• Multi-Centre Phase III Open Label Randomized Trial Comparing CPT-11 In Combination With A 5-FU/FA Infusional Regimen To The Same 5-FU/FA Infusional Regimen Alone, As Adjuvant Treatment After Resection Of Liver Metastases For Colorectal Cancer. (knowcancer.com)
  • Complete surgical resection (R0) of the liver metastasis(es) within a minimum of 3 weeks, and a maximum of 8 weeks prior to the first study treatment infusion. (knowcancer.com)
  • Prior radiofrequency ablation or cryoablation Incomplete surgical resection of liver metastasis (es). (knowcancer.com)
  • Hepatectomy is the surgical resection (removal of all or part) of the liver. (wikipedia.org)
  • those arising from colorectal cancer are among the most common, and the most amenable to surgical resection. (wikipedia.org)
  • Liver Resection for Colorectal Cancer Metastases. (lu.se)
  • Proper liver resection strategy is the cornerstone of metastatic CRC treatment, because only a successful liver resection significantly improves long-term treatment outcomes (e.g., complete removal of metastatic lesions allows to achieve an overall survival rate of 43-65%) [ 2 ]. (biomedcentral.com)
  • The treatment options for NET liver metastases include surgical resection, liver transplantation, loco-regional therapies, and medical treatment. (cancertreatmentjournal.com)
  • Curative surgical resection is possible in only 10%-25% of NET patients with liver metastases. (cancertreatmentjournal.com)
  • summarized 29 studies on NET liver metastases, and reported that 63% of the patients achieved R0 resection, with the 5- and 10-year overall survival rates of 70.5% and 42%, respectively 1,2 . (cancertreatmentjournal.com)
  • Although 80% of the patients experienced recurrence within 5 years after resection, the outcome of liver resection was still better when compared to other treatments 3 . (cancertreatmentjournal.com)
  • Synchronous resection of the primary tumor and liver metastases showed acceptable complication rates (18%-25%) and favorable 5-year survival rates (70%-71%) 6-10 . (cancertreatmentjournal.com)
  • Compared to the non-surgical group, palliative resection of the primary tumor significantly improved the 5-year survival rate (35.7%-83% versus 5.4%-50%), even in patients with primary tumors and unresectable metastases sites 4 . (cancertreatmentjournal.com)
  • This report and review present a 58-year-old man who was diagnosed with rectal cancer (RC) and underwent abdominoperineal resection. (ircmj.com)
  • Despite surgical resection and chemoradiotherapy can control most cancer cells [ 5 ], a surgical resection has been rarely indicated for liver metastasis from gastric cancer [ 6 ]. (biomedcentral.com)
  • Background: Studies have suggested that hepatic arterial infusion of chemotherapy (HAI) after resection of colorectal liver metastasis (CRLM) may improve patient's survival. (biu.ac.il)
  • Although ovarian cancer is a heterogeneous malignancy with different histopathologic types, treatment for advanced tumors is usually based on chemotherapy and cytoreduction surgery. (bvsalud.org)
  • Selective hepatic angiography may demonstrate hypervascular liver metastases by showing capillary blush in involved areas, highlighting the potential response of tumors to embolization. (medscape.com)
  • My work on liquid biopsies has involved blood based protein signatures for pancreatic cancer, and single-cell morphometric, proteomic and genomic characterization of circulating tumor cells, in comparison to solid tumors. (lu.se)
  • Treatment strategies for liver metastatic lesions vary significantly between different tumors, because of their unique biological characteristics. (cancertreatmentjournal.com)
  • In this review, we have summarized the therapeutic options for non-colorectal cancer liver metastases in neuroendocrine tumors, gastrointestinal stromal tumors, pancreatic cancer, kidney cancer, and breast cancer. (cancertreatmentjournal.com)
  • Criteria for patients to receive surgery include: well-differentiated G1/G2 tumors, absence of distant lymph node metastasis, absence of extrahepatic metastasis, absence of diffuse peritoneal metastasis, and absence of right cardiac dysfunction. (cancertreatmentjournal.com)
