Clinical glucose clamp technique. Medical search. Frequent questions

It is used for the study of metabolic rates (e.g., in glucose, lipid, amino acid metabolism) at constant glucose concentration. (umassmed.edu)
This hyperglycemic plateau is maintained by adjustment of a variable glucose infusion, based on the rate of insulin secretion and glucose metabolism. (wikipedia.org)
Because the plasma glucose concentration is held constant, the glucose infusion rate is an index of insulin secretion and glucose metabolism. (wikipedia.org)
In 80 morbidly obese women, mean visceral (omental) and subcutaneous fat cell sizes were related to in vivo markers of inflammation, glucose metabolism and lipid metabolism. (nih.gov)
The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. (cambridge.org)
However, beta-cell dysfunction and IR induce impaired glucose metabolism, thus leading to the progression to T2D. (e-apem.org)
Insulin resistance (IR) has been identified as a cardinal trigger of impaired glucose metabolism, T2D, and cardiovascular diseases [ 3 , 4 ]. (e-apem.org)
[2] [3] The pancreatic islets are arranged in density routes throughout the human pancreas, and are important in the metabolism of glucose . (wikipedia.org)
Baroreflex-mediated changes in sympathetic vasomotor tone may have a limited acute effect on muscle glucose metabolism in patients with treatment-resistant hypertension. (shengsci.com)
In pancreatic beta-cells, glucose metabolism signals insulin secretion by altering the cellular array of messenger molecules. (shengsci.com)
Diabetes causes suppressed glucose oxidation leading to inefficient energy production, enhanced fatty acid metabolism, and increased susceptibility to myocardial ischemia and reperfusion injury. (biomedcentral.com)
Hansen D , De Strijcker D, Calders P. Impact of endurance exercise training in fasted state on muscle biochemistry and metabolism in healthy subjects: are these effects of particular clinical benefit to type 2 diabetes and insulin resistant patients? (uhasselt.be)
To determine the mechanism, we examined insulin-stimulated glucose uptake and metabolism during hyperinsuline-mic-euglycemic clamp in control and muscle GLUT4 KO mice before and after development of diabetes. (elsevierpure.com)
Janowska J, Chudek J, Olszanecka-Glinianowicz M, Semik-Grabarczyk E, Zahorska-Markiewicz B. Interdependencies among Selected Pro-Inflammatory Markers of Endothelial Dysfunction, C-Peptide, Anti-Inflammatory Interleukin-10 and Glucose Metabolism Disturbance in Obese Women. (medsci.org)
We have studied the relationship between clinical and biochemical parameters and C-peptide and anti-inflammatory IL-10, as well as selected markers of inflammation and endothelial dysfunction such as: CCL2, CRP, sICAM-1, sVCAM-1 and E-selectin in obese women with various degree of glucose metabolism disturbance. (medsci.org)
Obese patients were spited in subgroups based on the degree of glucose metabolism disorder. (medsci.org)
Although a focus is often placed on insulin as a regulator of blood glucose, insulin plays a key role in the regulation of lipid and protein metabolism, in addition to cellular growth and development. (basicmedicalkey.com)
Journal of Clinical Endocrinology and Metabolism , 84 (1), 220-227. (elsevierpure.com)
These observations suggest that abnormal glucose metabolism likely plays a role in some aspects of AD pathogenesis, leading us to investigate the link between aberrant glucose metabolism, T2DM, and AD in murine models. (jci.org)
To accomplish this, we used the glucose clamp technique with isotopic determination of glucose disposal and indirect calorimetry for measuring the pathways of glucose metabolism, and vastus lateralis muscle biopsies to determine the effects of insulin on glycogen synthase and PDH activities. (arizona.edu)
We conclude that prevailing fasting hyperglycemic normalizes the nonoxidative and oxidative pathways of insulin-stimulated glucose in metabolism in NIDDM and may act as a homeostatic mechanism to normalize muscle glucose metabolism. (arizona.edu)
Journal of Clinical Endocrinology and Metabolism , 71 (6), 1544-1551. (arizona.edu)
We investigate mechanisms that regulate metabolism in health and disease by combining experiments on mice and cell models with clinical studies, and we try to apply new knowledge in clinical medicine. (cas.cz)
The Glucose Homeostasis Unit (PI: M. Rossmeisl), investigates the mechanisms associated with the effect of dietary lipids on metabolism, with a special focus on omega-3 fatty acids and different lipid forms of their administration. (cas.cz)
Specifically, we study the changes in ectopic lipid accumulation, glucose metabolism and insulin sensitivity in response to dietary supplementation with omega-3 using various mouse models of diet-induced obesity and non-alcoholic fatty liver disease (NAFLD). (cas.cz)

