Clinical responses patient dropouts. Medical search. Frequent questions

Pharmaceutical Product Development (PPD) is refining its design capabilities for adaptive clinical trials through a licence agreement with information technology and consulting services company Tessella and Berry Consultants, a statistical consulting group specialising in the Bayesian approach to medical statistics. (pharmatimes.com)
FACTS comprises a suite of programmes with built-in facilities for simulating interim and final patient responses, patient drop-outs and patient accrual in clinical trials. (pharmatimes.com)
Additional Phase II clinical trials are underway. (wikipedia.org)
Cenicriviroc is also in two separate clinical trials for COVID-19: the ACTIV-I trial run by the National Center for Advancing Translational Sciences, where it is compared with a number of other immunomodulatory agents, and the Charité Trial of Cenicriviroc at the Charité Hospital in Berlin. (wikipedia.org)
The EU Clinical Trials Register currently displays 43694 clinical trials with a EudraCT protocol, of which 7248 are clinical trials conducted with subjects less than 18 years old. (clinicaltrialsregister.eu)
On Friday, the state government confirmed that only 73 NSW patients had been approved for cannabis-based products, not including individuals on clinical trials. (echo.net.au)
Response adaptive randomization methods that skew allocation towards the superior treatment arm in clinical trials have been shown to maintain power and maximize total expected response. (amstat.org)
While findings from clinical trials thus far suggest some efficacy for specific pharmacological treatments, conflicting reports also exist. (springer.com)
In clinical trials, phenotypic data on drug response are often longitudinal, with some patients dropping out early due to physiological or other unpredictable reasons. (psu.edu)
METHODS: We performed a cross-sectional analysis of relevant clinical trial registry databases, methodological guidelines for conducting systematic reviews, and other sources that would define or regulate clinical trials. (bvsalud.org)
CONCLUSION: The concept of "ongoing clinical trials" lacks a transparent and homogeneous definition across relevant sources. (bvsalud.org)
Objectives: Unpredictable variation in placebo response within and among clinical trials can substantially affect conclusions about the efficacy of new antipsychotic medications. (rug.nl)
Methods: Pooled PANSS data from 15 clinical trials (n=1338), which included both acute and chronic schizophrenic patients with different study periods (6, 8, 12 and 54 weeks), were used to describe the time course of PANSS using NONMEM VI. (rug.nl)
Preliminary covariate analysis indicated that females, subjects in long-term studies and chronic patients had lower probability of dropping out from trials compared to males, subjects of short-term studies and acute schizophrenic patients. (rug.nl)
Michael Lambert, a professor at Brigham Young University, summarized the results of 12 clinical trials that measured and monitored patient progress and feedback throughout the course of therapy and observed the effect of feedback on treatment outcomes. (madinamerica.com)
Previous literature has found that approximately 20-40% of patients fail to respond to treatment in clinical trials, and prospects are even worse in child or adolescent samples. (madinamerica.com)
suggest that they estimate about 85% of their patients improve or recover, an estimate that far exceeds estimates based on measured outcomes in clinical trials and routine care. (madinamerica.com)
The main aim for the future should be the careful design of clinical trials, by choosing the most clinically meaningful end-point and keeping in mind that combination of various agents may be more effective. (ersjournals.com)
Modern clinical trials span multiple sites and locations, requiring intense communication, documentation, and data management. (transperfect.com)
They delve into the challenges and opportunities of adopting decentralized clinical trials (DCTs) and explore topics such as mixed modalities for data capture, patient burden, site. (transperfect.com)
Over the past few decades, clinical trials have witnessed remarkable developments - but they are not without challenges. (transperfect.com)
Methods A systematic search of records up to March 2020 was performed on PubMed, CINAHL, Medline (Ovid), Cochrane and Embase to retrieve clinical trials that evaluated the efficacy of OPEP devices in patients with COPD. (bmj.com)
Though various authors have used varied definitions of treatment resistant schizophrenia, the most common definition of treatment resistant schizophrenia denotes patients who despite at least two adequate trials of classical neuroleptic drugs have persistent moderate to severe, positive, or disorganization, or negative symptoms together with poor social and work function over a prolonged period of time (Meltzer 1997). (priory.com)
Abstract: Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TIL) mediates objective responses in 30% to 50% of patients with metastatic melanoma according to multiple, small phase 2 trials. (tau.ac.il)
As clinical associate director of neurology at Allegheny Medical Center, Pittsburgh, he has overseen the care of several hundred patients with generalized MG, as well as participated in clinical trials. (medscape.com)
Conclusions and relevance A COS for clinical trials and other research studies involving infants receiving neonatal care in a high-income setting has been identified. (bmj.com)
This COS for neonatology will help standardise outcome selection in clinical trials and ensure these are relevant to those most affected by neonatal care. (bmj.com)

At 5 years there was no longer any significant difference for clinical and radiographic outcomes between treatment strategies applied during the first 2 years. (bmj.com)
Patients with advanced melanoma treated with nivolumab had higher and more durable responses compared with investigator's choice of chemotherapy, but these increases did not result in improved survival outcomes. (cancernetwork.com)
The primary outcome will be the response rate, determined by the Children's Depression Rating Scale-Revised (CDRS-R). Secondary outcomes include the change in scores on the Beck Depression Inventory (BDI), the Screen for Child Anxiety-Related Emotional Disorders (SCARED) and the Safe Assessment. (biomedcentral.com)
The use of nutritional ERPs may enhance short-term and long-term recovery and mitigate frailty progression while improving patient-reported outcomes. (bmj.com)
Data gathered from the PROTein to Enhance outComes of (pre)frail paTients undergoing Cardiac Surgery Study will be published in peer-reviewed journals and presented at national and international conferences. (bmj.com)
These methods assume patients that withdraw from the study have outcomes similar to those that complete the study. (amstat.org)
Clinical outcomes of a novel, family-centered partial hospitalization program for young patients with eating disorders. (medscape.com)
As confirmed by previous studies, the brief multifamily program (consisting of six sessions over a period of 1.5 months) was found to be effective in improving outcomes for caregivers (e.g., burden, depression, knowledge) and patients (e.g., preventing relapse) in the context of routine care. (frontiersin.org)
For patients, family psychoeducation has been effective in improving outcomes in schizophrenia with a better level of global functioning, medication adherence, and a reduction in the use of healthcare resources and the frequency of relapse ( 6 - 8 ). (frontiersin.org)
identified program characteristics (eg, leadership support, well-defined staff roles, use of support and maintenance sessions) associated with successful program implementation (9,11,12) and better patient weight-loss outcomes (13). (cdc.gov)
I blog about therapist variables leading to poor outcomes, aspects of the therapeutic relationship and outcomes, and psychological therapies and patient quality of life. (uottawa.ca)
This can prevent synthesis of trial results in meta-analyses, and selected outcomes may not be relevant to former patients, parents and health professionals. (bmj.com)

