• Oncology Nurse Advisor offers clinical updates and evidence-based guidance to the oncology nurse community online and in print. (oncologynurseadvisor.com)
  • Children's Oncology Group: Under the leadership of Jeffrey R. Andolina, M.D. , the Division participates as a full member of this national cooperative group of pediatric cancer researchers- allowing our patients to participate in ongoing clinical trials and receive cutting-edge diagnostic studies and treatments. (rochester.edu)
  • Aetiology of cancer, influence of nutrition on cancer development, nutrition of oncology patients Pharmacotherapy of malignant diseases and adverse effects of these drugs- Radiotherapy of malignant diseases, adverse effects of radiotherapy Basic information's about most frequent cancer diseases Urological cancer Digestive tract cancer Lung cancer Gynaecologic cancer Bone marrow transplantation, indication, methods, results. (muni.cz)
  • As a patient in the Center for Hematologic Oncology, you will be treated by a dedicated care team that includes oncologists, surgeons, hematologists, physician assistants, nurses and clinical social workers who are committed to delivering high-quality, safe, patient care. (dana-farber.org)
  • Eileen P. Smith, M.D., has spent nearly three decades at City of Hope, beginning in 1988 as a fellow in medical oncology and bone marrow transplantation. (cityofhope.org)
  • The Dana-Dwek Children's Hospital Pediatric Hemato-oncology and Bone Marrow Transplantation Department treats infants, children, and adolescents suffering from acute and chronic blood diseases and from malignant hematological and non-hematological disorders. (tasmc.org.il)
  • The Pediatric Hemato-oncology Department performs a full array of bone marrow transplants (BMT) for children, sourced by self-donated (autologous) marrow, peripheral blood donations and donations from related or unrelated donors (allogeneic). (tasmc.org.il)
  • Dr. Seth Maliske specializes in hematology, oncology and blood and bone marrow transplants. (sanfordhealth.org)
  • The clinical training exposes fellows to all domains of our subspecialty including general oncology, hematology, bone marrow transplantation, palliative care, and neuro-oncology. (ohsu.edu)
  • Pediatric Hematology/Oncology and bone marrow transplant patients are admitted to Doernbecher Children's Hospital state-of-the-art 21-bed unit, known as 10-South. (ohsu.edu)
  • Clinical haematology and haemato-oncology only. (materonline.org.au)
  • We are a nationally recognized center of excellence, fully accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and a proud member of the Blood and Marrow Transplant Clinical Trials Network of the National Cancer Institute. (stanford.edu)
  • In addition to conventional treatment approaches, you may have the opportunity to participate in clinical trials that offer access to new, innovative treatments for your type of cancer. (dana-farber.org)
  • Tandem Autologous Hematopoietic Cell Transplantation for Patients with Primary Progressive or Recurrent Hodgkin Lymphoma: A SWOG and Blood and Marrow Transplant Clinical Trials Network Phase II Trial (SWOG S0410/BMT CTN 0703). (cityofhope.org)
  • In randomised clinical trials, a subcutaneous dose of 230 µg/m 2 /day (4.0 to 8.4 µg/kg/day) was used. (medicines.org.uk)
  • Clinical trials using antibodies to fight the virus were disappointing, Hill said. (sciencedaily.com)
  • Since earlier clinical trials had used antibodies from pooled sources, the strain-specific CMV protection had been hidden. (sciencedaily.com)
  • The Food and Drug Administration (FDA) has announced that breast implants filled with silicone gel may only be used in clinical trials. (stopgettingsick.com)
  • He believes clinical trials could be redesigned to test the effects of bone marrow transplantation on particular subpopulations of ALS. (jax.org)
  • They will describe multiple novel compounds with promising preclinical in vivo profiles that may be suitable for clinical trials testing their cognitive enhancement capabilities. (jhu.edu)
  • Brazilian Register of Clinical Trials: RBR-4z7cnh. (bvsalud.org)
  • The evidence basis is primarily derived from clinical trials, but data can also be extracted from alternate sources such as national or regional data registries. (lu.se)
  • Next, we will explore the possibility of combining clinical trials and registry data, by using registry infrastructure to conduct simplified randomized trials. (lu.se)
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
  • Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • A short-chain fatty acid made by bacteria in the gut could play an important role in graft-versus-host disease (GVHD) after allogeneic bone marrow transplant in mice. (oncologynurseadvisor.com)
  • Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation (BMT). (nih.gov)
  • 2. Clinical and Histological diagnosis of gastrointestinal Graft-versus-Host Disease from any site in the GI tract. (who.int)
  • Recipients will be patients who have had an allogeneic bone marrow transplant and who have steroid dependent (SD) or steroid refractory (SR) Graft-versus-Host Disease. (who.int)
  • The BMT-CT program at Stanford performs autologous and allogeneic transplantations for over 450 patients each year. (stanford.edu)
  • 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
  • The study aimed to evaluate the short-term clinical effect, therapeutic response rate (TRR%), and therapy safety of a single intra-articular autologous MFAT injection for symptomatic knee OA. (mdpi.com)
  • Management of acute and chronic leukaemia, myeloma, lymphoma and autologous/allogeneic haematopoietic stem cell transplantation. (materonline.org.au)
  • A respected specialist in the field, Dr. Smith is a professor and chair of City of Hope's Department of Hematology & Hematopoietic Cell Transplantation . (cityofhope.org)
  • Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
  • Departmental bone marrow transplant services offer essential medical expertise and complementary services to patients with complex health conditions. (tasmc.org.il)
  • Three of the four were successfully treated with allogenic human leukocyte antigen (HLA)-matched bone marrow transplants. (bgu.ac.il)
  • In human patients who receive bone marrow transplants, GVHD can cause severe gut damage from donor cells attacking host cells. (oncologynurseadvisor.com)
  • This study, published in Nature Immunology , first examined chemicals made by gut bacteria after the mice received allogeneic bone marrow transplants. (oncologynurseadvisor.com)
  • Bone marrow transplants can be important components for treating some types of leukemia and lymphoma. (oncologynurseadvisor.com)
  • Self-donation transplants are performed for malignant conditions, such as recurrent lymphoma, metastasized bone cancers, high-risk neuroblastoma, and specific types of brain tumors. (tasmc.org.il)
  • Whether or not anti-inflammatory drugs or bone marrow transplants help ALS patients has been studied and debated for years. (jax.org)
  • We hypothesized that clinical risk factors could be identified within 2 weeks of onset of severe (stage 3 or 4) acute gut GVHD for identifying a patient population with a very poor outcome. (nature.com)
  • Efficacy with respect to GVHD response will be assessed using European Society for Blood and Marrow Transplantation-National Institutes of Health- Centre for International Blood and Marrow Transplant Research (EBMT-NIH-CIBMTR) Task Force Criteria. (who.int)
  • malignant haematological disorders, lymphomas, acute and chronic leukaemias, myeloma and stem cell transplantation as well as non-malignant haematology - thrombosis and haemostasis, obstetric haematology and red cell disorders. (materonline.org.au)
  • While the graft-versus-tumor effect provided by the donor graft can be very powerful in controlling the disease, disease relapse is still the primary reason that patients do not do well after an allogeneic transplantation. (stanford.edu)
  • While the role for the individual cell population of the donor graft is not fully understood after allogeneic transplant, recent works in the field have yielded some interesting observations which may lead to advances in clinical care. (stanford.edu)
  • Craig A. Mullen, M.D., Ph.D. , Jeffrey R. Andolina, M.D. and Lauren B. Bruckner, M.D., Ph.D. are developing state-of-the-art clinical research programs for bone marrow transplantation, including the use of haploidentical blood stem cell donors for patients who need a bone marrow transplant but lack a suitable donor. (rochester.edu)
  • Three months later, the researchers gave the mice a bone marrow transplant, effectively wiping away their immune systems and replacing them with new donor marrow. (sciencedaily.com)
  • 2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
  • While allogeneic transplantation can be life saving for patients with hematologic malignancies, or inherited disorders such as several forms of immuno-deficiency, the transplant-related side effects and complications remain the biggest hurdles. (stanford.edu)
