Combination adjuvants immunologic. Medical search. Frequent questions

This information may open new doors in the development of novel strategies for the treatment of malignancies using adjuvant immunotherapy in combination with surgery, chemotherapy and/or radiotherapy. (nih.gov)
This included sessions dedicated to systems biology on immunotherapy, immunogenicity and gene expression profiling, biomarkers, and combination treatment strategies. (biomedcentral.com)
Although current management of allergic rhinitis includes one or a combination of pharmacotherapy, immunotherapy, and/or surgery, novel treatments such as toll-like receptor agonists used as targets or adjuvants for immunotherapy are being tested and may hold promising roles in future allergic rhinitis treatment. (johnshopkins.edu)
BACKGROUND: There is an immunologic rationale to evaluate immunotherapy in the older glioblastoma population, who have been underrepresented in prior trials. (jax.org)
Focusing on the early onset of TNBC, neoadjuvant trials could represent excellent in vivo platforms to test immunotherapy agents and their potential combinations, allowing the performance of translational studies for biomarker implementation and improved patient selection. (biomedcentral.com)
Boca Raton, FL, October 7, 2021 (GLOBE NEWSWIRE) - Curative Biotechnology, Inc. (OTC: CUBT) ("Curative Biotech" or the "Company") announced today that the Company has reached agreement with Mid-Atlantic BioTherapeutics (MABT) to broaden its previously announced license of IMT504, a novel patented immunotherapy and adjuvant, to include the development of a next generation COVID-19 vaccine. (mabt.us)

MF59 is the first oil-in-water influenza vaccine adjuvant to be commercialized in combination with a seasonal influenza virus vaccine. (wikipedia.org)
NT-I7 is being studied in multiple clinical trials in solid tumors and as a vaccine adjuvant. (wspa.com)
A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening. (uchicago.edu)
Aluminum is the most commonly used vaccine adjuvant and may actually be as dangerous as mercury. (truthseekerforum.com)

The NUTMEG study evaluated the combination of nivolumab and temozolomide in patients with glioblastoma aged 65 years and older. (jax.org)
The experimental arm consisted of hypofractionated chemoradiation with temozolomide, then adjuvant nivolumab and temozolomide. (jax.org)

Combinations of these checkpoint therapies with other agents are now being explored to improve outcomes and enhance benefit-risk profiles of treatment. (biomedcentral.com)
Last year was a fruitful year for the cancer research community, which witnessed 16 new approvals and seven new indications by the FDA that included immunotherapies, targeted therapies, and combination therapies. (aacr.org)
Several protocols of adjuvant therapies based on NK cell allo-reactivity have been extensively used in clinics for both hematologic and non-hematologic malignancies either alone or in combination with antibodies and tumor-sensitizing drugs. (biomedcentral.com)
No evidence suggests that these adjuvant therapies are as effective as bacillus Calmette-Guérin (BCG). (medscape.com)
Finally, the concept of "outcome" may be extended when considering the specific setting of cancer surgery, in which variables like cancer recurrence, early access to adjuvant therapies, and, finally, long-term survival are as important as the reduced perioperative complications. (hindawi.com)

Neither chemoradiation nor chemotherapy in the neoadjuvant or adjuvant settings is considered as a prior line of systemic therapy. (moffitt.org)
Approximately 60% of the enrolled patients (451 for each treatment arm) experienced relapse after prior adjuvant/neoadjuvant treatment, while 37% presented with de novo stage IV disease. (biomedcentral.com)

A bevacizumab and chemotherapy combination are encouraged as a prior line of treatment. (moffitt.org)
Any prior therapy directed at the malignant tumor, including chemotherapy, biologic/targeted agents, and immunologic agents must be discontinued at least 28 days prior to tumor resection. (moffitt.org)
PSK has further been shown to have antioxidant capacity which may allow it to play a role as a normal tissue chemo- and radio-protector when used in combination with adjuvant or definitive chemotherapy and/or radiotherapy in the treatment of cancer, while it may also enable it to defend the host from oxidative stress. (nih.gov)
Another very important aspect of chemoimmunotherapy, in general is that it may be used on debilitated patients such as those with AIDS and the elderly who might otherwise be denied potentially helpful adjuvant cytotoxic chemotherapy. (nih.gov)
Adjuvant chemotherapy. (ox.ac.uk)
[ 6 ] Chemotherapy combinations, such as gemcitabine plus docetaxel and epirubicin plus interferon, have demonstrated possible efficacy. (medscape.com)