  • Tumors or cancer of the LIVER. (lookformedical.com)
  • Experimentally induced tumors of the LIVER. (lookformedical.com)
  • Tumors or cancer of the PANCREAS. (lookformedical.com)
  • Tumors or cancer of the SKIN. (lookformedical.com)
  • Tumors or cancers of the KIDNEY. (lookformedical.com)
  • Aims and background: Splenic metastases associated with mucinous intraabdominal tumors have been an enigma in the radiologic and oncology literature. (johnshopkins.edu)
  • Methods: Information on 9 patients who underwent splenectomy with intraparenchymal splenic masses associated with appendiceal or colorectal mucinous tumors with peritoneal dissemination was collected. (johnshopkins.edu)
  • Results: Eight of these patients had mucinous appendiceal tumors and 1 a mucinous sigmoid colon cancer. (johnshopkins.edu)
  • Under grants awarded by the Department of Defense and National Institutes of Health (NIH), he works on designing novel immunotherapies (treatments that harness the immune system to fight tumors), particularly for liver metastases from colon cancer. (ucsf.edu)
  • Colonic neuroendocrine neoplasms (NENs) are relatively rare tumors with an incidence rate of 0.11-0.21/100,000. (biomedcentral.com)
  • Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
  • The tumor initially spreads via a hematogenous route to the pulmonary arterioles and capillaries with retrograde spread from hilar nodal metastases or upper abdominal tumors, but subsequently extends through the vascular walls, invades the low resistant peribronchovascular lymphatics, and spreads along the lymphatics. (medscape.com)
  • Hepatectomy may also be the procedure of choice to treat intrahepatic gallstones or parasitic cysts of the liver. (wikipedia.org)
  • The Pringle manoeuvre is usually performed during a hepatectomy to minimize blood loss - however this can lead to reperfusion injury in the liver due to Ischemia. (wikipedia.org)
  • Artificial stimulation of future liver remnant hypertrophy via the ligation or embolization of the portal vein branches in an attempt to proceed with a two-stage hepatectomy was the most prominent one, while other strategies had been introduced just recently [ 5 ]. (biomedcentral.com)
  • A retrospective analysis of surgery and loco-regional therapy showed that the 5-year survival rate was 71% in partial hepatectomy compared to 31% in liver chemoembolization 4,5 . (cancertreatmentjournal.com)
  • Placement of an arterial hepatic catheter after a major hepatectomy for colorectal liver metastases: Is this safe? (biu.ac.il)
  • both had undergone catheter insertion after a major hepatectomy associated with contralateral procedures resulting in a small remnant liver volume with low outflow capacity. (biu.ac.il)
  • Dive into the research topics of 'Placement of an arterial hepatic catheter after a major hepatectomy for colorectal liver metastases: Is this safe? (biu.ac.il)
  • A 5-year disease-free survival (DFS) rates of patients with peripheral and central liver cites metastatic lesions were 31 ± 7 % and 15 ± 7%, p = 0,12. (biomedcentral.com)
  • The 5-year survival rate is more than 70% for patients without distant metastasis, while it is 10-20% for those with distant metastatic disease, suggesting the essential development of effective perioperative therapy. (nih.gov)
  • In order to make an impact on survival in this type of aggressive breast cancer, new targeted therapeutic agents are urgently needed. (biomedcentral.com)
  • Another primary malignant liver tumor is the cholangiocarcinoma. (wikipedia.org)
  • Prior to surgery, cytotoxic agents such as oxaliplatin given systemically for colorectal metastasis, or chemoembolization for hepatocellular carcinoma can significantly decrease the size of the tumor bulk, allowing then for resections which would remove a segment or wedge portion of the liver only. (wikipedia.org)
  • Similar to colorectal cancer, liver metastases of neuroendocrine cancer, gastrointestinal stromal tumor, and pancreatic cancer also determine patient prognosis to some extent. (cancertreatmentjournal.com)
  • 1. What are the incidence, prevalence, and prognosis characteristics of different tumor liver metastases? (cancertreatmentjournal.com)