Methods Clinical and radiographic 5-year outcome was compared between initial strategies. (bmj.com)
Methods The INTENSE study is a multicentre, open-label, randomised, pragmatic, phase-IV clinical trial to demonstrate the non-inferiority of a 7-day vs 14-day course for the treatment of uncomplicated enterococcal bacteraemia and incorporating the early switching to oral antibiotics when feasible. (bmj.com)
This study aimed to investigate stakeholders' experiences with alternative consenting methods as well as their views on any regulatory or legal guidelines for eIC implementation in clinical research. (frontiersin.org)
The majority of each stakeholder group considered validated electronic methods moderately or extremely useful to re-consent previously enrolled research participants upon study amendments or to obtain consent from COVID-19 patients. (frontiersin.org)
A number of alternative consenting methods were recommended, for example by the European Medicines Agency, to ensure clinical study continuation during the COVID-19 pandemic. (frontiersin.org)
Methods A short-term observational trial of glucocorticoids in RA (the 'BEst LIfe with Rheumatoid Arthritis' (BELIRA) trial) was evaluated, using randomised controlled clinical trial (RCT) data for confirmation. (bmj.com)
The objective of this document is to outline the available methods and tools for screening and sequencing patient specimens for the detection of VOC or VOI, with a focus on those that offer a rapid turn-around time so as to support rapid implementation of public health actions for COVID 19 control. (who.int)

The genetic analysis of such missing longitudinal data presents a significant challenge in clinical pharmacogenomics. (psu.edu)
The selection models is a statistical approach for analyzing missing longitudinal data by assuming that dropout depends on the outcome of drug response. (psu.edu)
2] Hu C, Sale M. A joint model for nonlinear longitudinal data with informative dropout. (rug.nl)

HIV-infected patients taking cenicriviroc had significant reductions in viral load, with the effect persisting up to two weeks after discontinuation of treatment. (wikipedia.org)
We propose a response adaptive allocation ratio that adjusts for dropout, unrelated to unobserved treatment response, and factors in losses associated with discontinuation of treatment. (amstat.org)

citation needed] A double-blind, randomized, placebo-controlled clinical study to assess the antiviral activity, safety, and tolerability of cenicriviroc was conducted in 2010. (wikipedia.org)
A total of 38 patients will have 80% power to detect a probability of 0.231 that an observation in the treatment group is less than an observation in the placebo group using a Wilcoxon rank-sum test with a 0.050 two-sided significance level assuming a true difference of 2.5 points between nabilone and placebo in the primary outcome measure and a standard deviation of the change of 2.4 points. (springer.com)
One-hundred and fifty CS patients will be randomised to receive either a leucine-rich protein supplement or a placebo with no supplemented protein. (bmj.com)
Such conflicting data may be partially due to the high rates of placebo responses reported among individuals with GD or difficulties inherent when interpreting findings from studies without appropriate control conditions (e.g., case reports). (springer.com)
Developing a robust placebo model accounting for factors like dropouts, disease progression and trial design is crucial in order to facilitate better quantification of drug effect. (rug.nl)
The objectives of this study were i) to develop a model for placebo response in schizophrenia as measured with the Positive and Negative Syndrome Scale (PANSS) under varying clinical trial conditions, accounting for dropout and other relevant predictors of the placebo response, ii) to compare different Time to Event (TTE) modeling approaches used to describe the dropout patterns following placebo treatment in schizophrenia. (rug.nl)
Several placebo models with determinants of placebo response were tested [1]. (rug.nl)
Influence of dropouts was investigated by exploring three TTE hazard models in conjunction with the best performing placebo models. (rug.nl)
Results: The Weibull model and an indirect response model (IRM) with exponential infusion type of kinetic-PD function described the PANSS data well compared to other placebo models. (rug.nl)
Results of simultaneous modeling of dropout model with placebo model indicated that the probability of patients dropping out from a clinical trial is associated with both the last observed PANSS measurement and unobserved PANSS score as predicted by the placebo model. (rug.nl)
In this study, 121 nonabstinent outpatients with alcohol dependence (DSM-IV) were treated with sessions of cognitive coping skills (N = 67) or supportive therapy (N = 54) and either naltrexone 50 mg/day (N = 63) or placebo (N = 58) daily for the first 12 weeks and thereafter for 20 weeks only when craving alcohol (i.e., targeted medication) in a prospective one-center, dual, double-blind, randomized clinical trial. (erowid.org)
Naltrexone was not better than placebo in the supportive groups, but it had a significant effect in the coping groups: 27% of the coping/naltrexone patients had no relapses to heavy drinking throughout the 32 weeks, compared with only 3% of the coping/placebo patients. (erowid.org)
This is a randomized, parallel-group, double-blind, placebo-controlled, multi-center, phase II study in which patients, treating physicians, and the associated clinical staff as well as the sponsor clinical team are blinded. (biomedcentral.com)
Fifty patients are randomly assigned in a 1:1 ratio to receive either 300 mg secukinumab or placebo subcutaneously at baseline, weeks 1, 2 and 3, and every 4 weeks from week 4. (biomedcentral.com)
The primary endpoint is the proportion of patients in sustained remission until week 28 in the secukinumab group compared to the proportion of patients in the placebo group. (biomedcentral.com)
The trial design allows the first placebo-controlled data collection on the efficacy and safety of secukinumab in patients with GCA. (biomedcentral.com)
In the MycarinG study, patients received weekly injections of 7 mg/kg, 10 mg/kg rozanolixizumab, or placebo over a 6-week period. (medscape.com)