The hyperinsulinemic clamp, which requires maintaining a high insulin level by perfusion or infusion with insulin, is a way to quantify how sensitive the tissue is to insulin. (wikipedia.org)
The hyperinsulinemic clamp is also called euglycemic clamp, meaning a normal blood sugar level is maintained. (wikipedia.org)
Hyperinsulinemic-euglycemic clamp technique: The plasma insulin concentration is acutely raised and maintained at 100 μU/ml by a continuous infusion of insulin. (wikipedia.org)
The hyperinsulinemic clamps are often used to measure insulin resistance. (wikipedia.org)
To quantify the effects of the drug, researchers used a very sophisticated test of insulin sensitivity, the hyperinsulinemic-euglycemic clamp or "the clamp," which is largely regarded as the gold standard in insulin sensitivity measurement. (sciencedaily.com)
Classical assessment techniques for exercise tolerance (cardiopulmonary exercise testing and dynamometry testing), cardiac function (echocardiography), body composition (dexa scan), glycemic control and insulin sensitivity (oral glucose tolerance test, euglycemic hyperinsulinemic clamp test), skeletal muscle physiology (by muscle biopsy and subsequent in vitro techniques) and adipocyte physiology (by subcutaneous fat biopsy and subsequent in vitro techniques) are often applied. (uhasselt.be)
however, the most commonly performed is probably the euglycemic hyperinsulinemic clamp. (basicmedicalkey.com)
Insulin sensitivity was assessed using the euglycemic hyperinsulinemic clamp technique. (elsevierpure.com)
We examined the effect of three months of rosiglitazone treatment (4 mg b.i.d.) on whole-body insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol release in microdialysis from subcutaneous fat during a two-step (20 and 120 mU · m −2 · min −1 ) hyperinsulinemic-euglycemic clamp in nine type 2 diabetic subjects. (diabetesjournals.org)
Improvement was assessed by using the hyperinsulinemic-euglycemic clamp technique. (asayesh.org)
Insulin sensitivity is actually mentioned by the hyperinsulinemic euglycemic clamp in advance of procedure and you will 62 ladies was together with re-tested two years article-operatively. (asayesh.org)
However, technical demands associated with directly assessing insulin sensitivity using the hyperinsulinemic euglycemic clamp, and a lack of studies in animal models, have precluded demonstrating that a cause-and-effect relationship exists between OSA and insulin resistance independent of obesity. (atsjournals.org)
We also focus on insulin-sensitizing effects of omega-3 administered as triacylglycerols, phospholipids (Krill oil) or wax esters (Calanus oil), which are studied at the whole-body as well as organ level (muscle, adipose tissue, liver) using in vivo technique of hyperinsulinemic-euglycemic clamps. (cas.cz)
This study aimed to evaluate the effects of metformin and conjugated linoleic acid (CLA) on insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp technique and insulin pathway expression molecules in muscle biopsies of children with obesity. (medscape.com)
Improvement of insulin sensitivity, measured via euglycemic-hyperinsulinemic clamp and IRS2 upregulation, favored patients treated with CLA. (medscape.com)