  • Debulking surgery, which involves removal of the majority of liver lesions, can release the tumor burden and help in controlling symptoms. (cancertreatmentjournal.com)
  • Except for CRLM, neuroendocrine tumor (NET) liver metastases are brought into indications of liver transplantation. (cancertreatmentjournal.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • These splenic tumor masses had a CT image compatible with metastases and not compatible with mucinous tumor layered out of the splenic capsule. (johnshopkins.edu)
  • This demonstrates that distant metastasis can occur during the early phase of tumor growth in these aggressive lesions. (biomedcentral.com)
  • [ 1 ] The development of pulmonary metastases in patients with known malignancies indicates disseminated disease and places the patient in stage IV in TNM (tumor, node metastasis) staging systems. (medscape.com)
  • however, some tumor cells pass through the vascular wall and develop parenchymal metastasis in the alveolar space or the interstitium. (medscape.com)
  • Targeted tailored management of the breast cancer patient at risk for harboring a germline mutation-current trends affecting the selection of patients considering surgical prophylaxis for breast cancer. (nebraska.edu)
  • KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer. (ox.ac.uk)
  • We searched for differences in oncogene mutation profiles between colorectal cancer metastases from different sites and evaluated these as markers for site of relapse. (ox.ac.uk)
  • Mutation prevalence was compared between (a) metastases from liver (n = 65), lung (n = 50), and brain (n = 46), (b) metastases and matched primary cancers, and (c) metastases and an independent cohort of primary cancers (n = 604). (ox.ac.uk)
  • Mutation status was highly concordant between primary cancer and metastasis from the same individual. (ox.ac.uk)
  • CONCLUSIONS: KRAS mutation seems to be associated with metastasis in specific sites, lung and brain, in colorectal cancer patients. (ox.ac.uk)
  • This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes ( MSH1 , MSH2 , MSH6 ) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)
  • Even with all the recent technological improvements, recurrence and metastasis still are the main cause of death. (oaepublish.com)
  • Even with all the recent technological improvements, recurrence and metastasis still are the main causes of death. (oaepublish.com)
  • A systematic review of the therapeutic approaches for various cancer-related liver metastases would provide a better understanding of the latest progression and controversies regarding the surgical options, systematic chemotherapy, and palliative treatment. (cancertreatmentjournal.com)
  • Gemcitabine (Gem) is widely used as chemotherapy for pancreatic cancer (PaCa), but its effect is not fully satisfactory. (cancerindex.org)
  • The most common primary malignant tumour of the liver is the hepatocellular carcinoma. (wikipedia.org)
  • It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (curehunter.com)
  • CRC is ranged 3rd in the structure of the most common malignant neoplasms in Ukraine [ 1 ]. (biomedcentral.com)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
  • Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C. (lookformedical.com)
  • In China, gastric cancer is also a main malignant tumour and a chief reason of cancer deaths. (biomedcentral.com)
  • Other terms used are malignant tumours and neoplasms. (allcountries.org)
  • Axial CT scan in a 58-year-old man with malignant melanoma shows multiple round nodules and masses of varying sizes in both lungs, consistent with metastases. (medscape.com)
  • Is lung involvement a favorable prognostic factor for pancreatic ductal adenocarcinoma with synchronous liver metastases? (lu.se)
  • The subsequent computer tomography (CT) led to a diagnosis of unifocal hepatocellular carcinoma (HCC) in VI hepatic segment, defined the other two nodules in the VI and VII segment as suspected metastases, and showed a luminal narrowing with marked segmental circumferential thickening of the hepatic flexure of the colon. (wjgnet.com)
