• Reproductive performance consisting of mean litter size, number of pups that wean (wean: born ratio) and mean reproductive index of three inbred mice strains, which are BALB/cMlac, C57BL/6Mlac and DBA/2Mlac, were investigated to provide some basic information on the breeding and maintaining of a foundation colony. (mahidol.ac.th)
  • While langerin+ cells are observed in comparable numbers and with comparable phenotypes in the epidermis, two distinct DC subsets bear langerin in peripheral, skin-draining lymph nodes of BALB/c mice (CD11c(high) CD8alpha(high) and CD11c(low) CD8alpha(low)), whereas only the latter subset is present in C57BL/6 mice. (cnrs.fr)
  • The CD11c(high) subset is detected in mesenteric lymph nodes and spleen of BALB/c mice, but is virtually absent from C57BL/6 mice. (cnrs.fr)
  • Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
  • Fifty 6-week-old female C57BL/6J mice were subjected to five different treatments: sham surgery, OVX surgery, OVXandL. (bvsalud.org)
  • Together they generated the DBA (Dilute, Brown and non-Agouti) inbred mouse strain and initiated the systematic generation of inbred strains. (wikipedia.org)
  • The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. (wikipedia.org)
  • There are hundreds of established inbred, outbred, and transgenic strains. (wikipedia.org)
  • Here, we describe striking differences in langerin-expressing cells between inbred mouse strains. (cnrs.fr)
  • Similar differences are observed in other mouse strains. (cnrs.fr)
  • Genetically modified mouse strains derived from embryonic stem (ES) cells have become essential tools for functional genomics and biomedical research. (liveconscience.com)
  • PCR tests for the genetic background of inbred and wild-derived strains by using microsatellite or single nucleotide polymorphism (SNP) markers. (riken.jp)
  • Recombinant inbred (RI) strains of mice are an important resource used to map and analyze complex traits. (nervenet.org)
  • Recombinant inbred (RI) strains have been used to map a wide range of Mendelian loci and quantitative traits (Taylor, 1989). (nervenet.org)
  • Recently, RI strains have also been used to map QTLs that that are responsible for biometric variation in the architecture of the mouse CNS (Belknap et al. (nervenet.org)
  • [4] Familiar albino animals include in-bred strains of laboratory animals (rats, mice and rabbits), but populations of naturally occurring albino animals exist in the wild, e.g. (wikipedia.org)
  • MIP-1 alpha enhances interleukin-3 (IL-3)/and granulocyte-macrophage colony-stimulating factor (GM-CSF)/induced colony formation of normal bone marrow progenitor cells (BMC) and lineage-negative (Lin-) progenitors, but has no effect on G-CSF or CSF-1/induced colony formation. (ox.ac.uk)
  • Effects of granulocyte/macrophage colony-stimulating factor on the de" by K Takahashi, K Miyakawa et al. (jax.org)
  • Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
  • In co-cultures of either the murine pre-B cell line J13, fetal liver cells, or adult peritoneal or bone marrow cells with ST2 mouse bone marrow stromal cells in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF), the development of CD5+ macrophages was demonstrated by immunohistochemical staining and flow cytometry. (jax.org)
  • Takahashi K, Miyakawa K, Wynn AA, Nakayama KI, Myint YY, Naito M, Shultz LD, Tominaga A, Takatsu K. Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice. (jax.org)
  • transgenic mice generated by using BAC clone, cTG: conditional transgenic mice, KO: knockout mice, KI: knock-in mice, cKO: conditional knockout mice, CRIPR/Cas9: Endonuclease-mediated mice. (riken.jp)
  • After inbreeding for 20 generations, a surprisingly high incidence of hydronephrosis was encountered and we finally obtained a strain of mice with a very high incidence of severe hydronephrosis affected on both sides of kidney and in both sexes as the process of inbreeding has been increased. (mahidol.ac.th)
  • finally, the classical BALB/c sponsor strain is definitely not very efficient for generating a good quantity of quality embryos. (liveconscience.com)
  • Clarence Cook Little begins to develop the first inbred strain, designated DBA for dilute, brown, and non-agouti. (jax.org)
  • The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
  • Consequently, colony experience of T. t. strain ABTS-1857 had a bad influence on generation growth below field-realistic conditions along with induced dysbiosis in the belly microbiome. (pkc-signal.com)
  • Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
  • Dispersed pneumococci also upregulated genes associated with production of bacteriocins and downregulated colonization-associated genes related to competence, fratricide, and the transparent colony phenotype. (lu.se)
