• Secondary objectives include the identification of biomarkers that correlate with disease phenotype and predict clinical outcomes, and the creation of an international SSADHD data repository for future investigation of pathogenesis and therapy. (childrenshospital.org)
  • CSF biomarkers are widely used in clinical observational research and interventional trials. (unil.ch)
  • This absence of clinical biomarkers within the diagnosis process and the bible of psychiatry, the DSM-5, is leading to more and more misdiagnoses. (medium.com)
  • To record and analyse various neurophysiological parameters (sleep, cerebral hemodynamics, autonomic nervous activity) at 3 and 6 weeks of life, in order to determine whether they are correlated to the levels of chronic radiofrequency-EMF exposure. (ebea.org)
  • At baseline and after completion of all therapeutic sessions, neurophysiological recordings registering corticospinal and spinal neural excitability changes along with clinical assessment measures of standing and walking, and autonomic function via questionnaires regarding bowel, bladder, and sexual function are taken. (biomedcentral.com)
  • Cardiovascular and autonomic reactivity to psychological stress: Neurophysiological substrates and links to cardiovascular disease. (baylor.edu)
  • METHODS: To link pathophysiological processes in an animal model to clinical findings, we have here utilized the recently developed Df(h15q13)/+ mouse model for detailed investigations of cortical neuronal engagement during pre-attentive processing of auditory information from two back-translational auditory paradigms. (lu.se)
  • For instance, it is unclear to what extent commonly used behavioural tests in animals can inform us on the mental and affective aspects of schizophrenia.METHODS: To link pathophysiological processes in an animal model to clinical findings, we have here utilized the recently developed Df(h15q13)/+ mouse model for detailed investigations of cortical neuronal engagement during pre-attentive processing of auditory information from two back-translational auditory paradigms. (lu.se)
  • Within the group, we plan to organise tri-monthly seminars open for all members of MultiPark to discuss spectroscopic imaging of cells and tissues at MAX IV related to in vitro microglia/inflammatory screening, protein aggregation, synapse analysis, and neurophysiological properties, early microglia and neuronal dysfunction using correlative imaging methods to combine traditional brain imaging data with MAX IV generated data, collaborative opportunities. (lu.se)
  • To the best of our knowledge, the effects of a long-term exposure to radiofrequency-EMF on the neurophysiological development of preterm neonates have never been studied till today, whereas children (and therefore preterm neonates even more) could be particularly vulnerable due to a deeper penetration of radiofrequency waves in cerebral masses during a crucial neurodevelopmental period. (ebea.org)
  • Eligibility criteria for selecting studies Included literature must have addressed 1 of 9 predetermined clinical topics: (1) preoperative predictors for postoperative outcome, (2) effectiveness of physical therapy, (3) open and closed kinetic chain quadriceps exercises, (4) strength and neuromuscular training, (5) electrostimulation and electromyographic feedback, (6) cryotherapy, (7) measurements of functional performance, (8) return to play and (9) risk for reinjury. (bmj.com)
  • and to identify neurophysiological and biochemical predictors of clinical severity. (childrenshospital.org)
  • We argue that adaptive tests, which automatically adjust to each individual's performance level, are efficient methods for both clinical evaluations and neuropsychological investigations and have the potential to detect subtle deficits even in chronic stages, when flagrant clinical signs have frequently resolved. (cambridge.org)
  • Neurophysiological evidence of error-monitoring deficits in patients with schizophrenia. (psychologyofproductivity.org)
  • Purpose: The objective of this paper is to describe standardized methods of applying TMS motor cortex assessments in an international clinical trial of a pharmacological intervention for stroke patients, which was conducted at 15 centers in three countries. (longdom.org)
  • Subsequently, TMS assessments of motor hot spot location, motor threshold, and recruitment curve were conducted in stroke patients on post-stroke Days 5, 30, and 112. (longdom.org)
  • Mild cognitive impairment (MCI) is a clinical state intermediate between elderly normal cognition and dementia that affects a significant amount of the elderly population, featuring memory complaints and cognitive impairment on neuropsychological testing, but no dementia [ 1 - 3 ]. (hindawi.com)
  • Increased computer use in clinical settings offers an opportunity to develop new neuropsychological tests that exploit the control computers have over stimulus dimensions and timing. (cambridge.org)
  • Dissociation can be conceptualized both as a general tendency (trait dissociation) and transient state (state dissociation) and can also be observed in nonclinical populations, albeit at a much lesser extent than in clinical populations [ 2 , 4 ]. (springer.com)
