AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
FluorouracilLeucovorinAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsDihydrouracil Dehydrogenase (NADP)Organoplatinum CompoundsDrug Administration ScheduleColorectal NeoplasmsThymidylate SynthaseCisplatinInfusions, IntravenousCamptothecinMethotrexateUracilFloxuridineChemotherapy, AdjuvantAdenocarcinomaEpirubicinFluorodeoxyuridylateCombined Modality TherapyColonic NeoplasmsTreatment OutcomeCyclophosphamideTegafurMitomycinAntimetabolitesSurvival AnalysisSemustineDisease-Free SurvivalStomach NeoplasmsDoxorubicinRectal NeoplasmsDeoxycytidineLevamisoleAntineoplastic AgentsNeoplasm MetastasisBreast NeoplasmsSurvival RateInfusions, Intra-ArterialStomatitisLiver NeoplasmsLevoleucovorinBromouracilAntidotesDrug SynergismFlucytosineDose-Response Relationship, DrugChronotherapyTaxoidsCarcinoma, Squamous CellProdrugsHead and Neck NeoplasmsEsophageal NeoplasmsPhosphoribosyl PyrophosphateLeukopeniaNeoplasm StagingMucositisDrug Resistance, NeoplasmNeutropeniaNeoadjuvant TherapyThymidine PhosphorylaseCytosine DeaminaseDrug EvaluationInjections, IntravenousPancreatic NeoplasmsOxonic AcidDihydropyrimidine Dehydrogenase DeficiencyNauseaNeoplasm Recurrence, LocalHepatic ArteryPaclitaxelDeoxyuracil NucleotidesUridinePhosphonoacetic AcidInterferon-alphaTrimetrexateUridine PhosphorylaseMaximum Tolerated DoseAdministration, OralMitomycinsCell Line, TumorRadiotherapy, AdjuvantFluorineDeoxyuridineTime FactorsGastrointestinal NeoplasmsAntineoplastic Agents, PhytogenicDiarrheaHistidinolAntibiotics, AntineoplasticCarcinomaLymphatic MetastasisPrognosisOrotate PhosphoribosyltransferaseCell SurvivalThiophenesAntibodies, Monoclonal, HumanizedFollow-Up StudiesDrug Screening Assays, AntitumorTumor Cells, Cultured
IrinotecanCisplatinLeucovorinToxicityCombination with 5-fluorouracilOxaliplatinTherapyRadiotherapyTrialsOutcomeTopicalColorectal cancer patientsEpirubicinEfficacyIntralesionalAntimetaboliteMetastaticAcuteTherapeutic Drug MonitChemotherapeuticPractice GuidelinesInjectionHarmCause severeCancerFetusOncologyIncidenceRadiationPathwayDeficiencyStudyDosePrognosticLesionsAdministrationDecreaseDiarrheaORALStudiesRapid
Irinotecan6
  • This phase II trial compares two treatment combinations: gemcitabine hydrochloride and nab-paclitaxel, or fluorouracil, leucovorin calcium, and liposomal irinotecan in older patients with pancreatic cancer that has spread to other places in the body (metastatic). (rochester.edu)
  • Drugs used in chemotherapy, such as gemcitabine hydrochloride, nab-paclitaxel, fluorouracil, leucovorin calcium, and liposomal irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (rochester.edu)
  • The study used a computer simulation model that follows hypothetical patients treated with the FOLFIRI (5-fluorouracil/leucovorin with irinotecan) chemotherapy regimen for metastatic colorectal cancer. (scienceblog.com)
  • oxaliplatin, irinotecan, leucovorin, fluorouracil) vs mFOLFIRINOX plus hypofractionated radiotherapy in patients with borderline resectable pancreatic ductal adenocarcinoma. (ascopost.com)
  • First-line treatment with 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX) and second-line treatment including 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) plus panitumumab showed inefficiency in controlling disease progression. (karger.com)
  • Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens. (cdc.gov)
Cisplatin4
Leucovorin1
Toxicity10
  • The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. (medscimonit.com)
  • TDM in colorectal cancer can reduce toxicity, improve efficacy and clinical outcome, and can be routinely used in 5-FU-based chemotherapy. (medscimonit.com)
  • Clinical studies have demonstrated that TDM improves treatment by lowering toxicity and improving effectiveness. (saladax.com)
  • Withhold or permanently discontinue fluorouracil in patients with evidence of acute early-onset or unusually severe toxicity, which may indicate near complete or total absence of dipyrimidine dehydrogenase (DPD) activity. (nih.gov)
  • Withhold fluorouracil for cardiac toxicity. (nih.gov)
  • Background/aims The aim of this study was to evaluate the long-term corneal toxicity of topical chemotherapy with 1% 5-fluorouracil (5-FU) as a sole or adjuvant treatment of ocular surface squamous neoplasia (OSSN). (bmj.com)
  • Clinical confocal microscopy was used to check for 5-FU long-term corneal toxicity. (bmj.com)
