Coactivator histone acetyltransferase activity protein binding. Medical search. Frequent questions

In addition, these coactivators also possess intrinsic histone acetyltransferase (HAT) activity and bind to each other and another HAT, p300/CBP-associated factor. (drugbank.com)
The histone acetyltransferase (Head wear) p300/CBP is a transcriptional coactivator implicated in lots of gene regulatory pathways and protein acetylation events. (woofahs.com)
In this research, we concentrate on the paralog HATs p300 and CBP (known as p300/CBP), that have been originally uncovered as E1A oncoprotein binding companions and cyclic AMP effectors, respectively (Goodman and Smolik, 2000). (woofahs.com)
p300/CBP frequently acts as a transcriptional coactivator and continues to be recommended to bind to a variety of essential transcription elements (Goodman and Smolik, 2000). (woofahs.com)
In 1996, p300/CBP was reported to obtain intrinsic Head wear activity (Ogryzko et al. (woofahs.com)
1996). Within the ensuing years, p300/CBP provides been shown to be always a rather promiscuous acetyltransferase, with an increase of than 75 proteins substrates referred buy 1062159-35-6 to including p53, MyoD, and NFB (Gu et al. (woofahs.com)
2008). Dissecting the need for the enzymatic activity of p300/CBP instead of its proteins recruitment features in clarifying p300/CBP's natural roles would reap the benefits of selective cell permeable Head wear inhibitors. (woofahs.com)
Recent research claim that the biologic features of p300/CBP Head wear activity could be connected with tumorigenesis, which is as a result plausible that p300/CBP Head wear inhibitors may provide as potential anti-cancer real estate agents (Dekker et al. (woofahs.com)
Inhibition of the histone acetyltransferase activity of CREB-binding protein (CBP)/p300 blocked the induction of COX-2 by PMA. (johnshopkins.edu)
Because AP-1 binding was unaffected by RA, we investigated whether RA inhibited COX-2 transcription via effects on the coactivator CBP/p300. (johnshopkins.edu)
Overexpressing c-Jun but not CBP/p300 reversed the suppressive effect of carnosol on PMA-mediated stimulation of COX-2 promoter activity. (johnshopkins.edu)
Citation: Ding Z, Cao J, Shen Y, Zou Y, Yang X, Zhou W, Guo Q and Huang C (2018) Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury. (vinomis.com)
In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. (vinomis.com)
Inactivation of p300 acetyltransferase reversed the resveratrol-induced expression of VEGFs and motor repair in rats that had undergone sciatic nerve crush injury. (vinomis.com)
Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair. (vinomis.com)
Predicated on results that curcumin can inhibit p300 histone acetyltransferase activity[26,27], we hypothesized that deacetylation of cccDNA-bound histones may donate to the inhibitory actions of curcumin on HBV. (brain-tumor-cancer-information.com)
STATs interact with histone acetyltransferases (HATs) including p300/CBP and GCN5 and GCN5 acetylates histones on the promoter in an IFN-dependent manner (6 7 Interestingly inhibition of histone deacetylase (HDAC) activity which opposes activity of HAT leads to a global impairment of the ISG transcription (8-10). (techblessing.com)
The p300/CBP-associated aspect (PCAF) has been proven to act being a co-activator to modify gene transcription possibly including AR-regulated transcriptional activity in PCa cells [6 7 PCAF possesses histone acetyltransferase (Head wear) activity where it makes the chromatin environment easier available for the transcriptional equipment. (opioid-receptors.com)
Following a best-candidate approach to identify such a partner, we demonstrated through NMR-monitored titrations and glutathione S-transferase pulldown assays that the OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300. (ubc.ca)