Objective To investigate the long-term effects of the tight control (TC) and conventional (CT) methotrexate-based strategies of the Computer Assisted Management in Early Rheumatoid Arthritis trial in early rheumatoid arthritis and evaluate the predictive value of an early response to treatment. (bmj.com)
Patients who participated in the Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA 12 ) trial were evaluated. (bmj.com)
It will enable PPD to run clinical trial simulations on particular characteristics of competing designs, which will help the CRO deliver both time- and cost-savings to clients. (pharmatimes.com)
The trial randomly assigned patients 2:1 to nivolumab 3 mg/kg every 2 weeks or investigator's choice of chemotherapy (dacarbazine or carboplatin/paclitaxel). (cancernetwork.com)
The TORDIA study previously reported that in adolescents with no improvement in depression after one appropriate trial of a selective serotonin reuptake inhibitor (SSRI), there were similar response rates between switching to another SSRI or switching to the norepinephrine reuptake inhibitor (SNRI) venlafaxine. (biomedcentral.com)
That's when Dan's doctor suggested a clinical trial at Memorial Sloan Kettering. (mskcc.org)
His doctor recommended a clinical trial at Memorial Sloan Kettering. (mskcc.org)
Although open-label observations report a positive effect of cannabinoids on non-motor symptoms (NMS) in Parkinson's disease (PD) patients, these effects remain to be investigated in a controlled trial for a broader use in NMS in PD patients. (springer.com)
In this trial patients with newly diagnosed glioblastoma with an unmethylated MGMT-promoter are treated with targeted substances according to the results of a molecular and genomic characterization of their tumor tissue. (clinicaltrialsregister.eu)
We evaluate the features of our novel allocation ratio using traditional clinical trial operating characteristics. (amstat.org)
OBJECTIVE: To analyze the definitions of "ongoing clinical trial" across different clinical trial registries, methodological guidelines, and other sources. (bvsalud.org)
RESULTS: We identified various heterogeneous definitions used by eligible sources at both the start and end of a clinical trial. (bvsalud.org)
Further efforts are necessary to determine the best definition for the start and end of a clinical trial. (bvsalud.org)
Further, patients provided self-reports on clinical measures pre- and post-trial, as well as at a 12-month follow-up. (jmir.org)
Clinical trial registration ClinicalTrials.gov ID: NCT04383704 (First registration date: 05/05/2020). (nature.com)
As a result, many trial sites operate under a vast constellation of vendors to address patient, process, and regulatory needs, yet the external support. (transperfect.com)
In a 12-month follow-up randomized clinical trial, we aimed to measure the efficacy of a brief family psychoeducation program in terms of reducing relapse risk and improving medication adherence in patients, as well as reducing caregiver burden, depression and increasing knowledge of the illness. (frontiersin.org)
Jalenques et al (1992), in an open prospective trial of clozapine in treatment resistant schizophrenic patients reported significant improvement in positive symptoms by 1 month and negative symptoms by 3 months with improvement in social functions and reduction in use of concomitant medications. (priory.com)
Single arm, phase II trial, enrolling patients with ER+/HER2- breast tumors ≥ 15mm, N0-N1. (esmo.org)
A total of 179 refractory melanoma patients were enrolled in the ACT trial. (tau.ac.il)
clinical trial protocol number CAIN457ADE11C. (biomedcentral.com)
April 24, 2015: This clinical trial is no longer open. (inviafertility.com)
8 , - , 10 Nevertheless, looking at clinical trial patients attaining stringent remission who have no activity governing disability, the residual HAQ is closely related to joint damage 11 and apparently not importantly influenced by other factors. (bmj.com)
Further analyses from the Prediction of Remission to Individual and Combined Treatments (PREDICT) randomized controlled trial, which included 344 treatment-naive patients with MDD, as well as findings from the 1000 patient‒strong international Study to Predict Optimized Treatment in Depression (iSPOT-D), were presented here at the Anxiety and Depression Association of America (ADAA) 2018 Conference. (medscape.com)
Specifically, whereas the receipt of a patient's preferred modality (CBT or antidepressant medication) did not predict remission at 12 weeks ( P = .31), those patients who did not receive their preferred treatment modality were significantly more likely to drop out of the trial ( P = .01), usually within the first few weeks of treatment, said Dunlop. (medscape.com)

The clinical diagnosis of painful ACJ disorders is important to enable efficient application of appropriate treatment interventions and to inform decisions regarding the need for further diagnostic investigations or specialist consultation. (biomedcentral.com)
It is feasible to argue the hypothesis of the involvement of the foetus' olfactory bulb as one of the indelible pathophysiological manifestations to the clinical diagnosis of COVID-19 with neurosensory olfactory deficit in foetuses and newborns affected by intrauterine infection. (bvsalud.org)

The present study investigates 5-year data of a 2-year methotrexate (MTX) based tight control treatment (TC) strategy compared to conventional MTX-based treatment (CT) strategy, and the (added) predictive value of an early response (at 6 months) to treatment for 5-year outcome with respect to disease activity and radiographic progression. (bmj.com)
Although there were no survival differences between nivolumab and investigator choice chemotherapy treatments, nivolumab treatment after progression on ipilimumab with or without a BRAF inhibitor does provide a higher rate of response and more durable responses," the researchers wrote. (cancernetwork.com)
With a medium follow-up time of 7.2 years, OR patients reached a median overall survival (OS) of 58.45 months and a median progression-free survival (PFS) of 15.43 months, as compared with nonresponders, with 6.73 months OS and 2.60 months PFS. (tau.ac.il)
By 6 years, 50% of OR patients were alive and 43% had no documented progression. (tau.ac.il)

