• Cutaneous squamous cell carcinoma (SCC) is an invasive malignant neoplasm of epidermal keratinocytes showing squamous phenotypic differentiation (see the following image). (medscape.com)
  • The majority (70%) of cutaneous squamous cell carcinoma (SCC) occurs on the head and neck, with an additional 15% found on the upper extremities. (medscape.com)
  • Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the first and second most common types of skin cancer, respectively. (medscape.com)
  • Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in the United States. (medscape.com)
  • Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two. (jofskin.org)
  • Clear cells in cutaneous squamous cell carcinoma. (jofskin.org)
  • This is a retrospective case series of cutaneous squamous cell carcinomas (SCCs) which were incompletely excised in National Skin Centre, Singapore from 1991 to 1995. (annals.edu.sg)
  • This report describes four unusual cases of cutaneous squamous cell carcinoma resembling nonhealing wounds, highlighting the importance of tissue biopsy in these instances. (medscape.com)
  • Genetic factors play a role in the development of cutaneous squamous-cell carcinoma. (cdc.gov)
  • Inherited phenotypic characteristics - such as light skin, red or blonde hair, and light-colored eyes - are associated with an increased risk of cutaneous squamous-cell carcinoma. (cdc.gov)
  • A family history of cutaneous squamous-cell carcinoma is associated with a risk that is two to four times that in persons without a family history. (cdc.gov)
  • Inherited disorders such as xeroderma pigmentosum also increase the risk of cutaneous squamous-cell carcinoma, often with an earlier age at onset. (cdc.gov)
  • Numerous researches have shown that circRNAs can be used as new biomarkers for clinical diagnosis and treatment of cancer [ 12 - 14 ]. (hindawi.com)
  • Therefore, it is important to explore candidate genes that could have significance to the clinical diagnosis, as well as the treatment of esophageal squamous cell carcinoma (ESCC) at the molecular level [ 4 ]. (hindawi.com)
  • Cases were retrieved and included based on a search of the terms "clear cell squamous cell carcinoma" in the diagnosis field of the CSP database and reviewed for accuracy and the degree of clear cell change in each lesion. (jofskin.org)
  • This study aims to provide oral mouth inspection and brush biopsy screening combined with comprehensive cancer screening for people with FA at regular intervals to determine if this practice improves early cancer diagnosis and overall clinical care. (fanconi.org)
  • Immunohistochemistry along with routine histopathology is essential in establishing the diagnosis of spindle cell carcinoma. (scirp.org)
  • Most clinical testing is performed within 24 hours, giving rapid results to pathologists for final diagnosis. (rochester.edu)
  • Because many urothelial carcinomas contain a minor squamous cell component, a diagnosis of squamous cell carcinoma of the bladder should be rendered only when the tumor is solely composed of a squamous cell component in the absence of a conventional urothelial carcinoma component. (medscape.com)
  • They also investigated the influence of multiple variables on survival: sociodemographic factors (age at diagnosis, sex, and education level), lifestyle factors (comprehensive histories of tobacco use and alcohol consumption), and clinical factors (stage at diagnosis, and human papillomavirus (HPV) status among patients with oropharyngeal cancer). (who.int)
  • Material and Methods: A selection was made of 35 cases diagnosed with oral squamous cell carcinoma from 2004 to 2007 at Pernambuco Cancer Hosptial. (bvsalud.org)
  • Bowen disease (BD) is a squamous cell carcinoma in situ (SSCIS) with full-epidermal thickness dysplasia that has the potential for significant lateral spread before invasion. (medscape.com)
  • A squamous-cell carcinoma is often preceded for years by squamous-cell metaplasia or dysplasia in the respiratory epithelium of the bronchi, which later transforms to carcinoma in situ. (wikipedia.org)
  • Early squamous-cell carcinoma of the lung (generally as squamous-cell carcinoma in situ) is asymptomatic and may only appear as an incidental imaging finding on CT scan or magnetic resonance imaging as a lung nodule. (wikipedia.org)
  • stock code: 2257, together with its subsidiaries, the "Group" or "Sirnaomics"), a leading biopharmaceutical company in discovery and development of RNAi therapeutics, today announced the advancement of STP705 for the treatment of Squamous Cell Carcinoma in situ (isSCC) into late-stage clinical development after encouraging Phase IIa and Phase IIb clinical results were shared with the U.S. Food and Drug Administration (FDA) in an End of Phase-2 meeting. (medicaex.com)
  • Sirnaomics is well-positioned currently to advance STP705 into a confirmatory clinical study for treatment of Squamous Cell Carcinoma in situ (isSCC). (medicaex.com)
  • There are currently three product pipeline programs prioritized by STP705: a late-stage clinical development for Squamous Cell Carcinoma in situ (isSCC), completion of a Phase II for Basal Cell Carcinoma (BCC) and a Phase I for the fat remodeling. (medicaex.com)
  • 4. Al-Arashi MY, Byers HR. Cutaneous clear cell squamous cell carcinoma in situ: Clinical, histological and immunohistochemical characterization. (jofskin.org)
