• Fibroblasts are activated post MI, leading to increased collagen synthesis and fibrosis of the heart. (wikipedia.org)
  • On the mobile level, cardiac redecorating is seen as a cardiomyocyte hypertrophy, fibroblast hyperplasia associated with a rise in collagen deposition inside the interstitial matrix (fibrosis) and cell loss of life. (researchassistantresume.com)
  • Endothelial-to-mesenchymal transition (EndMT) is an important mechanism underlying cardiac fibrosis. (dovepress.com)
  • This study aimed to investigate the possible effect of TMZ on cardiac fibrosis exerted via the inhibition of NOX2-mediated EndMT. (dovepress.com)
  • A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)
  • Rats injected with ISO exhibited severe interstitial cardiac fibrosis and perivascular fibrosis, decreased left ventricular ejection fraction, and increased NOX activity. (dovepress.com)
  • TMZ treatment mitigated cardiac fibrosis, ameliorated left ventricular dysfunction, and reduced NOX activity. (dovepress.com)
  • TMZ may ameliorate EndMT and ISO-induced cardiac fibrosis through the NOX2/NF-κB/Snail pathway. (dovepress.com)
  • The findings of the study may provide new insights into the potential role of TMZ in the pathophysiology of cardiac fibrosis. (dovepress.com)
  • Myocardial fibrosis, characterized as interstitial fibroblast proliferation and excessive collagen deposition, is the structural basis of myocardial stiffness and the key process of cardiac function transformation from the compensatory phase to heart failure. (dovepress.com)
  • Cardiac fibroblasts are generally the primary effector cells of fibrosis and have been reported to be partly derived from cardiac endothelial cells through the endothelial to mesenchymal transition (EndMT) process. (dovepress.com)
  • Recently, EndMT has been increasingly recognized as a vital process that contributes to various cardiovascular pathologies in adults, which include atherosclerosis, valvular heart disease, cardiac fibrosis, and myocardial infarction. (dovepress.com)
  • These results indicate that cardiac Hmox1 induction not only prevents heme toxicity, but also regulates the timing and registration of genetic programs for mitochondrial quality control that limit cell death, pathological remodeling, and cardiac fibrosis. (jci.org)
  • CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
  • in the cardiac fibrosis development associated with myocardial infarction (MI). (hiv-proteases.com)
  • The results shown that puerarin could inhibit the recruitment and activation of monocytes/macrophages reduce the manifestation of TGF-β1 in the cardiac cells and consequently considerably attenuated cardiac fibrosis after MI. (hiv-proteases.com)
  • Thus this research revealed the system by which avoided cardiac fibrosis after MI through a reduction in MCP-1 manifestation and an inhibition TEI-6720 TGF-β1 pathway and indicated puerarin is actually a potential agent in attenuating MI-induced cardiac fibrosis. (hiv-proteases.com)
  • Keywords: Puerarin monocyte chemoattractant proteins (MCP-1) transforming development element-β1 (TGF-β1) cardiac fibrosis myocardial infarction (MI) Intro Maladaptive pathological adjustments lead to center failing in the cardiac redesigning procedure after myocardial infarction (MI) including cardiomyocyte hypertrophy improved swelling and fibrosis. (hiv-proteases.com)
  • Many evidences indicated that cardiac fibroblasts proliferation and extreme extracellular matrix (ECM) deposition induced myocardial fibrosis and added to ventricular dysfunction ventricular dilation and center failing [1]. (hiv-proteases.com)
  • Myofibroblast was changed from fibroblasts and additional cell types and performed essential jobs in fibrosis [2 3 Nevertheless the precise etiology of myocardial fibrosis and obtainable pharmacological interventions are removed remains poorly looked into [4-6]. (hiv-proteases.com)
  • Earlier intensive studies possess taken notice TEI-6720 of the TGF-β-induced ECM and fibrosis in a variety of illnesses including cardiac fibroblast-myofibroblast changeover [7 11 TGF-β1 function was mediated by TGF-β type I and type II receptors. (hiv-proteases.com)
  • Nuclear Smad2/3 complex activates transcription of α-SMA and collagen I [12 13 In addition fibrosis typically results from simultaneous chronic inflammation tissue remodeling during repair processes [14 15 Therefore therapies that target the inflammatory response or TGF-β1 signaling pathways might effectively attenuate the progression of fibrosis in cardiac remodeling. (hiv-proteases.com)
  • Recently several reporters demonstrated it had healing and anti-fibrotic effects on cardiac remodeling through its anti-inflammatory anti-oxidant effects [20 22 In TEI-6720 light of above points we supposed that puerarin could abolish cardiac fibrosis by inhibition of TGF-β1 signaling pathways and inflammatory responds. (hiv-proteases.com)
