spectrometry (oa-TOF-MS), and multivariate statistical analysis (MVA) as the analytical tools (8). (spectroscopyonline.com)

The authors have focused on extraction and cleanup procedures, in order to develop and optimize more fully automated and miniaturized methods, including solid-phase extraction, solid-phase microextraction, microwave-assisted extraction, and on-line tandem liquid chromatography (LC/LC) trace enrichment, among others. (nhbs.com)
In this study, Quadrupole Isotope Dilution Mass Spectrometry ((IDMS)-M-4) strategy was coupled with Liquid Chromatography-Quadrupole Time of Flight-Tandem Mass Spectrometry (LC-QTOF-MS/MS) for the accurate and precise determination of glycine in body fluids at trace levels. (itu.edu.tr)
A targeted ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was established and validated for the simultaneous determination of 34 amino acids in tissue samples from colorectal cancer (CRC) patients. (sagepub.com)

DB-5 elastic quartz capillary column (30 m×0.25 mm×0.25 um). (hagf.com)

A 10 m fused silica capillary column HP-1 was used. (medline.ru)

The main purpose of our study was to detect native zopiclone, its decomposition products and 2-amino-5-chloropyridine in blood and urine by means thin-layer chromatography and gas chromatography (FID and ECD). (medline.ru)
Aliquots of blood, urine samples and zopiclone hydrolysis products were first analyzed by thin-layer chromatography in solvent system benzene-1,4-dioxane-conc. (medline.ru)

The Department also has an associated flavour analytical suite, including proton transfer reaction mass spectrometry ( PTR-MS ) and gas chromatography ( GC ) suite. (otago.ac.nz)
By combining the functionalities of GC and MS, the GC-MS technique dramatically enhances analytical accuracy, overcoming the limitations of each. (infinitalab.com)

Non-purified extracts of the overground parts of the species were subjected to ultra-high performance liquid chromatography - high resolution electrospray ionisation mass spectrometry ( UHPLC - HRESIMS ) analysis and the results were compared to authentic reference substances. (pensoft.net)

Weigh about 10 g of garlic skin raw material, soak garlic skin raw material with 70% ethanol solution as entrainer, then put the above garlic skin sample into the extraction tank, set the extraction pressure, extraction temperature, and extraction time to 370 bar, 38 ℃, 9 h (collect the supercritical CO2 extract of garlic skin every 3 h, collect a total of 3 times), and combine the three extracts. (hagf.com)
Supercritical Fluid Chromatography (SFC): A Powerful. (chromatographytoday.com)
The high separation power and short analysis time obtained demonstrate for the first time that supercritical fluid chromatography is a fast and reliable technique for the analysis of lignin-derived phenols in complex environmental samples. (lu.se)
Alkaline cupric oxide (CuO) oxidation is one of the mostly performance supercritical fluid chromatography (UHPSFC) adopted methods for analyzing lignin in various complex using columns with sub-2 m packing can further improve environmental matrices such as soils and sediments [9]. (lu.se)
UHPSFC , ultra- pacted by other parameters, such as the addition of the mod- high performance supercritical fluid chromatography ifier and the change of the mobile phase density [20]. (lu.se)

