• Morphologically, GISTs vary from cellular spindle cell tumors (70% - 80%) to epithelioid (20% - 30%) or mixed. (scirp.org)
  • These tumors are usually more than 5 cm in their greatest dimension, but a uterine mass of any size that has features different from the usual whorled, white, cut surface of a leiomyoma should be sampled. (medscape.com)
  • There were 49 cases of smooth muscle tumors: 27 leiomyomas and 22 leiomyosarcomas. (bvsalud.org)
  • Nine thousand seven hundred and seventy histopathologic exams were accomplished during this period and only 64 (0,092%) were diagnosed as smooth muscle tumors, that corresponded to 49 cases, being 27 (55%) leiomyomas e 22 (45%) leiomyossarcomas. (bvsalud.org)
  • The aim of this study was to evaluate the prognostic factors of recurrence in uterine tumors resembling ovarian sex-cord tumors (UTROSCT) and to determine clinical-pathological characteristics, treatment options and outcome. (turkjpath.org)
  • It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)
  • Case Report: We reported a case of 55-year-old post menopausal woman who presented to us as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
  • Our case was also presented as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
  • Histopathology report showed the retroperitoneal mass to be a malignant epithelioid gastrointestinal tumor. (scirp.org)
  • In appearance, leiomyosarcomas of the uterus have features that range from those similar to leiomyoma (rare) to overtly malignant, gross features similar to those of high-grade sarcomas that may occur anywhere in the body, with infiltrative edges, necrosis, hemorrhage, and a variegated cut surface. (medscape.com)
  • There are rare AMLs of epithelioid type that can exhibit malignant behavior. (pediagenosis.com)
  • Uterine leiomyoma must be differentiated from other diseases that cause uterine mass, such as: uterine adenomyoma , pregnancy , hematometra , uterine sarcoma , uterine carcinosarcoma, and metastasis . (wikidoc.org)
  • Common risk factors in the development of uterine leiomyoma include African-American race, early menarche , prenatal exposure to diethylstilbestrol , having one or more pregnancies extending beyond 20 weeks, obesity , significant consumption of beef and other red meats, hypertension , family history , and alcohol consumption. (wikidoc.org)
  • The mainstay of therapy for uterine leiomyoma is oral contraceptive pills , either combination pills or progestin-only , Gonadotropin-releasing hormone analogs . (wikidoc.org)
  • Surgery is also part of mainstay therapy for uterine leiomyoma. (wikidoc.org)
  • they range from benign leiomyomas to low-grade and high-grade leiomyosarcomas . (medscape.com)
  • Leiomyomas and leiomyosarcomas are believed to develop independently and are not progressive. (medscape.com)
  • In the differential diagnosis of UTROSCT, we considered ESTSCLE, low-grade endometrial stromal sarcoma, epithelioid leiomyoma, and endometrioid carcinoma with sex-cord-like elements. (turkjpath.org)
  • ESTSCLE has a tendency for recurrence and metastases, whereas UTROSCT usually shows more benign clinical behavior 3 . (turkjpath.org)
  • The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
  • Microscopic examination of the pelvic mass showed a biphasic tumor composed of epithelial and mesenchymal components, suggestive of synovial sarcoma. (ochsnerjournal.org)
  • The leiomyoma/myometrial interface is smooth and very well circumscribed (see the image below). (medscape.com)
  • The histologic distinction between atypical leiomyoma and low grade leiomyosarcoma is difficult and is based on the following criteria: number of mitosis, cellular atypia and pattern of necrosis 5,6 . (bvsalud.org)
  • On gross pathology , round, well circumscribed, non-encapsulated, solid white or tan nodules , and whorled are characteristic findings of leiomyoma. (wikidoc.org)
  • On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)
  • Limited data in the literature suggests that PM generally has a poor clinical prognosis. (bvsalud.org)