The fact that histones are modified by acetylation has been known for almost 30 years. (embl-heidelberg.de)
The recent identification of enzymes that regulate histone acetylation has revealed a broader use of this modification than was suspected previously. (embl-heidelberg.de)
Acetylation regulates many diverse functions, including DNA recognition, protein-protein interaction and protein stability. (embl-heidelberg.de)
Histone acetylation is important in chromatin remodelling and gene activation. (embl-heidelberg.de)
Collectively, these results suggest that targeted histone acetylation by recruited HAT cofactors and histone deacetylation are important factors affecting PR transactivation. (drugbank.com)
Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). (jensenlab.org)
Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. (jensenlab.org)
The code is an array of post-translational modifications (acetylation, phosphorylation, methylation, ubiquitination, and sumoylation) of NH 2 -terminal tails of core histone and to a lesser degree their globular domains. (aacrjournals.org)
In the meantime, period- and dose-dependent reductions in the histone H3 acetylation amounts had been also recognized upon treatment with curcumin, followed by reductions in H3- and H4-destined cccDNA. (brain-tumor-cancer-information.com)
Summary Curcumin inhibits HBV gene replication down-regulation Ki16425 of cccDNA-bound histone acetylation and gets the potential to become developed like a cccDNA-targeting antiviral agent for hepatitis B. reductions in covalently shut round DNA-bound histone acetylation. (brain-tumor-cancer-information.com)
Hepatitis B disease X (HBx) proteins could be recruited onto a cccDNA minichromosome to accelerate acetylation. (brain-tumor-cancer-information.com)
2022 ). Among all types of histone modifications, the reversible N-terminal lysine acetylation, regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC), is one of the best-characterized machineries (Kurdistani and Grunstein 2003 ). (biomedcentral.com)
Under physiological circumstances co-activators are essential for the forming of a successful transcriptional AR complicated by facilitating DNA occupancy chromatin redecorating and/or AR proteins balance and acetylation [4]. (opioid-receptors.com)
In addition to the acetylation of FR 180204 histones HATs have already been shown to acetylate AR advertising AR transcriptional activity [5]. (opioid-receptors.com)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)

In transient transfection assays, we found that addition of a histone deacetylase inhibitor, trichostatin A, strongly potentiated PR-driven transcription. (drugbank.com)
In contrast, directing histone deacetylase-1 (HD1) to a promoter using the GAL4 DNA binding domain inhibited transcription. (drugbank.com)
To dissect the epigenetic regulation of GLS pathogenesis, we characterized a histone deacetylase gene Cfhos2 in Colletotrichum fructicola , the causing agent of GLS. (biomedcentral.com)
It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)

Here, we show that the lncRNA Panct1 regulates the transient recruitment of a putative X-chromosome-encoded protein A830080D01Rik, hereafter referred to as transient octamer binding factor 1 (TOBF1), to genomic sites resembling the canonical Oct-Sox motif. (ku.dk)
Linker histone H1 binds near to the entry and exit sites of the nucleosome core particle (NPC) which consists of a 147-base-pair (bp)-long deoxyribonucleic acid (DNA) wrapped around a histone octamer consisting of two copies each of the core histone proteins H2A H2B H3 and H4 and facilitates the higher order chromatin structure (17-19). (techblessing.com)
A histone chaperone that facilitates nucleosome assembly by mediating the formation of the histone octamer and its transfer to DNA. (lookformedical.com)

Acetylates all four core histones in nucleosomes. (jensenlab.org)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)

A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)

2007). While research on histone deacetylases buy 1062159-35-6 possess resulted in the breakthrough of highly powerful compounds with scientific impact in tumor, the id of histone acetyltransferase inhibitors provides proved more difficult (Cole, 2008). (woofahs.com)
More recently, Tim has completed a drug discovery project, developing acetyltransferase inhibitors and a new class of anti-cancer therapeutics. (edu.au)

8-11 A series of in vitro studies used reconstituted nucleosomes to demonstrate that Cas9/gRNA binding and cleaving are completely blocked at nucleosome-bound DNA. (aip.org)
A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. (lookformedical.com)

E2a changes the position of Smad2 /3 binding at the Nodal inhibitor lefty , resulting in direct repression of lefty that is critical for mesendoderm specification. (xenbase.org)
Utilizing a cccDNA chromatin immunoprecipitation (ChIP)-Seq assay, Tropberger et al[18] reported that low degrees of histone posttranslational adjustments (PTMs) had been connected with transcriptional repression and promoter silencing. (brain-tumor-cancer-information.com)
2022 ). Such positive charge generally facilitates histone-DNA binding, thereby favors chromatin condensation and transcriptional repression (Bannister and Kouzarides 2011 ), but in rare case leads to transcription activation as well (Wang et al. (biomedcentral.com)

CDK8 can directly interact with Mad in vitro through the linker region between the DNA-binding MH1 (Mad homology 1) domain and the carboxy terminal MH2 (Mad homology 2) transactivation domain. (sdbonline.org)
SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. (axonmedchem.com)