  • For this purpose we developed a mouse model to investigate whether puerarin is a potential therapeutic compound for cardiac fibrosis induced by MI. (hiv-proteases.com)
  • Non-ischemic cardiomyopathy (NICM) can cause left ventricular dysfunction through interstitial fibrosis, which corresponds to the failure of cardiac tissue remodeling. (nature.com)
  • Recent evidence implicates monocytes/macrophages in the etiopathology of cardiac fibrosis, but giving their heterogeneity and the antagonizing roles of macrophage subtypes in fibrosis, targeting these cells has been challenging. (nature.com)
  • Here we focus on WWP2, an E3 ubiquitin ligase that acts as a positive genetic regulator of human and murine cardiac fibrosis, and show that myeloid specific deletion of WWP2 reduces cardiac fibrosis in hypertension-induced NICM. (nature.com)
  • This increases interstitial myocardial fibrosis, causing ventricular stiffening and a decrease in diastolic filling. (geriatricfastfacts.com)
  • In addition, other studies demonstrated that AngII activated platelet-derived growth factor-A (PDGF-A), a novel contributor to cardiac remodelling, to result in atrial fibrosis in pressure-overloaded mouse model [ 13 ] . (medsci.org)
  • For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
  • Atherosclerotic plaque rupture is the leading cause of cardiovascular death resulting from acute coronary syndrome (ACS) and leads to cardiac remodeling and fibrosis following ACS. (archivesofmedicalscience.com)
  • After hyperoxia, HO-1(CM) -/- hearts showed suppression of the Pgc-1α/nuclear respiratory factor-1 (NRF-1) axis, swelling, low electron density mitochondria by electron microscopy (EM), increased cell death, and extensive collagen deposition. (jci.org)
  • In the aging heart, an increase in fibroblast number leads to increased collagen deposition. (geriatricfastfacts.com)
  • At day 7, infarct size was increased by cigarette smoking in males only, which was accompanied by enhanced collagen deposition in both the infarcted and peri-infarcted areas. (biomedcentral.com)
  • Dilated cardiomyopathy (DCM) refers to dilation and systolic dysfunction of the ventricles (predominantly the left ventricle) with or without congestive cardiac failure. (medscape.com)
  • Dilation is more pronounced than hypertrophy, and the left ventricle is affected more often than the right ventricle. (medscape.com)
  • As right ventricular hypertrophy ensues, a right ventricular heave may be palpated at the lower left sternal border and increased right atrial pressure may cause elevation of the jugular venous pressure. (medscape.com)
  • Kato S, Spinale FG, Tanaka R, Johnson W, Cooper Gt, Zile MR. Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function. (pitt.edu)
  • Besides age and gender, diagnosis of MFS, diastolic function (e′ and E/e′), Z-Score of aortic diameter, and left ventricular size were identified as significant independent parameters with impact on NT-proBNP levels. (scipedia.com)
  • The aim of the present study was to evaluate left ventricular diastolic function, type of cardio-vascular hypertrophy and NT-proBNP levels in out-patients with MFS and a control group with similar clinical manifestations referred for evaluation of suspected MFS in whom the diagnosis was ruled out. (scipedia.com)
  • These consequences also led to the increase in oxidative stress on the heart, causing the proliferation of fibroblasts, activation of metalloproteinases, and induction of apoptosis, which would be explained below. (wikipedia.org)
  • We found that reduced kidney function resulted in the expansion of cardiac macrophages, in particular through local proliferation of resident populations. (biomedcentral.com)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • We thus sought to investigate the role of macrophages in uremic cardiac disease. (biomedcentral.com)
  • Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
  • The surviving cardiac myocytes either arrange in parallel or in series to each other, contributing to ventricular dilatation or ventricular hypertrophy, depending on the loading stress on the ventricular wall. (wikipedia.org)
  • Besides, reduced expression of V1 myosin and L-type calcium channels on cardiac myocytes are also thought to cause cardiac remodeling. (wikipedia.org)
  • Post MI, as fatty acid oxidation decreases, it leads to reduced energy supply for the cardiac myocytes, accumulation of fatty acids to toxic levels, and dysfunction of mitochondria. (wikipedia.org)
  • The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and myocardial scarring that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. (wikipedia.org)
  • Lindsey ML, Hall ME, Harmancey R, Ma Y. Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction. (pitt.edu)
  • The term "reverse remodeling" in cardiology implies an improvement in ventricular mechanics and function following a remote injury or pathological process. (wikipedia.org)