  • Coincidental consort clear cell cutaneous carcinoma: facial squamous cell carcinoma in situ containing human papillomavirus and cancer cells with clear cytoplasm in an octogenarian couple. (jofskin.org)
  • Terminology changed for different sites and variable terms such as condyloma, dysplasia, intraepithelial neoplasia and carcinoma in-situ were employed. (cancer.org.au)
  • [ 25 ] Rarely, bacillus Calmette-Guérin (BCG) treatment for carcinoma in situ has been reported to lead to development of squamous cell carcinoma. (medscape.com)
  • [ 3 ] occupational exposure, medical treatment (psoralen + ultraviolet A [PUVA]), or tanning beds is principally responsible for the development of squamous cell carcinoma (SCC). (medscape.com)
  • In addition to traditional risk factors including smoking and alcohol consumption, over the last two to three decades it has become apparent that the human papillomavirus ( HPV ) and Epstein Barr Virus ( EBV ) are associated with development of squamous cell carcinoma of the oropharynx and nasopharynx, respectively. (guidelinecentral.com)
  • [ 12 ] Bladder exstrophy has been associated with the development of squamous cell carcinoma at a younger age than usual. (medscape.com)
  • Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
  • As per DelveInsight analysis, the head and neck squamous cell carcinoma market is expected to grow positively at a significant CAGR during the study period (2019-2032). (advfn.com)
  • Head and neck squamous cell carcinoma (HNSCC) is a type of cancer that originates in the squamous cells lining the mucous membranes of the head and neck region. (advfn.com)
  • The head and neck squamous cell carcinoma epidemiology section provides insights into the historical and current head and neck squamous cell carcinoma patient pool and forecasted trends for individual seven major countries. (advfn.com)
  • You don't have access to Immunotherapy for Treatment of Squamous Cell Carcinoma of the Head and Neck Pocket Guide. (guidelinecentral.com)
  • Squamous cell carcinoma of the head and neck ( HNSCC ) is the 9th leading cancer by incidence worldwide and constitutes 90% of all head and neck cancers. (guidelinecentral.com)
  • Most head and neck cancers are squamous cell cancers . (medlineplus.gov)
  • ABSTRACT: Spindle cell carcinoma of head and neck, a subtype of squamous cell carcinoma is a unique and rare neoplasm. (scirp.org)
  • The purpose of this work was to evaluate the potential of functional imaging with 18 F-FDG PET, 18 F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI to provide an appropriate and reliable biologic target for dose painting in radiotherapy for head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
  • Since its introduction in the previous decade, intensity-modulated radiotherapy has been widely applied in head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
  • New research coordinated by scientists from the International Agency for Research on Cancer (IARC) estimated 3-year survival rates among patients with squamous cell carcinoma of the head and neck (including the larynx, hypopharynx, oral cavity, and oropharynx) in South America. (who.int)
  • This research is part of the InterCHANGE study, a multicentre collaborative prospective study coordinated by IARC aimed at better understanding the roles of genetics, HPV, tobacco use, and alcohol consumption in the etiology and outcomes of squamous cell carcinoma of the head and neck in South American countries. (who.int)
  • The Phase 1 part of Replimune's Phase 1/2 clinical trial of RP1 enrolled 36 patients with advanced heavily pre-treated cancers who have failed available therapy, evaluating treatment with RP1 alone given up to five times, and RP1 given up to eight times in combination with Opdivo® (nivolumab) from the second RP1 dose. (biospace.com)
  • Following completion of the Phase 1 part of the clinical trial, the Company opened enrollment for Phase 2 cohorts of 30 patients each in patients with melanoma, non-melanoma skin cancers, bladder cancer, and MSI-H tumors. (biospace.com)
  • Oral squamous cell carcinoma (OSCC) is the third most common cancer in developing countries and ranks sixth among systemic cancers worldwide [ 1 , 2 ]. (hindawi.com)
  • The safety data generated from prior clinical studies for both types of cancers has shown that STP705 was safe without grade 3 or higher adverse events. (medicaex.com)
  • The KEYTRUDA clinical program seeks to understand the role of KEYTRUDA across cancers and the factors that may predict a patient's likelihood of benefitting from treatment with KEYTRUDA, including exploring several different biomarkers. (merck.com)
  • The FDA's acceptance of our application adds to our momentum of advancing new treatment options to address the most challenging cancers facing women," said Dr. Scot Ebbinghaus, vice president, clinical research, Merck Research Laboratories. (businesswire.com)
  • Merck is rapidly advancing a broad portfolio in gynecologic and breast cancers with an extensive clinical development program for KEYTRUDA and several other investigational and approved medicines across these areas. (businesswire.com)
  • more than 90% of uterine body cancers occur in the endometrium, so the actual numbers for endometrial carcinoma cases and deaths are slightly lower than these estimates). (businesswire.com)