We also made key contributions to identifying the eIF2α kinase Gcn2 and elucidating its regulation by amino acids, via allosteric control of kinase activity by uncharged tRNAs and Gcn2 regulatory domains, and by the TOR pathway through Gcn2-Ser577 phosphorylation. (nih.gov)

8-11 Recently, several groups have investigated the impact of chromatin states on the binding and cutting of DNA by Cas9 guide RNA complexes (Cas9/gRNA). (aip.org)
2014 ). Different HDACs interact with different sets of proteins and form distinct HDAC protein complexes, which function differently in terms of the histone and lysine sites being modified, the targeted genomic regions, and the associated biological effects (Jeon et al. (biomedcentral.com)
The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. (axonmedchem.com)

Orthologous to human CREBBP (CREB binding protein). (zfin.org)

Structure and ligand of a histone acetyltransferase bromodomain. (embl-heidelberg.de)
Using an in vitro transcription assay, we found that progesterone receptor (PR)-driven transcription is inhibited by a dominant negative PR ligand-binding domain-interacting region of SRC-1A, indicating that SRC-1A is required for actual transcriptional processes. (drugbank.com)
Furthermore, PR transactivation was repressed by recruiting HD1 into the PR-DNA complex by fusing HD1 to a PR ligand-binding domain-interacting portion of SRC-1. (drugbank.com)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)

In addition, we show by a combination of structural and site-directed mutagenesis studies that bromodomains can interact specifically with acetylated lysine, making them the first known protein modules to do so. (embl-heidelberg.de)

ATM inhibition affected cell-cycle regulatory protein expression, blocked cell-cycle progression at the G2/M phase and resulted in apoptosis. (bvsalud.org)

and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)
Proteins found in the nucleus of a cell. (lookformedical.com)
Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)

Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). (jensenlab.org)

Lately, using DNA-cleaving enzymes, including zinc-finger nucleases (ZFN), TAL effector nucleases (TALENs), and CRISPR-associated program 9 (Cas9) protein, specific focusing on of HBV cccDNA was proven to cleave cccDNA[11-15]. (brain-tumor-cancer-information.com)
Histone-modifying enzymes, which regulate eukaryotic chromatin conformation and gene expression, are key epigenetic factors controlling fungal development, virulence, and secondary metabolism. (biomedcentral.com)
Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histones. (lookformedical.com)

Recruitment of coactivators and HATs by the liganded PR in vivo may result in (i) remodeling of transcriptionally repressed chromatin to facilitate assembly and (ii) enhanced stabilization of the preinitiation complex by the activation functions of coactivators and the liganded PR itself. (drugbank.com)

which have a variety of binding sites for sequence-specific transcription factors and specify characteristic chromatin structures mediated by nucleosome positioning specific histone modifications histone variants and other factors (1 2 For the transcription of type-I interferon (IFN)-stimulated genes (ISGs) promoters containing sequence motifs known as IFN-stimulated response element (ISRE) are the binding sites of the sequence-specific transcription factors activated by IFN stimulation. (techblessing.com)

Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
Acetylases are now known to modify a variety of proteins, including transcription factors, nuclear import factors and alpha-tubulin. (embl-heidelberg.de)
The nuclear receptor peroxisome proliferator activated receptor Î³ (PPARÎ³) binds inflammatory mediators in obesity and its expression is reduced in human breast cancer. (bvsalud.org)

SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
SUMOylation of proteins is an important mechanism in cellular responses to environmental stress ( 21 , 22 ). (frontiersin.org)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)

In starvation conditions, the reinitiating ribosomes bypass uORFs 2-4 and reinitiate at GCN4 instead, owing to lowered availability of the ternary complex (TC)-comprised of initiation factor 2 (eIF2), GTP, and initiator Met-tRNAi-which binds to the small (40S) ribosomal subunit to assemble a 43S preinitiation complex (PIC). (nih.gov)

This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)

The activity of the p53 gene product is regulated by a plethora of posttranslational modifications. (rupress.org)
Cross-talk between different histone modifications, as well as DNA methylation, seems complex. (aacrjournals.org)
Single-cell profiling of transcriptome and histone modifications with EpiDamID. (axonmedchem.com)

Upon binding of their respective ligands and activation, intracellular signalling cascades, often involving phophorylation are induced which eventually terminate at inducible TFs and regulate their activity. (amegroups.org)

