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  • glomerular
  • Collagen XVIII/endostatin-deficient mice developed more severe glomerular and tubulointerstitial injury than wild-type mice. (world-of-links.com)
  • HSPGs get excited about biologic processes such as for example glomerular purification cell adhesion migration proliferation and differentiation 3 that are mediated with the binding of chemokines cytokines enzymes development factors or various other bioactive substances.6 Collagen XVIII (Col 18) is a HSPG connected with BMs of virtually all epithelia and endothelia. (world-of-links.com)
  • The human glomerular basement membrane belongs to the collagen family of proteins. (sciencemag.org)
  • occurs
  • Type III collagen is found in the walls of arteries and other hollow organs and usually occurs in the same fibril with type I collagen. (news-medical.net)
  • Collagen occurs in many places throughout the body. (wikipedia.org)
  • Gradual calcium deposition within collagen occurs as a natural function of aging. (wikipedia.org)
  • Receptor activation happens when collagen binds into preformed DDR dimers on cell membrane, when collagen is bound, a conformational change probably occurs, which causes cytosolic kinases to rotate to face each other, and their autophospohorylation. (wikipedia.org)
  • Unlike other tyrosine-kinase receptors, maximal activation of receptors occurs 18 hours after collagen stimulation. (wikipedia.org)
  • When damage occurs, endotelial collagen is uncovered and is bound by GPVI receptor on platelets. (wikipedia.org)
  • Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury. (wikipedia.org)
  • bone
  • Bone Grafts can now be preformed using collagen and the patients bone marrow as opposed to bone (painfully) harvested from the patient. (everything2.com)
  • In bone for example, entire collagen triple helices lie in a parallel, staggered array. (news-medical.net)
  • Type I collagen gives bone its tensile strength. (news-medical.net)
  • Collagen has been widely used in cosmetic surgery, as a healing aid for burn patients for reconstruction of bone and a wide variety of dental, orthopedic, and surgical purposes. (wikipedia.org)
  • Several studies have shown that a daily intake of hydrolyzed collagen increases bone mass density in rats. (wikipedia.org)
  • It seems that hydrolyzed collagen peptides stimulated differentiation and osteoblasts activity- the cells that build bone- over that of osteoclasts (cells that destroy bone). (wikipedia.org)
  • proteoglycans
  • Different collagen types form larger fibrillar bundles with the help of several different classes of proteins like glycoproteins and proteoglycans. (news-medical.net)
  • Collagen, and to a lesser extent, elastin, were among the earliest of this group to be studied in more detail than the proteoglycans and adhesive glycoproteins. (springer.com)
  • tendon
  • Low resolution structure and packing investigations of collagen crystalline domains in tendon using Synchrotron Radiation X-rays, Structure factors determination, evaluation of Isomorphous Replacement methods and other modeling. (wikipedia.org)
  • vitro
  • It has been suggested, based on mouse and in vitro studies, that hydrolyzed collagen peptides have chemotactic properties on fibroblasts or an influence on growth of fibroblasts. (wikipedia.org)
  • Corneal
  • Corneal collagen cross-linking with riboflavin (vitamin B2) and UV-A light is a surgical treatment for corneal ectasia such as keratoconus, PMD, and post-LASIK ectasia. (wikipedia.org)
  • A 2015 Cochrane review that looked at all high quality evidence on corneal collagen cross-linking found that it was insufficient to determine if it is useful in keratoconus. (wikipedia.org)
  • The standard protocol of Corneal Collagen Cross-linking, with epithelium removal, is approved for use throughout Europe. (wikipedia.org)
  • strands
  • The process of hydrolysis involves breaking down the molecular bonds between individual collagen strands and peptides using combinations of physical, chemical or biological means. (wikipedia.org)
  • induces
  • This makes one wonder if the collagen used in cosmetic treatments induces, increases or hastens the development of arthritis of humans , even in some small way. (everything2.com)
  • subunit
  • These an receptors comprise an α and β transmembrane subunit, which are noncovalently bound.Collagen binding is primarily provided by integrins α1β1, α2β1, α10β1 a α11β1. (wikipedia.org)
  • There are six human genes associated with it: COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6 The alpha-3 subunit (COL4A3) of collagen IV is thought to be the antigen implicated in Goodpasture's disease, wherein the immune system attacks the basement membranes of the glomeruli and the alveoli upon the antigenic site on the alpha-3 subunit becomes unsequestered due to environmental exposures. (wikipedia.org)
  • Therapy
  • Anti- Cancer therapy utilizes collagen as a mode of transport to get the anti-cancer agent to the tumor . (everything2.com)
  • Collagen induction therapy (CIT) also known as microneedling RF or skin needling is a cosmetic procedure that involves repeatedly puncturing the skin with tiny, sterile needles (microneedling the skin). (wikipedia.org)
  • Serum Collagen Type IV for the Assessment of Fibrosis and Resistance to Interferon Therapy in Chronic Hepatitis C". Scandinavian Journal of Gastroenterology. (wikipedia.org)
  • Creams
  • Eye Creams - Cucumber Eye Firming Cream, Firming Eye Gels, Cucumber Collagen Creams, Eye Wrinkle Cream and Serum. (dermasoft.com)
  • In cosmetics, hydrolyzed collagen may be found in topical creams, acting as a product texture conditioner, and moisturizer. (wikipedia.org)
  • Urinary
  • Urinary Incontinence is treated by injecting collagen into the urethra , where it forms a small bulk , decreasing the diameter of the urethra. (everything2.com)