  • Merck is continuing to study KEYTRUDA across multiple settings and stages of gastrointestinal cancer through its broad clinical program, including studies in esophageal, gastric, hepatobiliary, pancreatic, colorectal and anal cancers. (merck.com)
  • Cigarette smoke exerts inflammatory and suppressive effects on immune cells, alters mucosal immunity and promotes autoimmunity, resulting in oral cancers [ 10 ]. (biomedcentral.com)
  • The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers. (medsci.org)
  • Collaborative molecular research projects will focus on the analysis of clinical biological materials collected from the study to develop an understanding of the natural history of squamous cell cancers in individuals with FA. (fanconi.org)
  • Approximately 80% of non-melanoma skin cancers are basal cell carcinomas and the rest are squamous cell carcinomas (SCCs). (annals.edu.sg)
  • There are many known risk factors for basal and squamous cell skin cancers , but it's not always clear exactly how these factors might cause cancer. (cancer.org)
  • Most basal cell and squamous cell skin cancers are caused by repeated and unprotected skin exposure to ultraviolet (UV) rays from sunlight, as well as from man-made sources such as tanning beds. (cancer.org)
  • Researchers don't yet know all of the DNA changes that result in basal or squamous cell skin cancer, but they have found that in many skin cancers the cells have changes in tumor suppressor genes or DNA repair genes. (cancer.org)
  • La présente étude a estimé les fréquences relatives du cancer de la cavité buccale et du pharynx chez des patients yéménites atteints de cancers enregistrés en 2007 et 2008. (who.int)
  • L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
  • Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
  • However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). (hindawi.com)
  • Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). (hindawi.com)
  • Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. (hindawi.com)
  • We first confirmed that hsa_circ_001242, which is located at chr10: 17157441-17168917 (Figure 1 ), was significantly downregulated in OSCC cell lines and OSCC tissues. (hindawi.com)
  • Zang, Xiao 2017-11-28 00:00:00 The article "HPV and oral squamous cell carcinoma: a review of HPV-positive OSCC and possible strategies for future" provides inspiring insights into the association between human papillomavirus (HPV) infection and oral squamous cell carcinoma (OSCC), as well as the possible strategies that we can adopt in future to minimize its health impact on the population [1]. (deepdyve.com)
  • The article "HPV and oral squamous cell carcinoma: a review of HPV-positive OSCC and possible strategies for future" provides inspiring insights into the association between human papillomavirus (HPV) infection and oral squamous cell carcinoma (OSCC), as well as the possible strategies that we can adopt in future to minimize its health impact on the population [1]. (deepdyve.com)
  • Notably, many lncRNAs dysregulation are associated with Oral squamous cell carcinoma (OSCC) and affect various aspects of cellular homeostasis, including proliferation, survival, migration or genomic stability. (biomedcentral.com)
  • This review expounds the up- or down-regulation of lncRNAs in OSCC and the molecular mechanisms by which lncRNAs perform their function in the malignant cell. (biomedcentral.com)
  • In the present study, the anticancer potential of pristimerin was investigated in two oral squamous cell carcinoma (OSCC) cell lines, CAL‑27 and SCC‑25. (spandidos-publications.com)
  • Because it is very invasive, the prognosis of oral squamous cell carcinoma (OSCC) is poor ( 5 ). (spandidos-publications.com)
  • In the present study, the potent antitumor effects of pristimerin on OSCC cells were investigated. (spandidos-publications.com)
  • Pristimerin exhibited potent anti-proliferative and apoptosis-inducing effects on the OSCC cell lines CAL-27 and SCC-25. (spandidos-publications.com)
  • The tion and oral squamous cell carcinoma (OSCC) in a Brazilian variables marital status, occupation, alcoholism and smoking population. (bvsalud.org)
  • of those, approximately 80% were basal cell carcinoma (BCC) and 20% were cSCC. (medscape.com)
  • A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm to rule out basal cell carcinoma and other dermal lesions. (medscape.com)
  • Sirnaomics is also studying STP705 for Basal Cell Carcinoma (BCC), which will be the next candidate to move into late-stage development pending the FDA's review. (medicaex.com)
  • Transient SIM2 expression followed by 3D culture induced expression of differentiation markers and suppressed epithelial-mesenchymal transition - and basal- cell markers. (bvsalud.org)
  • In squamous epithelia, this is defined as continuous strong nuclear, or nuclear plus cytoplasmic, staining of the basal cell layer with extension upward involving at least one-third of the epithelial thickness. (cancer.org.au)
  • My skin cancer surveillance examinations focus on early detection of melanoma, basal cell carcinoma and squamous cell carcinoma, while reducing the need for biopsies with aid of dermoscopy and total body imaging. (dukehealth.org)
  • Basal Cell Carcinoma Basal cell carcinoma is a superficial, slowly growing papule or nodule that derives from certain epidermal cells. (msdmanuals.com)