  • Transarterial radioembolization (TARE) with yttrium 90 is increasingly utilized for the treatment of hepatic neoplasms, whether primary (particularly hepatocellular carcinoma [HCC]) or metastatic (particularly colorectal). (thieme-connect.com)
  • Profiling evidences of selectin demonstrate that they play an crucial role in cancer progression and metastasis. (biomedcentral.com)
  • In recent years, the Hedgehog (Hh) signalling pathway has emerged as a critical determinant of cancer initiation, progression and metastasis of an important subset of human cancers [ 3 - 5 ]. (biomedcentral.com)
  • After melanoma and lung cancer, colorectal cancer was the third most prevalent cause of cutaneous metastases in men and the seventh most common cause in women. (ircmj.com)
  • Environmental tobacco smoke (passive smoking) causes lung cancer. (allcountries.org)
  • Risk of lung cancer according to mild steel and stainless steel welding. (who.int)
  • Winter PD, Gardner MJ, Fletcher AC, Jones RD. A mortality follow-up study of pottery workers: preliminary findings on lung cancer. (who.int)
  • Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL‑8 production in pancreatic cancer. (cancerindex.org)
  • It is also a problem, to a lesser degree, in patients with previous hepatectomies (e.g. repeat resections for reincident colorectal cancer metastases). (wikipedia.org)
  • Plain chest radiographs are routinely obtained in patients who are suspected of having cancer and are also used in the staging of cancer, but plain abdominal radiography has a limited role in the investigation of liver metastases. (medscape.com)
  • The 5-year OS for CRC patients whose metastatic lesions were predominantly located within peripheral and central liver segments was 56 ± 8% and 27 ± 9%, respectively ( p = 0.08). (biomedcentral.com)
  • Parenchyma-sparing surgery should be a priority pathway for complex treatment of patients with deeply located lesions of the right liver lobe. (biomedcentral.com)
  • However, there is a subcategory of CRC patients with bilobar spread of lesions who require major resections (removal of ≥ 3 anatomical liver segments). (biomedcentral.com)
  • Treatment of liver metastases, to some extent, determines the prognosis of patients. (cancertreatmentjournal.com)
  • Mutations differing between metastasis sites were evaluated as markers for site of relapse in 859 patients from the VICTOR trial. (ox.ac.uk)
  • 95% CI, 1.2 to 3.5, P = 0.007) but not liver relapse in patients from the VICTOR trial. (ox.ac.uk)
  • Over the last several decades advances in the management and treatment of patients with liver metastases from colorectal cancer (CRC) has changed a disease with a dismal prognosis to one with a potential for cure in some patients. (elsevierpure.com)
  • This review discusses the advances made in management of patients with liver-limited metastatic disease. (elsevierpure.com)
  • In fact, the high mortality as a consequence of distant metastasis in patients remains a bottleneck for an effective treatment in clinic [ 1 , 2 ] . (oaepublish.com)
  • 1 ) About 20% of patients may have distant metastases at the time of diagnosis, and the remaining 30% may develop metastases during the course of the disease. (ircmj.com)
  • It is critical to recognize suspicious skin lesions as probable harbingers of undiscovered visceral malignancy in patients with and without a history of cancer. (ircmj.com)
  • The serum level of DC-SIGNR was evaluated in gastric cancer patients by ELISA. (biomedcentral.com)
  • DC-SIGNR serum level was significantly increased in gastric cancer patients compared with healthy group. (biomedcentral.com)
  • Additionally, DC-SIGNR level was associated with an advanced pathological stage in gastric cancer patients. (biomedcentral.com)
  • Also, serum of soluble E-selectin (sE-selectin) concentration in gastric cancer patients are detected by ELISA, but increasing only in gastric cancer patients with peritoneal metastasis [ 9 ]. (biomedcentral.com)
  • DC-SIGNR (DC-SIGN-related protein, also known as L-SIGN, CD299) as a member of C-type lectin belonging to selectin is found high serum concentration in colon cancer patients [ 13 ]. (biomedcentral.com)
  • None of the patients had evidence of metastases to other sites such as liver or lymph nodes. (johnshopkins.edu)
