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CytomegalovirusCytomegalovirus InfectionsColitisColitis, UlcerativeCytomegalovirus RetinitisMuromegalovirusCytomegalovirus VaccinesColitis, IschemicGanciclovirColitis, MicroscopicDextran SulfateColitis, CollagenousImmediate-Early ProteinsColonTrinitrobenzenesulfonic AcidDNA, ViralViral ProteinsAntiviral AgentsHerpesviridae InfectionsFoscarnetColitis, LymphocyticAntigens, ViralVirus ReplicationAntibodies, ViralCrohn DiseaseIntestinal MucosaGenes, Immediate-EarlyInflammatory Bowel DiseasesViral Matrix ProteinsGene Expression Regulation, ViralFibroblastsViral Envelope ProteinsCell LineVirus ActivationCells, CulturedMesalamineGenes, ViralPolymerase Chain ReactionMolecular Sequence DataRoseolovirusMice, Inbred BALB CHerpesviridaeAIDS-Related Opportunistic InfectionsViremiaBase SequenceOrgan TransplantationHerpesvirus 6, HumanViral Plaque AssayDisease Models, AnimalBetaherpesvirinaePneumonia, ViralImmunocompromised HostImmunocompetenceMice, Inbred C57BLRectumPhosphoproteinsRibonucleosidesOpportunistic InfectionsTime FactorsRetinitisKidney TransplantationAcyclovirPromoter Regions, GeneticImmunoglobulin GEye Infections, ViralCytopathogenic Effect, ViralViral LoadComplement Fixation TestsVirus LatencySulfasalazinePeroxidasePregnancy Complications, InfectiousColonoscopySalivary GlandsAmino Acid SequenceImmunoglobulin MVirologyFluorescent Antibody TechniqueTransplantation, HomologousGenome, ViralOpen Reading FramesGastrointestinal AgentsColectomyProctocolectomy, RestorativeGenetic VectorsCD8-Positive T-LymphocytesOrganophosphonatesInclusion Bodies, ViralImmunosuppressive AgentsDysentery, AmebicMembrane GlycoproteinsAcquired Immunodeficiency SyndromeVirionAntibodies, MonoclonalEnzyme-Linked Immunosorbent AssayCD4-Positive T-LymphocytesBone Marrow TransplantationIleostomyTranscription, GeneticVirus Cultivation

Ulcerative colitisUlcerationGanciclovirImmunocompetent patientCrohnSteroidsInflammatoryColonPseudomembranousInfectionsDiagnosisPathophysiologyInfectiousPrevalenceCCMVStomach or intestineCongenitalIntravenousViralHCMVConclusionsReactivationImmunosuppressionPatientSymptomsSigmoidoscopyRecipientsCharacteristicColectomyDifficileSystemicAIDSDiseaseHumanChronicPathologicHerpesviridaeImmunohistochemicalCaseDiarrheaBiopsies