  • Basal cell carcinomas arise from keratinocytes near the basal layer, which are. (msdmanuals.com)
  • The incidence of keratinocyte cancer (basal cell and squamous cell carcinomas of the skin) is 17-fold lower in Singapore than the UK, despite Singapore receiving 2-3 times more ultraviolet (UV) radiation. (cdc.gov)
  • Five patients with CSCC have been enrolled and treated with RP1 combined with Opdivo in this clinical trial, including one from the Phase 1 expansion in combination with Opdivo, and four from the Phase 2 non-melanoma skin cancer cohort. (biospace.com)
  • Our purpose was to determine whether clinical stages based on the 8th edition American Joint Committee on Cancer Tumor-Node-Metastasis staging system could guide treatment decision. (springer.com)
  • Induction therapy does not improve survival for clinical stage T2N0 esophageal cancer. (springer.com)
  • Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study. (springer.com)
  • This study aimed to investigate the effects of xanthoxyletin, a plant-derived coumarin, on human oral squamous cancer cells in vitro and in mouse xenografts in vivo . (medscimonit.com)
  • The study included SCC-1 human oral cancer cells and EBTr normal embryonic bovine tracheal epithelial cells, which were treated with 0 µM, 5 µM, 10 µM, and 20 µM of xanthoxyletin for 24 hours. (medscimonit.com)
  • Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)
  • This multicenter trial included esophageal cancer patients with clinical T4 disease and/or unresectable regional lymph node metastasis. (nih.gov)
  • Squamous-cell lung carcinoma share most of the signs and symptoms with other forms of lung cancer. (wikipedia.org)
  • Squamous-cell carcinoma of the lung is closely correlated with a history of tobacco smoking, more so than most other types of lung cancer. (wikipedia.org)
  • citation needed] Large scale studies such as The Cancer Genome Atlas (TCGA) have systematically characterized recurrent somatic alterations likely driving lung squamous-cell carcinoma initiation and development. (wikipedia.org)
  • SCARA5 expression is significantly downregulated in various tumor tissues including liver cancer (LC), rectal cancer, and glioblastoma [ 15 , 16 ] and might affect cell proliferation and invasion abilities by the focal adhesion kinase (FAK) signaling pathway and epithelial-mesenchymal transition (EMT) [ 5 , 17 - 20 ]. (hindawi.com)
  • Squamous cell carcinoma of the skin is a type of cancer that starts as a growth of cells on the skin. (mayoclinic.org)
  • Squamous cell carcinoma is a common type of skin cancer. (mayoclinic.org)
  • This phase III ALCHEMIST trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB IIIA or IIIB non-small cell lung cancer that has been removed by surgery. (ucsd.edu)
  • Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (ucsd.edu)
  • Giving pembrolizumab with usual chemotherapy may help increase survival times in patients with stage IIA, IIB IIIA or IIIB non-small cell lung cancer. (ucsd.edu)
  • This phase II Lung-MAP trial studies how well rucaparib works in treating patients with genomic loss of heterozygosity (LOH) high and/or deleterious BRCA1/2 mutation stage IV non-small cell lung cancer or that has come back. (ucsd.edu)
  • It has been suggested that radiation sensitivity and chemosensitivity of cancer cells may play an important role in the local control of the tumor following these therapies. (researchsquare.com)
  • Dublin, May 26, 2023 (GLOBE NEWSWIRE) -- The "Squamous-Cell Carcinoma of the Larynx in the United States, 2022-2042: Cancer Populations USA Report and Data Dashboard" report has been added to ResearchAndMarkets.com's offering. (globenewswire.com)
  • HPV infection has been reported to correlate with several cancer types, especially squamous cell carcinomas. (biochain.com)
  • The preliminary efficacy data with complete histological clearance of cancer cells was observed in majority of the treatment groups. (medicaex.com)
  • Patients in Europe with MSI-H/dMMR colorectal cancer have had only chemotherapy-containing regimens available to them in the first-line treatment setting and have historically faced poor outcomes," said Dr. Vicki Goodman, vice president, clinical research, Merck Research Laboratories. (merck.com)
  • Microsatellite instability (or MSI) is defined by the National Cancer Institute as a change that occurs in the DNA of certain cells, such as tumor cells, in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different from the number of repeats that was in the DNA when it was inherited. (merck.com)
  • Endometrial carcinoma begins in the inner lining of the uterus, which is known as the endometrium, and is the most common type of cancer in the uterus. (businesswire.com)
  • The cancer cells may spread into deeper tissue as the cancer grows. (medlineplus.gov)
  • A biopsy or other procedure to collect cells from the area that might have cancer. (medlineplus.gov)
  • however, the antitumor effects and underlying mechanisms of pristimerin in oral cancer cells have not yet been identified. (spandidos-publications.com)
  • Pristimerin has also been reported to induce apoptosis of various human cancer cells, including in multiple myeloma ( 10 ), breast ( 11 ), liver ( 12 ), pancreatic ( 13 ) and prostate cancer ( 14 ). (spandidos-publications.com)