The effects of DNA methylation and the histone code are due, at least in part, to modification-specific recruitment of factors, such as heterochromatin-associated proteins (HP1) and methyl-binding domain proteins, which establish and maintain higher order of chromatin structure. (aacrjournals.org)
In addition TAF-I KD and histone H1 KD affected the chromatin structure near the promoters. (techblessing.com)
On the basis of these findings we propose that TAF-I and its target histone H1 are key regulators of the chromatin structure at the promoter to maintain the silent state of ISG transcription. (techblessing.com)

These studies suggest that ISG transcription via promoters is under the control of the N-Methyl Metribuzin combined effects of histone modification and specific chromatin structures. (techblessing.com)
The activity of these elements is controlled by transcription factors (TFs) which bind to DNA wrapped into chromatin, leading to the modification of the chromatin landscape, and the assembly of the transcription machinery. (amegroups.org)

Central to the epigenetic control of gene expression is the histone code through which input signals can be translated into a heritable pattern of gene expression defining cellular output states ( Fig. 1 ). (aacrjournals.org)
The Thomas lab has a long-term interest in understanding the epigenetic regulation of embryonic development and in particular has characterised the function of histone acetyltransferases. (edu.au)

The induction of COX-2 transcription by PMA was mediated by increased binding of AP-1 to the cyclic AMP response element (CRE) of the COX-2 promoter. (johnshopkins.edu)
Treatment with carnosol but not RA blocked increased binding of AP-1 to the COX-2 promoter. (johnshopkins.edu)
By contrast, carnosol inhibited the induction of COX-2 by blocking PKC signaling and thereby the binding of AP-1 to the CRE of the COX-2 promoter. (johnshopkins.edu)

E) Embryos were injected at the two-cell stage with mE2a-GFP- and RFP-tagged histone H2b mRNA and monitored for fluorescence at stage 10.5. (xenbase.org)
Focusing on of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells. (opioid-receptors.com)

Both oncoproteins exert pleiotropic functions on their host cells, such as inactivation of the major tumour suppressors, p53 and retinoblastoma protein (pRB), respectively [ 10 ]. (biomedcentral.com)

1,2 However, recent work has shown that chromatin, the RNA-DNA-protein complex that controls chromosomal organization and gene expression in mammalian nuclei, 3-5 blocks access of Cas9 to certain DNA target sites in vitro 6-8 and in mammalian cells. (aip.org)
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. (lookformedical.com)

Here, we investigate how perturbation of the cofactor E2a affects global patterns of Smad2 /3 binding and gene expression during gastrulation. (xenbase.org)

2008). This strike and operate kinetic mechanism requires initial, steady binding of acetyl-CoA accompanied by weakened and transient discussion with histone substrate which. (woofahs.com)

Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). (jensenlab.org)

This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl-heidelberg.de)
E2a Is Required for Subsets of Smad2/3 Binding and for Global Patterns of Smad2/3 Target Gene Expression (A) Smad2/3 targets 1,027 distinct genomic regions in control stage 10.5 embryos (yellow) and 1,671 regions in E2a -depleted embryos (blue). (xenbase.org)
D) Genes that retain Smad2/3 binding at the same genomic coordinates in E2a -depleted embryos (red box in B) are more likely to be downregulated by 2-fold or more in E2a -depleted embryos. (xenbase.org)
Smad2/3 targets in which binding is at the same genomic position in control and E2a -depleted embryos are more likely to be downregulated in E2a -depleted embryos. (xenbase.org)
This protein interaction variation is able to be monitored on a genomic scale via the change of gene pair co-expression. (biomedcentral.com)

In silico analysis of the MCP-1 upstream region proposed a putative p53 binding side about 2.5 kb upstream of the transcriptional start. (biomedcentral.com)

This network included the abundant pattern recognition proteins, signal transduction compo nents involved with Toll, Imd and JAK/STAT pathways, modulation molecules in proPO activating cascade and immune responsive effectors. (cox2-inhibitors.com)

SND1 is Tudor domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster. (wikipedia.org)

Treatment with retinoic acid (RA) or carnosol, two structurally unrelated compounds with anticancer properties, inhibited phorbol ester (PMA)-mediated induction of activator protein-1 (AP-1) activity and cyclooxygenase-2 (COX-2) expression in human mammary epithelial cells. (johnshopkins.edu)
Our results demonstrate the use of DNA-binding, activator-associated fusion proteins as an effective method to enhance Cas9 editing within polycomb-repressed chromatin. (aip.org)