Arterial baroreflexes may regulate resistance vessels supplying glucose to skeletal muscle by modulating efferent sympathetic nervous system activity. (shengsci.com)
To address whether these latter changes were caused by glucose toxicity, we treated muscle GLUT4 KO mice with phloridzin to prevent hyperglycemia and found that insulin-stimulated whole body and skeletal muscle glucose uptake were decreased substantially, whereas insulin-stimulated glucose uptake in adipose tissue and suppression of hepatic glucose production were normal after phloridzin treatment. (elsevierpure.com)
Subsequent studies showed that most subjects with type 2 DM had resistance to insulin action in adipose tissue (inhibition of lipolysis), liver (inhibition of glucose production), and skeletal muscle (stimulation of glucose disposal) ( 14 , 15 , 16 ). (basicmedicalkey.com)
The training also enhances insulin sensitivity and glucose elimination in skeletal muscle. (forgottenportal.com)
Nicolaas E.P. Deutz In 1982 and 2011, Clinical Science published papers that used infusion of stable isotope -labeled amino acids to assess skeletal muscle protein synthesis in the fasted and fed state and before and after a period of increased intake of omega-3 fatty acids. (silverchair.com)
The present studies were undertaken to determine whether fasting hyperglycemic can compensate for decreased insulin-stimulated glucose disposal, oxidation, and storage in noninsulin-dependent diabetes mellitus (NIDDM) as well as to determine whether hyperglycemic normalizes insulin-stimulated skeletal muscle glycogen synthase and pyruvate dehydrogenase (PDH) activities. (arizona.edu)

When the steady-state is achieved, the glucose infusion rate equals glucose uptake by all the tissues in the body and is therefore a measure of tissue insulin sensitivity. (wikipedia.org)
Insulin resistance (IR), i.e., whole-body decreased glucose uptake in response to physiological insulin levels, determines impaired glucose homeostasis and it is recognized as cardinal trigger of T2D and cardiovascular disease in both adults and children. (e-apem.org)
The term 'insulin resistance' refers to a reduced glucose uptake in response to physiological insulin levels. (e-apem.org)
In the ischemic myocardium, an increase in glucose uptake and subsequent ATP generated through glycolysis helps to sustain myocardial electric and mechanical performance, maintains cellular ultrastructure, promotes myocardial recovery. (biomedcentral.com)
Accordingly, mechanism of enhancing myocardial energetic efficiency by stimulating glucose availability and utilization has led to the vigorous pursuit of therapeutic approaches designed to augment glucose uptake and oxidation. (biomedcentral.com)
One such area of interest is the ability to modulate myocardial glucose uptake and its impact on cardioprotection. (biomedcentral.com)
Insulin-stimulated whole body glucose uptake was decreased by 55% in muscle GLUT4 KO mice, an effect that could be attributed to a 92% decrease in insulin-stimulated muscle glucose uptake. (elsevierpure.com)
Surprisingly, insulin's ability to stimulate adipose tissue glucose uptake and suppress hepatic glucose production was significantly impaired in muscle GLUT4 KO mice. (elsevierpure.com)
Insulin-mediated glucose uptake was found to vary by up to eightfold in healthy subjects. (basicmedicalkey.com)

Patients were submitted to a frequently sampled intravenous glucose tolerance test (FSIGT) with the stimulator on and with the stimulator off on separate days in a randomized, double-blind, crossover study. (shengsci.com)
Improvement was assessed by using the Frequently Sampled Intravenous Glucose Tolerance Test. (asayesh.org)

However, their impact on whole-body insulin sensitivity using the hyperinsulinaemic-euglycaemic clamp technique remains under-studied. (bvsalud.org)
In conclusion, acute changes in baroreceptor stimulation did not elicit significant changes in muscular glucose delivery and whole-body insulin sensitivity. (shengsci.com)