In this application note Dr. Daniela Peroni demonstrates the feasibility of thermally-modulated GC×GC with parallel MS/FID detection to combine enhanced identification capability and robust, reliable quantification in fragrance analysis. (chromatographytoday.com)
The MS instrument allows unambiguous identification/quantification of e.g. peptides, by first recording the molecular mass of a compound (single MS) and then creating a "molecular fingerprint" by fragmenting the compound to smaller parts (MS/MS). Separating compounds in a mixture (e.g. plasma) prior to MS detection further strengthens identification and sensitivity. (nature.com)
To improve the accuracy of chemical molecule structure analysis, Gas Chromatography-Mass Spectrometry (GC-MS) combines the functions of Gas Chromatography (GC) and Mass Spectrometry (MS). Drug detection, fire investigati on, environmental analysis, investigating explosives, and identifying unidentified materials are some applications of GC-MS. Utilizing its extensive network of laboratories, Infinita Lab, USA, provides this test to its clients in the USA and other locations. (infinitalab.com)
HPLC can be combined with various detection methods, such as UV absorption or fluorescence, to improve the accuracy of the analysis. (pharmiweb.com)
Once separated by LC, the amino acids enter the mass spectrometer for detection and quantification. (pharmiweb.com)
Solid-phase microextraction (SPME) with gas chromatographic/mass spectrometric (GC/ MS) analysis can achieve such detection limits in small water samples, which greatly reduces the quantity of sediment pore water that has to be collected, shipped, stored, and prepared for analysis. (who.int)

Gas chromatography-mass spectrometry (GC-MS) is a method that combines the features of gas-liquid chromatography and mass spectrometry to identify different substances within a test sample. (iitk.ac.in)
Liquid Chromatography as a Game-Changer in Measuring. (chromatographytoday.com)
Djordjevic S, Kovacevic I, Miljkovic B, Vuksanovic J, Pokrajak M. Liquid chromatographic-mass spectrometric method for the determination of fluoxetine and norfluoxetine in human plasma: application to clinical study. (scielo.br)
We describe a robust nano liquid chromatography-mass spectrometry (nanoLC-MS) platform for measuring the total amount of OT in human plasma/serum. (nature.com)
Peptides are typically separated using liquid chromatography (LC). (nature.com)
The GCMS-TQ8040 use AOC-5000 GC sample injection system that combines liquid, large volume and headspace injection in one single instrument. (utm.my)
Pharmacokinetic studies and tissue distributions were performed and detected by an ultra-high performance liquid chromatography/mass spectrometry system. (dovepress.com)
After derivatization, the amino acids are separated using liquid chromatography. (pharmiweb.com)
Using UltraPerformance liquid chromatography/orthogonal acceleration (oa)-TOF mass spectrometry and exact mass measurement, the authors developed a high-resolution method using multivariate statistical analysis for separating and identifying differences between Chinese ginseng and Korean ginseng at the molecular level. (spectroscopyonline.com)

The analysis of individual components usually involves separation of the components by column chromatography (i.e., packed or capillary column) followed by a suitable quantification method. (cdc.gov)
Comprehensive two-dimensional gas chromatography (GC×GC) couples two columns in a single analysis to achieve superior separation power. (chromatographytoday.com)
Capillaries offer much better efficiency (narrow peaks) which leads to greatly better-quality peak separation. (utm.my)
Chromatography-mass-spectrometry combines chromatography as method for mix separation with mass spectrometry as the most informative method for determination of the structure of organic compounds. (itcras.ru)
Combining mass spectrometry with separation techniques such as HPLC or CE can improve the accuracy and sensitivity of amino acid analysis. (pharmiweb.com)

The most common type of mass spectrometer (MS) associated with a gas chromatograph (GC) is the quadrupole mass spectrometer, sometimes referred to by the Hewlett-Packard (now Agilent) trade name "Mass Selective Detector" (MSD). (iitk.ac.in)