  • Individual antibodies only partially neutralize GM-CSF activity using an in vitro bioassay, depending on the experimental conditions, while, when injected in mice together with human GM-CSF, they lead to the accumulation of a large pool of circulating GM-CSF that remains partially bioavailable. (nih.gov)
  • Furthermore, MIP-1 alpha has no effect on high proliferative potential colony-forming cells 1 or 2 (HPP-CFC/1 or /2) colony formation in vitro, whereas TGF beta inhibits both HPP-CFC/1 and HPP-CFC/2. (ox.ac.uk)
  • Inhibition of EHMT2 expression or activity in human ERMS cell lines reduced DKK1 expression and elevated canonical Wnt signaling resulting in myogenic differentiation in vitro and in mouse xenograft models in vivo. (elifesciences.org)
  • Mice belong to the Euarchontoglires clade, which includes humans. (wikipedia.org)
  • This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
  • Mice are mammals of the clade (a group consisting of an ancestor and all its descendants) Euarchontoglires, which means they are amongst the closest non-primate relatives of humans along with lagomorphs, treeshrews, and flying lemurs. (wikipedia.org)
  • The effects of MIP-1 alpha and TGF beta on the growth of Lin- progenitors were direct and correlate with colony formation in soft agar. (ox.ac.uk)
  • In contrast, the antibodies induced 50-65% down-modulation in NIH3T3 cells expressing the mutated human neu protein and could inhibit these cells to form colonies in soft agar. (prinsesmaximacentrum.nl)
  • Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). (modelorg.com)
  • Cancer cell line-derived xenograft (CDX) model is a well-established mouse model type commonly used for cancer research and anti-tumor drug development, due to its user-friendly techniques and outstanding repeatability. (modelorg.com)
  • Right) Subcutaneous tumor formed by HepG2 cells on nude mice. (modelorg.com)
  • Fig 3: A549-mediated subcutaneous tumor formation on NMG mice. (modelorg.com)
  • Fig 4: Evaluation of efficacy and toxicity of anti-tumor drug candidates D1 and D2 on A549 (A&B)- and MSTO-211H (C&D)-bearing mouse models. (modelorg.com)
  • E) Immunohistological analysis of Vegf expression in tumors harvested from MSTO-211H -bearing nude mice either treated with anti-tumor drug or not. (modelorg.com)
  • Humanized tumor target mice are immunocompetent chimeric mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigen, etc. (modelorg.com)
  • Heterozygous (sp/wt) mice carry only one copy of the nude mutation and have hair. (taconic.com)
  • In the peritoneal cavity of GM-CSF-treated mice, the percentages of hematopoietic progenitor cells doubly positive for CD5 and CD34 or c-kit and of macrophage precursor cells doubly positive for CD5 and ER-MP58 or ER-MP20 were increased significantly during the development of CD5+ macrophages and CD5 B cells, suggesting that CD5+ macrophages and B cells may share a bipotential progenitor in vivo. (jax.org)
  • Moreover, treatment with rhGH increased the frequency of hematopoietic stem/progenitor cells as measured by flow cytometry and colony forming unit assays in bone marrow harvested at day 14 after irradiation, suggesting the effects of rhGH are at the hematopoietic stem/progenitor level. (duke.edu)
  • Microbial QC tests are performed quarterly by using dirty bedding sentinel mice housed in each rack. (riken.jp)
  • Deposited mice are housed separately based on the microbial test results at deposition, and then, all the mice are cleaned-up by a rederivation procedure. (riken.jp)
  • Mice feces were taken for Illumina high-throughput sequencing to analyze the microbial composition and characteristics. (bvsalud.org)
  • Balb/c nude mice, NOD/SCID or other immunodeficient mice. (modelorg.com)
  • The autosomal recessive nude gene in homozygous (sp/sp) mice causes the lack of fur and an abnormal thymus. (taconic.com)
  • A-B) Human colon cancer cells genetically engineered to express firefly luciferase gene were injected via carotid artery into nude mice. (modelorg.com)
  • Nude mice were subcutaneously inoculated with A549 cells that constitutively express EGFP. (modelorg.com)
  • We therefore hypothesized that selective breeding of mice aiming at a high similarity in the gut microbiota would increase the interindividual similarity of the gut microbiota. (ku.dk)
  • Selective inbreeding of this mutant led us to the establishment of a colony of inbred hydronephrosis mice. (mahidol.ac.th)
  • In a mouse model of LPS-induced acute inflammation, DSO2-ONJ demonstrated anti-inflammatory activity by inhibiting the production of the pro-inflammatory interleukin-6. (cnrs.fr)
  • The laboratory mouse genome has been sequenced and many mouse genes have human homologues. (wikipedia.org)
