Co stimulatory antigens cd86. Medical search. Frequent questions

This study assessed the value of morphological grading and the expression of the co-stimulatory markers CD40, CD80 and CD86 and their ligands to predict clinical outcome in 23 consecutive low-grade MALT lymphoma patients treated with H. pylori eradication. (nih.gov)
CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. (biolegend.com)
In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. (biolegend.com)
In LPS assay at 120 min CD80 and CD86 colocalized with neutrophil elastase (NE) in NETs. (annexpublishers.co)
A higher number of MLRs was formed in samples with presence of CD80 and CD86 in NETs. (annexpublishers.co)
The presence of CD80 and CD86 in NETs could influence the cell environment through the B7-1/B7-2:CD28/CTLA-4 pathway. (annexpublishers.co)
This is the first communication of CD80 and CD86 costimulatory molecules in NETs. (annexpublishers.co)
Both express co‐stimulatory molecules such as CD80 and CD86, which belong to the B7 family. (fdxbhc.com)
T cell activation leads to increased expression of CTLA-4 an inhibitory receptor which binds to CD80 and CD86 on APCs. (scienceexhibitions.org)
CTLA-4 depletes CD80 and CD86 ligands of neighboring APCs through trans-endocytosis to impair the CD28-CD80/CD86 stimulation so as to down regulate the T-cell immune response (Qureshi et al. (scienceexhibitions.org)
It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. (neobiotechnologies.com)
The CD40L-activated B cells may be continually expanded and the B cells significantly up-regulate the expression of major histocompatibility complex (MHC) class I and class II and induce the expression of CD80 and CD86. (biomedcentral.com)
CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. (hostforstudent.com)
CTLA-4 is related to the T cell co-stimulatory receptor CD28, and acts to suppress T cell function by competing with CD28 for binding to CD80 and CD86 on antigen presenting cells and recruiting inhibitory molecules into the TCR signaling synapse. (sanguinebio.com)
To perform this function, DC are capable of capturing antigens, processing them, and presenting them on the cell surface complexed to major histocompatibility (MHC) molecules, for example, human leukocyte antigen- (HLA-) DR. Along with that, context-dependent expression of costimulatory molecules, such as CD80 and CD86, and secretion of cytokines occurs. (hindawi.com)
However, TIGIT exerts its functions not only by direct cell-intrinsic inhibitory signaling, but like CTLA4 which blocks binding of its co-stimulatory counterpart CD28 to their shared ligands CD80 and CD86, also in an indirect way. (greatlakeshighereducationnow.com)