  • For fluorouracil: Patients with dihydropyrimidine dehydrogenase (DPD) deficiency are unable to metabolize fluorouracil normally and may have severe unexpected toxicity to fluorouracil. (medscape.com)
  • Background: The ESPAC-3 trial showed that adjuvant gemcitabine is the standard of care based on similar survival to and less toxicity than adjuvant 5-fluorouracil/folinic acid in patients with resected pancreatic cancer. (lu.se)
  • A mutation for screening patients to prevent fluorouracil-related toxicity. (cdc.gov)
Combination with 5-fluorouracil1
  • It is indicated for the reduction of cytotoxicity when used in combination with 5-fluorouracil in the treatment of colorectal cancer and for the treatment of megaloblastic anemia due to folic acid deficiency when folic acid cannot be replaced orally. (janusinfo.se)
Oxaliplatin1
  • Purpose: This multicenter phase II study was designed to determine the efficacy and tolerability of oxaliplatin, levoforinate, and infusional 5-fluorouracil (FOLFOX4) as a second-line therapy for Japanese patients with unresectable advanced or metastatic colorectal cancer. (elsevierpure.com)
Therapy6
  • Withhold fluorouracil and initiate ammonia-lowering therapy. (nih.gov)
  • Our aim was to integrate our previously reported clinical-genetic prognostic score with new immunogenetic markers of 5-year disease-free survival (DFS) to evaluate the recurrence risk stratification before fluoropyrimidine (FL)-based adjuvant therapy. (frontiersin.org)
  • It has been demonstrated that this healthcare service, known as medication therapy management, improves clinical, economic, and humanistic outcomes of care and decreases health expenditures when provided within the practice of pharmaceutical care. (medscape.com)
  • The authors evaluated the efficacy of photodynamic therapy (PDT) with or without topical 5-fluorouracil (F5U) pretreatment in patients with actinic keratoses, precancerous lesions that can progress to squamous cell carcinoma of the skin. (aacr.org)
  • Please consult the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines™) for Antiemesis for appropriate antiemetic therapy. (medscape.com)
  • Therapy with 5-fluorouracil cream has not been evaluated in controlled studies, frequently causes local irritation, and is not recommended for the treatment of genital warts. (cdc.gov)
Radiotherapy2
  • Fluorouracil is contraindicated in patients who are severely debilitated and in patients with bone marrow suppression due to either radiotherapy or chemotherapy. (wikipedia.org)
  • [ 1 ] Common drugs include 5-fluorouracil and mitomycin, as well as radiotherapy. (medscape.com)
Trials5
  • Dr. Chung is conducting clinical trials to develop less toxic but effective molecularly targeted agents which can potentially benefit this subset of HNC patients. (moffitt.org)
  • 5-Fluorouracil is being increasing replaced in clinical trials with 3rd generation 5-FU drugs such as capecitabine. (dcu.ie)
  • With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. (ehealthme.com)
  • Other clinical trials have shown better survival and tumour response with gemcitabine and capecitabine than with gemcitabine alone in advanced or metastatic pancreatic cancer. (lu.se)
  • A multitude of randomized clinical trials and other treatment studies have demonstrated that currently available therapeutic methods are 22%-94% effective in clearing external exophytic genital warts, and that recurrence rates are high (usually at least 25% within 3 months) with all modalities. (cdc.gov)
Outcome3
  • Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
  • Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)
  • Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
Topical4
  • Fluorouracil Cream USP is topical preparations containing the fluorinated pyrimidine 5-fluorouracil, an antineoplastic antimetabolite. (nih.gov)
  • If applied twice daily, this would indicate systemic absorption of topical fluorouracil to be in the range of 5 to 6 mg per daily dose of 100 mg. (nih.gov)
  • Fluorouracil Cream USP is recommended for the topical treatment of multiple actinic or solar keratoses. (nih.gov)
  • There are no adequate and well-controlled studies in pregnant women with either the topical or the parenteral forms of fluorouracil. (nih.gov)
Colorectal cancer patients1
  • Removal rate of 5-fluorouracil and its metabolites in patients on hemodialysis: a report of two cases of colorectal cancer patients with end-stage renal failure. (bvsalud.org)