The hyperglycemic clamp, which requires maintaining a high blood sugar level by perfusion or infusion with glucose, is a way to quantify how fast beta-cells respond to glucose. (wikipedia.org)
citation needed] Hyperglycemic clamp technique: The plasma glucose concentration is acutely raised to 125 mg/dl above basal levels by a continuous infusion of glucose. (wikipedia.org)
The hyperglycemic clamps are often used to assess insulin secretion capacity. (wikipedia.org)
MATERIALS AND METHODS: Plasma samples were obtained from 10 healthy subjects during four conditions: euglycemic (5 mmol/L) and hyperglycemic (12 mmol/L) 90-minute glucose clamps with co-infusion of GIP (4 pmol/kg/min for 15 min, followed by 2 pmol/kg/min for 45 min) or placebo. (ku.dk)

In conclusion, these findings demonstrate that a primary defect in muscle glucose transport can lead to secondary defects in insulin action in adipose tissue and liver due to glucose toxicity. (elsevierpure.com)

Metformin (MET) is a biguanide used for the treatment of type 2 diabetes in children and adolescents due to its ability to decrease hepatic glucose production and increase peripheral insulin sensitivity. (medscape.com)

Glucose clamp technique is a method for quantifying insulin secretion and resistance. (wikipedia.org)
1] DeFronzo RA, Tobin JD, Andres R. "Glucose Clamp Technique: a Method for Quantifying Insulin Secretion and Resistance. (wikipedia.org)
We aimed to determine the effects of strawberry and cranberry polyphenols (SCP) on insulin sensitivity, glucose tolerance, insulin secretion, lipid profile, inflammation and oxidative stress markers in free-living insulin-resistant overweight or obese human subjects (n 41) in a parallel, double-blind, controlled and randomised clinical trial. (bvsalud.org)
At the beginning and at the end of the experimental period, insulin sensitivity was assessed by a hyperinsulinaemic-euglycaemic clamp, and glucose tolerance and insulin secretion by a 2-h oral glucose tolerance test (OGTT). (bvsalud.org)
Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. (shengsci.com)

Insulin resistance Metabolic Score for Insulin Resistance (METS-IR) Homeostatic model assessment Diabetes mellitus Diabetes management Linda von Wartburg, "What's a Glucose Clamp, Anyway? (wikipedia.org)
The next phase will be to determine clinical success in patients with type 2 diabetes on the whole range of diabetic medications or perhaps with less severe lipid problems. (sciencedaily.com)
Although consumption of brown seaweed extract had no effect on body weight or blood glucose, an early attenuation of the inflammatory response was observed in association with marginal changes in metabolic parameters related to the prevention of diabetes type 2. (bvsalud.org)
GLP-1 has insulinotropic, insulinomimetic, and glucagonostatic effects, thereby exerting multiple complementary actions to lower blood glucose in subjects with type 2 diabetes mellitus. (biomedcentral.com)
As a result, we study the physiology of exercise in these patients, and the molecular and clinical impact of (different types of) exercise training in patients with obesity, type 2 diabetes, coronary heart disease, or heart failure. (uhasselt.be)
Many diabetes care professionals around the world do continuously observe differences between human and animal insulin in clinical practice: unawareness of hypoglycaemia symptoms, unstable diabetes control, increased severity of hypoglycaemic episodes without warning symptoms. (iddt.org)
ADO09, a co-formulation of the amylin-analog pramlintide and the insulin analog A21G, lowers postprandial blood glucose versus insulin lispro in type 1 diabetes (T1D). (profil.com)
Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA). (profil.com)
This impaired suppression of endogenous glucose production by hyperglycemia.CONCLUSION These data show that GLP1R blockade impairs islet function, implying that intra-islet GLP1R activation alters islet responses to glucose and does so to a greater degree in people with type 2 diabetes.TRIAL REGISTRATION This study was registered at ClinicalTrials.gov NCT04466618.FUNDING The study was primarily funded by NIH NIDDK DK126206. (jci.org)
Epidemiological studies show that patients with type 2 diabetes (T2DM) and individuals with a diabetes-independent elevation in blood glucose have an increased risk for developing dementia, specifically dementia due to Alzheimer's disease (AD). (jci.org)
In addition to complications related to the chronic ovulatory dysfunction, metabolic disturbances such as dyslipidemia, impaired glucose tolerance, and type 2 diabetes mellitus (T2DM) can concomitantly occur with PCOS [ 3 ]. (ogscience.org)
Stable isotope tracers of palmitate and glucose were infused for 2h at rest and 1h of bicycle exercise at 40% peak oxygen consumption ( V O 2 max) in volunteers with Type II diabetes and a healthy control group. (silverchair.com)
3 Valencia WM, Florez H. How to prevent the microvascular complications of type 2 diabetes beyond glucose control. (scielo.br)
Type 2 diabetes (T2D) is the major form of diabetes and obesity and physical inactivity influence the disease development leading to the elevated blood glucose level. (lu.se)
offers exceptional research competence in obesity, metabolic syndrome, diabetes, and cardiovascular disease with a huge scope of well-established and up-to-date clinical investigations for the pharmacodynamic evaluation of new molecules. (crs-group.de)
CRS is a highly experienced, strong, and reliable partner in the early and advanced clinical assessment of investigational drugs or medical devices for the prevention or treatment of obesity, metabolic syndrome, diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), etc., - in brief: in the indication of cardiometabolic and cardiovascular diseases. (crs-group.de)