When they encounter foreign pathogens, the antigen presenting cells activate the T cells-"the soldiers of the immune system"- by delivering stimulatory signals that alert there is foreign material in the body with specific cell surface molecules (epitopes). (wikipedia.org)
T cells need another signal to become activated in addition to Signal 1, this is done by co-stimulatory molecules such as the proteins CD80 (B7.1) or CD86 (B7.2), although other additional co-stimulation molecules have been identified. (wikipedia.org)
Cell-based aAPCs have been produced by transfecting murine fibroblasts to express specific peptide-loaded HLA molecules with co-stimulatory signal B7.1, and cell adhesion molecules ICAM-1 and LFA-3. (wikipedia.org)
While IL-2 or other soluble molecules can be progressively released from within the aAPC, immunomodulatory substances (recognition and co-stimulatory ligands) can be attached to the surface of polymeric particles. (wikipedia.org)
Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4 + T cells. (frontiersin.org)
The adipocyte was reported as an antigen-presenting cell (APC) which expresses CD1d and MHC class I and II molecules. (frontiersin.org)
In our recent research, we observed that adipocytes express MHC class II molecules and co-stimulatory molecules CD80/CD86, and that their expression significantly increases in response to high fat diet (HFD) challenges ( 8 ). (frontiersin.org)
a1) T cells can also interact with, and be activated by, DCs presenting via MHC/HLA a specific antigen matching the T-cell receptor, and accompanied by co-stimulatory (CD80/CD86 DCs, and CD28 T cells) and adhesive molecules (ICAM-1/LFA-3 DCs, and LFA-1/CD2 T cells). (weizmann.ac.il)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
Function of T helper cells: Antigen presenting cells ( APCs ) present antigen on their Class II MHC molecules ( MHC2 ). (wikidoc.org)
Polymorphonuclear neutrophils (PMNs) activated in vitro may express molecules normally associated with antigen presenting cells (APCs). (annexpublishers.co)
We marked of B7-1(CD80) and B7-2(CD86) costimulatory molecules. (annexpublishers.co)
PMNs activated in vitro may express molecules normally associated with antigen presenting cells required for T cell activation. (annexpublishers.co)
B7 molecules (B7-1/CD80 and B7-2/CD86) are integral membrane glycoproteins that are expressed on the surface of APCs. (annexpublishers.co)
The second involves a network of co-inhibitory and co-stimulatory molecules pathways such as CD80/CD86-CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4), inducible co-stimulator (ICOS)-ICOS ligand (ICOSL), programmed death-1 (PD-1), programme death ligand-1/2 (PD-L1/PD-L2), 4-1BB-4-1BB ligand (4-1BBL), CD40-CD154 ligand, OX40-OX40 ligand and CD27-CD70. (biomedcentral.com)
CD80(B7-1) and CD86(B7-2) co-stimulatory molecules have been reported to activate Th1/Th2 development pathways differentially. (keyopinionleaders.com)
It is well known that Langerhans cells (LC), potent antigen-presenting dendritic cells in the epidermis, express several co-stimulatory molecules and that this expression is modulated by several cytokines. (keyopinionleaders.com)
During this process, LC become mature DC with augmented expression of various co-stimulatory molecules and MHC class II antigens. (keyopinionleaders.com)
This finding shows that these immunological checkpoint molecules have a role in fine‐tuning the T‐cell response by mediating stimulatory and inhibitory signals. (fdxbhc.com)
The endocytic capacity and the expression of surface expression of mannose receptor C-type 1-like B, MHC-II, myeloid markers CD11c, DEC205, and co-stimulatory molecules CD40, CD80, CD86 by MoDCs at different maturation states are assessed by flow cytometry. (re-place.be)
Like conventional antigens/haptens, superantigens stimulate antigen-presenting dendritic cells by increasing the expression of HLA-DR antigen and co-stimulatory molecules (CD54, CD83, and CD86) as well as the generation of tumour necrosis factor (TNF) -α. (microbiologynote.com)
In spite of interacting with MHC class II molecules outside the antigen-binding groove, they are nevertheless able to induce a fruitful contact with T cells. (microbiologynote.com)
The expression of CD80, CD86, major histocompatibility complex (MHC) classes I and II molecules on the sCD40L-activated B cell was significantly increased after long-time culture. (biomedcentral.com)
Whereas cells of the innate immune system can directly sense non self molecules using their panoply of PRRs, the T‐lymphocytes of the adaptive immune system need to have antigen "presented" to them in a special format. (pediagenosis.com)
RESULTS: Less than half the cells in the mixture expressed DC co-stimulatory molecules. (ox.ac.uk)
Using tumor cells constitutively expressing a cytomegalovirus (CMV) antigen, we show that expansion of CMV-specific cytotoxic T lymphocytes (CTLs) restricted by DCs' MHC class I molecules was higher when DC-tumor hybrids were the stimulators. (ox.ac.uk)
Hybrids expressed more co-stimulatory and MHC molecules, induced higher antigen-specific T-cell expansion and were the only cells able to induce IFN-γ-producing antigen-specific T cells. (ox.ac.uk)
However, tumor cells can evade host's immune surveillance using a number of protective mechanisms, including downregulation of MHC-I molecules, secretion of anti-inflammatory cytokines, in other words, TGF-β and IL-10, secretion of immunosuppressive factors, VEGF, upregulation of PD-L1 and downregulation of co-stimulatory molecules thereby preventing activation of T cells, resulting in cancer invasion. (studylib.net)