Gas chromatography/mass spectroscopy analysis showed that the extract contained monoterpene hydrocarbons and phenolic compounds, the major ones being carvacrol and thymol and to a lesser extent p-cymene, 1-octacosanol, creosol, and phytol. (hindawi.com)
In the usual Mass spectrometry step of GC-MS, compounds leaving the GC column are fragmented by electron impact. (spectrophotometers.com)
Gas chromatography Mass Spectrometry (GC-MS) is broadly employed for the analysis of allergens and aroma compounds in fragrances. (chromatographytoday.com)
The first section examines who uses mass spectrometers followed by how compounds are ionized in the source to be analyzed by mass spectrometers. (chromatographyonline.com)
A description of the various types of mass spectrometers is next and a discussion of the important topics of mass accuracy and resolution - or how well we can tell differences between closely related compounds. (chromatographyonline.com)
Mass Spectrometry works by ionizing chemical compounds to generate charged ions, with a range of molecular masses. (infinitalab.com)
Individual compounds have their own unique mass spectrum since every pure compound always produces the same family of ions. (infinitalab.com)
These devices combining two mutually complementary vibrational spectroscopy methods enable qualitatively determining the structure of organic and inorganic compounds, materials, and analyzing availability of additives. (itcras.ru)
The new ultra-high performance super- critical fluid chromatography method was also applied for the qualitative and quantitative analysis of lignin-derived phenolic compounds obtained upon alkaline cupric oxide oxida- tion of a commercial humic acid. (lu.se)

The method is based on the combined use of headspace gas chromatography-mass spectrometry (HS-GC-MS) and artificial neural networks (ANN) for predictive modeling. (ibecbarcelona.eu)
For Solid Phase Micro Extraction (SPME), it is an equilibrium sampling method and can be used for gases, solids (Headspace) and liquids (direct). (utm.my)

The GC-MS is composed of two major building blocks: the gas chromatograph and the mass spectrometer. (iitk.ac.in)
The molecules take different amounts of time (called the retention time) to come out of (elute from) the gas chromatograph, and this allows the mass spectrometer downstream to capture, ionize, accelerate, deflect, and detect the ionized molecules separately. (iitk.ac.in)
The mass spectrometer does this by breaking each molecule into ionized fragments and detecting these fragments using their mass to charge ratio. (iitk.ac.in)
Another relatively common detector is the ion trap mass spectrometer. (iitk.ac.in)
The addition of a multi-capillary gas chromatography column using the ion mobility spectrometer as detector has been proposed in the past to increase chemical resolution. (ibecbarcelona.eu)
and be analyzed in the gas chromatograph-mass spectrometer. (chinesestandard.net)
The mass spectrometer ionizes the derivatized amino acids, generating charged ions that are subsequently analyzed based on their mass-to-charge ratio (m/z). (pharmiweb.com)

The procedure involves enzymatic hydrolysis of urine, extraction, derivatization and analysis using capillary gas chromatog-raphy combined with high resolution mass spectrometry (GC-HRMS). (cdc.gov)
Gas chromatographic screening for Zopiclone presence in blood and urine. (medline.ru)
It is chromatographic absorbent device in which, drugs within a urine sample, competitively combined to a limited number of drug monoclonal antibody (mouse) conjugate binding sites. (hematologyanalyzerreagent.com)
When the test is activated, the urine is absorbed into test by capillary action, mixes with the respective drug monoclonal antibody conjugate, and flows across a pre-coated membrane. (hematologyanalyzerreagent.com)
Analyses of the organic acids in blood and urine suggested MMA combined with homocysteinemia. (biomedcentral.com)

According to the above experimental method, GC-MS analysis of garlic skin components, computer mass spectrometry system search (NIST08.L), using the area normalization method to determine the mass fraction of each component. (hagf.com)
Furthermore, in this chapter, we provide a protocol for mitochondrial enrichments from Drosophila larvae and flies together with a procedure to generate high-quality peptides for further analysis by mass spectrometry. (biomed.news)
The instrument enables mass spectrum measurement for qualitative analysis or identification of unknowns and Selected Ion Monitoring (SIM) and MRM Measurement for quantitation of trace elements. (utm.my)
This goal has been obtained by combining different inorganic and organic chemical proxies such as trace elements, polycyclic aromatic hydrocarbons, and lead isotope ratios and exploiting both principal component and factor analysis to associate chemical proxies to human-driven contamination processes. (springer.com)
Combining these two layers of information poses challenges to the application of traditional statistical approaches in differential expression analysis. (biomedcentral.com)
Gas chromatography is suitable for the analysis of complex protein samples. (pharmiweb.com)