We monitored interstitial glucose, lactate, and pyruvate in the vastus lateralis muscle using microdialysis. (shengsci.com)

Hyperplasia (many small adipocytes) in both adipose regions may be protective against lipid as well as glucose/insulin abnormalities in obesity. (nih.gov)
Volanesorsen, an experimental lipid-lowering medication, improved insulin sensitivity and glucose control by significantly decreasing patients' overall hemoglobin A1c -- the standard clinical measurement of blood glucose levels for diabetics -- in a new study. (sciencedaily.com)

Clinical Endocrinology , 63 (4), 428-436. (elsevierpure.com)
Journal of Clinical and Translational Endocrinology. (wustl.edu)

These and subsequent studies showed that more insulin-resistant subjects had greater plasma insulin concentration, VLDL-TG, and plasma glucose during the oral glucose tolerance test than did insulin-sensitive subjects, findings supporting the relationship between IR and MS ( 26 ). (basicmedicalkey.com)

Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance. (umassmed.edu)

There are multiple ways to measure insulin resistance such as fasting insulin levels or glucose tolerance tests, but these are not often used in clinical practice. (wikipedia.org)

Common metabolic abnormalities related to PCOS are central obesity, dyslipidemia, and impaired glucose tolerance, and all of these are known to be highly associated with insulin resistance [ 4 ]. (ogscience.org)
The dramatic growth of obesity in association with its metabolic, cardiovascular, and mutagenic comorbidities has inspired basic and clinical research and increased our understanding of the molecular pathways driving these diseases. (crs-group.de)

Interstitial glucose, lactate, and pyruvate increased similarly during FSIGT regardless of the stimulator settings. (shengsci.com)
We assessed a potential coupling among plasma insulin, glucose, and lactate concentrations, by frequent blood sampling for 24 h in 11 healthy volunteers. (elsevierpure.com)
The daytime profiles showed significant temporal coupling and pattern synchrony among insulin, lactate, and glucose. (elsevierpure.com)
Here, we combined two techniques - glucose clamps and in vivo microdialysis - as a means to dynamically modulate blood glucose levels in awake, freely moving mice while measuring real-time changes in amyloid-β (Aβ), glucose, and lactate within the hippocampal interstitial fluid (ISF). (jci.org)

Maintenance of a constant blood glucose level by perfusion or infusion with glucose or insulin. (umassmed.edu)