  • Collectively, these considerations led the large level mouse mutagenesis projects structured under the umbrella Aliskiren hemifumarate of the World Knockout Mouse Consortium (IKMC) to select M6-produced Sera cells as the parental lines in which to mutate all Aliskiren hemifumarate protein coding genes of Aliskiren hemifumarate mouse [5], [6]. (liveconscience.com)
  • 1939 International Committee on Standardized Nomenclature for Mice begins, bringing order to the naming of mice and their genes. (jax.org)
  • In the early part of the 20th century, Harvard undergraduate Clarence Cook Little was conducting studies on mouse genetics in the laboratory of William Ernest Castle. (wikipedia.org)
  • The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
  • BALB/cCrl mice were, however, found to have a mean heterozygosity of only 0.8% in their genome, and selection of breeders with a high similarity in the gut microbiota for three generations did not change the overall gut microbiota similarity, which was 66% in the P generation and 66%, 64% and 63% in the F1, F2 and F3 generations, respectively. (ku.dk)
  • The mice were backcrossed nine generations (N9). (taconic.com)
  • The mice were derived by embryo transfer in 2002 by Taconic US. (vivobio.com)
  • The Taconic foundation colony was at F? (vivobio.com)
  • Taconic cannot routinely accept orders by weight for this model due to colony size. (taconic.com)
  • These mice have both BALB/c inbred and NIH(S) outbred stock in their genetic background. (vivobio.com)
  • Improved methods for the generation of germline transmitting chimeric mice from M6 Sera cell lines will make the IKMC and additional M6 Sera cell resources more accessible to the broader biomedical Aliskiren hemifumarate study community. (liveconscience.com)
  • Aggregation of cleavage stage embryos with Sera cells [29] gives an accessible method for generating Sera cell chimeric mice. (liveconscience.com)
  • The objective of this study was to investigate the effects of L. acidophilus and L. reuteri on bone mass in OVX mice and their associated mechanisms. (bvsalud.org)
  • The bone volume fraction and trabecular number, trabecular thickness, trabecular separation, and cortical thickness of the mice were analyzed by micro-CT in both femurs. (bvsalud.org)
  • After probiotic feeding, the bone volume fraction, the trabecular number, and the trabecular thickness increased, and the trabecular separation decreased in OVX mice. (bvsalud.org)
  • The deficiency in T cell function allows athymic mice to accept and grow xenografts as well as allografts of normal and malignant tissues. (taconic.com)
  • Little and Castle collaborated closely with Abbie Lathrop who was a breeder of fancy mice and rats which she marketed to rodent hobbyists and keepers of exotic pets, and later began selling in large numbers to scientific researchers. (wikipedia.org)
  • A mouse model of primary liver cancer can be established in about 6 months after intraperitoneal injection of DEN. (modelorg.com)
  • Breeding & trading of animals: Below mentioned animal colonies are maintained by in-breeding, out-breeding, or random breeding systems as per the species characteristics. (cadilapharma.com)
  • Twenty Mlac:WR breeding pairs were randomized to determine the percentage of hydronephrosis in the original National Laboratory Animal Center colony. (mahidol.ac.th)
  • Breeder selection for breeding was carried out by using the progeny selection method, which selects offspring based on their characteristics, in combination with the breeding principle of maximum avoidance of inbreeding and the rotational mating system. (mahidol.ac.th)
  • Breeding pairs that produced hydronephrosis offspring were removed from the colony and replaced with offspring from other healthy breeding pairs within the same group in the next generation. (mahidol.ac.th)
  • First successful transplantations of ovaries between female mice are performed by William Russell at JAX. (jax.org)
  • In this study, we disrupted circadian rhythms in female and male mice using both environmental (i.e., shifting diurnal cycles) and genetic (i.e. (mdpi.com)
  • Alcohol consumption and preference, as well as food and water consumption, total caloric intake, and weight were assessed in adult female and male Clock Δ19/Δ19 mutant mice or wild-type (WT) litter-mates, housed under a 12-hour:12-hour light:dark (L:D) cycle or a shortened 10-hour:10-hour L:D cycle. (mdpi.com)
  • Therefore increased interindividual gut microbiota similarity may be seen as a way to reduce group sizes in mouse experiments. (ku.dk)
  • In 1902 Lucien Cuénot published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