  • I present materials to enhance our ongoing staff educational opportunities through our Overview of Hematologic Malignancies and Nursing Considerations Program and the Bone Marrow Transplant/HST Program. (mskcc.org)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • Characteristics and clinical outcomes of patients with myeloid malignancies and DDX41 variants. (cdc.gov)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • 15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)
  • Craig A. Mullen, M.D., Ph.D. leads a laboratory that studies the interaction of leukemia cells with supportive elements in the bone marrow in order to develop therapies that will interfere with leukemia survival and prevent relapse. (rochester.edu)
  • [ 1 ] identified Pityrosporum folliculitis as a separate clinical and histologic diagnosis. (medscape.com)
  • The diagnosis of Pityrosporum folliculitis is based on clinical suspicion of the classic presentation of pruritic papulopustules found in a follicular pattern on the back, chest, upper arms, and, occasionally the neck. (medscape.com)
  • An improvement in the lesions with empiric antimycotic therapy supports a clinical diagnosis of Pityrosporum folliculitis. (medscape.com)
  • The goal of this regional workshop is to perfectly blend research with clinical care practices and to address newly discovered defects, protocols for diagnosis, and treatments, including newborn screening, bone marrow transplantation and gene therapy. (prnewswire.com)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • The goal of this activity is for learners to be better able to understand the role of the complement pathway in the management of patients with atypical hemolytic uremic syndrome (aHUS), PNH, and hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA). (medscape.org)
  • To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • Hematological investigations and diagnostics including bone marrow testing and spinal taps: These tests are performed pain-free with the help of the Tel Aviv Sourasky Medical Center's Dream Service (pediatric service that helps children undergo treatment and testing under sedation). (tasmc.org.il)
  • For other discussions on osteoporosis, see the topics Osteoporosis and Pediatric Osteoporosis , as well as Bone Markers in Osteoporosis and Nonoperative Treatment of Osteoporotic Compression Fractures . (medscape.com)
  • I also care for patients who need to be readmitted for health issues and complications that can arise following transplantation. (mskcc.org)
  • Journal of clinical and experimental hematopathology : JCEH 2023 9 63 (3): 173-176. (cdc.gov)
  • Welcome to the Blood and Marrow Transplantation & Cellular Therapy Division. (stanford.edu)
  • Since 2007, the program has trained more than 45 physicians with majority of our graduates now working in the field of transplantation and cellular therapy throughout the country. (stanford.edu)
  • Osteoporosis is very common among patients awaiting lung transplantation. (medscape.com)
  • Ferrari et al also prospectively evaluated changes in bone mass in 21 consecutive lung transplant candidates and confirmed this increased osteoporosis prevalence. (medscape.com)
  • Moreover, following lung transplantation, nearly three quarters (73%) of patients were at or below the fracture threshold. (medscape.com)
  • MSCs were initially isolated from bone marrow but are now known to exist in a wide range of tissues in the human adult, including brain, thymus, lung, liver, spleen, kidney, and dental pulp [ 11 , 12 ]. (hindawi.com)
  • Transplantation modalities were heart , lung , kidney , liver , pancreas , combined pancreas and kidney and bone marrow transplantation . (bvsalud.org)
  • Histological and clinical staging. (muni.cz)
  • Journal of Investigational Allergology and Clinical Immunology is indexed/abstracted in Chemical Abstracts, Current Biology, Current Contents - Clinical Medicine, Database Subidase, Excerpta Medica - Immunology, Serology and Transplantation EMBASE, Index Medicus - Medline/Medlars, IBECS, Pascal INIST and Science Citation Index and its impact factor reaches 7.2 (2022) . (jiaci.org)
  • Bone marrow transplantation 2022 9 57 (12): 1781-1787. (cdc.gov)
  • We has been related to underlying conditions, such as alco- have conducted a 12-year retrospective study to establish holism, diabetes mellitus, malignancy, intravenous sub- the incidence, clinical features, epidemiologic characteris- stance abuse, or breakdown of the skin (2-7,9,10). (cdc.gov)
  • Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
  • Moreover, patients are often exposed to therapeutic agents such as steroids, heparin, or loop diuretics, which promote negative calcium balance and bone loss. (medscape.com)
  • Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
  • All blood cells originate from a population of relatively few haematopoietic stem cells residing in the bone marrow, which give rise to specific progenitors through different lineages. (lu.se)
  • This computational approach to the haematopoietic system is novel and provides insight into the dynamics and the nature of possible solutions, with potential applications in both fundamental and clinical research. (lu.se)
  • The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • The aim of the present study was to describe the clinical and hematologic picture of members of a Bedouin family with severe congenital thrombocytopenia associated with neutropenia and anemia and to determine the possible involvement of hematopoietic transcription factor genes in their disease. (bgu.ac.il)
  • Clinical disease ranges from a mild, nonspecific febrile illness to severe disease with jaundice and hemorrhage. (cdc.gov)
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
  • Thus any process or systemic condition that alters this optimal inflammatory milieu, such as bone diseases like osteoporosis or severe trauma, steroid therapy, diabetes, or advanced age, can disrupt the normal fracture healing process, resulting in nonunions or delayed healing, pain, disfigurement, and loss of function. (hindawi.com)
  • These bone marrow stem cells do not contribute to the formation of blood cells, and so do not express the hematopoietic stem cell marker CD34. (wikipedia.org)
  • The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and cryoprecipitate) in critically injured patients who require large-volume blood transfusions. (nih.gov)
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Bone marrow/stem cell transplantation , including traditional and reduced-intensity transplant, using related, unrelated or umbilical cord blood cells for transplant. (dana-farber.org)
  • Dr. Maliske has unique training in blood and bone marrow transplantation. (sanfordhealth.org)
  • A new study challenges long-held theories of why a common virus -- cytomegalovirus, or CMV -- can reactivate and become a life-threatening infection in people with a compromised immune system, including blood cancer patients undergoing bone marrow transplantation. (sciencedaily.com)
  • Knockout mice that received a bone marrow transplant lived on average 43 days longer, weighed more, and had a greater number of blood platelets throughout their lifespan. (jax.org)
  • launching them to have careers as R01 funded physician-scientists, clinical leaders involved in clinical trial design and development, and clinician educators to name a few paths our fellows have chosen after fellowship. (ohsu.edu)
  • First author Aaron Burberry, a postdoctoral fellow in the Eggan lab with a background in immunology, designed an experiment to test whether providing the sick mice with cells capable of making new immune cells via a bone marrow transplant would help. (jax.org)
  • Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
  • Susceptibility tests were performed on 570 Gram-negative isolates obtained from clinical samples of patients infected after at least 72 hours stay in the hospital. (who.int)
  • Designed to prepare board eligible/certified pediatricians or med-peds trained MDs, MD/PhDs, or DOs for academic or clinical careers as future leaders in this subspecialty, we are an ACGME-accredited comprehensive training program. (ohsu.edu)
  • Cystitis describes a broad range of diseases with diverse etiology and pathologic mechanisms but with similar clinical presentations. (medscape.com)
  • A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. (medlineplus.gov)
  • This destroys the faulty stem cells in your bone marrow. (medlineplus.gov)
  • In some cases, you can donate your own bone marrow stem cells in advance. (medlineplus.gov)
  • Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (wikipedia.org)
  • They are sometimes referred to as bone marrow stromal stem cells. (wikipedia.org)
  • She is currently running a clinical trial examining the effectiveness of administering a double or "tandem" dose of a patient's own healthy stem cells within a relatively short period of time. (cityofhope.org)