To elucidate the mechanism by which carnosol inhibited COX-2 transcription, its effects on protein kinase C (PKC) signaling were determined. (johnshopkins.edu)
We identified the eIF2α phosphatases in yeast and made key contributions to elucidating the mechanism whereby phosphorylated eIF2 inhibits its GDP-GTP exchange factor, eIF2B, defining the catalytic and regulatory subcomplexes of eIF2B and their distinct roles in binding phosphorylated or nonphosphorylated eIF2. (nih.gov)

Histone hyperacetylation and H3K4 methylation are associated with unmethylated DNA, euchromatin, and gene expression ( Fig. 2 ). (aacrjournals.org)

TAF-I and histone H1 double KD did not show the additive effect in ISG transcription suggesting that TAF-I and histone H1 may act on the same regulatory pathway to control ISG transcription. (techblessing.com)
We uncovered the functions of ABCE proteins Rli1/ABCE1 and Arb1 in PIC assembly and ribosome biogenesis, and identified the tRNA methyltransferase Gcd10/Gcd14, which contributed to the discovery of the TRAMP-mediated RNA surveillance pathway. (nih.gov)

The proposed p53 binding side could be confirmed in vitro by electrophoretic-mobility-shift assays and in vivo by chromatin immunoprecipitation. (biomedcentral.com)
Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)

In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). (embl-heidelberg.de)
In mammalian cells, histone H3 Lys 9 (H3K9) methylation and histone hypoacetylation are usually associated with methylated DNA, heterochromatin, and gene silencing. (aacrjournals.org)

Thus, the bromodomain is functionally linked to the HAT activity of co-activators in the regulation of gene transcription. (embl-heidelberg.de)

When cells that carried a polycomb-repressed transgene (luciferase) were treated with UNC1999 or the AAP fusion Gal4P65, we observed loss of histone 3 lysine 27 trimethylation (H3K27me3), a silencing-associated chromatin feature, at the transgene. (aip.org)

C) DAVID clustering analysis shows enrichment for developmental (dev) terms in all Smad2/3-associated genes and for genes that have stable Smad2/3 binding when E2a is depleted (red box in B) but not other subcategories of Smad2/3 binding. (xenbase.org)
Plays a role as a coactivator of NEUROD1- dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. (jensenlab.org)

Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. (jensenlab.org)
Curcumin can inhibit HBV down-regulation from the gluconeogenesis gene coactivator PGC-1[24] or trans-activation of transcription and improved balance of p53[25]. (brain-tumor-cancer-information.com)
Histone H1-dependent chromatin dynamics have been shown to be important in a variety of biological phenomena and in the transcriptional regulation of a certain gene (20-24). (techblessing.com)

Coactivators, such as steroid receptor coactivator 1 (SRC-1A) and CREB (cAMP response element binding protein)-binding protein (CBP), are required for efficient steroid receptor transactivation. (drugbank.com)
Glucocorticoids are steroid hormones secreted from the zona fasciculata of the adrenal cortex, and play numerous important roles in the maintenance of internal homeostasis by influencing activities of virtually all organs and tissues, such as the brain, liver, skeletal muscles and the immune-related organs and cells [1]. (brainimmune.com)

We are particularly interested in the function of the MYST family of histone acetyltransferases in stem cell populations. (edu.au)
HDACs function by removing acetyl residues from the ε-amino group of lysine residues in the histone N-terminal tail, which restores the positive charge on the histone (Lai et al. (biomedcentral.com)
The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)

Anatomy17

Organisms11

Diseases3

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes66

Disciplines and Occupations1

Information Science3

P30019

Acetylation15

Deacetylase4

Octamer3

Core histones3

Deacetylation1

Inhibitors2

Nucleosomes2

Repression3

Linker2

Phosphorylation1

Complexes4

CREB-Binding1

Ligand4

Interact1

Inhibition1

Nucleus3

Regulates1

Enzymes3

HATs1

Nucleosome1

Nuclear3

Sumoylation3

Subunit1

Substrates1

Modifications3

Regulate1

Chromatin structure3

Modification2

Epigenetic2

Promoter3

MRNA2

Retinoblastoma protein1

Chromosomal2

Cofactor1

Transient1

Acetylates1

Genomic5

Putative1

Pathways1

Drosophila1

Activator2

Mechanism2

Gene Expression1

Pathway2

Assays2

Mammalian2

Functionally1

Polycomb1

Genes2

Regulation3

Steroid2

Function3