In Gas Chromatography (GC), a sample is volatilized and carried by an inert gas through a coated glass capillary column. (spectrophotometers.com)

Example MeCAT Workflow Ultra sensitive absolute and relative MeCAT protein quantification is performed by ICP-MS (inductively coupled plasma mass spectrometry) on protein level down to low attomol range. (mecat.eu)
After that they are analysed with state-of-the-art mass spectrometric methods including ICP-MS with its extraordinary advantages in quantification. (mecat.eu)
ICP-MS (inductively coupled plasma mass spectrometry) allows an ultra sensitive (absolute) quantification of the metals (lanthanides) tagged to proteins on protein level . (mecat.eu)
ICP-MS has several unrivaled advantages in quantification compared to 'classical' bioanalytical mass spectrometry. (mecat.eu)
Allows identification and quantification of amino acids by measuring their mass-to-charge ratio. (pharmiweb.com)

In a gas chromatograph, the sample chemical mixture is vaporized in an oven and transported by an inert carrier gas into a column (packed or capillary), containing the solid phase (termed stationary phase). (infinitalab.com)
This combined device provides exploration of materials' properties with use of measuring mass loss flows as dependent on time and temperature in diapason of room temperature up to 1100 °C, is usable to qualitatively appraise thermal stability, to quantitatively determine kinetic parameters of thermal destruction process in either dynamic, or static medium of air or inert gases. (itcras.ru)

HRGC) combined with flame ionization detector (FID), or infrared (IR) spectroscopy. (cdc.gov)

The gas chromatograph utilizes a capillary column which depends on the column's dimensions (length, diameter, film thickness) as well as the phase properties (e.g. 5% phenyl polysiloxane). (iitk.ac.in)
Gas Chromatography-Mass Spectrometry (GC-MS) utilizes Gas chromatography (GC) to separate a chemical mixture into individual molecules followed by Mass spectrometry (MS) to identify the molecules. (infinitalab.com)
Gas Chromatography utilizes the principle that intermolecular (physical adsorption) forces between molecules in a gas and a solid surface depend upon the molecular structure and the nature of the solid surface. (infinitalab.com)

For example, a common phenomenon in mass spectrometry (MS)-based metabolomics data is that the data matrix frequently contains missing values, which complicates some quantitative analyses. (biomedcentral.com)
For example, mass spectrometry (MS)-based metabolomics data is typically characterized by high dimensionality, small sample size, high correlation structure between metabolites, redundant information (such as adducts and fragments), and especially the sparse data matrix, which is comprised of the samples, the variable ID (m/z, retention time), and peak area. (biomedcentral.com)

Development of a Microbore Capillary Column GC-Focal Plane Mass Spectrograph with an Array Detector for Field Measurements. (cdc.gov)
A gas chromatography/mass spectrometry (GC/MS) system using a microbore column and a miniaturized mass spectrograph with an array detector was developed for use in field measurements of pollutants. (cdc.gov)
A short microbore column, when combined with the MS/electrooptical ion detector resolved the early eluted gases satisfactorily. (cdc.gov)

Michael Balogh begins a three-part overview series, answering questions about mass spectrometers, their use and capabilities, and including links to more detailed further reading in readily available articles written for the nonspecialist. (chromatographyonline.com)
This primer covers a wide range of topics related to modern MS practices and answers some frequently asked questions about the use and capabilities of mass spectrometers. (chromatographyonline.com)
Using mass spectrometers, they monitor enzyme reactions, confirm amino acid sequences, and identify large proteins from databases that include samples derived from proteolytic fragments. (chromatographyonline.com)
Mass Spectrometers can work in both full scan and selective ion monitoring (SIM) modes. (infinitalab.com)