Modeled after APCs, aAPCs need to have at least two signals to stimulate antigen specific T cells. (wikipedia.org)
Even in the absence of T cells, natural APCs have been found to precluster antigens. (wikipedia.org)
The lymphatic vessels and secondary lymphoid organs (SLOs) are arranged in a manner that optimizes interactions among antigens, APCs, and innate and adaptive effector cells. (jci.org)
Class II MHC proteins are generally only found on the surface of professional antigen-presenting cells (APCs). (wikidoc.org)
Some APCs also bind native (or unprocessed) antigens to their surface, such as follicular dendritic cells , but unprocessed antigens do not interact with T cells and are not involved in their activation. (wikidoc.org)
During an immune response, professional antigen-presenting cells (APCs) endocytose (absorb) foreign material (typically bacteria or viruses ), which undergoes processing , then travel from the infection site to the lymph nodes . (wikidoc.org)
The first signal confers specificity to the immune response and plays an essential role in rec‐ognizing antigen presentation by MHC‐II on the surface of APCs. (fdxbhc.com)
All pets succumbed to tumors and the ones treated using the monovalent non-depletion of porcine antigen showing cells (APCs) for research looking Xanthiazone into the induction of transplantation tolerance autoimmune disease and tumor treatment. (scienceexhibitions.org)
We aimed to clarify whether soluble CD40 ligand (sCD40L) activated B cells may be loaded with HBcAg18-27 peptide and served as antigen-producing cells (APCs) to induce HBV-specific cytolytic T lymphocytes (CTLs). (biomedcentral.com)
Efficient antigen presentation by antigen presenting cells (APCs) is critical for inducing T-cell mediated immunity in vivo [ 1 , 2 ]. (biomedcentral.com)
APCs, antigen-presenting cells. (greatlakeshighereducationnow.com)
[ 11 ] Immature dendritic cells respond to GM-CSF (not to macrophage colony-stimulating factor [M-CSF]) and become committed to generating dendritic cells, which are "professional" antigen-presenting cells (APCs). (medscape.com)

CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. (biolegend.com)
La interacción de CD86 con el ANTÍGENO CD28 proporciona una señal coestimuladora a los LINFOCITOS T, mientras que la interacción con el ANTÍGENO CTLA-4 puede desempeñar un papel en la inducción de la TOLERANCIA PERIFÉRICA. (bvsalud.org)
It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. (bvsalud.org)
The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE. (bvsalud.org)
CD28 (Antigen CD28) is characterized as a co-receptor for the TCR (T-Cell Receptor)/CD3 (CD3 Antigen) complex and is responsible for providing the co-stimulatory signal required for T-cell activation. (proteinlounge.com)
Priming of naive T-cells in lymphoid organs depends on the interaction between CD28, which is constitutively expressed in T-cells, and both CD80 (CD80 Antigen) and CD86 (CD86 Antigen) and induces subsequent IL-2 (I. (proteinlounge.com)
CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. (mytaq.net)
Costimulatory interaction (i.e., second signal) is between CD80(B7.1)/CD86(B7.2) on the dendritic cell, and CD28 on the T cells. (medscape.com)

This is the molecule which is loaded with the specific antigen. (wikipedia.org)
Despite lower co-stimulatory molecule expression, ProGP-4-generated Class II+/CD11c+ cells stimulated proliferation of allogeneic T cells and an antigen-specific T cell hybridoma as efficiently as bone marrow derived dendritic cells from untreated mice. (medscimonit.com)
Cytotoxic T-Lymphocyte Antigen-4 Xanthiazone (CTLA-4) also called CD152 can be an essential co-stimulatory molecule which acts as a poor regulator for T cell proliferation and differentiation. (scienceexhibitions.org)
George-Chandy A., Eriksson K., Lebens M., Nordstrom I., Schon E., Holmgren J. Cholera toxin B subunit as a carrier molecule promotes antigen presentation and will increase CD40 and CD86 expression on antigen-presenting cells. (laaz.org)
It has been found that the differentiation of myeloid progenitor cells and monocytes into immature dendritic cells was accompanied with the loss of CD14 antigen , minimization of expression rate of co-stimulatory molecule CD86 and appearance of CD11b-antigen marker, which is the feature of these cells. (kiev.ua)

CD11c+ cells from ProGP-4 treated mice co-expressed DEC205 and also expressed CD80, CD86 and CD40, albeit at lower levels as compared to Class II+/CD11c+ cells from untreated animals. (medscimonit.com)

Signal 3 is the aAPC secretion of stimulatory cytokines such as IL-2 which enhances T cell stimulation, though this is not required for T cell activation. (wikipedia.org)
LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. (jci.org)
The activation of a resting helper T cell causes it to release cytokines and other stimulatory signals (green arrows) that stimulate the activity of macrophages , killer T cells and B cells , the latter producing antibodies . (wikidoc.org)
Further, the mucosal administration of CTB conjugated to autoantigens was shown to mediate synthesis of T cell cytokines in response to the antigen or autoantigen complicated. (laaz.org)

The first signal is the major histocompatibility complex (MHC), which in humans is also called the human leukocyte antigen (HLA). (wikipedia.org)

Conversely, nearly all CD11c(+)Her2/neu(+) hybrids expressed CD80, CD86, CD83, HLA-DR and MHC class I from both tumor cells and DCs. (ox.ac.uk)

Different from pre-cDCs, tDCs have less turnover, capture antigen, respond to stimuli and activate antigen-specific naive T cells, all characteristics of differentiated DCs. (stanford.edu)
[ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)