The prognostic value of early response to treatment in addition to established predictors was analysed by multiple linear regression analyses. (bmj.com)
Multiple regression analysis showed that early response to treatment is an independent predictor of 5-year outcome, irrespective of treatment strategy. (bmj.com)
Good-response to treatment independently predicts significantly better 5-year clinical and radiographic outcome. (bmj.com)
1 , - , 4 Next to known predictors of long-term outcome of RA, which are assessed at baseline, 5 , - , 8 early response to treatment also could be predictive. (bmj.com)
9 Disease activity during the first 3 months of treatment has been related to clinical and radiographic outcome after the first year of treatment, 6 10 11 and an early treatment response can predict the long-term work disability outcome. (bmj.com)
A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals with phosphodiesterase-5 inhibitors (PDE5i). (ersjournals.com)
32 patients (52%) experienced study drug-related adverse events and 10 (16%) experienced serious adverse events (2 (3%) study drug-related, none during the PDE5i treatment-free period). (ersjournals.com)
The overall survival outcome may have been impacted by the increased dropout rate before treatment and increased systemic therapy received after assigned therapy in the investigator's choice of chemotherapy group, as well as an increased proportion of patients with poor prognostic factors in the nivolumab group," wrote James Larkin, PhD, FRCP, of Royal Marsden NHS Foundation Trust, United Kingdom, and colleagues. (cancernetwork.com)
According to Larkin and colleagues treatment options were needed for patients with advanced melanoma that had progressed with ipilimumab and BRAF inhibitor-based therapy. (cancernetwork.com)
The guidelines provided by the National Institute of Clinical Excellence (NICE) in the United Kingdom explicitly recommend prescribing fluoxetine only in conjunction with psychotherapy [ 7 ], but the depression practice parameters of the American Academy of Child and Adolescent Psychiatry (AACAP) suggest administration of fluoxetine alone is also a reasonable strategy, and offers no preferred for monotherapy versus combined treatment [ 6 ]. (biomedcentral.com)
Regarding the clinical management of enterococcal bacteraemia, the evidence on the duration of antibiotic treatment is scarce and the studies do not discriminate between complicated and uncomplicated bacteraemia. (bmj.com)
The primary efficacy endpoint is the clinical cure at day 30±2 after the end of the treatment. (bmj.com)
Barriers surrounding the healthcare system seem to hinder patients to seek help through conventional healthcare, even after entering opioid substitution treatment (OST), resulting in a high level of unmet healthcare needs. (hindawi.com)
Patients in opioid substitution treatment (OST) are suspected to suffer from poor health due to prior, or ongoing, substance use [ 1 ]. (hindawi.com)
The flaws of this method are particularly prevalent if dropout rates differ between the treatment arms. (amstat.org)
Inference-based cognitive-behavioral therapy (I-CBT) is a specialized psychological treatment for obsessive-compulsive disorder (OCD) without deliberate and prolonged exposure and response prevention (ERP) that focuses on strengthening reality-based reasoning and correcting the dysfunctional reasoning giving rise to erroneous obsessional doubts and ideas. (karger.com)
For GD patients not willing to consider drug treatment, n-acetyl cysteine or behavioral therapies may be effective. (springer.com)
Four patients receiving exercise and three receiving flexibility treatment dropped out before completion. (bmj.com)
16 of 29 patients rated themselves as better after completing exercise treatment compared with eight of 30 patients who completed flexibility treatment. (bmj.com)
12 of 22 patients who crossed over to exercise after flexibility treatment rated themselves as better after completing exercise treatment. (bmj.com)
32 of 47 patients rated themselves as better three months after completing supervised exercise treatment. (bmj.com)
35 of 47 patients rated themselves as better one year after completing supervised exercise treatment. (bmj.com)
There were no missing data and no treatment dropouts. (jmir.org)
The aim of the present study was to explore whether single nucleotide polymorphisms (SNPs) within HSP90AA1 gene affect the response of systemic lupus erythematosus (SLE) patients to GCs treatment. (springeropen.com)
SLE disease activity index (SLEDAI) was used to assess the response of SLE patients to GCs treatment, and patients were classified into sensitive group and insensitive group. (springeropen.com)
Univariate and multivariate logistic regression analyses were used to discriminate the impact of SNPs of HSP90AA1 gene on the response of SLE patients to GCs treatment. (springeropen.com)
The present study demonstrates that HSP90AA1 gene SNPs may affect the response of SLE patients to GCs treatment. (springeropen.com)
Failure to recognize that a patient is not responding to treatment is a serious problem in routine care and one that appears to be made worse by the clinicians' confidence in their clinical judgment and unique healing gifts. (madinamerica.com)
This is despite deliberate attempts to provide evidence-based treatment from demonstrably successful therapists after patients with the same "disorder" have been carefully screened. (madinamerica.com)
The discrepancy between clinician estimates of success and measured success suggests the need for formally measuring and monitoring treatment response. (madinamerica.com)
Lambert suggests that this discrepancy between clinicians' ability to discern client progress and their realistic state of progress may be underlying issues in psychotherapy treatment including patient deterioration, treatment failure, and client dropout. (madinamerica.com)
Clinicians could benefit from employing formal mental health vital sign tracking systems because of their proven accuracy in identifying treatment failure and thereby overcoming a clinician's overly optimistic estimates of their patients' treatment responses and because of their inability to predict treatment failure, specifically negative change. (madinamerica.com)
The treatment resistance of patients with schizophrenia is a frequent and important clinical problem. (priory.com)
The proportion of patients with treatment resistant schizophrenia has been consistent over time since the introduction of conventional antipsychotics (Conley and Buchanan, 1997). (priory.com)
The demonstration of efficacy of clozapine in treatment resistant schizophrenia has led to studies looking into the efficacy of various treatments in this patient group. (priory.com)
Clinical history (previous treatment) No good level of functioning over past 5 years Received 3 periods of treatment in preceding 5 years with antipsychotics of at least 2 different chemical classes for at least 6 weeks, with an equivalent of at least 1000 mg chlorpromazine daily without significant relief. (priory.com)
Fujii et al (1997) reported that patients with treatment resistant schizophrenia show significant global cognitive improvement, as measured by Wechsler Adult Intelligence Scale-Revised (WAIS-R) Full Scale, after a minimum of one year of treatment with clozapine. (priory.com)
Meltzer and Okayli (1995) have reported decrease in suicidality of treatment resistant schizophrenic patients with clozapine treatment of 6 months to 7 years duration. (priory.com)
Subjects' response to therapy will be evaluated before and after treatment by ultrasound, using WHO criteria. (esmo.org)
Several studies have shown the opioid antagonist naltrexone to be effective when combined with psychosocial therapies for the treatment of patients who are dependent on alcohol with fixed medication and time (12 weeks). (erowid.org)
Patients in both treatment arms receive a 26-week prednisolone taper regimen. (biomedcentral.com)
PHOENIX - Open-label extension studies of two neonatal Fc receptor-blocking antibodies showed good safety and efficacy in patients with myasthenia gravis (MG). The two drugs, rozanolixizumab (Rystiggo, UCB) and efgartigimod PH20 (Vyvgart, Argenx SE), received Food and Drug Administration approval in June 2023 and December 2021, respectively, for the treatment of MG. (medscape.com)
The new efficacy analysis focused on 110 patients who underwent two or more consecutive symptom-driven treatment cycles. (medscape.com)
A safety analysis focused on 188 patients who received at least one cycle of treatment. (medscape.com)
The post hoc analysis showed that the clinically meaningful improvements in the generalized myasthenia gravis symptoms were maintained over time for the cohort across rozanolixizumab cycles, while individual patients move through the consecutive treatment cycles, rozanolixizumab had an acceptable safety profile that was maintained across repeated treatments cycles. (medscape.com)
Drs. Karande and Klipstein chose the Ideal Protein Diet as a weight loss method for their patients based on its healthy approach and improved fertility treatment results. (inviafertility.com)
The overall response rate (50% reduction in symptoms) was 41% for psychotherapy and 16% for no treatment. (uottawa.ca)
Remission from depression (no clinically elevated depressive symptoms) at post-treatment was about 33%, whereas about 10% of patients in control conditions (no treatment or treatment as usual) remitted after therapy. (uottawa.ca)
Overall, time-limited psychotherapy is modestly to moderately better than no treatment, with about one-third of treated patients no longer being depressed after time-limited psychotherapy. (uottawa.ca)
Results in more severely depressed patients are better with combined treatment of pharmacotherapy plus psychotherapy. (uottawa.ca)
Results showed that after switching treatment, 48.2% of the patients experienced remission. (medscape.com)
Even patient preference for treatment modality was found to be associated with treatment completion, as reported in findings published i n 2017. (medscape.com)
This study was performed on 56 patients with leprosy: 28 under treatment and 28 treated for the disease. (bvsalud.org)
The treatment group had more women (Pearson ÷2=12.47, p=0.0004) and younger patients (Pearson ÷2=9.688, p=0.0079) than the healed group. (bvsalud.org)
The sample consisted of 56 patients of both genders with a history of leprosy: 28 under treatment and 28 were already treated for the disease. (bvsalud.org)