  • Clinical patient data will be incorporated into a digital platform and analyzed to identify potential cancer-promoting risk factors in the FA population. (fanconi.org)
  • In the process, we have developed the ability to analyze heterogeneity and phenotypic plasticity within cancer cell lines, patient-derived xenografts, and primary human cancer samples based on molecular and functional criteria. (upenn.edu)
  • As a result, rapid compensation to targeting these pathways occurs not only at the level of signaling networks in individual cells but also through dynamics among diverse cell states cooperatively sustaining cancer progression. (upenn.edu)
  • A pathologist (a doctor specially trained to diagnose diseases with laboratory tests) will look at the tissue sample with a microscope to see if cancer or pre-cancer cells are present and, if so, what type it is. (cancer.org)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • [ 27 ] The presence of eggs was associated with the development of cancer at a younger age and with a predominance of squamous cell carcinoma, relative to egg-negative cases. (medscape.com)
  • RÉSUMÉ Des études en milieu hospitalier ont révélé des fréquences relatives très élevées du cancer oropharyngé au Yémen. (who.int)
  • Workers with low professional qualification are at greater risk ranked the sixth most prevalent cancer in various countries in for developing squamous cell carcinoma (SCC) of the orophar- the world1. (bvsalud.org)
  • RÉSUMÉ Les données sur l'incidence du cancer de la peau en République islamique d'Iran font défaut. (who.int)
  • Pendant la période de l'étude, 30 701 cas de cancer ont été identifiés, passant de 2353 en 2000 à 8484 en 2005. (who.int)
  • L'incidence croissante du cancer de la peau en République islamique d'Iran est similaire aux incidences notifiées dans d'autres pays. (who.int)
  • The objective of this study was to describe the epidemiological, clinical, and histopathological features of gynecological cancer in clinical oncology practice in Lomé. (bvsalud.org)
  • Hepatocellular Carcinomas from Iran: Evidence study of lung cancer among European asphalt carcinoma among postmenopausal women in the for Lack of Association between HBV Genotype workers. (who.int)
  • Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
  • 99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)
  • Our data suggest that NCRT strategy improved survival compared with UE in clinical stage III ESCC but not in clinical stage II tumors. (springer.com)
  • Similarly, the squamous cell differentiation pathway, whose components include SOX2, TP63 and NOTCH1, is altered in 44% of the tumors. (wikipedia.org)
  • Tumor-related studies have shown the clinical application and research prospects of this gene, suggesting that it might play the important role in the treatment of tumors. (hindawi.com)
  • KEYNOTE-158 (ClinicalTrials.gov, NCT02628067 ) is an ongoing global, open-label, non-randomized, multi-cohort, multi-center, Phase 2 study evaluating KEYTRUDA in patients with multiple types of advanced solid tumors - including endometrial carcinoma - that have progressed on standard of care therapy. (businesswire.com)
  • When the degree of clear cell change was evaluated there was no statistically significant increase of percentage clear cell change in tumors with age. (jofskin.org)
  • My lab's work has pursued how multiple discrete subpopulations of malignant cells within these tumors cooperatively resist therapy via both tumor cell autonomous mechanisms and crosstalk with the stromal microenvironment. (upenn.edu)
  • The highest incidence has been seen in areas where schistosomiasis is endemic, notably Sudan and Egypt, where squamous cell carcinoma ranges from two thirds to three quarters of all malignant tumors of the bladder. (medscape.com)
  • Comparison of neoadjuvant chemotherapy versus upfront surgery with or without chemotherapy for patients with clinical stage III esophageal squamous cell carcinoma. (springer.com)
  • The aim of this study (JGOG1063) was to determine the recommended dose (RD) for combination chemotherapy with irinotecan hydrochloride (CPT-11) and nedaplatin (NDP) for advanced cervical squamous cell carcinoma. (nih.gov)
  • Chemotherapy drugs, such as cisplatin, pemetrexed, carboplatin, gemcitabine hydrochloride, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (ucsd.edu)
  • KEYTRUDA plus chemotherapy is the first anti-PD1 therapy approved in Europe in this first-line setting, allowing these patients to be treated with immunotherapy earlier in the course of their treatment," said Dr. Scot Ebbinghaus, vice president, clinical research, Merck Research Laboratories. (merck.com)
  • Furthermore, pristimerin exhibited a more potent anti‑proliferative activity in CAL‑27 and SCC‑25 cells than the common chemotherapy drugs cisplatin and 5‑fluorouracil. (spandidos-publications.com)
  • Currently, surgical removal, chemotherapy and radiotherapy are the most common and effective treatments for patients with oral carcinoma. (spandidos-publications.com)
  • The objective of the study is to prepare the patient's body before a stem cell transplant by using an antibody-drug instead of radiation/chemotherapy to make transplants safer. (fanconi.org)
  • Cyclophosphamide chemotherapy has also been reported to increase the incidence of squamous cell carcinoma of the bladder. (medscape.com)
  • Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you. (centerwatch.com)
  • This study was registered at the UMIN Clinical Trials Registry as UMIN000000861. (nih.gov)
  • Continued approval may be contingent upon verification and description of clinical benefit in the confirmatory trials. (businesswire.com)
  • Listed below are current clinical trials and research opportunities available. (fanconi.org)
  • We are proud to partner with the Be The Match Jason Carter Clinical Trials Search & Support (CTSS), an organization that helps individuals learn about and potentially participate in clinical trials. (fanconi.org)
  • Click the logo to view more information about FA clinical trials. (fanconi.org)
  • Relative to Bowen disease, actinic keratosis (AK) only occurs on sun-damaged skin, is usually smaller, and retains a squamous differentiation toward the surface, often even when dermal invasion is developing. (medscape.com)
  • However, in squamous cell carcinomas , a key transcriptional factor regulating tumor differentiation is largely unknown. (bvsalud.org)
  • Here, we investigated the correlation between SIM2 expression and its clinical implication, and in vitro and in vivo functions of SIM2 in tumor differentiation and in CRT sensitivity . (bvsalud.org)
  • Squamous cell carcinoma with clear cells: how often is there evidence of trichilemmal differentiation? (jofskin.org)
  • The clinical appearance is highly variable, but any nonhealing lesion on a sun-exposed surface should be suspect. (msdmanuals.com)
  • Wherever possible, this has been into meaningful groupings based on recommended clinical practice (NCCN, 2023). (globenewswire.com)
  • We are preparing to move forward in 2023 with a well-designed single dosage study as a sub-group of subjects in a large Phase III clinical study. (medicaex.com)
  • Upfront surgery and pathological stage-based adjuvant chemoradiation strategy in locally advanced esophageal squamous cell carcinoma. (springer.com)
  • The approval was based on data from KEYNOTE-590 ( NCT03189719 ), a multicenter, randomized, double-blind placebo-controlled trial that enrolled 749 patients with locally advanced unresectable or metastatic esophageal or GEJ carcinoma (Siewert Type I) who were not candidates for surgical resection or definitive chemoradiation. (merck.com)
  • By using immunohistochemistry we investigated the expression of EphA2 and EphrinA-1 in 217 early squamous cell cervical carcinomas and examine their prognostic relevance. (medsci.org)
  • The Immunohistochemistry (IHC) Laboratory provides clinical testing on surgical and cytology specimens for proteins, enzymes and infectious agents by immunohistochemical methods. (rochester.edu)
  • Squamous-cell carcinoma (SCC) of the lung is a histologic type of non-small-cell lung carcinoma (NSCLC). (wikipedia.org)
  • Squamous-cell carcinoma of the lung is strongly associated with tobacco smoking, more than any other forms of NSCLC. (wikipedia.org)
  • Squamous-cell lung carcinoma is one of the tumor types with the highest number of mutations since smoking, the main driver of the disease, is a strong mutagenic factor. (wikipedia.org)
  • No significant differences were found in the survival from tumours largely refractive to therapy, e.g., carcinomas of the pancreas, lung and liver. (who.int)
  • In this report on squamous-cell carcinoma of the larynx (SCC-L), forecast estimates are provided of incident cases by stage, age and gender, race-ethnicity, anatomical subsite, and PD-1/PD-L1 status. (globenewswire.com)
  • Immunohistochemical analysis show concurrent presence of malignant epithelial and sarcomatoid spindle cell components by co-expression of cytokeratin (CK) and vimentin to various degrees. (scirp.org)
  • HPV-related squamous disease reflects a unified epithelial biology. (cancer.org.au)
  • The benefits of neoadjuvant chemoradiation (NCRT) compared to upfront esophagectomy (UE) in esophageal squamous cell carcinoma (ESCC) is controversial. (springer.com)
  • Data from 2503 patients with clinical stages II and III ESCC diagnosed between 2008 and 2014 were obtained from a nationwide database. (springer.com)
  • After matching, patients who underwent UE for clinical stage II ESCC had median survival/3-year overall survival (OS) rates of 27.8 months/39.2% compared with 32.7 months/49.8% in the NCRT group ( p = 0.508). (springer.com)
  • Thrombospondin type 1 domain-containing 7A ( THSD7A ) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). (hindawi.com)
  • SCARA5 promoted cell proliferation and migration but inhibited apoptosis in ESCC. (hindawi.com)
  • A two-tiered nomenclature system has been accepted for non-invasive HPV associated squamous proliferations of cervix and lower anogenital tract. (cancer.org.au)
  • HSIL is the morphologic expression of persistent HPV infection that has the potential to progress to invasive carcinoma. (cancer.org.au)
  • The term 'microinvasive carcinoma' is no longer recommended, and the term 'superficially invasive squamous cell carcinoma' (SISCCA) should be used instead. (cancer.org.au)
  • A propensity-matched analysis comparing survival after esophagectomy followed by adjuvant chemoradiation to surgery alone for esophageal squamous cell carcinoma. (springer.com)
