Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. (medscape.com)
The glomerulopathies associated with monoclonal light chains are Light Chain Deposition Disease (LCDD) and AL (light chainrelated) amyloidosis, each creating completely different alterations in the mesangium. (heraldopenaccess.us)
Lymphoproliferative1
Primary cold agglutinin disease is characterized by a clonal lymphoproliferative disorder. (medscape.com)
Regulate2
The VH genes appear to regulate not only the production of cold agglutinins, but also the formation of normal antibodies to other carbohydrate antigens, both sharing the same fundamental mechanism of production. (medscape.com)
The glomerulopathic light chains interact with mesangial cells where purported receptors regulate the downstream cellular mechanisms that will be activated and result in glomerular alterations. (heraldopenaccess.us)
Cells4
High CD8 expression precedes the dual expression of CD4 and CD8 but following clonal selection and expansion, avian T cells cease to express either CD4 or CD8. (wikipedia.org)
Thus, in disease states, the finding of a clone of B cells producing this antibody may be the result of expansion of a normal clone that is specific for the production of an immunoglobulin with these properties. (medscape.com)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Results1
Different light chains are responsible for two diseases with diametrically opposite mesangial alterations: Light chain deposition disease which results in the expansion of the mesangium due to accumulation of matrix proteins not present in the normal mesangium and AL (light chain-associated) amyloidosis where the native mesangial matrix is replaced by fibrils (amyloid). (heraldopenaccess.us)
Normal2
Normal light chains are small molecular weight proteins that are filtered through the peripheral capillary walls and are delivered to the proximal tubules where they are catabolized by endosomal activity in the apical portions of the tubules and their amino acids are then returned to the circulation. (heraldopenaccess.us)
Normal and tubulopathic light chains do not interact with the mesangium thus mesangial homeostasis is maintained intact. (heraldopenaccess.us)
Expression1
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
Function2
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
These regulators include canonical genes that control lipid metabolism as well as genes involved in ubiquitination, transcription, and mitochondrial function. (stanford.edu)
Cold1
[ 1 ] Donath-Landsteiner hemolytic anemia is also caused by a cold-reacting immunoglobulin, but most cases are due to polyclonal IgG. (medscape.com)
Antibody molecule2
The CDRs of a heavy chain together with the CDRs of the associated light chain essentially constitute the antigen binding site of the antibody molecule. (allindianpatents.com)
Because CLL is clonal, all the leukemic cells make the same antibody molecule. (rochester.edu)
Heavy-chain2
Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody. (medscape.com)
Both heavy and light chains comprise a variable domain and a constant part An antigen binding site consists of the variable domain of a heavy chain associated with the variable domain of a light chain. (allindianpatents.com)
Regions1
More particularly, the antigen binding characteristics of an antibody are essentially determined by 3 specific regions in the variable domain of the heavy and light chains which are called hypervariable regions or complementarity determining regions (CDRs). (allindianpatents.com)
Variable1
The variable domains of the heavy and light chains have the same general structure. (allindianpatents.com)
HN - 2008 MH - Acetogenins UI - D054378 MN - D2.33.415.54 MN - D2.455.326.146.49 MN - D2.540.205 MN - D3.383.312.200 MN - D10.289.54 MS - Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. (nih.gov)