Modeling and simulation of the time course of asenapine exposure response and dropout patterns in acute schizophrenia. (rug.nl)
In adults, olfactory loss is one of the earliest and most frequent acute clinical manifestations of SARS-CoV-2 infection. (bvsalud.org)

Here we report the long-term clinical results, intent-to-treat analysis, predictors of response and toxicity profile in a large patient cohort. (tau.ac.il)
Predictors of response were performance status, time of TIL in culture and CD8 frequency in the infusion product. (tau.ac.il)
WASHINGTON - Predictors of response to mainstream therapies for major depressive disorder (MDD) range from baseline comorbid anxiety, brain connectivity patterns on neuroimaging, genomic patterns, and novel findings of inflammatory system abnormalities, new research suggests. (medscape.com)

Patients who do not achieve remission by week 12 experience a flare after remission or cannot adhere to the prednisolone tapering will enter the escape arm and receive prednisolone at a dose determined by the investigator's clinical judgment. (biomedcentral.com)
Recent analysis of recurrence rates in 94 patients who experienced remission after receiving 12 weeks of either CBT or pharmacotherapy showed that 15.5% experienced a recurrence during the maintenance period, study coauthor W. Edward Craighead, PhD, Department of Psychiatry and Behavioral Sciences at Emory University, Atlanta, Georgia, reported. (medscape.com)
In addition to the clinical predictors, findings from pretreatment resting-state functional MRI (fMRI) for 112 patients showed significant differences between those who did and those who did not achieve remission with CBT compared with antidepressant therapy, reported coauthor Boadie Dunlop, MD, of Emory University. (medscape.com)

Schizophrenia is recognized for its severe impact on both patients and caregivers. (frontiersin.org)
A total of 25 days of patients with schizophrenia (DSM-IV-TR) and family primary caregivers were recruited in a single regional psychiatric outpatient facility located in Bordeaux. (frontiersin.org)
Schizophrenia is a chronic and severe mental disorder which has serious consequences for both the patient and caregivers. (frontiersin.org)

citation needed] Phase IIb data presented at the 20th Conference on Retroviruses and Opportunistic Infections (CROI) in March 2013 showed similar viral suppression rates of 76% for patients taking 100 mg cenicriviroc, 73% with 200 mg cenicriviroc, and 71% with efavirenz. (wikipedia.org)
Non-response rates were higher with cenicriviroc, however, largely due to greater drop-out of patients. (wikipedia.org)
Hence, ways to optimize the delivery of CBT, improve response rates, and increase the treatment's availability represent important goals for the field. (jmir.org)
Dropout rates of up to 20% indicate that patient burden and engagement remain key areas of concern. (transperfect.com)
Sociodemographic, symptom severity (PANSS) and medication adherence (MARS) from patients were assessed at baseline and relapse rates was recorded during the 12 months follow-up period. (frontiersin.org)
A recent systematic review including 11 studies demonstrates consistent improvement in many outcome measures of patients, such as relapse rates and medication adherence, but heterogeneity in symptoms reliefs ( 9 ). (frontiersin.org)

