• compounds
  • These effects also manifested in combinations of three or four test compounds, and at the level of cell proliferation, that was assessed via an E-screen-like approach in Ishikawa cells. (frontiersin.org)
  • Modern medicine makes use of many plant-derived compounds as the basis for evidence-based pharmaceutical drugs. (wikipedia.org)
  • Endocrine disrupting compounds encompass a variety of chemical classes, including drugs, pesticides, compounds used in the plastics industry and in consumer products, industrial by-products and pollutants, and even some naturally produced botanical chemicals. (wikipedia.org)
  • strains
  • In some markets, the drug is supplied as an over-the-counter cream (Lonol in Mexico from Boehringer Ingelheim) used for topical treatment of musculoskeletal system disorders: sprains, strains, bursitis, tendinitis, synovitis, myalgia, periarthritis. (wikipedia.org)
  • vitro
  • The lyophilized nanoparticles could get dispersed quickly with the similar size distribution, zeta potential and encapsulation efficiency to the pre-lyophilized nanoparticles suspension, and maintain the synergistic in vitro release ratio of drugs. (mdpi.com)
  • Hence
  • Hence, we screened a large multi-class drug panel comprising the NIH clinical collection (NCC) that includes 446 FDA-approved drugs, with the goal of identifying new GBM therapeutics for rapid entry into clinical trials for GBM. (biomedcentral.com)
  • This is because remifentanil will be rapidly eliminated from the blood plasma on termination of the remifentanil infusion, hence the effects of the drug will quickly dissipate even after very long infusions. (wikipedia.org)
  • Synbiotics refer to food ingredients or dietary supplements combining probiotics and prebiotics in a form of synergism, hence synbiotics. (wikipedia.org)
  • clinical
  • Accordingly, our goals were to identify and characterize single and combination agents having anti-GBM activity that we can potentially introduce into clinical trials quickly. (biomedcentral.com)
  • To this end, using GBM cell lines and patient-derived GBM cell cultures, we screened a 446-compound NIH Clinical Collection (NCC) library comprising FDA-approved drugs. (biomedcentral.com)
  • Cao proposed a new concept of off-tumor targets of antiangiogenic drugs as potential clinical benefits by improving systemic disease in cancer patients. (wikipedia.org)
  • Clinical interest in synergism dates back to the early 1950s when practitioners noted that patients with enterococcal endocarditis experienced a high relapse rate when penicillin G alone was used for treatment and a demonstrably lower relapse rate when streptomycin was combined with penicillin G to combat the infection. (wikipedia.org)
  • therapies
  • Although the therapeutic inefficacy of imatinib monotherapy for mesothelioma has recently been reported, combination therapies with imatinib in mice yielded successful results. (docplayer.net)
  • Tissue-engineered nerve guidance conduits are a combination of many elements: scaffold structure, scaffold material, cellular therapies, neurotrophic factors and biomimetic materials. (wikipedia.org)
  • treatment
  • Here, we investigated the effect of combination treatment with suberoylanilide hydroxamic acid (SAHA) and 5-fluorouracil (5-FU) on HCC cells. (springer.com)
  • 29 The aim of the present study is to investigate a translational approach which assesses the possible efficacy of imatinib as a single agent and in combination treatment for MMe. (docplayer.net)
  • Patients with this kind of cancer have three options for treatment: surgery, radiotherapy, chemotherapy, or a combination. (hindawi.com)
  • Continued development of novel drugs is necessary to improve patient survival and limit treatment-associated toxicities. (jcancer.org)
  • Benzydamine (also known as Tantum Verde and branded in some countries as Difflam and Septabene), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. (wikipedia.org)
  • Cao´s laboratory was one of the first proposing the concept of combination therapy comprising angiogenic and arteriogenic factors for treatment of ischemic muscle disease. (wikipedia.org)
  • In 2005 he founded Clanotech (2005-present), which develops novel antiangiogenic drugs for treatment of ocular disease and fibrosis disease. (wikipedia.org)
  • The Food and Drug Administration (FDA) approved milnacipran for treatment of fibromyalgia in the United States of America in January 2009, however it is currently not approved for depression in that country. (wikipedia.org)
  • Sibutramine was the first drug for the treatment of obesity to be approved in 30 years. (wikipedia.org)
  • The drug is also under investigation as an antidepressant and for the treatment of neuropathic pain. (wikipedia.org)