  • Thus, clinical high-risk populations are now available for tracking prospectively the development and emergence of psychosis. (unc.edu)
  • Research to further refine the criteria should focus on optic nerve involvement, validation in diverse populations, and incorporation of advanced imaging, neurophysiological, and body fluid markers. (scienceopen.com)
  • The order of the items has been modified to group similar items (see http://www.equator-network.org/reporting-guidelines/spirit-2013-statement-defining-standard-protocol-items-for-clinical-trials/ ). (biomedcentral.com)
  • In multi-site clinical trials, this technique has some advantages over other neuroimaging methods owing to its relatively low cost, low personnel and equipment infrastructure requirements, and greater ease in consistently applying technology to collect and analyze data. (longdom.org)
  • The methodology described is potentially valuable to investigators who might construct future multi-site clinical trials using TMS. (longdom.org)
  • Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. (scienceopen.com)
  • Design Clinical practice guideline underpinned by systematic review and expert consensus. (bmj.com)
  • We anticipate that this mechanistic clinical trial will greatly impact clinical practice because, in real-world clinical settings, noninvasive transspinal stimulation can be more easily and widely implemented than invasive epidural stimulation. (biomedcentral.com)
  • I will review several challenges to bring brain morphometry into daily clinical practice, from robust image processing algorithms to efficient workflows and unbiased statistical analysis. (unil.ch)
  • The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. (scienceopen.com)
  • PD has been traditionally considered as a pure movement disorder secondary to focal degeneration of dopaminergic neurons in the substantia nigra, but, in recent years, the clinical phenotype has been better illuminated, showing that PD is a multisystem neurodegenerative disorder with motor and nonmotor features (Table 1 ) [ 3 ]. (hindawi.com)
  • The results of this mechanistic randomized clinical trial will demonstrate that tonic transspinal stimulation strengthens corticomotoneuronal connectivity and dynamic neuromodulation through posture-dependent corticospinal and spinal neuroplasticity. (biomedcentral.com)
  • Introduction: Transcranial Magnetic Stimulation (TMS) is a neurophysiological tool capable of assessing the motor nervous system and its change over time. (longdom.org)
  • This article reviews the current knowledge and clinical applications of spinal cord stimulation for chronic pain management. (thieme-connect.com)
  • 9 Shealy C N, Mortimer J T, Reswick J B. Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report. (thieme-connect.com)
  • Recruitment of dorsal column fibers in spinal cord stimulation: influence of collateral branching. (thieme-connect.com)
  • Paresthesia thresholds is spinal cord stimulation: a comparison of theoretical results with clinical data. (thieme-connect.com)
  • 23 Linderoth B. Dorsal Column Stimulation and Pain: Experimental Studies of Putative Neurochemical and Neurophysiological Mechanisms. (thieme-connect.com)
  • Current research indicates that there is developmental delay and significant neurophysiological and biochemical alterations in SSADHD patients, but whether disease presentation varies with age is not known. (childrenshospital.org)
  • Blood based biomarker discovery will provide essential insights in very early pathophysiological disease features and their changes over time, and offer large opportunities for both clinical and translational research. (unil.ch)
  • Dr. Miocinovic is a movement disorders neurologist and a biomedical engineer with expertise in translational and clinical electrophysiology studies. (aapmr.org)
  • Guillain-BarrĂ© syndrome (GBS) can be described as a collection of clinical syndromes that manifests as an acute inflammatory polyradiculoneuropathy with resultant weakness and diminished reflexes. (medscape.com)
  • Such a pattern seems to emerge because, rather than a classification based on clinical parameters, discrete hippocampal volume differences (about 1 cm 3 ) are analyzed. (hindawi.com)
  • As part of Frente de Accion de Latinos en Minnesota (FALM) with Dr. Miguel Fiol, Edith helped organize the logistics and planning of trips that provided essential mental health support, including trauma-informed mental health workshops for children and adolescents, to refugees at the U.S./Mexico border and victims of the 2020 earthquakes in Puerto Rico. (umn.edu)
  • The overall objective is to define the natural course of the clinical, neurophysiological and biochemical spectrum of SSADHD. (childrenshospital.org)
  • Currently, having a clinical "objective" measure of hyperacusis is not always easy. (tinact.eu)
  • The overarching objective of my work is to better understand the neurocognitive underpinnings of our thought patterns, how they impact our cognitive and emotional experiences, and how to translate these basic science discovery into applications in the clinical and ageing domains. (plymouth.ac.uk)