The pre-to-post decreases in nodal clustering of the left lingual gyrus and the left fusiform gyrus positively correlated with the improvements in obsessive-compulsive symptoms in the CBT-responding patients. (nih.gov)
The primary end point was the proportion of week 12 responders (patients with moderate or substantial improvement in IBS symptoms) on the 7-point Likert Global Improvement Scale (GIS). (researchgate.net)
Patients in OST have a high degree of physical symptoms and a high degree of unmet healthcare needs. (hindawi.com)
Patients in OST carry a heavy burden of physical symptoms and unmet healthcare needs, potentially due to societal barriers. (hindawi.com)
Reducing levodopa or dopamine agonist (DA) dosages may partially reduce GD symptoms among patients with co-occurring PD. (springer.com)
14 A similar training programme improved symptoms and physiological findings in an open study of patients with the "effort syndrome. (bmj.com)
Clinical signs and symptoms of PMR include stiffness and aching in the shoulder and pelvic girdles and cervical region. (biomedcentral.com)
The average response rate (50% reduction in symptoms) was 29% for psychotherapy or pharmacotherapy alone, but combining treatments resulted in 12% to 16% higher response rate. (uottawa.ca)
It is widely believed that treatments for major depression (psychotherapy and antidepressant medications) have improved patients' symptoms since the 1980s. (uottawa.ca)

Although data exist on the prevalence of some immunosuppressive conditions, the total burden of these conditions in the United States remains unknown, particularly when considering patients who are receiving emerging immunosuppressive therapies ( 6 - 8 ). (cdc.gov)
Some situations may still exist that necessitate the use of ipilimumab as first-line therapy and nivolumab provides a safer option with a better maintained quality of life for patients who have experienced failure with prior systemic therapies compared with cytotoxic chemotherapy. (cancernetwork.com)

Results 5 years of data were available for 205 of 299 patients, with no indication for selective drop-out. (bmj.com)
will allow obtaining results with 194 patients recruited. (bmj.com)
Analysis by intention to treat gave similar results (17/33 v 9/33 patients better). (bmj.com)
Results may serve as the cornerstone to rethink the informed consent process in clinical research. (frontiersin.org)
This is consistent with previous results of rozanolixizumab," said Bril, who is a clinical investigator at University of Toronto. (medscape.com)

T0 features among dropout, stable and healed participants were compared. (biomedcentral.com)
We used a simple formula - weight reduction of 1.0% or more at the end of 4 weeks (1 month) - to achieve our primary study objective: to determine if an early response would predict successful weight reduction (5% or more) at 6 months among participants in a weight-reduction program. (cdc.gov)
Following a standardised clinical examination and diagnostic injection into the subacromial bursa, all participants received a fluoroscopically guided diagnostic block of 1% lidocaine hydrochloride (Xylocaine TM ) into the ACJ. (biomedcentral.com)
Ongoing clinical studies required protocol modifications to safeguard the wellbeing, safety, and rights of the research participants ( 3 ). (frontiersin.org)
These clinical studies also faced challenges to embody ethical principles such as informing participants and obtaining their IC for participation in the study. (frontiersin.org)
Les participants ont été interrogés à la sélection puis à la fin du traitement pour connaître leur opinion en matière d'accès aux soins et de qualité de ceux-ci. (who.int)

Obesity management guidelines specify initial goals for participation and weight reduction for the first 6 months of a weight-reduction intervention, but guidelines do not specify when to assess early response and make adjustments. (cdc.gov)
early response also predicted 1-year success, suggesting that the 2-week point may be an ideal time to assess initial response and make intervention adjustments. (cdc.gov)
For patients, the family psychoeducation intervention significantly reduced the risk of relapse with a significant effect found at 12 months follow-up ( p = 0.014). (frontiersin.org)
Therefore, family intervention should be developed to reduce the burden of caregivers and enhance patients' prognosis. (frontiersin.org)

Detection of painful ACJ conditions is also of prognostic significance having been identified as one of the strongest factors associated with reduced patient satisfaction[ 8 ] and with reduced functional ability following rotator cuff repair surgery[ 9 ]. (biomedcentral.com)

Missing Not At Random (MNAR), where dropout depends on predicted PANSS [2]. (rug.nl)

Six patients (10%) experienced clinical worsening, including death in two (not study drug-related). (ersjournals.com)
Clinical effectiveness data are sparse, but a recent observational study demonstrated lower vaccine effectiveness against influenza illness (≈20%) in patients with cancer compared with the general population (≈42%) ( 12 , 13 ). (cdc.gov)
This study should be the basis for further evaluations of long-term efficacy and safety of the use of cannabinoids in PD patients. (springer.com)
The aim of this study is to assess OST patients' self-rated physical health and healthcare seeking behaviour. (hindawi.com)
The study involved 15 patients with mild to moderate anxiety or depression (or both). (jmir.org)
Despite numerous methodological flaws in previous study designs and the lack of validation in primary care populations, clinical tests for identifying acromioclavicular joint (ACJ) pain are widely utilised without concern for such issues. (biomedcentral.com)
The aim of this study was to estimate the diagnostic accuracy of traditional ACJ tests and to compare their accuracy with other clinical examination features for identifying a predominant ACJ pain source in a primary care cohort. (biomedcentral.com)
The dropout rate for all subjects was 16.5% during the first 12-week period and approximately twice that level by the end of the study. (erowid.org)
The main reason for the drop out of the study was clinical deterioration. (tau.ac.il)
During the Q&A session, George Small, MD, asked if the study had shown a reduction in steroid use among patients with MG. (medscape.com)
The aim of this study was to describe the clinical features, haematological findings and CD4 + and CD8 + cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection. (biomedcentral.com)
The objective of this study was to report the clinical features, haematological findings and CD4 + and CD8 + lymphocyte subsets of severely malnourished children with regard to their HIV status. (biomedcentral.com)
We conducted a KAP study among 70 CL patients attending 4 clinics in Aleppo. (who.int)
Thus, the present study aimed to evaluate the oral health status of patients with leprosy in relation to the presence of associated lesions, prevalence of caries and plaque accumulation. (bvsalud.org)