Cortisol counteracts insulin and can lead to increased hepatic gluconeogenesis , reduced peripheral utilization of glucose, and increased insulin resistance. (wikipedia.org)
0.005) and reduced glucose utilization in oxidative muscle fibers, but did not cause a change in hepatic glucose output. (atsjournals.org)
We conclude that IH can cause acute insulin resistance in otherwise lean, healthy animals, and that the response is associated with decreased glucose utilization of oxidative muscle fibers, but that it occurs independently of activation of the ANS. (atsjournals.org)

The objective of the present study was to test whether a brown seaweed extract rich in polyphenols combined with a low-calorie diet would induce additional weight loss and improve blood glucose homeostasis in association with a metabolic and inflammatory response in overweight/obese prediabetic subjects. (bvsalud.org)
The injured myocardium develops an evolving dependence on glucose as its preferred metabolic substrate while development of myocardial insulin resistance is associated with the progression of heart failure and increased incidence as well as severity of the damaged hearts. (biomedcentral.com)
Insulin, glucose and potassium (GIK) are touted as useful metabolic adjuvant, associated with improvement of cardiac function in acute myocardial function, but the general acceptance of this therapeutic approach is limited by requirements for concomitant infusion of glucose and concerns regarding hypoglycemia. (biomedcentral.com)
The total daily dose of Aminosyn II 5% in 25% Dextrose Injection to be infused depends on daily protein and caloric requirements and on the patient's metabolic and clinical response. (rxlist.com)
Before input, there were zero clinical or metabolic differences when considering the 2 organizations. (asayesh.org)
Recently, data from epidemiologic cohorts and clinical populations have indicated that OSA may also contribute to the development of insulin resistance ( 6 - 8 ), another component of the metabolic syndrome. (atsjournals.org)
These methods range from a broad spectrum of metabolic clamp investigations and tests, over several biomarkers, up to high resolution imaging techniques and tissue biopsies. (crs-group.de)

Glucose and insulin concentrations in arterialized venous blood before and during FSIGT were virtually identical with the stimulator on and with the stimulator off. (shengsci.com)
fasting islet hormone concentrations were unchanged, but inappropriate for the higher fasting glucose observed. (jci.org)

In study 1, there was an approximate 2-fold increase in muscle insulin sensitivity (relative increase in glucose disposal during insulin infusion) and a 4-fold increase in hepatic insulin sensitivity 12 months after RYGB alone and RYGB plus omentectomy, compared with baseline values (p (asayesh.org)

For the first time, it has been shown that profoundly lowering triglycerides in diabetics improves their insulin sensitivity over time, which helps them maintain healthy glucose -- blood sugar -- levels. (sciencedaily.com)
This technique infuses insulin at fixed rates, and infuses glucose at a varying rate to keep blood glucose constant, in order to determine how well a patient responds to insulin. (sciencedaily.com)
No effect was observed on blood glucose. (bvsalud.org)
Research has already demonstrated that human insulin has no clinical advantage for patients and that it has a faster absorption and consequently a shorter duration of action, so accounting for the greater fluctuations in blood-glucose levels. (iddt.org)
Those who do not have access to frequent blood-glucose monitoring, e.g. in developing countries. (iddt.org)
Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood glucose (blood sugar). (wikipedia.org)
In states of insulin resistance, the same amount of insulin does not have the same effect on glucose transport and blood sugar levels. (wikipedia.org)
Blood glucose also fluctuated during daytime at an interval of 89 ± 32 min. (elsevierpure.com)
The evolution of nephropathy was observed using a urine test strip and the DM, through the analysis of blood glucose with a reagent strip on a digital monitor. (scielo.br)
The main hormone regulating the blood glucose levels is insulin, secreted from beta cells, and glucagon, secreted from alpha cells. (lu.se)