  • It includes the systematic and equitable implementation of evidence-based strategies for cancer prevention, early detection of cancer and management of patients with cancer. (allcountries.org)
  • Chest radiography (CXR) is the initial imaging modality used in the detection of suspected pulmonary metastasis in patients with known malignancies. (medscape.com)
  • In patients with primary renal or testicular cancer, chest CT scanning performed should be performed based on the presence of metastatic disease elsewhere. (medscape.com)
  • The microscopic spread of metastasis through lymphatics and perilymphatic connective tissue is seen histopathologically in 56% of patients with pulmonary metastasis. (medscape.com)
  • However, it has a favorable prognosis because the majority of patients present at an early stage, resulting in only 4% of cancer deaths in women. (medscape.com)
  • The role of staging laparoscopy in primary gall bladder cancer--an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. (cancercentrum.se)
  • Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms. (who.int)
  • Liver metastases occur during the progression of various malignancies. (cancertreatmentjournal.com)
  • The liver is one of the most common sites of metastases in various malignancies. (cancertreatmentjournal.com)
  • Radioembolization with 90 yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. (thieme-connect.com)
  • Aberrant activation of the Hedgehog (Hh) signalling pathway has been unambiguously tied to cancer development and progression in a variety of solid malignancies, and the recent approval of vismodegib, an orally bioavailable small-molecule inhibitor of Smoothened, validates Hh signalling as a valuable therapeutic target. (biomedcentral.com)
  • Pulmonary metastasis is seen in 20-54% of extrathoracic malignancies. (medscape.com)
  • [ 1 ] Lungs are the second most frequent site of metastases from extrathoracic malignancies. (medscape.com)
  • The most common of these malignancies is uterine cancer. (medscape.com)
  • A 68-year-old Caucasian man with hepatitis C virus-related cirrhosis was admitted to our Unit in February 2010 for a diagnostic evaluation of three centimetric hypoechoic focal liver lesions detected by regular surveillance ultrasound. (wjgnet.com)
  • Finally, ultrasound-guided liver biopsy of the three focal liver lesions confirmed the diagnosis of HCC for the nodule in the VI segment, and characterized the other two lesions as metastases from colorectal cancer. (wjgnet.com)
  • For detection and characterization of small lesions and to evaluate the liver with background fatty liver changes, MRI may be superior to multidector CT and positron emission tomography (PET). (medscape.com)
  • Late-phase pulse-inversion harmonic imaging is a useful technique for characterizing hepatic lesions and for demonstrating both greater numbers of liver metastases and smaller liver metastases. (medscape.com)
  • Preliminary study results demonstrated parenchyma-sparing surgery (PSS) as an effective approach which allowed to remove colorectal cancer (CRC) metastatic lesions within the central liver cites and increased the probability of the liver re-resections. (biomedcentral.com)
  • Compared with the previous case, in this instance scalp metastasis developed before visceral metastasis, and the cutaneous lesions were confined to the scalp alone. (biomedcentral.com)
  • In experimental metastasis studies, researchers demonstrate that liver sinusoidal endothelial cell lectin (LSECtin) mediated colon cancer cells metastasis to liver displays enhanced abilities to the specific organ [ 8 ]. (biomedcentral.com)
  • Radical surgery was performed to remove his colon cancer on Feb 16th, 2013. (biomedcentral.com)
  • Sometimes the first indication is an abnormal laboratory test result (eg, anemia resulting from colon cancer). (msdmanuals.com)
  • Besides colon cancer, women affected have a 40-60% risk of endometrial cancer by age 70 years, compared to a baseline population risk of 1.5% at the same age. (medscape.com)
  • These mutations lead to microsatellite instability in 90% of colon cancers and 75% of endometrial cancers. (medscape.com)