  • Leiomyomas are more frequent in Black women. (medscape.com)
  • Leiomyoma was more frequent in the fifth decade of life. (bvsalud.org)
  • On clinical examination her vitals were normal and a soft large mobile mass was felt arising from the pelvis. (scirp.org)
  • Leiomyomas are usually difficult to palpate on physical examination unless they are large. (medscape.com)
  • The aim of this retrospective study is to evaluate and compare clinical features, like gender, age, location and symptomatology of leiomyoma and leiomyosarcoma, and review the literature from 1970 to 2010, since there isn't any recent comparative article. (bvsalud.org)
  • Records of oral leiomyoma and leiomyosarcoma from Oral Pathology Department of Dental School at University of São Paulo during the period 1962-2010 were analysed. (bvsalud.org)
  • Most leiomyomas are found incidentally. (medscape.com)
  • From 27 leiomyomas, 21 (78%) were vascular type and only 6 (22%) were solid, no epithelioid was found. (bvsalud.org)
  • Microscopic evaluation showed anastomosing cords, trabeculae, nests, and tubules of epithelial-like cells found in a fibroblastic stroma (Figure 1 ). (turkjpath.org)
  • Leiomyoma is more commonly observed among patients aged 40 years and older. (wikidoc.org)
  • 15. Development of uterine Leiomyosarcoma During Follow-up After Caesarean Section in a Woman With uterine Leiomyoma. (nih.gov)
  • The histologic distinction between atypical leiomyoma and low grade leiomyosarcoma is difficult and is based on the following criteria: number of mitosis, cellular atypia and pattern of necrosis 5,6 . (bvsalud.org)
  • The aim of this retrospective study is to evaluate and compare clinical features, like gender, age, location and symptomatology of leiomyoma and leiomyosarcoma, and review the literature from 1970 to 2010, since there isn't any recent comparative article. (bvsalud.org)
  • Records of oral leiomyoma and leiomyosarcoma from Oral Pathology Department of Dental School at University of São Paulo during the period 1962-2010 were analysed. (bvsalud.org)
  • In terms of staging, 53% of GIST tumours stage as localized, 19% as regional, 23% as distant, and 5% as unstaged. (rgare.com)
  • Critical Illness Claims Issue # 1 - Is the tumour a GIST? (rgare.com)
  • Those with spindle cell GISTs have a slightly better survival rate compared to epithelioid or mixed histology GIST tumours. (rgare.com)
  • Another tyrosine kinase mutation that is occasionally seen in KIT mutation-negative GIST tumours is the platelet-derived growth factor receptor alpha (PDGFRA). (rgare.com)
  • The clinical presentation of GIST is variable but the most usual symptoms include the presence of a mass or bleeding. (biomedcentral.com)
  • The clinical presentation of GIST is erratic. (biomedcentral.com)
  • The belief that the risk of ULMS is elevated among women with a "rapidly growing" uterus or leiomyoma was proven false in a study of 1322 women admitted to two community hospitals for hysterectomy or myomectomy . (sarcomahelp.org)
  • Their clinical characteristics, histological subtypes, immunophenotypes and molecular characteristics were analyzed. (bvsalud.org)
  • For this reason, clinical data are of paramount importance and must be considered in the diagnosis. (bvsalud.org)
  • Objective: To describe the case of a patient attended for neurological involvement due to hypertrophic pachymeningitis with initial diagnosis of inflammatory myofibroblastic tumour and final diagnosis of IgG4-related disease. (bvsalud.org)
  • The patient presented for consultation with the result of an incisional biopsy that reported a proliferative lesion combining fibrous elements of fascicular or swirling arrangement with collagenized streaks with dense, lymphoplasmacytic infiltrate and some macrophages, with negative staining for ALK 1, with a diagnosis of inflammatory myofibroblastic tumour.Due to suspicion of IgG4-related disease (IgG4-RD) the biopsy was sent for review and pertinent complementary studies were requested. (bvsalud.org)