  • Using this protocol, centers were formally certified to perform TMS-based neurophysiological measures in this clinical trial of stroke patients. (longdom.org)
  • [ 3 , 4 ] Any patients exhibiting clinical signs of respiratory compromise to any degree also should be admitted to an ICU. (medscape.com)
  • These studies are discussed in the context of earlier findings regarding methodological differences and limitations and concerning possible implications for future research and the clinical setting. (springer.com)
  • Adrina is studying how neurochemicals in the brain encode value during decision making in order to integrate neuroscientific findings with clinical medicine. (umn.edu)
  • Brenner RP, Snyder RD. Late EEG findings and clinical status after organic mercury poisoning. (cdc.gov)
  • Aging Clinical and Experimental Research. (elsevierpure.com)
  • Yet, neuroimaging research in clinical samples characterized by high dissociation (e.g. (springer.com)
  • Research assistants will be assisting with database management and statistical analysis of research and clinical data collected in the Pediatric Neuropsychology Clinic in the Masonic Institute for the Developing Brain. (umn.edu)
  • Although the classic description of GBS is that of a demyelinating neuropathy with ascending weakness, many clinical variants have been well documented in the medical literature. (medscape.com)
  • The unconscious eye opener: Pupil dilation reveals strategic recruitment of resources upon presentation of subliminal reward cues. (psychologyofproductivity.org)
  • Recruitment in personnel psychology and beyond: Where we've been working, and where we might work next [https://doi.org/10.1111/peps.12548]. (ntu.edu.sg)
  • These lines are especially valuable, as many participating donors also received detailed clinical and genetic characterizations, and are available to researchers through SFARI Base . (sfari.org)
  • My goal is to develop a new clinical tool to assess hyperacusis. (tinact.eu)
  • The continuing advances in technologies offer unprecedented opportunities to develop neuromodulatory or neurophysiological devices that are safe and effective SUD treatments. (everydayconcerned.net)
  • Cognitive System and Arousal Regulation in this proposal), and constructs (working memory capacity and stress regulation) that represent fundamental behaviors expressed by individuals with clinical risk symptoms for psychosis. (unc.edu)
  • Limited published details exist regarding methods to deliver TMS and analyze data in a standardized and consistent manner as part of an international, multicenter, clinical trial. (longdom.org)
  • Materials and methods: A standardization process was developed to ensure TMS protocol adherence and data quality, and each clinical site was required to successfully complete standardization procedures prior to collecting patient data. (longdom.org)
  • Ongoing standardization was maintained by regular review of patient data and communication between the clinical site and standardization administrator. (longdom.org)
  • Standardized descriptions published in 1996 based on a survey of international MS experts provided purely clinical phenotypes based on data and consensus at that time, but imaging and biological correlates were lacking. (scienceopen.com)
  • As a results-driven recruitment team, we pride ourselves on our ability to source top talent from all over the country, especially in the often-overlooked field of Intraoperative Neurophysiological Monitoring (IONM) Technologists. (ceteravitae.com)
  • Our recruitment team work their magic by developing a customized search strategy based solely on the results of your needs assessment. (ceteravitae.com)
  • Journal of Basic and Clinical Physiology and Pharmacology. (manipal.edu)
  • Understanding the central underpinnings of fatigue in these movements are of paramount importance at basic and clinical levels. (nature.com)
  • The central drive to the muscle reduces when muscle force wanes during sustained MVC, and this is generally considered the neurophysiological footprint of central fatigue. (nature.com)
  • GBS is generally diagnosed on clinical grounds. (medscape.com)
  • RESULTS: We find a decreased amplitude in the response to auditory stimuli and reduced recruitment of neurones to fast steady-state gamma oscillatory activity. (lu.se)
  • Following the promising pre-clinical and clinical results with t. (biomedcentral.com)
  • As this thesis will be part of a larger partnership, in particular with a medical unit, good personal investment, organisation and teamwork skills are expected in order to ensure an effective recruitment and good communication between the different teams. (ebea.org)
  • In addition to coordinating annual local and national recruitment, Edith helped design a monthly curriculum to better prepare and create community among local and national participants in the pre-MSTP Mentoring Program. (umn.edu)
  • With minimal volitional activity, the recruitment patterns of muscle are normal. (medscape.com)
  • Additionally, by applying multiple interventions to accelerate motor recovery, we are employing a treatment regimen that reflects a true clinical approach. (biomedcentral.com)
  • Determination of the recruitment pattern, however, is not dependent on patient cooperation. (medscape.com)