Meanwhile, the plasma glucose concentration is held constant at basal levels by a variable glucose infusion. (wikipedia.org)
A major advantage over conventional insulin is the fact that the insulinotropic actions of GLP-1 are dependent upon ambient glucose concentration, mitigating the risks of hypoglycemia. (biomedcentral.com)
This new ability to measure both plasma glucose and insulin concentration allowed the development of oral glucose tolerance testing ( 7 ) and the glucose clamp techniques ( 8 ). (basicmedicalkey.com)
Nine patients with NIDDM and eight matched non-diabetic subjects were infused with insulin (40 mU/m 2 ·min) while plasma glucose was maintained at the prevailing fasting concentration. (arizona.edu)

Subcutaneous, but not visceral, adipocyte size was significantly associated with plasma insulin and glucose, insulin-induced glucose disposal and insulin sensitivity (p ranging from 0.002 to 0.005, partial r ranging from -0.34 to 0.35). (nih.gov)
In this protocol, a constant infusion of insulin is administered to the subject to cause hyperinsulinemia, and the rate of glucose infusion (glucose disposal) necessary to maintain euglycemia is determined. (basicmedicalkey.com)
During insulin infusion, rates of glucose disposal, storage, and oxidation were the same in the two groups. (arizona.edu)

glucose insulin, potassium as an adjunct in cardiac surgery. (stanford.edu)
Inward rectifying, ATP-sensitive potassium (K ATP ) channels mediated the response to elevated glucose levels, as pharmacological manipulation of K ATP channels in the hippocampus altered both ISF Aβ levels and neuronal activity. (jci.org)

This article discusses the pathophysiology and techniques of organ preservation and describes various preservation solutions currently used for kidney , liver , pancreas , small-bowel , lung , and heart transplantation . (medscape.com)

In my early scientific years, I learned the patch-clamp technique and used capacitance measurements to study exocytosis. (lu.se)

The elevated levels of insulin detected in response to glucose challenge together with increased fasting insulin levels in older mice suggest that they progressively develop IR. (biomedcentral.com)
Significant relationships were found between levels of glucose and sICAM-1and also E-selectin and HOMA-IR. (medsci.org)

Electrical activity of pancreatic islets has been studied using patch clamp techniques. (wikipedia.org)

If improved insulin sensitivity and improved glucose control are truly the result of lowering triglycerides, researchers suggest these other novel drugs should show the same effect. (sciencedaily.com)

Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone secreted postprandially from the small intestine. (ku.dk)

Hiit training has been demonstrated in several clinical investigations to improve endothelial function. (forgottenportal.com)

Furthermore, at the end of a clamp, HIIT improves the expression of pAkt Thr308/Akt total and pAkt Thr642/GAPDH. (forgottenportal.com)

Clinical and biochemical parameters of MS and the presence of IR were recorded. (biomedcentral.com)

Several tests of glucose control, including hemoglobin A1c, were also significantly improved. (sciencedaily.com)

The incretin effect denominates the phenomenon that oral glucose elicits a higher insulin response than does intravenous glucose. (shengsci.com)

Anatomy1

Organisms1

Diseases9

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology1

Phenomena and Processes11

Disciplines and Occupations1

Information Science1

Metabolism25

Hyperinsulinemic15

Skeletal muscle6

Uptake9

Frequently sampled intravenous glucose tole2

Whole-body insulin sensitivity2

Hyperglycemic4

Adipose Tissue1

Hepatic glucose production1

Secretion5

Diabetes16

Vastus latera1

Lipid2

Endocrinology2

Tolerance test1

Intolerance1

Measure insulin resistance1

Obesity2

Lactate4

Perfusion or infusion1

Utilization3

Metabolic7

Concentrations2

Increase in glucose1

Blood10

Concentration4

Disposal3

Potassium2

Liver1

Measurements1

Levels2

Pancreatic1

Triglycerides1

Insulinotropic1

Endothelial1

Improves1

Biochemical parameters1

Significantly1

Oral1