  • Different pathological and physiological stimuli are responsible for cardiac remodeling. (biomedcentral.com)
  • Ischemic injury due to coronary artery disease is the most common pathological cause of cardiac remodeling [ 6 ]. (biomedcentral.com)
  • Ventricular hypertrophy and/or dilatation are main structural changes that reflect a pathological response of the heart, accompanied by molecular and cellular changes that functionally translate into diastolic and/or systolic dysfunction [ 7 ]. (biomedcentral.com)
  • The pathological consequences associated with normal cardiovascular aging include hypertrophy, altered left ventricular (LV) diastolic and systolic function, heart failure, enhanced arterial stiffness, and endothelial dysfunction, all of which can alter the structure and function of the heart and arterial system [ 5 , 6 ] . (oaepublish.com)
  • Expression levels of RCAN homologs are responsive to external stressors such as reactive oxygen species, Ca 2+ , amyloid β, and hormonal changes and upregulated in pathological conditions, including Alzheimer's disease, cardiac hypertrophy, diabetes, and degenerative neuropathy. (molcells.org)
  • In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to improve symptoms, NYHA class, and quality of life. (hindawi.com)
  • Beta-blocker therapy in children with chronic heart failure due to DCM has been shown to improve symptoms and left ventricular ejection fraction. (medscape.com)
  • Several etiologies with distinct mechanisms ultimately bring about signs of heart exhaustion such as reduced ejection fraction, reduced compliance and ventricular dilatation. (pitt.edu)
  • CS-exposed males exhibited enhanced increases in left ventricular end systolic and diastolic volumes, as well as reductions in ejection fraction and fractional area changes of left ventricular base. (biomedcentral.com)
  • MiR-126 expression in serum is positively correlated with left ventricular ejection fraction (LVEF). (justia.com)
  • Increase expression of MMP1 and MMP9 led to degradation of collagen fibres, and subsequently dilatation of the heart. (wikipedia.org)
  • Idiopathic dilated cardiomyopathy (DCM) refers to congestive cardiac failure secondary to dilatation and systolic dysfunction (with or without diastolic dysfunction) of the ventricles (predominantly the left ventricle) in the absence of congenital, valvular, or coronary artery disease or any systemic disease known to cause myocardial dysfunction. (medscape.com)
  • After the insult occurs, a series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. (wikipedia.org)
  • Alveoli, pulmonary vessels, α -smooth muscle actin content in pulmonary arterioles, size of cardiomyocytes, right to left ventricular wall diameter ratio, and endothelin-1 plasma concentrations were assessed. (biomedcentral.com)
  • Macitentan treatment significantly increased pulmonary vessel count (p = 0.004) and decreased right to left ventricular wall diameter ratios (p = 0.002). (biomedcentral.com)
  • After 48 hours of exposure, these mice showed persistent cardiac inflammation and oxidative tissue damage that caused sarcomeric disruption, cardiomyocyte death, left ventricular dysfunction, and cardiomyopathy, while control hearts showed minimal damage. (jci.org)
  • ECG may show the degree of left ventricular enlargement and reveal any abnormal heart rhythm. (medscape.com)
  • First-pass test and multiple gated acquisition (MUGA) scans help to measure the left and right ventricular stroke volumes and cardiac outputs. (medscape.com)
  • Cardiac resynchronization therapy with AV synchronous biventricular pacing has been successful in some children with DCM and left bundle branch block (LBBB). (medscape.com)
  • Increased left ventricular mass has been associated with increased mortality. (geriatricfastfacts.com)
  • Prevalence, clinical profile, and significance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy. (pitt.edu)
  • The thickening of the left ventricle, known as left ventricular hypertrophy , can result in complications such as heart failure, which is the inability of the heart to pump sufficient quantities of blood to the body. (medicalnewstoday.com)
  • We observed that cigarette smoking exacerbated both left and right ventricular remodeling only in males at an early stage of post-MI. (biomedcentral.com)
  • Areas covered: This article reviews the outpatient pharmacological management of chronic HF due to left ventricular systolic dysfunction and offers recommendations on the use of various drugs. (docksci.com)
  • The aim of this review is to provide an update on the pharmacological interventions indicated in the outpatient management of HF due to left ventricular (LV) systolic dysfunction. (docksci.com)
  • as, an Critical Disease Thin, by introducing type from cardiac form age repair to more healthy spaces, may often determine post-infarct agonists left with the number of CHF. (worldclassbows.com)