Ulcerative colitis30

• A 56-year-old man with a history of ulcerative colitis (UC), treated with Adalimumab, returned from a 10-day cruise to Puerto Rico. (shmabstracts.org)
• Effect of intensive granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis positive for cytomegalovirus. (adacyte.com)
• Background: It remains controversial whether or not cytomegalovirus infection in patients with active ulcerative colitis reflects a nonpathogenic colonization or a pathogenic disease warranting antiviral therapy. (ewha.ac.kr)
• Goals: The aim of this study was to determine the prevalence of cytomegalovirus infection in patients with active ulcerative colitis and the therapeutic efficacy of ganciclovir against cytomegalovirus infection in patients with steroid-refractory ulcerative colitis. (ewha.ac.kr)
• Study: A prospective, multicenter study was conducted in 72 patients with moderate-to-severe ulcerative colitis who were treated with intravenous steroids. (ewha.ac.kr)
• In patients with steroid-refractory ulcerative colitis, cytomegalovirus infections were treated with intravenous ganciclovir. (ewha.ac.kr)
• In patients with steroid-responsive ulcerative colitis, steroid therapy was continued irrespective of cytomegalovirus infection. (ewha.ac.kr)
• Results: The evidence of cytomegalovirus infection was found in 31 patients (43%) with moderate-to-severe active ulcerative colitis. (ewha.ac.kr)
• In patients with steroid-refractory ulcerative colitis, the cytomegalovirus infection rate increased to 67% (14 of 21). (ewha.ac.kr)
• Eleven of 14 patients (79%) with steroid-refractory ulcerative colitis and a cytomegalovirus infection improved with ganciclovir treatment. (ewha.ac.kr)
• Conclusions: Cytomegalovirus infections are frequently observed in patients with moderate-to-severe ulcerative colitis, especially steroid-refractory ulcerative colitis. (ewha.ac.kr)
• Ganciclovir was effective in patients with steroid-refractory ulcerative colitis who had a cytomegalovirus infection. (ewha.ac.kr)
• Ulcerative colitis is a relapsing and remitting inflammatory bowel disease of the large intestine. (aafp.org)
• Risk factors include recent Salmonella or Campylobacter infection and a family history of ulcerative colitis. (aafp.org)
• Ulcerative colitis is a relapsing and remitting inflammatory bowel disease frequently encountered in primary care. (aafp.org)
• This article provides a summary of ulcerative colitis and a review of the available evidence for management. (aafp.org)
• Overall, extraintestinal manifestations are only 6% more common in patients with inflammatory bowel disease than in the general population and are more common with Crohn disease compared with ulcerative colitis. (aafp.org)
• Fecal calprotectin testing has a high negative predictive value and helps to differentiate inflammatory bowel disease from irritable bowel syndrome, but no serum biomarkers alone are sufficient for the diagnosis of ulcerative colitis. (aafp.org)
• Endoscopic evidence of continuous colonic inflammation starting at the rectum with confirmatory biopsies establishes the diagnosis of ulcerative colitis. (aafp.org)
• Findings from sigmoidoscopy confirmed ulcerative colitis. (medscape.com)
• Whereas the typical ulcerative colitis inflammatory response is limited to the mucosa, toxic megacolon is characterized by severe inflammation extending into the smooth muscle layer, thus paralyzing the colonic smooth muscle and leading to dilatation. (medscape.com)
• gt;Cytomegalovirus (CMV) infection has been associated with ulcerative colitis (UC). (uwi.edu)
• Indeterminate colitis is a term to describe a chronic idiopathic colitis that cannot be separated based on conventional diagnostic modalities to either Crohn colitis or ulcerative colitis. (medscape.com)
• Ulcerative colitis was initially diagnosed and sulfasalazine was prescribed. (scipedia.com)
• In this report, we discuss how to diagnose ulcerative colitis. (scipedia.com)
• The purpose of this study was to determine whether the mucosal expression of interleukin (IL)-23p19 has a role in the pathogenesis of ulcerative colitis, and to determine its relation to disease severity. (scipedia.com)
• This study was performed on 50 patients with ulcerative colitis and 10 normal individuals as the controls. (scipedia.com)
• There was a significant increase in IL-23p19 gene expression and IL-23R level in patients with ulcerative colitis, compared to the controls. (scipedia.com)
• Increased expression of the IL-23p19 gene has a role in the pathogenesis of ulcerative colitis. (scipedia.com)
• Many reports have documented the increasing impact of Clostridium difficile infection (CDI) in patients with ulcerative colitis (UC). (biomedcentral.com)

Ulceration3

• Gross specimen of bowel showing ulceration secondary to cytomegalovirus colitis. (medscape.com)
• Distal colitis associated with ulceration is the most common colonoscopic pattern. (nebraska.edu)
• Pathology revealed CMV colitis with ulceration, viral inclusions and positive immunohistochemical staining. (shmabstracts.org)

Ganciclovir2

• A 66-year-old woman with myelodysplastic syndrome developed CMV colitis, which responded to treatment with ganciclovir. (mun.ca)
• Cytomegalovirus infections in the steroid-responsive group (17 of 31) did not require ganciclovir therapy. (ewha.ac.kr)

Immunocompetent patient2

• Case of cytomegalovirus colitis in an immunocompetent patient: a rare cause of abdominal pain and diarrhea in the elderly. (librepathology.org)
• However, synchronous onset of CMV colitis and UC in an immunocompetent patient is rare. (uwi.edu)

Crohn1

• Other causes of bloody diarrhea include ischemic colitis, Crohn disease, and colitis caused by medications or radiation. (aafp.org)

Steroids2

• however, the amount of steroids used during the flare-up period was significantly higher in patients with a cytomegalovirus infection (P=0.013). (ewha.ac.kr)
• Antibiotic exposure within 3 months prior to the study ( P = 0.004), hospitalization within 1 month prior to the study ( P = 0.025), systemic use of steroids ( P = 0.002) and active cytomegalovirus (CMV) infection ( P = 0.001) were higher in CDI than non-CDI patients. (biomedcentral.com)