Programmed cell death 1 (PD‐1) and its ligands PD‐L1 and PD‐L2 are receptors that act in co‐stimulatory and coinhibitory immune responses. (fdxbhc.com)

Thus differential affinities of IgG subclasses to functionally different Fcg receptors are thought to mediate the variation in clinical effectiveness of different antibodies targeting the same antigen. (sanguinebio.com)
T‐cells inspect antigen presented on DCs using their membrane‐borne T‐cell receptors (TCRs), which are specialized for the recognition of peptide-MHC complexes. (pediagenosis.com)

Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)

This function, called antigen presentation , is carried out largely, but not exclusively, by a cell that has relatively recently come to the fore as being of critical importance as a conduit between the innate and adaptive immune systems: the dendritic cell (DC). (pediagenosis.com)

It showed how the lipid membrane functions as a support structure for antigen presentation. (wikipedia.org)
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. (wikidoc.org)
They are exceptionally efficient at antigen presentation and also adept at generating just the right type of T cells in response to a given pathogen. (aacrjournals.org)
However, unlike the macrophage, DCs do not stand and fight upon PRR engagement but rather take flight to the nearest lymph node (which acts as a kind of army barracks for lymphocytes) to carry out a special function, called antigen presentation , which awakens cells of the adaptive immune system (Figure 1.44 and Figure 1.45). (pediagenosis.com)
Antigen presentation by the DC is achieved via a membrane complex called the major histocompatibility complex (MHC), which was originally discovered for its role in graft rejection (hence the unwieldy name). (pediagenosis.com)

Description: CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. (mytaq.net)

The importance of dendritic cells in presenting antigens to T and B lymphocytes is increasingly recognized. (medscape.com)

It is the specific antigen or epitope that is loaded into the MHC determines the antigen-specificity. (wikipedia.org)
In the synthetic niche, interactions with the functionalized scaffold are expected to provide the signals needed for T-cell activation (with or without antigen specificity), lineage selection, proliferation, and survival. (weizmann.ac.il)
The vast number of activated T-cells produces a massive immunological response that is not specific to any one epitope on the SAg, so undermining one of the key advantages of the adaptive immune system, namely its capacity to target antigens with great specificity. (microbiologynote.com)

This is achieved by calling upon cells of the adaptive immune system and instructing these cells in the nature of the particular antigens that are giving cause for concern. (pediagenosis.com)

DCs comprise a family of antigen presenting cells that act like 'conductors' of the immune response in their capacity to orchestrate signals derived from the different parts of the immune system [ 2 ]. (biomedcentral.com)

The function of the adaptive immune system is to recognize, remember and destroy invading pathogens through their antigens, and relieve pathogen-associated toxicities. (frontiersin.org)
The adaptive immune system, discovered by Paul Ehrlich, involves the production of circulating antibodies that can provide long lasting, systemic immunity that is specific to antigens expressed by a given pathogen. (aacrjournals.org)
The CTLA-4/Compact disc28-CD80/CD86 pathway is a critical co-stimulatory pathway for adaptive immune responses. (scienceexhibitions.org)

Superantigens (SAgs) are a type of antigens that stimulate the immune system excessively. (microbiologynote.com)

Artificial antigen presenting cells (aAPCs) are engineered platforms for T-cell activation. (wikipedia.org)
Following T cell development , matured, naïve (meaning they have never been exposed to the antigen to which they can respond) T cells leave the thymus and begin to spread throughout the body, including the lymph nodes . (wikidoc.org)
The T cell receptor (TcR) consists of both constant and variable regions, the latter of which determines what antigen the T cell can respond to. (wikidoc.org)
Professional antigen presenting cells are primarily dendritic cells , macrophages and B cells , although dendritic cells are the only cell group that expresses MHC Class II constitutively (at all times). (wikidoc.org)
In a normal antigen-induced T-cell response, 0.0001-0.001% of the body's T-cells are activated, but these SAgs can activate up to 20% of the body's T-cells. (microbiologynote.com)
Antigen-specific CD40L-activated B cells may efficiently endocytose and present antigens, such as protein, RNA, and cDNA, to prime primary T cells and boost robust memory T-cell responses [ 9 ]. (biomedcentral.com)
In addition, during sepsis caused by gram-negative bacteria antigen showing cell (APC) function may be lost16,17 due to launch of soluble mediators. (ebat2018.org)
Typically this involves protein antigens becoming internalized and broken down into small peptide fragments by an antigen‐presenting cell (APC), such as a DC. (pediagenosis.com)
Dendritic cells (DCs) can take up an array of different antigens, including microorganisms which they can process and present more effectively than any other antigen presenting cell. (biomedcentral.com)
The ability of tolDC to present antigens is clearly critical to the success of tolDC therapy, because the main goal of tolDC therapy is to induce T cell tolerance to relevant autoantigens. (jak-inhibitors.com)
Cell phenotype was evaluated by flow cytometry and antigen-presenting ability by co-culture with syngeneic T cells followed by tetramer analysis and interferon (IFN)-γ ELISPOT. (ox.ac.uk)
Interestingly, the number of CD80 + pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens. (hindawi.com)
Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)