  • Left ventricular (LV) failure causes shortness of breath and fatigue, and right ventricular (RV) failure causes peripheral and abdominal. (msdmanuals.com)
  • Cardiomegaly (220 g) and symmetric left ventricular hypertrophy from the autopsy of a 6-year-old boy who suddenly collapsed while on a walk with his family. (medscape.com)
  • Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
  • Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. (rupress.org)
  • Collagen remodeling and cardiac dysfunction in patients with hypertrophic cardiomyopathy: the significance of type III and VI collagens. (pitt.edu)
  • Therefore, an intervention at the ET-1 receptor level might have a positive effect on pulmonary vascular resistance and right ventricular remodelling. (biomedcentral.com)
  • Worsened right ventricular remodeling in males was independent of pulmonary congestion. (biomedcentral.com)
  • Such symptoms can be shared with a variety of pulmonary and cardiac diseases. (medscape.com)
  • Other autopsy findings included pulmonary edema and ascites, as well as hypertensive changes in the lungs and early cardiac cirrhosis. (medscape.com)
  • Diabetic cardiomyopathy (DCM), a substantial contributor to morbidity and mortality in diabetics, is seen as a ventricular dysfunction, within the lack of coronary atherosclerosis and hypertension. (researchassistantresume.com)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • However, it is unclear how cerebral ischemic stroke regulates cardiac function, what are the direct effects of stroke on cardiac function, and what are the underlying molecular mechanisms. (justia.com)
  • Clinical presentation, long-term follow-up and outcomes of 1001 arrhythmogenic right ventricular dysplasia/cardiomyopathy patients and family members // Circulation: Cardiovascular Genetics. (vitapol.com.ua)
  • Herren T., Gerber P. A., Duru F. Arrhythmogenic right ventricular cardiomyopathy /dysplasia: a not so rare «disease of the desmosome» with multiple clinical presentations // Clin. (vitapol.com.ua)
  • Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. (mdpi.com)
  • Fibromas are more often resected because they do not regress and have a strong association with ventricular arrhythmias. (sts.org)
  • Respiratory rate, if abnormal, may indicate cardiac decompensation or a primary lung disorder. (msdmanuals.com)
  • Congenital cardiac tumor is defined as a congenital malformation consisting of growth of abnormal tissue within the heart. (sts.org)
  • The long-term functional performance may be affected by residual atrioventricular valve insufficiency, ventricular aneurysms, and global myocardial reserve. (sts.org)
  • In patients under optimal medical therapy with moderate to severe HF and cardiac dyssynchrony, cardiac resynchronization therapy (CRT) with a defibrillator improves contractile function and reverse ventricular remodeling, ameliorating symptoms, quality of life (QoL), and clinical outcomes [ 7 , 8 ]. (hindawi.com)
  • During embryogenesis endothelial cells exhibit substantial plasticity that contribute to cardiac development by undergoing endothelial-to-mesenchymal transition (EndoMT). (surrey.ac.uk)
  • Biomarkers, Socioeconomic Factors, and Right Ventricular Function After Surgical Repair for Tetralogy of Fallot. (stanford.edu)
  • Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). (encyclopedia.pub)
  • The aim of this narrative review is to summarize contemporary evidence on the use of circulating cardiac biomarkers of heart failure (HF) and to identify a promising biomarker model for clinical use in personalized point-of-care HF management. (annlabmed.org)
  • In cardiology, ventricular remodeling (or cardiac remodeling) refers to changes in the size, shape, structure, and function of the heart. (wikipedia.org)
  • Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume. (wikipedia.org)
  • Ventricular mass and volume increase, which together adversely affect cardiac function. (wikipedia.org)
  • Retinoid Receptor-Mediated Signaling in Cardiac Redecorating Cardiac remodeling includes a main role within the development to HF, that is associated with modifications within the ventricular framework and function, caused by myocardial damage, pressure or quantity overload. (researchassistantresume.com)
  • Cardiorenal Syndrome is a specific condition which is characterized by a rapid or chronic worsening of cardiac function leading to acute or chronic kidney injury (A/CKI) and the reciprocal organ dysfunction sequence can be possible. (cardiologyresearchjournal.com)
  • The study indicates that inducing the expression of LAV-BPIFB4 in aged mice improved cardiac function and regulation of blood flow to the heart. (medicalnewstoday.com)
  • A recent study published in Cardiovascular Research suggests that LAV-BPIFB4 , a gene variant that previous research ha shown to be highly expressed by individuals with an exceptionally long lifespan, could also protect cardiac and vascular function in old age. (medicalnewstoday.com)