Approximately 30% of schizophrenic patients (10-45%) meet these criteria. (priory.com)
Rodriguez et al (1998) compared clozapine responders, partial responders and non-responders from a group of resistant schizophrenic patients. (priory.com)

Initial Response to Program, Program Participation, and Weight Reduction Among 375 MOVE! (cdc.gov)
Very early response was defined as achieving a weight reduction of 0.5% or more at week 2, and early response was defined as achieving weight reduction of 1.0% or more at week 4. (cdc.gov)
Weight reduction is a challenge for health care providers and patients (1). (cdc.gov)
Several studies examined initial response to weight-reduction interventions as a predictor of later achievement of weight-reduction goals. (cdc.gov)
Initial response in these studies was defined in multiple ways, including various descriptions of weight reduction at various times (3). (cdc.gov)
Enhanced recovery protocols (ERPs), such as prehabilitation, have been associated with a reduction in complications after CS in vulnerable patients. (bmj.com)
Melatonin was superior to amitriptyline in the percentage of patients with a greater than 50% reduction in migraine frequency. (bmj.com)
half of the patients show 50% reduction in attack frequency. (bmj.com)

These findings indicated that the network segregation of the whole-brain white matter network in OCD patients was abnormally higher and might recover to normal after CBT, which provides mechanistic insights into the CBT response in OCD and potential imaging biomarkers for clinical practice. (nih.gov)
These findings support the use of appropriately prescribed graded aerobic exercise in the management of patients with the chronic fatigue syndrome. (bmj.com)
The clinical detection of painful ACJ conditions also aids interpretation of the relevance of abnormal radiological findings, the prevalence of which is known to be high in asymptomatic individuals[ 7 ]. (biomedcentral.com)
These findings were published in March in the Journal of Consulting and Clinical Psychology . (medscape.com)

Accrual started in July 2017 and 38 patients have been enrolled thus far. (esmo.org)

However, a review of immunogenicity studies suggests that antibody responses to inactivated influenza vaccines (IIVs) in persons who are immunocompromised could be suboptimal compared with persons without immunosuppression ( 11 ). (cdc.gov)
This is not just hippy-talk, we are seeing that major universities, government scientists, and big pharma are studying psychedelic drugs for mental health - with almost 100 clinical studies happening right now and more than 300 university psychedelic programs in place! (netgalley.com)
Rather, studies demonstrate that patients at risk of deterioration can often be identified after just the first few sessions. (madinamerica.com)
Conclusion The use of OPEP devices can have a positive impact in COPD, but confidence in effect sizes is low and there is a need for further, higher quality studies to examine their long-term efficacy in COPD as well as to identify specific patient phenotypes that are more likely to respond. (bmj.com)
Its effectiveness has also been demonstrated for individuals at clinical high risk for psychosis although rigorous further studies are required ( 10 ). (frontiersin.org)
After completing MycarinG, patients were eligible to enroll in one of two open-label studies, one of each dose. (medscape.com)
Most patients in these studies had moderate to severe depression. (uottawa.ca)
Despite the oral examination being part of the comprehensive examination of a patient with leprosy, there are few studies describing the oral health and dental care of these patients. (bvsalud.org)

We observed significant group-by-time interactions on the global network clustering coefficient and the nodal clustering of the left lingual gyrus, the left middle temporal gyrus, the left precuneus, and the left fusiform gyrus of 26 CBT responders in OCD patients. (nih.gov)

TIL ACT can yield durable objective responses, even as salvage therapy in highly advanced metastatic melanoma patients. (tau.ac.il)

Typical clinical manifestations of GCA related to the inflammation of large- and medium-sized arteries are new-onset headaches, jaw claudication (cramping pain and/or fatigue felt in the jaw muscles during mastication), scalp tenderness, and visual disturbances. (biomedcentral.com)

Establishing a case definition for and quantifying the burden of immunosuppressive conditions might facilitate evaluation and use of influenza vaccines to enhance immune response in this high-risk target group. (cdc.gov)
Introduction In the past 20 years, the increasing burden of heart disease in an ageing population has resulted in cardiac surgery (CS) being offered to more frail and older patients with multiple comorbidities. (bmj.com)
There is little information on the effect of the added burden of HIV infection on the clinical features [ 5 - 7 ] and cellular immunity of severely malnourished children. (biomedcentral.com)

To assess OST patients' self-rated physical health and healthcare seeking behaviour. (hindawi.com)
to assess the role of plasma ctDNA in monitoring response to P/ET. (esmo.org)

Biomarkers that help us predict primary resistance to P may lead to better patient selection and thus avoid toxicity and reduce costs. (esmo.org)

3) specific combinations of high-resolution computed tomography and surgical lung biopsy patterns in patients subjected to surgical lung biopsy [ 1 , 4 ]. (ersjournals.com)

Assuming a resistance rate of 20%-25% and a 10% dropout, 100 subjects are needed to develop a binary predictor. (esmo.org)

Using clinical data from 375 MOVE! (cdc.gov)
Here, we collected diffusion MRI data from 34 unmedicated OCD patients before and after 12 weeks of CBT. (nih.gov)
Introduction: In the field of clinical research, a robust data management process is essential for driving success. (transperfect.com)
A clinical form was prepared to include demographic and leprosy data. (bvsalud.org)

When there is no dropout, our allocation ratio reduces to previously published response adaptive allocation ratios. (amstat.org)

Patients assigned to nivolumab had a higher overall response rate (27% vs 10%) and a longer median duration of response (32 vs 13 months) compared with the investigator's choice arm. (cancernetwork.com)
For a 6% non-inferiority margin and considering a 5% withdrawal rate, 284 patients will be included. (bmj.com)
Analysis The difference in proportions with one-sided 95% CIs will be calculated for the clinical cure rate using the control group as reference. (bmj.com)

