• CONTEXT: Bladder urothelial carcinoma (BUC) and upper tract urothelial carcinoma (UTUC) have genetic differences, which may influence therapy. (wustl.edu)
  • PATIENT SUMMARY: Urothelial carcinoma of the bladder has distinct genomic features, which are different from distinct genomic features of urothelial carcinoma of the renal pelvis and/or ureter. (wustl.edu)
  • Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the first and second most common types of skin cancer, respectively. (medscape.com)
  • Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in the United States. (medscape.com)
  • A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm to rule out basal cell carcinoma and other dermal lesions. (medscape.com)
  • The group has described the genomic landscape of head & neck squamous cell carcinoma, esophageal cancer and medullary thyroid cancer, and has developed assays using tumor DNA as a biomarker in saliva and plasma. (uchicago.edu)
  • The Impact of Tonsillectomy upon the Risk of Oropharyngeal Carcinoma Diagnosis and Prognosis in the Danish Cancer Registry. (uchicago.edu)
  • Cetuximab every 2 weeks (Q2W) dosing schedule is approved by the US FDA and by the Japanese Pharmaceuticals and Medical Devices Agency in patients with metastatic colorectal cancer and squamous cell carcinoma of the head and neck. (bvsalud.org)
  • Among the adult population, renal cell carcinoma (RCC) constitutes the most prevalent form of kidney neoplasm. (biomedcentral.com)
  • Among malignant neoplasms of the penis, squamous cell carcinoma (SCC) is the most common. (medscape.com)
  • Prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients. (jsco-cpg.jp)
  • Comparing the joint effect of arsenic exposure, cigarette smoking and risk genotypes of vascular endothelial growth factor on upper urinary tract urothelial carcinoma and bladder cancer. (jsco-cpg.jp)
  • Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma. (jsco-cpg.jp)
  • As their name suggests, PUNLMPs are neoplasms, i.e. clonal cellular proliferations, that are thought to have a low probability of developing into urothelial cancer, i.e. a malignancy such as bladder cancer. (wikipedia.org)
  • Bladder cancers are a leading cause of death from malignancy. (ox.ac.uk)
  • Any cancer/malignancy (either a "solid tumor" or a leukemia/lymphoma/bone marrow malignancy/"liquid tumor", i.e. any ICD10 code from C00-C99) can be a comorbid diagnosis --- BUT it's vital to distinguish malignancies in this category based on whether they are believed to be cured or not. (kuality.ca)
  • A type of clonal malignancy characterized by excess accumulation of lymphoblasts that phenotypically resemble the early stages of normal B-cell differentiation. (lab-ally.com)
  • Emerging evidence indicates that tumor heterogeneity may play an important role in cancer progression, resistance to therapy, and metastasis. (johnshopkins.edu)
  • Cigarette smoking and cancers of the renal pelvis and ureter. (jsco-cpg.jp)
  • Molecular genetics and immunopathologic analysis of bladder cancer have shown some abnormalities in a number of genes and proteins that have been implicated in the development and progression of such tumors, mainly in the p53 pathway. (ijpmonline.org)
  • Dr. Agrawal's lab is devoted to the study of the genetics and molecular diagnostics of head and neck cancer. (uchicago.edu)
  • En mayo de 2007 obtuve el Certificate of Training in Molecular Biological Techniques en el Department of Molecular Biology y desde Junio de 2008 a Junio de 2009 completé el Certificate in Clinical Research en el Center for Translational Science Activities en Mayo Clinic College of Medicine, Rochester Minnesota. (unav.edu)
  • 14 j Habuchi T. Origin of multifocal carcinomas of the bladder and upper urinary tract: molecular analysis and clinical implications. (jsco-cpg.jp)
  • Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an exophytic (outward growing), (microscopically) nipple-shaped (or papillary) pre-malignant growth of the lining of the upper genitourinary tract (the urothelium), which includes the renal pelvis, ureters, urinary bladder and part of the urethra. (wikipedia.org)
  • A type of hyperplasia that is characterized by variable thickening of the urinary tract epithelium and a slight papillary growth. (nih.gov)
  • Papillary urothelial hyperplasia: relationship to urothelial neoplasms. (nih.gov)
  • A precursor to papillary neoplasms. (nih.gov)