  • KEYTRUDA was also granted accelerated approval in September 2019, and received full approval in July 2021, in combination with LENVIMA ® (lenvatinib) for the treatment of patients with advanced endometrial carcinoma that is not MSI-H or dMMR, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (businesswire.com)
  • Indications are that the incidence of squamous cell carcinoma of the mobile tongue has been rising among younger women in industrialized nations. (medscape.com)
  • The report found that the incidence of primary mobile tongue squamous cell carcinoma has significantly risen in persons under age 45 years within the populations of Australia and Singapore, with the rate of increase being significantly higher in females. (medscape.com)
  • Worldwide, the incidence of squamous cell carcinoma of the bladder varies. (medscape.com)
  • A study by Joseph et al found that the incidence of squamous cell carcinoma of the oral tongue has risen among white females in the United States while at the same time decreasing among African American women. (medscape.com)
  • Most squamous cell carcinomas of the skin are caused by too much ultraviolet (UV) radiation. (mayoclinic.org)
  • Radiation is a feasible option for patients with squamous cell carcinoma of the anterior nasal cavity mucosa who refuse rhinectomy, according to our recent research. (mskcc.org)
  • My clinical expertise is in the field of dermato-oncology and I see patients with melanoma, merkel cell carcinoma, and cutaneous B and T cell lymphomas often as part of a multidisciplinary team with medical, surgical and radiation oncologists and dermatopathologists. (dukehealth.org)
  • The Company also announced plans to initiate a new clinical trial of RP1 as monotherapy in organ transplant recipients with CSCC in early 2020. (biospace.com)
  • We are pleased to announce the initiation of our first registration-directed clinical trial for which we believe the data generated to date for RP1 in CSCC is strongly supportive," said Robert Coffin, Ph.D., President and CEO of Replimune. (biospace.com)
  • Having reviewed the initial data in CSCC, we also intend to initiate a new clinical trial of single agent RP1 in organ transplant recipients with CSCC, which we expect to begin enrolling early next year. (biospace.com)
  • The registration-directed Phase 2 clinical trial in CSCC is a multi-center, randomized, controlled clinical trial intended to enroll approximately 240 patients. (biospace.com)
  • Replimune intends to initiate a new Phase 1b clinical trial of single agent RP1 in organ transplant recipients with CSCC, for which the clinical trial protocol has been accepted by the FDA under the Company's Investigational New Drug application. (biospace.com)
  • This clinical trial is intended to enroll approximately 30 patients and assess the safety and efficacy of RP1 in liver and kidney transplant recipients with recurrent CSCC, and is expected to initiate in the first quarter of 2020. (biospace.com)
  • PD-L1 and CD8 T cell levels were also substantially increased post-treatment as compared to baseline (this data remains pending for the other patients). (biospace.com)
  • Moving STP705 for the treatment of isSCC into late-stage clinical development is a major milestone for our clinical program and for a dermatology/oncology application," said Dr. Patrick Lu , Founder, Chairman of the Board, Executive Director, President and Chief Executive Officer of Sirnaomics. (medicaex.com)
  • KEYTRUDA monotherapy is already playing a role for the treatment of certain patients with advanced endometrial carcinoma through the tumor-agnostic MSI-H indication which received accelerated approval four years ago. (businesswire.com)
  • New molecular markers that improve the prediction of clinical outcome could be of considerable value to design individualized treatment procedures. (medsci.org)
  • In addition, cell cycle distribution analysis revealed that G0/G1 phase arrest was induced following pristimerin treatment in CAL‑27 and SCC‑25 cells, which was strongly associated with upregulation of p21 and p27, coupled with downregulation of cyclin D1 and cyclin E. Meanwhile, pristimerin induced significant apoptosis of CAL‑27 and SCC‑25 cells, alongside decreased levels of caspase‑3 and specific cleavage of poly (ADP‑ribose) polymerase. (spandidos-publications.com)
  • The report also found the estimated 1-, 5-, and 10-year relative survival rates for squamous cell carcinoma of the oral tongue to be greater in white women than in African American females, but following multivariable analysis, the investigators attributed the higher survival rate not to race but to such factors as lower stage, younger age, married status, and receipt of surgical treatment. (medscape.com)
  • Using Diacarta's QuantiVirus™ HPV E6/E7 RNA test, BioChain offers HPV-characterized H&N and cervix squamous cell carcinoma tissue sections from various donors as control. (biochain.com)
  • Worldwide, cervical carcinoma is the second most frequent malignancy among women and the death rate is 8 per 100,000 [ 1 ]. (medsci.org)
  • The findings of the LAST project have been widely accepted and adopted by members of the Royal College of Pathologists of Australasia (RCPA) and the World Health Organization (WHO)[4], and have been referenced in the first edition (2013) of the RCPA protocol for structured reporting of cervical carcinoma[5]. (cancer.org.au)