After antigen uptake, DC rapidly migrate to the draining secondary lymphoid organ. (biomedcentral.com)
LPS) during antigen uptake [82, 84]. (jak-inhibitors.com)

The antigens that bind to MHC proteins are always short peptides , 8-10 amino acids long for MHC Class I, and up to 25 or so for MHC Class II. (wikidoc.org)
Once at the lymph nodes, the APC begins to present antigen peptides that are bound to Class II MHC, allowing CD4 + T cells that express specific TcR's against the peptide/MHC complex to activate. (wikidoc.org)
Dendritic cells (DCs), activated macrophages, and activated B cells are all capable of presenting antigen peptides. (biomedcentral.com)

DC are professional antigen-presenting cells with the unique capacity to polarize the differentiation of T cells, thereby regulating the balance between inflammation and tolerance [ 12 ]. (hindawi.com)

CD86 exhibits constitutive expression on resting monocytes, macrophages and dendritic cells. (annexpublishers.co)
Expression of IFN-γ- and IFN-α-responsive genes in pre-symptomatic Npc1 −/− /App −/− cerebella is upregulated compared with Npc1 −/− /App +/+ mice, compounding the dysregulation of microglial activation, anti-viral response, activation of antigen-presenting cells, and T-lymphocyte activation and chemotaxis pathways present in the NPC brain. (biomedcentral.com)

Importantly, DCs also help guide the immune system to respond to foreign antigens while avoiding the generation of autoimmune responses to self. (aacrjournals.org)

When Signal 2 is not expressed, but T cells receive Signal 1, the antigen-specific T cells become anergic and do not perform effector function. (wikipedia.org)
For full efficacy, T cells need a second,non‐specific co‐stimulatory signal. (fdxbhc.com)

Adipocytes can directly activate CD4 + T cells through antigen:MHCII complex in a contact-dependent manner. (frontiersin.org)

Spleens from ProGP treated mice were evaluated by immunocytochemistry and enriched CD11c+ populations were functionally assessed in a mixed lymphocyte assay and in an antigen dependent CTL assay. (medscimonit.com)

In that regard, neuroinflammation occurs early in the disease and we have recently unveiled an atypical pattern of interferon signaling in pre-symptomatic Npc1 −/− mice, with microglial activation, anti-viral response, activation of antigen-presenting cells, and activation and chemotaxis of T lymphocytes as the key affected pathologic pathways. (biomedcentral.com)

Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)

TCRs can recognize fragments of antigen attached to MHC on the surface of an APC. (medscape.com)

Following antigen-induced maturation (e.g. (re-place.be)

Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
The purpose of the present development is to use avian MoDCs to implement a cellular platform to increase understanding of the immune responses induced by various antigens of interest (e.g. vaccine candidates) and evaluate their immunogenic potential. (re-place.be)
However, little is known whether CD40L-activated B cells may present HBV antigen to T cells. (biomedcentral.com)

In addition, TIGIT can prevent co-stimulatory signaling CD226 by blocking CD226 homo-dimerization (52). (greatlakeshighereducationnow.com)

Anatomy18

Organisms5

Diseases2

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes19

Disciplines and Occupations1

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Health Care1

CD80 and CD8616

Molecules28

APCs12

CD288

Molecule5

CD401

Cytokines4

Human leukocy1

CD831

Capture antigen2

Ligands1

Receptors2

Specialized antigen-prese1

Dendritic cell1

Presentation7

Cytotoxic1

Importance of dendritic cells1

Specificity3

Cells of the adaptive immune1

Signals1

Adaptive3

Stimulate1

Cell13

Uptake2

Peptides3

Differentiation1

Expression2

Immune system1

Signal2

Activate1

Lymphocyte1

Lymphocytes1

Lipid1

Fragments1

Maturation1

Present3

Signaling1