  • Phenacetin and papillary necrosis: independent risk factors for renal pelvic cancer. (jsco-cpg.jp)
  • Muscle-invasive bladder cancer (MIBC), a highly heterogeneous disease, shows genomic instability and a high mutation rate. (johnshopkins.edu)
  • Urodrill - a novel MRI-guided endoscopic biopsy technique to sample and molecularly classify muscle-invasive bladder cancer without fractionating the specimen during transurethral resection. (lu.se)
  • Genomic characterization of time-series analyses at the single cell level, and of cell-free circulating tumor DNA or circulating tumor cells, are emerging technologies that enable dissection of the complex clonal architecture of MIBC. (johnshopkins.edu)
  • This study aimed to explore the genomic and transcriptomic landscape of bladder cancer (BC) and its implication for treatment with an immune checkpoint inhibitor (ICI). (e-crt.org)
  • A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. (lookformedical.com)
  • Central extension, with compression of the prostatic urethra, and local invasion into the bladder, rectum, and seminal vesicle may occur. (medscape.com)
  • narrow, flexible rubber, latex, or silastic tube that is inserted or passed through the urethra or lower abdomen and into the bladder for the purpose of draining urine or performing diagnostic tests of bladder or urethral function. (womenshealthsection.com)
  • Urothelial bladder cancer (BC) represents a highly heterogeneous disease with regard to natural history, ranging from non-muscle invasive BC (NMIBC), which represents 75% of primary diagnoses and is characterized by frequent recurrence but a low risk of mortality, to muscle invasive BC (MIBC), which requires platinum-based chemotherapy followed by radical surgery, to metastatic disease [ 1 ]. (e-crt.org)
  • Urothelial Proliferation of Unknown Malignant Potential Involving the Bladder: Histopathologic Features and Risk of Progression in De Novo Cases and Cases With Prior Neoplasia. (nih.gov)
  • Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer. (uchicago.edu)
  • Deletion of Atg16l1 in engineered murine colon cancer organoids inhibits tumor growth in primary (colon) and metastatic (liver and lung) niches in syngeneic female hosts, primarily due to increased sensitivity to IFN-γ-mediated immune pressure. (bvsalud.org)
  • 5 j Pommer W, Bronder E, Klimpel A, Helmert U, Greiser E, Molzahn M. Urothelial cancer at different tumour sites: role of smoking and habitual intake of analgesics and laxatives. (jsco-cpg.jp)
  • Results of the Berlin Urothelial Cancer Study. (jsco-cpg.jp)
  • Aristolochic acid-associated urothelial cancer in Taiwan. (jsco-cpg.jp)
  • CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
  • Here we use whole-genome sequencing to identify somatic mutations and chromosomal changes in 14 bladder cancers of different grades and stages. (ox.ac.uk)
  • We find strong positive associations between higher tumour stage/grade and greater clonal diversity, the number of somatic mutations and the burden of copy number changes. (ox.ac.uk)
  • CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. (biomedcentral.com)
  • Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract. (jsco-cpg.jp)
  • Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. (uchicago.edu)
  • STMN1 expression was associated with shorter progression-free survival and overall survival for all analyzed uterine cancer cases (Davidson and Micci 2017 ). (biomedcentral.com)
  • Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer. (uchicago.edu)
  • Cancer Epidemiol Biomarkers Prev. (jsco-cpg.jp)
  • Tumour-like lesions of the urinary bladder. (nih.gov)
  • BCC is a type of skin cancer that creates lesions and uncontrolled growth in the basal cells of the epidermis. (lab-ally.com)
  • The American Cancer Society predicts that there will be about 54,000 new cases of kidney cancer in the United States in 2008, and about 13,010 people will die from this disease http://www.cancer.org . (biomedcentral.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
  • If it's still present (or believed to be present), then just include the code for the specific cancer as a comorbid diagnosis. (kuality.ca)
  • A fast-growing cancer of the antibody-producing lymphocytes. (lab-ally.com)
  • This disease is characterized by a greater presence of immature lymphocytes (lymphoblasts) than normally needed in the blood and bone marrow, and is the most common of pediatric cancers. (lab-ally.com)
  • Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden. (ox.ac.uk)
  • As well as detecting the known bladder cancer driver mutations, we report the identification of recurrent protein-inactivating mutations in CDKN1A and FAT1. (ox.ac.uk)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • In a study of the US Medicare population, the treatment of nonmelanoma skin cancers ranked fifth among the most expensive cancers to treat in the head-and-neck region. (medscape.com)
  • His lab's research is focused on the application of cancer genetics to design diagnostic approaches to reduce morbidity and mortality from head and neck cancer. (uchicago.edu)
  • Lessons learned from next-generation sequencing in head and neck cancer. (uchicago.edu)
  • Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay. (uchicago.edu)
  • Activation of the NOTCH pathway in head and neck cancer. (uchicago.edu)
  • Use of fibrin sealant in closing mucocutaneous fistulas following head and neck cancer surgery. (uchicago.edu)
  • The use of ultrasound in the search for the primary site of unknown primary head and neck squamous cell cancers. (uchicago.edu)
  • External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society. (uchicago.edu)
  • Assessment of the Predictive Value of the Modified Frailty Index for Clavien-Dindo Grade IV Critical Care Complications in Major Head and Neck Cancer Operations. (uchicago.edu)
  • Cetuximab is a drug for patients with colorectal cancer or cancer of the head and neck. (bvsalud.org)
  • Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. (lookformedical.com)
  • These differences likely contribute to the behavior of these two cancers and imply that they and their metachronous recurrences should be treated as two related yet distinct entities. (wustl.edu)
  • Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. (bvsalud.org)
  • Increasing evidence suggested that CD73 highly expressed in a wide range of cancer types, including breast cancer, colorectal cancer, glioblastoma, melanoma, prostate cancer, ovarian cancer, and non-small-cell lung cancer (NSCLC). (biomedcentral.com)
  • A drug or substance used alongside a primary therapy during cancer therapy. (lab-ally.com)
  • Radiation therapy used after primary treatment for the prevention of a cancer relapse. (lab-ally.com)
  • As expected, the unfaltering developed a momentous urinary infection, for the treatment of which antibi- otic therapy was started. (mein-schoenefeld.info)
  • Is There a Statute of Limitations for Talcum Powder and Uterine Cancer, Ovarian Cancer, or Mesothelioma Lawsuits. (barcelona-girona-airport.com)
  • Clonal studies indicate that BUC after UTUC is also likely luminal, while UTUC after BUC is often basal. (wustl.edu)
  • Cancer stem cells (CSCs) represent a distinct group of cells within cancerous tissue that possess the ability to initiate tumorigenesis and exhibit potency, self-renewal, and drug resistance. (bmrat.org)
  • CD73 expression level in distinct cancers and its relationship with clinicopathlogical characteristics and prognosis were investigated using online database. (biomedcentral.com)
  • in 25% of patients a neoplasm is detected after neurologic symptoms onset (most common being ovarian teratoma). (medlink.com)
  • There are several types of breast cancer, and symptoms usually include a lump found in breast tissue or a change to the shape or texture of the breast. (lab-ally.com)
  • A form of cancer characterized by the presence of too many immature granulocytes in the bone marrow and blood. (lab-ally.com)
  • The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
  • In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
  • While chemotherapy is generally a standalone treatment or used in conjunction with radiation following surgical resection, adjuvant chemotherapy describes the use of chemotherapy in comparison to other cancer treatments. (lab-ally.com)
  • The most commonly used prognostic model for patients with metastatic disease is based on a multivariate analysis from the Memorial Sloan Kettering Cancer Centre [ 10 ]. (biomedcentral.com)
  • Use additional code (U85) , if desired, to identify resistance, non-responsiveness and refractive properties of the neoplasm to antineoplastic drugs. (who.int)
  • SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
  • High CD73 expression was significantly associated with lymph node metastases and a promising prognostic factor in different types of cancers. (biomedcentral.com)