Epirubicin1
  • Patients were treated with combined chemotherapy of epirubicin (EPIR), mitomycin C (MMC), 5-fluorouracil (5-FU), by hepatic infusion using a subcutaneously implanted reservoir. (nih.gov)
Efficacy2
  • Fluorouracil's efficacy is decreased when used alongside allopurinol, which can be used to decrease fluorouracil induced stomatitis through use of allopurinol mouthwash. (wikipedia.org)
  • To evaluate the efficacy of intra-arterial chemotherapy combined with hyperthermia for metastatic liver cancer, our cooperative study group carried out a randomized clinical trial comparing intra-arterial chemotherapy alone and intra-arterial chemotherapy combined with hyperthermia. (nih.gov)
Intralesional2
  • Weiss E, Amini S. A novel treatment for knuckle pads with intralesional Fluorouracil. (medscape.com)
  • Other common treatments include silicone sheets, compression, intralesional administration of 5-fluorouracil, and excision. (springer.com)
Antimetabolite1
  • Fluorouracil is in the antimetabolite and pyrimidine analog families of medications. (wikipedia.org)
Metastatic1
  • Our study points to significant potential benefits for pretreatment pharmacogenetic testing for metastatic colorectal cancer, but remains to be verified by clinical research. (scienceblog.com)
Acute1
  • 1% frequency): Local pain Itchiness Burning Stinging Crusting Weeping Dermatitis Photosensitivity Uncommon (0.1-1% frequency): Hyper- or hypopigmentation Scarring The United States package insert warns that acute cerebellar syndrome has been observed following injection of fluorouracil and may persist after cessation of treatment. (wikipedia.org)
Therapeutic Drug Monit1
  • Bethlehem, PA - September 19, 2018 - Saladax Biomedical Inc., a diagnostics company providing kits to test drug blood levels for personalized dose management and adherence, announced today that it welcomes new guidelines from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) that "strongly recommend" monitoring levels of 5-Fluorouracil (5-FU) in patients on treatment. (saladax.com)
Chemotherapeutic2
  • This study investigated changes in mTOR pathway and telomerase activity in hepatocarcinoma cell line SMMC-7721 treated with chemotherapeutic agent 5-fluorouracil (5-Fu). (biomedcentral.com)
  • The anti-metabolite - 5-Fluorouracil (5-FU) - is the most widely used chemotherapeutic drug. (dcu.ie)
Practice Guidelines3
  • Cite this: Key Neurology Clinical Practice Guidelines in 2017 - Medscape - Jan 16, 2018. (medscape.com)
  • Refer to NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)™ Myeloid Growth Factors. (medscape.com)
  • NCCN Clinical Practice Guidelines in Oncology: Anal Carcinoma. (medscape.com)
Injection2
  • HIGHLIGHTS OF PRESCRIBING INFORMATIONThese highlights do not include all the information needed to use FLUOROURACIL INJECTION safely and effectively. (nih.gov)
  • See full prescribing information for FLUOROURACIL INJECTION. (nih.gov)
Harm2
  • Fluorouracil can cause fetal harm. (nih.gov)
  • Fluorouracil cream may cause fetal harm when administered to a pregnant woman. (nih.gov)
Cause severe2
  • Fluorouracil can cause severe diarrhea. (nih.gov)
  • Fluorouracil can cause severe and fatal myelosuppression. (nih.gov)
Cancer8
  • 5-Fluorouracil (5-FU) is widely applied in the treatment of various cancers, including colorectal cancer (CRC) [1,2]. (medscimonit.com)
  • Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. (wikipedia.org)
  • Intraportal 5-fluorouracil for colorectal cancer: the AXIS trial. (ox.ac.uk)
  • There are clinical challenges related to adjuvant treatment in colorectal cancer (CRC) and novel molecular markers are needed for better risk stratification of patients. (frontiersin.org)
  • To improve our understanding of the biological and clinical significance of somatic mutations on RNA processing in cancer, the authors developed a new method, known as MIRA (mutation identification for RNA alterations). (aacr.org)
  • SEOM clinical guidelines for the treatment of head and neck cancer (2017). (medscape.com)
  • The ToGA trial must be characterized as a landmark in the treatment of gastric cancer and it has paved the way for a number of new HER2 targeted compounds such as pertuzumab, ado-trastuzumab emtansine, lapatinib, afatinib, and dacomitinib, which are currently undergoing phase II and III clinical testing. (wjgnet.com)
