• clonal rearrangements
  • The postulated cells of origin of T-LGLL leukemia are transformed CD8+ T-cell with clonal rearrangements of β chain T-cell receptor genes for the majority of cases and a CD8- T-cell with clonal rearrangements of γ chain T-cell receptor genes for a minority of cases. (wikipedia.org)
  • neoplastic
  • 14- 16 The neoplastic cells infiltrate around reactive secondary lymphoid follicles in a marginal zone distribution and spread outwards to form diffuse interfollicular sheets or, in some cases, a vaguely nodular pattern. (bmj.com)
  • Outcomes
  • Checkpoint blockade therapy for cancer has had tremendous impact on clinical outcomes, yet only a subset of patients respond. (labroots.com)
  • General clinical features were comparable to western patients, while therapeutic outcomes were slightly inferior. (medworm.com)
  • In recent years, increased ease and reduced costs of characterizing the composition of the microbiome has led to an examination of its impact on a variety of clinical outcomes. (medworm.com)
  • It provides an international standard for oncologists and pathologists for use in the design of studies monitoring response to therapy and clinical outcomes. (wikipedia.org)
  • cancers
  • Rather than inhibiting kinase activity, elimination of mutant kinases provides a new therapeutic strategy for treating BCR-ABL-induced leukemia as well as other cancers resistant to treatment with tyrosine kinase inhibitors. (bloodjournal.org)
  • refractory
  • Treatment alternatives are limited for patients that are relapse after or refractory to induction regimens for acute leukemia. (medworm.com)
  • But treatment of leukemia patients refractory after FLAG salvage regimen are very diffucult and complete remission rates are very low. (medworm.com)
  • cells
  • Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course. (wikipedia.org)
  • Treatment with IPI-504 resulted in BCR-ABL protein degradation, decreased numbers of leukemia stem cells, and prolonged survival of leukemic mice bearing the T315I mutation. (bloodjournal.org)
  • These results provide a rationale for use of an Hsp90 inhibitor as a first-line treatment in CML by inhibiting leukemia stem cells and preventing the emergence of imatinib-resistant clones in patients. (bloodjournal.org)
  • B-cell leukemia describes several different types of lymphoid leukemia which affect B cells. (wikipedia.org)
  • Aggressive NK-cell leukemia (ANKL) is a lymphoid leukemia that is a deficiency NK cells. (wikipedia.org)
  • The requirements for diagnosing ANKL are as follows: Immature-looking NK cells Certain immunophenotypes Germline configuration genes: TCR-β and IgH Restricted cytotoxicity The T-cell receptor (TCR) is an important factor when ANKL is being diagnosed along with T-cell leukemia. (wikipedia.org)
  • One problem when using NK cells in order to fight off lymphoid leukemia is the fact that it is hard to amount enough of them to be effective. (wikipedia.org)
  • Other chemotherapy agents, specifically epipodophyllotoxins and anthracyclines, have also been associated with treatment-related leukemias, which are often associated with specific chromosomal abnormalities in the leukemic cells. (wikipedia.org)
  • These white blood cells are not fully developed and are called blasts or leukemia cells. (wikipedia.org)
  • Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (wikipedia.org)
  • In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (wikipedia.org)
  • the lymphoid cell line produces B, T, NK and plasma cells. (wikipedia.org)
  • Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to decreased immunity, susceptible to infection. (wikipedia.org)
  • These genes, in turn, increase the risk that more mutations will occur in developing lymphoid cells. (wikipedia.org)
  • It is divided in two main categories: T-cell LGL leukemia (T-LGLL) and natural-killer (NK)-cell LGL leukemia (NK-LGL)L. As the name suggests, T-cell large granular lymphocyte leukemia is characterized by involvement of cytotoxic-T cells). (wikipedia.org)
  • morphology
  • If the patient has leukemia, the morphology and immunophenotype check is needed to make sure the type of leukemia. (wikipedia.org)
  • Anemia can be classified in a variety of ways, based on the morphology of RBCs, underlying etiologic mechanisms, and discernible clinical spectra, to mention a few. (wikipedia.org)
  • Adults
  • T-PLL is a very rare leukemia, primarily affecting adults over the age of 30. (wikipedia.org)
  • However, about 90% of all leukemias are diagnosed in adults, with AML and CLL being most common in adults. (wikipedia.org)
  • Central nervous system (CNS) symptoms such cranial neuropathies due to meningeal infiltration are identified in less than 10% of adults and less than 5% of children, particularly mature B-cell ALL (Burkitt leukemia) at presentation. (wikipedia.org)
  • syndrome
  • Rheumatoid arthritis is commonly observed in people with T-LGLL, leading to a clinical presentation similar to Felty's syndrome. (wikipedia.org)
  • patients
  • Below is a list of ALL clinical trials that are currently open and accepting patients at SCCA. (seattlecca.org)
  • FLAG regimen is combination therapy with fludarabine and cytarabine has been advocated as a potentially useful salvage regimen for the treatment of relapsed or refracory acute leukemia patients. (medworm.com)
  • The 5 year survival has been noted as 89% in at least one study from France of 201 patients with T-LGL leukemia. (wikipedia.org)
  • cancer
  • Thank you for sharing this Clinical Cancer Research article. (aacrjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Clinical Cancer Research. (aacrjournals.org)
  • This manuscript was supported in part by the MD Anderson Cancer Centre Leukaemia Support Grant (CCSG) CA016672 and the MD Anderson Cancer Center Leukemia SPORE CA100632. (medworm.com)
  • In children with acute leukemia who are cancer-free after five years, the cancer is unlikely to return. (wikipedia.org)
  • It is the most common type of cancer in children, with three quarters of leukemia cases in children being the acute lymphoblastic type. (wikipedia.org)