  • Schistosomiasis-induced squamous cell carcinoma of the bladder with pseudometastatic pulmonary nodules in a 30-year-old man from Mali. (cdc.gov)
  • Squamous cell carcinoma of the urinary bladder is a malignant neoplasm derived from bladder urothelium with pure squamous phenotype. (medscape.com)
  • In the United States, squamous cell carcinoma constitutes around 5% of all urinary bladder carcinomas. (medscape.com)
  • In certain parts of the African continent, the majority of bladder carcinomas are of the squamous cell type. (medscape.com)
  • Having bladder diverticula may increase the likelihood that an individual will develop squamous cell carcinoma. (medscape.com)
  • Smoking has a well-recognized role in the development of bladder carcinoma, with smoking duration and intensity directly related to increased risk. (medscape.com)
  • As previously mentioned, schistosomiasis is the major cause of squamous cell carcinoma of the bladder in African countries. (medscape.com)
  • In one study from Egypt, 82% of patients with bladder carcinoma were found to harbor Schistosoma haematobium eggs in the bladder wall. (medscape.com)
  • A higher degree of adenocarcinoma has also been reported in schistosomal-associated bladder carcinomas. (medscape.com)
  • The FDA provided Sirnaomics guidance to move forward with late-stage clinical development because of the efficacious data provided as well as the widespread prevalence of Squamous Cell Carcinoma (SCC) lesions. (medicaex.com)
  • To address this problem and to improve communication between the specialties, the Lower Anogenital Squamous Terminology (LAST) Standardization Project for HPV-Associated Lesions was convened, including five major working groups. (cancer.org.au)
  • These hyperpigmented, scaly lesions on the earlobe were diagnosed as squamous cell carcinoma on biopsy. (msdmanuals.com)
  • The normal function of EphA2 is not fully understood, but it is thought to function in the regulation of cell growth, angiogenesis, survival and migration [ 9 - 11 ]. (medsci.org)
  • In our previous study of cervical carcinomas FIGO stage I-IV we found that increase expression of EphA2 and EphrinA-1 was significantly associated with shorter overall survival in multivariate analysis [ 22 ]. (medsci.org)
  • My group seeks precise molecular definition of the epigenetic plasticity that promotes homeostasis of tumor cells that retain malignant potential in the face of standard therapy. (upenn.edu)
  • Keratinous squamous metaplasia has been associated with the increased risk of developing squamous cell carcinoma, with approximately one half of the cases arising subsequent to the metaplasia. (medscape.com)
  • In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
  • Results demonstrated that pristimerin was toxic against the two cell lines, and exhibited inhibitory effects against proliferation. (spandidos-publications.com)
  • Its tumor cells are characterized by a squamous appearance, similar to the one observed in epidermal cells. (wikipedia.org)
  • Rucaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. (ucsd.edu)
  • KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)
  • KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)
  • We look forward to sharing the latest results from KEYNOTE-158, including updated data for KEYTRUDA in certain types of MSI-H/dMMR advanced endometrial carcinoma, at the ESMO Congress in September. (businesswire.com)
  • Cohort K enrolled 79 patients with MSI-H endometrial carcinoma and Cohort D enrolled 11 patients with MSI-H endometrial carcinoma for a total of 90 pooled patients who received KEYTRUDA as monotherapy (200 mg fixed dose every three weeks). (businesswire.com)
  • The number of people diagnosed with endometrial carcinoma is increasing and is expected to continue to rise. (businesswire.com)
  • It is estimated that approximately 30% of endometrial carcinomas are MSI-H or dMMR. (businesswire.com)
  • Squamous cell carcinoma is by far the most common malignancy of the tongue, typically having 3 gross morphologic growth patterns: exophytic, ulcerative, and infiltrative. (medscape.com)
  • Randomization was stratified by tumor histology (squamous cell carcinoma vs. adenocarcinoma), geographic region (Asia vs. ex-Asia), and Eastern Cooperative Oncology Group (ECOG) performance status (PS) (0 vs. 1). (merck.com)
  • Levels of PDPN-high tumor basal cells and of expression of genes for DNA repair and antioxidant enzymes were reduced in stable transfectants, and they showed high CDDP and H2 O2 sensitivities, and their xenografts showed a well-differentiated histology . (bvsalud.org)
  • We report a case of chronic Schistosoma haematobium infection with pseudometastatic pulmonary nodules and high-grade squamous cell carcinoma in a 30-year-old man in Mali. (cdc.gov)
  • LSIL is the morphologic expression of acute HPV infection and is characterised by cells with increased nuclear to cytoplasmic ratios and irregular nuclear membranes. (cancer.org.au)
  • In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
  • 6. Misago N, Toda S, Narisawa Y. Tricholemmoma and clear cell squamous cell carcinoma (associated with Bowen's disease): immunohistochemical profile in comparison to normal hair follicles. (jofskin.org)
  • Our unit provides the university community with extensive knowledge on immunohistochemical testing in both clinical and research settings. (rochester.edu)