Inflammatory5

• Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander? (wikipedia.org)
• Severe immunosuppression caused by primary HIV infection resulted in cytomegalovirus colitis, and initiation of early combination antiretroviral therapy triggered an immune reconstitution inflammatory syndrome potentially leading to colonic perforation. (uzh.ch)
• CMV colitis superimposed on inflammatory bowel disease . (librepathology.org)
• In cases of uncomplicated colitis, the inflammatory response is confined to the mucosa. (medscape.com)
• Pseudomembranous colitis is a form of inflammatory colitis characterized by the pathologic presence of pseudomembranes consisting of mucin, fibrin, necrotic cells, and polymorphonuclear leukocytes (PMNs). (medscape.com)

Colon3

• Cytomegalovirus colitis, also known as CMV colitis, is an inflammation of the colon. (wikipedia.org)
• The term colitis refers to inflammation of the colon. (medscape.com)
• The resected colon showed amoeba, cytomegalovirus, and fungal infection. (scipedia.com)

Pseudomembranous3

• Gross pathology specimen from a case of pseudomembranous colitis demonstrating characteristic yellowish plaques. (medscape.com)
• Computed tomography scan from a patient with pseudomembranous colitis demonstrating the classic accordion sign. (medscape.com)
• Although every antibiotic has been reported to be associated with pseudomembranous colitis, cephalosporin and beta-lactam antibiotics are most frequently implicated in children. (medscape.com)

Infections1

• IMPORTANCE Infections with the human cytomegalovirus (HCMV) may cause severe and even life-threatening disease manifestations in newborns and immunosuppressed individuals. (asm.org)

Diagnosis4

• The diagnosis of CMV colitis is based on serology, CMV antigen testing and colonoscopy with biopsy. (wikipedia.org)
• Because asymptomatic CMV viremia and viruria is common and about 1/3 of symptomatic CMV infection is caused by reinfection of different strain of CMV, the diagnosis of CMV colitis needs more direct causality. (wikipedia.org)
• Definition and diagnosis of cytomegalovirus colitis in patients infected by human immunodeficiency virus. (librepathology.org)
• The diagnosis of cytomegalovirus disease was based on established endoscopic and histologic criteria. (nebraska.edu)

Pathophysiology1

• In addition, numerous different conditions can cause colitis, each of which has its own pathophysiology. (medscape.com)

Infectious1

• Infectious colitis without a distinctive morphology. (librepathology.org)

Prevalence1

• Human cytomegalovirus (CMV), which belongs to the Herpesviridae family and is the most common cause of congenital infection, has a prevalence of 0.2%-6%, even in developed countries [ 1 ]. (e-cep.org)

CCMV1

• Congenital human cytomegalovirus infection (cCMV) is a major cause of childhood disease, often leading to permanent neurologic sequelae ( 1 ). (asm.org)

Stomach or intestine2

• CMV gastroenteritis/colitis is inflammation of the stomach or intestine due to infection with cytomegalovirus. (medlineplus.gov)
• Tell your doctor if you have diarrhea or if you have ever had colitis or other conditions that affect your stomach or intestine. (epnet.com)

Congenital4

• Cytomegalovirus (CMV) expert Sallie Permar, M.D., Ph.D., of NewYork-Presbyterian/Weill Cornell Medical Center says the epidemiology of congenital CMV hasn't varied much over the years and that the condition does disproportionately affect lower socioeconomic populations and communities of color in the U.S. (managedhealthcareexecutive.com)
• Congenital cytomegalovirus (CMV) is the most common cause of congenital infection worldwide, the most common nongenetic cause of sensorineural hearing loss in children, and a cause of neurodevelopmental disorders in the brain. (e-cep.org)
• Congenital cytomegalovirus (CMV) infection is among the most common causes of nongenetic sensorineural hearing loss. (e-cep.org)
• Overview of the management of congenital cytomegalovirus infection. (e-cep.org)

Intravenous1

• He was admitted to the hospital with intravenous broad-spectrum antibiotics for acute colitis. (shmabstracts.org)

Viral1

• Cytomegalovirus (CMV) is the most common cause of life-threatening opportunistic viral infection in patients with acquired immunodeficiency syndrome (AIDS). (e-ce.org)