  • Contrast-enhanced US in the liver-specific phase of contrast enhancement improves the detection of hepatic metastases, relative to nonenhanced conventional US. (medscape.com)
  • Cutaneous metastasis is rare in rectal cancer, and it indicates a widespread disease and a poor prognosis. (ircmj.com)
  • Cutaneous metastasis to the scrotum happens seldom, accounting for less than one percent of the total surface area of the body. (ircmj.com)
  • This case is unusual because of the development of cutaneous metastasis before visceral metastasis. (biomedcentral.com)
  • time interval between the date of randomization and the earliest date of local, regional or distant relapse, or death due to cancer. (knowcancer.com)
  • The CT scan of the chest, abdomen, and pelvis exhibited a locally invasive RC with no distant metastases. (ircmj.com)
  • therefore, cutaneous metastases as initial distant metastases can be easily overlooked. (biomedcentral.com)
  • In this report an unusual case of a colonic NEC with initial distant metastasis confined to the scalp is presented. (biomedcentral.com)
  • Thus, the possibility of distant metastases should be assessed in the initial work up to avoid mistaken clinical staging especially when distant metastases occur only in skin. (biomedcentral.com)
  • Distant metastasis of NECs mostly occurred in the viscera, while cases of scalp metastasis were rarely reported. (biomedcentral.com)
  • The patient then went to a cancer hospital where a CT scan of his thorax and abdomen showed no distant metastases. (biomedcentral.com)
  • Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
  • Cutaneous metastases of colonic neuroendocrine carcinomas (NECs) are very infrequent, while cases of scalp metastasis are even fewer. (biomedcentral.com)
  • Improving resectability of hepatic colorectal metastases: expert consensus statement. (cancercentrum.se)
  • Clinical Colorectal Cancer. (lu.se)
  • A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment. (lookformedical.com)
  • Clinical colorectal cancer , 10 (4), 258-265. (elsevierpure.com)
  • Alberts, SR & Poston, GJ 2011, ' Treatment advances in liver-limited metastatic colorectal cancer ', Clinical colorectal cancer , vol. 10, no. 4, pp. 258-265. (elsevierpure.com)
  • 9 d'Abadie P, Hesse M, Louppe A, Lhommel R, Walrand S, Jamar F. Microspheres used in liver radioembolization: from conception to clinical effects. (thieme-connect.com)
  • 4 ) For this reason, the authors would like to present a clinical experience with rectal cancer that has metastases to the scrotal skin. (ircmj.com)
  • Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. (biomedcentral.com)
  • A number of recent publications have highlighted a role for Hh signalling in breast cancer models and clinical specimens. (biomedcentral.com)
  • 1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. (cancercentrum.se)
  • Colonoscopy revealed a colon mass and a computed tomography (CT) scan of the abdomen showed that the mass infiltrated the serosa of the transverse colon, which was adjacent to the omentum majus with mesenteric lymph node metastases. (biomedcentral.com)
  • In general, the imaging appearances of liver metastases are nonspecific, and biopsy specimens are required for histologic diagnosis. (medscape.com)
  • A diagnosis of cancer may be suspected based on history and physical examination but requires confirmation by biopsy and histopathologic examination. (msdmanuals.com)
  • These events suggest that selectin play a key role in tumour metastasis to the target organs. (biomedcentral.com)
  • In most recent years the minimal invasive approach, consisting in laparoscopic and then robotic surgery, has become increasingly common in liver resective surgery. (wikipedia.org)
  • He later completed a fellowship in surgical oncology at Memorial Sloan Kettering Cancer Center and then gained experience in minimally invasive surgical techniques at the University of Paris. (ucsf.edu)
  • With a lifetime risk of developing invasive breast cancer of 1 in 8, breast cancer is one of the top three cancers that caused the greatest economic impact worldwide in 2008 [ 2 ]. (biomedcentral.com)
  • Uterine cancer is defined as any invasive neoplasm of the uterine corpus. (medscape.com)