  • In the new study, inducing the expression of LAV-BPIFB4 in aged mice led to improvements in cardiac function that, translated to the human context, would be equivalent to a reduction in the heart's biological age by 10 years. (medicalnewstoday.com)
  • Cardiac function, histology, and infarct size were assessed, and inflammatory markers quantified by RT-PCR. (biomedcentral.com)
  • To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. (spandidos-publications.com)
  • Cardiomegaly that is incidentally detected on a chest radiograph or an arrhythmia that is incidentally detected on an electrocardiogram (ECG) may be the basis for initial cardiac referral. (medscape.com)
  • in offering the impetus for producing novel therapeutic methods for the avoidance and treatment of diabetes-induced cardiac problems and heart failing. (researchassistantresume.com)
  • Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
  • Blood pressure (BP) is measured in both arms and, for suspected congenital cardiac disorders or peripheral vascular disorders, in both legs. (msdmanuals.com)
  • Evidence of arthralgia, arthritis, photosensitivity, Raynaud phenomenon, dry eyes, and/or dry mouth on review of systems may indicate the presence of a collagen-vascular disease. (medscape.com)
  • Dysregulation of the remodeling process resulting in the breakdown of collagen by matrix metalloproteinases is a hallmark of heart failure pathophysiology and produces functional changes encompassing all matrix proteins. (pitt.edu)
  • It belongs to the superfamily of fibroblast growth factors (FGF) that exert pleiotropic effects on a vast range of biological processes, including the development of organogenesis and metabolism, being an essential part of the endocrine subfamily. (encyclopedia.pub)
  • Besides, the cardiac interstitium which consisted of largely Type I and Type III collagen fibres are also involved in cardiac remodeling. (wikipedia.org)
  • Discussed in this paper is the role of inflammation, collagen cross-linking and of myofibroblasts in matrix dysfunction and the mechanisms with which these changes occur in heart failure. (pitt.edu)
  • Acute or chronic systemic disorders can cause both cardiac and renal dysfunction. (cardiologyresearchjournal.com)
  • Complete examination of all systems is essential to detect peripheral and systemic effects of cardiac disorders and evidence of noncardiac disorders that might affect the heart. (msdmanuals.com)
  • The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)
  • Cardiorenal syndrome (CRS) is the term used to describe clinical conditions in which cardiac and renal dysfunctions coexist. (cardiologyresearchjournal.com)
  • In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. (spandidos-publications.com)
  • In addition, In vitro cell culture models will be studied to address the underlying cellular mechanisms by utilizing: 1) Adult mouse cardiac fibroblasts (F2KO and WT) and 2) Neonatal rat ventricular cardiomyocytes. (centerforpediatricresearch.org)
  • The frequency of pediatric cardiac tumors varies across the fetal, neonatal and pediatric age spectrum. (sts.org)
  • cardiac: A stored anemia of congestive cardiac medical diagnosis which is on the disorder of the central attempts, on the Clinical hypodermoclysis of the vein or on the components in the individual outpatients. (worldclassbows.com)
  • Indeed, even sublethal mitochondrial damage can impair cardiac ATP provision and ventricular contraction. (jci.org)
  • Camelliti P, Borg TK, Kohl P. Structural and functional characterisation of cardiac fibroblasts. (pitt.edu)
  • Females did not display a significant structural and/or functional alteration within 7 days of cardiac remodeling post-MI upon CS exposure. (biomedcentral.com)
  • The epidemiological data on the prevalence of cardiac tumors is based on post mortem autopsy studies. (sts.org)
  • The higher fetal prevalence as compared to the pediatric autopsy studies highlight probable in-utero demise or the natural post-natal regression that occurs with certain primary cardiac tumor subtypes. (sts.org)
  • 1 Department of Regenerative Medicine and Advanced Cardiac Therapeutics, 2 Cardiology Division, Department of Internal Medicine, 3 Department of Cardiovascular Surgery, 4 Division of Diagnostic Pathology, 5 Department of Pathology, Keio University School of Medicine, Tokyo, Japan. (jci.org)
  • Among cardiac macrophage subtypes, WWP2 dysfunction primarily affects Ly6c high monocytes via modulating Ccl5, and consequentially macrophage infiltration and activation, which contributes to reduced myofibroblast trans -differentiation. (nature.com)
  • The anti-ischemic drug trimetazidine (TMZ) is reportedly useful in ventricular remodeling and associated with NADPH oxidase (NOX) 2. (dovepress.com)
  • Using a mouse model, we investigated cardiac remodeling under the influence of acute cigarette smoke (CS) exposure following ischemic injury in both sexes. (biomedcentral.com)