  • For example, in a study of aged female rhesus macaques, treatment with GH alone, IGF-1 alone, and the combination of GH and IGF-1, were found to produce mammary gland hyperplasia and increased mammary gland size and epithelial proliferation by 2-fold, 3- to 4-fold, and 4- to 5-fold, respectively, changes that were directly correlated with serum concentrations of GH and IGF-1. (wikipedia.org)
  • dose
  • The result showed that C (128 mg/L) combined with ECg (16 mg/L) had the greatest effect and the combination also reduced the bacterial load in blood of septic mice challenged with a sublethal dose of MRSA, increased daunomycin accumulation within MRSA and down-regulated the mRNA expression of norA , norC and abcA , three important efflux pumps of MRSA. (mdpi.com)
  • The use of remifentanil has made possible the use of high-dose opioid and low-dose hypnotic anesthesia, due to synergism between remifentanil and various hypnotic drugs and volatile anesthetics. (wikipedia.org)
  • Owing to synergism between remifentanil and hypnotic drugs (such as propofol) the dose of the hypnotic can be substantially reduced. (wikipedia.org)
  • ADRs may occur following a single dose or prolonged administration of a drug or result from the combination of two or more drugs. (wikipedia.org)
  • Type A: Augmented pharmacologic effects - dose dependent and predictable Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g. bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g. nausea from digoxin), and they are therefore predictable. (wikipedia.org)
  • interactions
  • Tables are available to check for drug interactions due to P450 interactions. (wikipedia.org)
  • The risk of drug interactions is increased with polypharmacy. (wikipedia.org)
  • The principal plasma proteins for drug binding are: albumin α1-acid glycoprotein lipoproteins Some drug interactions with warfarin are due to changes in protein binding. (wikipedia.org)
  • Patients have abnormal metabolism by cytochrome P450 due to either inheriting abnormal alleles or due to drug interactions. (wikipedia.org)
  • mainly
  • Among the oldest, lengthiest, and most important medical papyri of ancient Egypt, the Ebers Papyrus dates from about 1550 BC, and covers more than 700 drugs, mainly of plant origin. (wikipedia.org)
  • These are mainly for drugs without much first-pass liver metabolism. (wikipedia.org)
  • synthetic
  • Whilst the majority of anti-cancer agents are of natural origin, the significance of 'made to order' synthetic drugs in the fight against cancer cannot be disputed. (jcancer.org)
  • effects
  • Pöch G. Combined effects of drugs and toxic agents. (springer.com)
  • Since that time the research community has conducted numerous studies regarding the effects and possibilities of antibiotic combinations. (wikipedia.org)
  • As research better explains the biochemistry of drug use, fewer ADRs are Type B and more are Type A. Common mechanisms are: Abnormal pharmacokinetics due to genetic factors comorbid disease states Synergistic effects between either a drug and a disease two drugs Various diseases, especially those that cause renal or hepatic insufficiency, may alter drug metabolism. (wikipedia.org)
  • pharmaceutical
  • Consequently, this allows saving time and cost and resources as well as increasing efficiency an effectiveness in medical, pharmaceutical research and new drug development. (wikipedia.org)
  • Food and Drug Admin
  • The U.S Food and Drug Administration defines a serious adverse event as one when the patient outcome is one of the following: Death Life-threatening Hospitalization (initial or prolonged) Disability - significant, persistent, or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities or quality of life. (wikipedia.org)
  • agent
  • In addition, this combination is safer and well tolerated compared to single agent irinotecan. (biomedcentral.com)
  • A closely related type of drug is a serotonin-norepinephrine releasing agent (SNRA), for instance the withdrawn appetite suppressant fenfluramine/phentermine (Fen-Phen). (wikipedia.org)
  • example
  • An example of synergism is two drugs that both prolong the QT interval. (wikipedia.org)
  • Some endocrine disruptors have been identified and removed from the market (for example, a drug called diethylstilbestrol), but it is uncertain whether some endocrine disruptors on the market actually harm humans and wildlife at the doses to which wildlife and humans are exposed. (wikipedia.org)
  • approximately
  • According to the World Health Organization, approximately 25% of modern drugs used in the United States have been derived from plants. (wikipedia.org)
  • early
  • Over a hundred of the 224 drugs mentioned in the Huangdi Neijing, an early Chinese medical text, are herbs. (wikipedia.org)
  • often
  • Using prebiotics and probiotics in combination is often described as synbiotic, but the United Nations Food & Agriculture Organization (FAO) recommends that the term "synbiotic" be used only if the net health benefit is synergistic. (wikipedia.org)