  • Clinical cancer research : an official journal of the American Association for Cancer Research 2004 Apr 10 (8): 2652-8. (cdc.gov)
Fetus1
  • Multiple birth defects have been reported in a fetus of a patient treated with intravenous fluorouracil. (nih.gov)
Oncology1
Incidence1
  • Hence, data on the incidence and clinical importance of Arcobacter remain scarce. (cdc.gov)
Radiation1
  • The ALDH+ cells were also resistant to 5-fluorouracil and radiation that is additionally augmented by both the lipid-mediators. (lu.se)
Pathway2
  • There is evidence that the metabolism of fluorouracil in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to thymidylic acid. (nih.gov)
  • The five articles in this edition of CCR Focus will address the various mechanisms of EGFR pathway activation and provide insight into the potential for translation into clinical relevance. (aacrjournals.org)
Deficiency1
  • Since DNA and RNA are essential for cell division and growth, the effect of fluorouracil may be to create a thymine deficiency which provokes unbalanced growth and death of the cell. (nih.gov)
Study6
  • In an additional study, negligible amounts of labeled material were found in plasma, urine, and expired CO 2 after 3 days of treatment with topically applied 14 C-labeled fluorouracil. (nih.gov)
  • Describes the nature of a clinical study. (mayo.edu)
  • The phase IV clinical study is created by eHealthMe based on 5,945 reports from the FDA, and is updated regularly. (ehealthme.com)
  • Dr. Bruce Schackman, senior author of the study, says, "Cost-effectiveness evaluations of pharmacogenetic tests can provide important insights into both the clinical and economic value of these new treatment paradigms, but few of these types of studies have been conducted. (scienceblog.com)
  • The aims of this study were to assess the feasibility of Arcobacter culture in a clinical microbiology laboratory and to determine the recent prevalence of Arcobacter spp. (cdc.gov)
  • The aim of this study was evaluate the LILT as OM treatment through the report of a clinical case. (bvsalud.org)
Dose6
  • No fluorouracil dose has been proven safe in patients with absent DPD activity. (nih.gov)
  • If severe, discontinue fluorouracil until resolved or decreased to Grade 1, then resume at a reduced dose. (nih.gov)
  • Withhold fluorouracil until severe myelosuppression resolves, then resume at a reduced dose. (nih.gov)
  • Discontinue fluorouracil until resolved or decreased to Grade 1, then resume at a reduced dose. (nih.gov)
  • Individualize the dose and dosing schedule of fluorouracil based on tumor type, the specific regimen administered, disease state, response to treatment, and patient risk factors. (nih.gov)
  • For fluorouracil: Liver function should be assessed prior to each cycle for potential dose evaluation. (medscape.com)
Prognostic1
  • For the clinical variables, calibrated on the samples, either using all the clinical param- eters or the Nottingham Prognostic Index (NPI) parameters, the areas under the receiver operating characteristics (ROC) curve were 0.78 and 0.79, respectively. (lu.se)
Lesions1
  • The success rate with Fluorouracil Cream USP is approximately 93%, based on 113 lesions in 54 patients. (nih.gov)
Administration3
  • Fluorouracil is recommended for administration either as an intravenous bolus or as an intravenous infusion. (nih.gov)
  • Thus far, published clinical data suggest that there is little room for the administration of gefitinib or erlotinib in the absence of EGFR mutations. (aacrjournals.org)
  • Hyperammonemia is a serious adverse effect of 5-fluorouracil ( 5FU ) administration . (bvsalud.org)
Decrease1
  • Second, the review presents some promising approaches to resolve the current barriers in clinical BNP measurement, such as how to decrease cross-reactions and increase the measurement consistency. (degruyter.com)
Diarrhea1
ORAL1
  • Tegafur, a prodrug of 5-fluorouracil (5-FU), is an oral fluorouracil antitumor drug used for the management of adenocarcinomas. (cun.es)
Studies2
  • Systemic absorption studies of topically applied fluorouracil have been performed on patients with actinic keratoses using tracer amounts of 14 C-labeled fluorouracil added to a 5% preparation. (nih.gov)
  • Our phase IV clinical studies alone cannot establish cause-effect relationship. (ehealthme.com)
Rapid1
  • The effects of DNA and RNA deprivation are most marked on those cells which grow more rapidly and take up fluorouracil at a more rapid rate. (nih.gov)