HCMV2

• Cell-free human cytomegalovirus (HCMV) may be inhibited by a soluble type of the mobile HCMV-receptor PDGFRα , resembling neutralization by antibodies . (aetox.com)
• The development of a vaccine against human cytomegalovirus infection (HCMV) is a high-priority medical goal. (asm.org)

Conclusions1

• Conclusions: Cytomegalovirus colitis in AIDS appears to have variable but stereotypical clinical and colonoscopic manifestations. (nebraska.edu)

Reactivation2

• Although it is known that CMV colitis is almost always caused by reactivation of latent CMV infection in immunocompromised patients, new infection of CMV or reinfection of different strain of CMV can cause colitis in immunocompetent hosts. (wikipedia.org)
• Serological testing demonstrated cytomegalovirus reactivation. (uzh.ch)

Immunosuppression1

• Dans cette étude, une présentation tardive accompagnée d'une immunosuppression sévère était fréquente, et était associée à une mortalité élevée en milieu hospitalier. (who.int)

Patient4

• Severe ulcerous cytomegalovirus pancolitis developed during primary human immunodeficiency virus (HIV) infection in a patient who underwent early combination antiretroviral treatment. (uzh.ch)
• A case of cytomegalovirus colitis in an immunocompetent hemodialysis patient. (librepathology.org)
• CMV colitis has not been reported in a patient with splenectomy in Korea. (e-ce.org)
• Recently, we experienced a case of fatal CMV colitis in a patient with splenectomy. (e-ce.org)

Symptoms1

• Contact your health care provider if you have symptoms of CMV gastroenteritis/colitis. (medlineplus.gov)

Sigmoidoscopy1

• On day 13 a repeat sigmoidoscopy showed severe colitis, proctosigmoiditis. (shmabstracts.org)

Recipients1

• Cytomegalovirus (CMV) prophylaxis may prevent CMV indirect effects in renal transplant recipients. (biomedcentral.com)

Characteristic1

• Giant cell with inclusion body characteristic of cytomegalovirus colitis. (medscape.com)

Colectomy1

• Severe CMV colitis may lead a colectomy. (wikipedia.org)

Difficile1

• This form of colitis is pathognomonic of infection by toxin-producing Clostridium difficile and develops as a result of altered normal microflora (usually by antibiotic therapy) that favors overgrowth and colonization of the intestine by Clostridium difficile and production of its toxins. (medscape.com)

Systemic1

• Colitis is a frequent manifestation of this acute systemic illness. (medscape.com)

AIDS2

• Background: Cytomegalovirus colitis is an important complication of the acquired immunodeficiency syndrome (AIDS), although the clinical and colonoscopic manifestations of this disease have not been systematically characterized. (nebraska.edu)
• Methods: Patients with AIDS and cytomegalovirus colitis were prospectively identified at two medical centers. (nebraska.edu)

Disease1

• Non-bloody diarrhea can be caused by microscopic colitis, irritable bowel syndrome, celiac disease, or food intolerances. (aafp.org)

Human1

• Human Cytomegalovirus (CMV) is a member of the family Herpesviridae, also known as Human Herpesvirus 5 (HHV-5). (medscape.com)

Chronic1

• Cytomegalovirus (CMV) colitis is a rare cause of chronic diarrhoea in immunocompetent children. (pap.es)

Pathologic1

• CMV colitis was diagnosed by colonoscopy and pathologic examination. (e-ce.org)

Herpesviridae2

• Cytomegalovirus (CMV) is a member of the Herpesviridae family, along with herpes simplex viruses 1 and 2 , Epstein-Barr virus , and varicella-zoster virus . (medscape.com)
• Cytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the Herpesviridae family. (medscape.com)

Immunohistochemical1

• The presence of cytomegalovirus was evaluated serologically and histopathologic examination, including immunohistochemical staining. (ewha.ac.kr)

Case2

• The present report describes the first recognized case of cytomegalovirus (CMV) colitis following azacitidine therapy. (mun.ca)
• Here, we present a case of CMV colitis and UC synchronously developing in an elderly immunocompetent woman. (uwi.edu)

Diarrhea1

• CMV colitis may be clinically manifested with diarrhea (usually non-bloody), abdominal pain, weight loss and anorexia. (wikipedia.org)

Biopsies1

• Biopsies of the rectal/sigmoid walls revealed active colitis with crypts. (shmabstracts.org)