It is Novartis' proprietary adjuvant that is added to influenza vaccines to help stimulate the human body's immune response through production of CD4 memory cells. (wikipedia.org)
Meningococcal conjugate vaccines were shown to achieve a seroresponse comparable to the MPSV4 and are able to elicit better immunologic memory [3]. (hopkinsvaccine.org)
But vaccines also contain adjuvants - agents that stimulate your immune system to greatly increase immunologic response to the vaccine - and one of the most toxic is aluminum. (truthseekerforum.com)
As none of the volunteers re-challenged with H10407 developed significant diarrhea 3 , we reasoned that the responses of these volunteers could provide important immunologic benchmarks for testing vaccines. (nature.com)

We hypothesized that adding toll-like receptor 3 agonist polyICLC to an incomplete Freund's adjuvant (IFA) would be safe and would support strong, durable CD4 + T cell and Ab responses. (bmj.com)

These results identify a combinatorial code by which DCs discriminate pathogens and provide (suggest) a rationale to design adjuvants for TH1 responses. (gsea-msigdb.org)
Samples from the ACE527 vaccine clinical trials proved to be an interesting comparison as despite robust responses to the canonical vaccine antigens (6 CFs and the B subunit of the heat-labile toxin) targeted in the vaccine, this vaccine had performed relatively poorly without additional adjuvant (protective efficacy ~27%) when volunteers were challenged with H10407 5 . (nature.com)
CTX-only treatment seemed to the best effect in these treatment and CTX-GVAX combination treatment can induce immune responses significantly. (ncl.edu.tw)

The rationale for this association is the immunologic privilege of a lymphedematous region. (medscape.com)

Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors. (rochester.edu)
Contrary to this finding, other researchers suggest that adjuvant radiotherapy increases the risk of breast angiosarcoma 9-fold. (medscape.com)

Since clinical operations such as surgery can be used to induce coagulation, coagulation-based synergistic therapy is promising for translation into a clinical combination regimen. (bvsalud.org)
Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity. (uchicago.edu)
Experimental research … clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. (truthseekerforum.com)

The combination of prednisolone and the antithrombotic drug dipyridamole was profiled using in vitro and in vivo models of anti-inflammatory activity and glucocorticoid-induced adverse effects to demonstrate a dissociated activity profile. (biomedcentral.com)
In rat models of acute lipopolysaccharide-induced endotoxemia and delayed-type hypersensitivity, and in chronic models of collagen-induced and adjuvant-induced arthritis, the combination produced anti-inflammatory activity that required only a subtherapeutic dose of prednisolone. (biomedcentral.com)
To inves- inflammatory cytokines and the timing of their production support tigate the interplay of proinflammatory and anti-inflammatory cyto- an immunologic response appropriate to the amount of Ag and kines in human granulomatous disease, we evaluated the ability of duration of exposure. (cdc.gov)

Further evaluation of 1 mg CEA peptide with stronger adjuvants, and/or combined with agents to overcome immune inhibitory pathways, may be warranted in PC pts. (bmj.com)

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment. (rochester.edu)

The number of new combinations treatment under development for melanoma provides options for the number of patients to achieve a therapeutic benefit. (biomedcentral.com)

and a novel monoclonal antibody/drug combination to treat brain cancer licensed from the National Cancer Institute at NIH. (mabt.us)

He is actively evaluating the immunologic effects of radiation therapy and exploring treatments combining radiation with novel immune oncology agents. (dana-farber.org)

Using microarray analysis we show that only 1.5% of the transcripts induced by single TLR agonists are synergistically regulated by combinations of TLR4 and TLR8 agonists. (gsea-msigdb.org)

To bypass resistance, combination treatment with immunotherapies and single or multiple TKIs have been shown to improve prognosis compared to monotherapy. (biomedcentral.com)