  • Invasive neoplasms of the female pelvic organs account for almost 15% of all cancers in women. (medscape.com)
  • The patient underwent laparotomic right hemicolectomy with removal of thirty-nine regional lymph nodes (three of them tested positive for metastasis at histological examination), and simultaneous laparotomic radio-frequency ablation of both nodule of HCC and metastases. (wjgnet.com)
  • Our experience emphasizes the potential coexistence of two different neoplasms in a cirrhotic liver and the complexity in the proper diagnosis and management of the two tumours. (wjgnet.com)
  • In their meta-analysis, Kinkel et al compared US, CT, MRI, and fluorodeoxyglucose (FDG) imaging in the detection of liver metastases from colorectal, gastric, and esophageal cancers and concluded that, with an equivalent specificity, FDG positron emission tomography (PET) is the most sensitive noninvasive imaging modality for the diagnosis of liver metastases. (medscape.com)
  • While endometrial cancer affects reproductive age as well as postmenopausal women, 75% of endometrial cancers occur in postmenopausal women, with the mean age of diagnosis at 61 years. (medscape.com)
  • However, DC-SIGNR as a family member of selectin participates in gastric cancer liver metastasis remains unknown. (biomedcentral.com)
  • Investigation the biological effects of DC-SIGNR were verified by MTT, wounding and transwell in vitro and experiments on animals to confirm gastric cancer liver metastasis by IVIS. (biomedcentral.com)
  • DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and suppressed the liver metastasis in vivo. (biomedcentral.com)
  • DC-SIGNR promoted gastric cancer liver metastasis mediated with HNRNPKP2 which expression was regulated by STAT5A. (biomedcentral.com)
  • These findings indicated potential therapeutic candidates for gastric cancer liver metastasis. (biomedcentral.com)
  • Recently, several long ncRNAs have been reported to have a role in gastric cancer metastasis. (biomedcentral.com)
  • In addition, we attempt to answer the following questions for different pathological liver metastases. (cancertreatmentjournal.com)
  • Pathological processes of the LIVER. (lookformedical.com)
  • The scalp nodules proved to be metastases from colonic NEC as determined using pathological and immunohistochemical examinations following lumpectomy. (biomedcentral.com)
  • Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. (lookformedical.com)
  • Cutaneous metastases are frequent and small 1-2 cm nodules that often simulate epidermal cysts, kerato-acanthomas, or pyogenic granulomas. (ircmj.com)
  • It has been demonstrated that the intraoperative blood loss during liver resections affects the outcome in terms of postoperative morbility and mortality. (wikipedia.org)
  • Ovarian cancer is the seventh most common cancer worldwide in women and the most lethal gynecologic malignancy due to the lack of accurate screening tools for early detection and late symptom onset. (bvsalud.org)
  • Maker's research aims to improve early detection of pancreas cancer and to develop new therapies for treating metastases (cancers that have spread from a primary site in the body). (ucsf.edu)
  • Imaging plays an important role in the screening and detection of pulmonary metastases. (medscape.com)
  • No evidence suggests that routine endometrial sampling or transvaginal sonography to evaluate the endometrial stripe in asymptomatic women has a role in early detection of uterine cancer, even in women who take tamoxifen after breast cancer or has a cancer syndrome. (medscape.com)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
  • Exclusively hepatic metastasis (es) : absence of bone, lung and brain metastases. (knowcancer.com)
  • Metastasis are characterized by a sequential and complex process during which cancer cells invade specific organs including lung, liver, brain, and bone [ 3 ] . (oaepublish.com)
  • The most common manifestations of metastatic colorectal cancer are found in the liver, lung, bone, and brain. (ircmj.com)
  • 2 ) The most common manifestations of disseminated colorectal cancer are found in the liver, lung, bone, and brain. (ircmj.com)
  • Множинна мієлома Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)