16 In addition, by using the structured clinical interview for the DSM-III-R ( Diagnostic and Statistical Manual of Mental Disorders , third edition, revised) 17 we excluded patients who also had a current psychiatric disorder or symptomatic insomnia because of the separate effects of these conditions on fatigue. (bmj.com)
In this cohort of primary care patients with predominantly subacute or chronic ACJ pain of non-traumatic onset, traditional ACJ tests were of limited diagnostic value. (biomedcentral.com)

abstract = "Clinical pharmacogenomics, integrating genomic information with clinical practices to facilitate the prediction of drug response, has recently emerged as a vital area of public health. (psu.edu)
Abstract Cutaneous leishmaniasis (CL) is endemic in Aleppo and yet the knowledge, attitudes and practices (KAP) of CL patients in Aleppo has never been studied. (who.int)

The Psychotherapy Practice Research Network (PPRNet) blog began in 2013 in response to psychotherapy clinicians, researchers, and educators who expressed interest in receiving regular information about current practice-oriented psychotherapy research. (uottawa.ca)
Can artificial intelligence be your angel to diagnose early gastric cancer in real clinical practice? (cdc.gov)

The panel of experts reviewed the pertinent physiological, epidemiologic, and clinical evidence, including primary research articles and recent review articles. (cdc.gov)

Draft Summary of Product Characteristics (SmPC), Patient Information Leaflet (PIL) and labels should be included as prepared using the format provided in the medicines section of the WHO prequalification website (under WHO Public Assessment Reports). (who.int)

Forty-one percent of patients in the investigator's choice arm received anti-PD-1 agents after therapy assignment compared with 11% of patients in the nivolumab arm. (cancernetwork.com)

The three-way agreement follows a collaboration initiated last year by PPD and Berry Consultants on Bayesian design and analysis in clinical research. (pharmatimes.com)
This research supports the predictive value of very early response and early response to MOVE! (cdc.gov)
Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. (mskcc.org)
1 The Department of Clinical Psychology, National Clinical Research Center for Mental Disorders, Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China. (nih.gov)
Preclinical and clinical research implicate several neurotransmitter systems in the pathophysiology of gambling disorder (GD). (springer.com)
CCMS: A Good Fit for Pharmaceutical and Clinical Research Organizations? (transperfect.com)
Kaarin Gordon discusses the choices and challenges for efficient content reuse facing Pharmaceutical and Clinical Research Organizations. (transperfect.com)
Although stakeholders support the use of eIC in clinical research, it seems that the experience with eIC is low. (frontiersin.org)
The COVID-19 pandemic heavily affected the conduct of clinical research ( 1 , 2 ). (frontiersin.org)

The MDH Public Health Laboratory (MDH-PHL) requested SARS-CoV-2 RT-PCR-positive specimens with SGTFs collected during November 1, 2020-January 12, 2021, from clinical laboratories that used the TaqPath assay, and 30 specimens were received. (cdc.gov)

In phase 1 (at baseline), patients will be recruited and grouped in fluoxetine group or fluoxetine combined with CBT group by patient self-selection. (biomedcentral.com)

No other clinical measures significantly predicted recurrence. (medscape.com)

In PREDICT, patients with MDD were randomly assigned to receive either 12 weeks of cognitive-behavioral therapy (CBT) or 12 weeks of therapy with antidepressant therapy with the selective serotonin reuptake inhibitor (SSRI) escitalopram ( Lexapro , Forest Labs) or the serotonin and norepinephrine reuptake inhibitor (SNRI) duloxetine ( Cymbalta , Lilly). (medscape.com)

See Clinical Presentation for more detail. (medscape.com)

Patients' frequent visits to the OST clinics offer a unique opportunity to build a base for easily accessible on-site primary healthcare. (hindawi.com)

66 patients with the chronic fatigue syndrome who had neither a psychiatric disorder nor appreciable sleep disturbance. (bmj.com)
Patients with the chronic fatigue syndrome perceive greater fatigue than healthy controls taking the same exercise. (bmj.com)
10 Fitness training improved both aerobic capacity and myalgia more than flexibility exercises in patients with the "fibrositis/fibromyalgia syndrome," 13 a condition which overlaps with the chronic fatigue syndrome. (bmj.com)
Patients met the Oxford criteria for the chronic fatigue syndrome. (bmj.com)

Ranked the #1 clinical journal covering gastroenterology and hepatology*, The American Journal of Gastroenterology (AJG) provides practical and professional support for clinicians dealing with the gastroenterological disorders seen most often in patients. (researchgate.net)
Clinicians appear to be overly optimistic about patient benefits compared to measured outcome. (madinamerica.com)
Unfortunately, the clinicians' view of their own patients' outcome is much more positive than the measured outcome using self-report scales. (madinamerica.com)

Straighten the path along your product's life cycle while driving quality, mitigating compliance risk, and enhancing patient engagement. (transperfect.com)
With rapid globalization and expanded marketing efforts, pharmaceutical organizations are discovering that pivoting from multichannel marketing to omnichannel marketing is key to revolutionizing patient engagement. (transperfect.com)

Comparison of Different Machine Learning Models in Prediction of Postirradiation Recurrence in Prostate Carcinoma Patients. (cdc.gov)

Our laboratory focuses on discovery, cloning, sequencing, and creating gene therapy approaches for patients with hereditary forms of epidermolysis bullosa, a serious (potentially lethal) skin disease. (stanford.edu)

Diseases1

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Psychiatry and Psychology1

Phenomena and Processes1

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Named Groups2

Trials27

Outcomes12

Methods7

Longitudinal data3

Discontinuation of treatment2

Placebo17

Trial25

Diagnosis2

Progression4

Treatment55

Acute2

Predictors of response3

Remission3

Schizophrenia3

Rates6

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Results5

Participants6

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Prognostic1

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Study14

Schizophrenic patients2

Reduction8

Findings4

20171

Studies8

Responders1

Metastatic melanoma1

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Assess2

Toxicity1

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Predictor1

Data4

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