The combination synergistically suppresses release of proinflammatory mediators, including tumour necrosis factor-α, IL-6, chemokine (C-C motif) ligand 5 (RANTES), matrix metalloproteinase-9, and others, from human peripheral blood mononuclear cells and mouse macrophages. (biomedcentral.com)

Several randomized clinical trials have demonstrated that PSK has great potential as an adjuvant cancer therapy agent, with positive results seen in the adjuvant treatment of gastric, esophageal, colorectal, breast and lung cancers. (nih.gov)
Therefore it is hypothesized that the combination of enzalutamide, abiraterone acetate, dutasteride, and degarelix will result in near-complete AR inhibition and produce favorable pathologic changes after 12 weeks of therapy. (druglib.com)
IRE and ECT show immunogenic effects that could be augmented when combined with immunomodulatory drugs, a combination therapy the authors term electroimmunotherapy . (rsna.org)

Purpose of review: The immunologic causes of allergic rhinitis underscore the important roles of both adaptive and innate immune systems. (johnshopkins.edu)
Like other adjuvants, aluminum is added to the vaccine in order to boost your immune response to the antigen. (truthseekerforum.com)
In our interview last year he mentioned a couple of studies on the more recent HPV vaccine, which found that the aluminum adjuvant had no effect at all on immune response. (truthseekerforum.com)
the potent combination of high-voltage electrical pulses with immune cascade-enhancing drugs may offer a bridge between local-regional and systemic treatments in oncology. (rsna.org)

Research is needed to identify biomarkers and new strategies including combinations. (jax.org)

This study investigates the pathologic effects of the combination of enzalutamide, abiraterone acetate, dutasteride, and degarelix when given for 12 weeks prior to prostatectomy in men with localized prostate cancer. (druglib.com)

Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control. (uchicago.edu)
Results Sixty-six patients were screened and 19 enrolled of whom 14 received at least 3 doses of the vaccine and thus evaluated for the primary immunologic endpoint. (bmj.com)

The IFN-alfa up-regulates the major histocompatibility complex/BCG vaccine antigen complex, which enhances the immunologic response. (medscape.com)
A consequence of kidney failure in general is the loss of a robust immunologic response to infections, including COVID-19. (mabt.us)

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant. (uchicago.edu)

4) Although the precise mechanisms for imiquimod's efficacy for LM are yet to be determined, it is assumed that a combination of these immunologic effects are responsible. (aad.org)

After 8 weeks of oral dosing in mice, treatment with the combination did not alter prednisolone-induced reduction in osteocalcin and mid-femur bone density, which are markers of steroid-induced osteoporosis. (biomedcentral.com)
When a combination of papillary tumor and CIS is present, the papillary tumor is removed before treatment of the CIS is initiated. (medscape.com)

NT-I7 (efineptakin alfa) (rhIL-7-hyFc) is the only clinical-stage long-acting human IL-7 and is being developed in oncologic and immunologic indications, where T cell amplification and increased functionality may provide clinical benefit. (nwahomepage.com)

95 Studies found from all possible combinations of your search terms. (nih.gov)

Adjuvant radiation following clear margin resection of high T-stage cutaneous squamous cell carcinoma halves the risk of local and locoregional recurrence: A dual-center retrospective study. (dana-farber.org)

Multidrug regimens typically are given as repetitive cycles of a fixed combination of drugs. (msdmanuals.com)

The diagnosis of bladder carcinoma in situ (CIS) is established by a combination of cystoscopy, urine cytology, and histologic evaluation of multiple bladder biopsies. (medscape.com)
Nitric oxide is the key regulatory molecule for circulation and arousal, as well as plays a role in multiple immunologic and physiologic body processes to maintain healthy living and energy. (ngvitamins.com)

NT-I7 exhibits favorable PK/PD and safety profiles, making it an ideal combination partner. (wspa.com)

An adjuvant amino acid and antioxidant combination designed for formula stability and to provide additional pathway benefits of lean muscle mass, energy and growth hormone enhancement. (ngvitamins.com)

In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. (truthseekerforum.com)

Severe malaria was independent from WHO HIV stage and from immunologic deficiency. (bvsalud.org)

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