High-purity helium is used as the carrier gas, the flow rate is 1.0 ml/min, and the temperature is programmed: the column temperature is increased from 60 ℃ (maintained for 0 min), 10 ℃/min to 80 ℃ (maintained for 2 min), and then at 8 ℃/min The temperature was raised to 180 ℃ (maintained for 2 min), and then increased to 260 ℃ (maintained for 20 min) at 5 ℃/min. (hagf.com)
The instrumental variables such as column temperature, injection volume, sample/gas flow rates, fragmentor/capillary voltages, were optimized. (itu.edu.tr)
5.3.1 Gas chromatography reference conditions a) Chromatographic column. (chinesestandard.net)
The molecules carried in the gas (termed mobile phase), are eluted at different times from the column depending on the affinity of molecules for the stationary phase. (infinitalab.com)
The author suggests that the combination of a microbore column and a miniaturized focal plane mass spectrograph is eminently suited for field measurements. (cdc.gov)

As a result, it was found that the combined pretreatment by radiation and catalytic oxidation with hydrogen peroxide is an effective method of preparation of lignocellulosic feedstock for hydrolysis. (gubkin.ru)
Superior enhancement was achieved for the accuracy and precision of proposed method when combined with (IDMS)-M-4 strategy. (itu.edu.tr)
Gas Chromatography/Mass spectrometry (GC/MS) is the preferred confirmatory method. (hematologyanalyzerreagent.com)

Gas Chromatography Mass Spectrometry analyses are performed on liquids, gases or solids. (spectrophotometers.com)

With two methods combined, the system enables to quantitatively analyze and to selectively detect the opted ions. (itcras.ru)

Various applications have been identified such as improvement of mass transfer during extraction or drying as well as gentle food preservation. (otago.ac.nz)

The ions are then accelerated in an electric field and separated in vacuum, depending on their mass as well as their charge. (infinitalab.com)
The separated ions are analyzed by spectrometry principles. (infinitalab.com)

CE separates amino acids based on their electrophoretic mobility in a capillary filled with a buffer solution. (pharmiweb.com)

Ionization mode: EI source, energy 70 eV, ion source temperature 200 ℃, scan mass range 30 to 550 amu, full scan mode, solvent delay 3 min. (hagf.com)
Cui LY, Ye WM, Wang Q, Chen YG, Chen B, Cui YJ (2019) Investigation on gas migration in saturated bentonite using the residual capillary pressure technique with consideration of temperature. (springer.com)

Several combined techniques have been applied in the measurements of intracellular metabolites, whether qualitative or quantitative, which reveal the biochemical status of the organism. (eurekaselect.com)

For liquids and gases, the sample is commonly directly injected the GC. (spectrophotometers.com)

Thus the protein amount can be accurately determinated down to low attomol range which is at least 2 to 3 orders of magnitude more sensitive than other mass spec (peptide based) techniques. (mecat.eu)

Carrier gas-nitrogen-1 ml/min. (medline.ru)
The extremely small carrier gas flow rate drastically reduced the mass and power needs of the mass spectrograph. (cdc.gov)

Amino acids are first converted into volatile derivatives, which are then separated and detected by gas chromatography. (pharmiweb.com)

PAHs constitute a group of chemicals which are formed during the incomplete combustion of coal, oil and gas, garbage, and other organic substances. (cdc.gov)

Anatomy7

Organisms8

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes25

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Health Care7

Electrophoresis8

Isotope dilution tandem mass1

Mobility Spectrometry3

Time-of-flight ma2

Tandem3

Quartz capillary column1

Fused silica capillary column1

Thin-layer chromato2

Analytical2

UHPLC1

Supercritical5

Detection6

Liquid9

Separation5

Quadrupole1

Compounds9

Headspace2

Spectrometer7

Urine5

Analysis6

Carried by an inert1

Quantification5

Inert2

Spectroscopy1

Utilizes3

Metabolomics2

Detector3

Spectrometers4

Column5

Method3

Solids1

Methods1

Extraction1

Ions2

Electrophoretic1

Temperature2

Quantitative1

Liquids1

Techniques1

Carrier2

Volatile1

Substances1