  • We would like to ask all the users to confirm the quality and characteristics of our mouse resources as soon as possible, before starting your full scale experiments. (riken.jp)
  • Most recently, mice were recognized to offer unique opportunities to explore the genetic basis of the response, as well as to evaluate associated detrimental effects of pathophysiological significance in animals exposed to carcinogens. (biomedcentral.com)
  • At 5 days after daily intravenous injection with GM-CSF, many CD5+ macrophages appeared in the peritoneal cavity and in omental milky spots of normal mice but fewer in osteopetrosis (op) mutant mice, deficient in macrophage (M)-CSF. (jax.org)
  • Since the early 1990s we have specifically used the aggregation method to generate multiple genetically revised mouse stresses from 129S1129X1 (L1) [30] and 129S6B6F1 (G4) [31] Sera cells. (liveconscience.com)
  • Although CD5+ macrophages were not present in the peritoneal cavities of normal mice, approximately 30% of the peritoneal macrophages in viable motheaten (mev/mev) mice, deficient in SHP-1 protein tyrosine phosphatase, expressed cell surface CD5 and B220, markers for B cells. (jax.org)
  • We have obtained monoclonal antibodies to the human neu protein by immunizing a Balb/c mouse with a Balb/c cell line expressing the human neu gene by transfection. (prinsesmaximacentrum.nl)
  • Similarly, TGF beta enhances GM-CSF/induced colony formation of normal BMC and Lin- progenitors. (ox.ac.uk)
  • Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. (duke.edu)
  • Specifically, the recovery of total white cells, CD4 and CD8 T cell subsets, B cells, NK cells and especially platelets post radiation exposure were significantly accelerated in the rhGH-treated mice. (duke.edu)
  • A variety of sponsor embryos and methods possess been used to generate germline chimeras from M6 Sera cells such as BALB/c and C57BT/6-blastocyst injections. (liveconscience.com)
  • In CDX models, cancer cells are inoculated into immuno-deficient mice via various routes. (modelorg.com)
  • Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)
  • however, in spite of the obvious advantages of Aliskiren hemifumarate the inbred background few targeted mutations have been published compared to the widely used 129 Sera cell lines [1]. (liveconscience.com)
  • In this study, we investigated anti-PEG IgM production in mice following i.m., intraperitoneal (i.p.) and subcutaneous (s.c.) administration of PEG-Lip. (matci.jp)
  • Compared with the saline control group, treatment with rhGH on irradiated BALB/c mice significantly accelerated overall hematopoietic recovery. (duke.edu)
  • Mice have been used in biomedical research since the 17th century (from May 30, 1678) when William Harvey used them for his studies on reproduction and blood circulation and Robert Hooke used them to investigate the biological consequences of an increase in air pressure. (wikipedia.org)
  • Inflammatory diseases in mouse models are under strong impact from the gut microbiota. (ku.dk)
  • Previously, a low incidence of mild hydronephrosis was observed mostly in male mice and found only on the right kidney. (mahidol.ac.th)
  • Laboratory mice are usually of the species Mus musculus. (wikipedia.org)
  • Other mouse species sometimes used in laboratory research include two American species, the white-footed mouse (Peromyscus leucopus) and the North American deer mouse (Peromyscus maniculatus). (wikipedia.org)
  • Note to the Reader Please cite this work as: Williams RW, Gu J, Qi S, Lu L (2001) The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. (nervenet.org)
  • The Jackson Laboratory in Bar Harbor, Maine is currently one of the world's largest suppliers of laboratory mice, at around 3 million mice a year. (wikipedia.org)
  • The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
  • Here, we show that treatment with lysophosphatidic acid (LPA) of mice aerogenically infected with MTB immediately after infection results in a significant early reduction of pulmonary CFUs and of histopathological damage in comparison with control mice. (unicatt.it)
  • These results indicate that GM-CSF, in combination with M-CSF, induces the development and differentiation of CD5+ macrophages in the peritoneal cavity, particularly in the omental milky spots of mice. (jax.org)
  • In this study, we investigated the ability of recombinant human growth hormone (rhGH) to mitigate against radiation injury in mice and nonhuman primates. (duke.edu)
  • This study established a low incidence hydronephrosis Wistar rat (Mlac:WR) colony at the National Laboratory Animal Center, Mahidol University, Thailand. (mahidol.ac.th)
  • The mice were derived by hysterectomy to achieve Germfree status prior to introduction into Restricted Flora™ IBU colonies. (vivobio.com)