AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Leukemia, LymphoidClathrinLeukemiaClathrin Heavy ChainsPrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, Myeloid, AcuteIntranuclear Inclusion BodiesLeukemia, Lymphocytic, Chronic, B-CellLeukemia, B-CellTumor Suppressor ProteinsLeukemia, ExperimentalNuclear ProteinsClathrin Light ChainsMonomeric Clathrin Assembly ProteinsMyeloid-Lymphoid Leukemia ProteinCell Nucleus StructuresTranscription FactorsLeukemia, MyeloidNeoplasm ProteinsBlast CrisisAcute DiseaseClathrin-Coated VesiclesCoated Pits, Cell-MembraneBone MarrowTumor Cells, CulturedRemission InductionSUMO-1 ProteinLeukemia, Promyelocytic, AcuteOxidesAdaptor Protein Complex 2Adaptor Proteins, Vesicular TransportArsenicalsLymphocytesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveEndocytosisCell NucleusPolymerase Chain ReactionLeukemia Virus, MurineAdaptor Protein Complex alpha SubunitsAdaptor Protein Complex 1Cell LineCoated VesiclesAuxilinsHeLa CellsProtein BindingMicroscopy, FluorescenceProtein Structure, TertiaryLeukemia, T-CellProtein TransportLeukemia, Monocytic, AcuteRecombinant Fusion ProteinsCarrier ProteinsDNA-Binding ProteinsMoloney murine leukemia virusEndosomesAntigens, NuclearZinc FingersMolecular Sequence DataLeukemia, Hairy Celltrans-Golgi NetworkCOS CellsLeukemia L1210Cell Line, TumorTranscriptional ActivationTransfectionAmino Acid SequenceLeukemia Virus, BovineRNA InterferenceLeukemia Virus, FelineRNA, Small InterferingMutationAdaptor Protein Complex beta SubunitsApoptosisHSC70 Heat-Shock ProteinsDynaminsAdaptor Proteins, Signal TransducingTranscription, GeneticOncogene Proteins, FusionProtein IsoformsGene Expression Regulation, LeukemicLeukemia, Radiation-InducedIntracellular Signaling Peptides and ProteinsVirus ReplicationTumor Suppressor Protein p53Adaptor Protein Complex mu SubunitsImmediate-Early ProteinsBlotting, WesternFibroblastsLeukemia P388Cells, CulturedAdaptor Protein Complex gamma SubunitsLeukemia, Biphenotypic, AcuteFriend murine leukemia virusRepressor ProteinsViral ProteinsHL-60 CellsLeukemia-Lymphoma, Adult T-CellCytarabineAdaptor Protein Complex 3Leukemia, Megakaryoblastic, Acute
Phosphatidylinositol clathrin assembly lymphoid-myeloid leukemiaPICALMAmyloid precursAcute myeloidCALMAssemblyGeneExpressionFormationFamilyLevels
Phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia2
  • 10. Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. (nih.gov)
  • PICALM (phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia) is a protein that is involved in clathrin-mediated endocytosis. (wustl.edu)
PICALM2
  • Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene. (wikipedia.org)
  • These data indicate that PICALM, an adaptor protein involved in clathrin-mediated endocytosis, regulates APP internalization and subsequent Aβ generation. (wustl.edu)
Amyloid precurs1
  • Aβ is a proteolytic fragment of the Amyloid Precursor Protein (APP), a transmembrane protein, which resides on the plasma membranes of neurons. (wustl.edu)
Acute myeloid2
  • 2003). "A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein" (PDF). (wikipedia.org)
  • The diagnoses included acute myeloid leukemia (AML) (49 patients, 82%), B- or T-lymphoblastic leukemia/lymphoma (7 patients, 12%), myeloid sarcoma (3 patients, 5%), and a single case (2%) of undifferentiated leukemia. (nih.gov)
CALM1
  • Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic" (PDF). (wikipedia.org)
Assembly1
  • HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Gene3
  • Global gene expression was then analyzed for molecular pathways and gene ontology enrichment, and Western blot analysis was performed to investigate the translation of gene expression changes to protein levels. (nih.gov)
  • Moreover, gene changes at this time point were correlated to altered protein levels. (nih.gov)
  • The MLLT10 (formerly AF10) gene is the fourth most common KMT2A fusion partner across all acute leukemias and requires at least 3 breaks to form an in-frame KMT2A/MLLT10 fusion due to the opposite orientation of each gene. (nih.gov)
Expression1
  • Microvesicles loaded with MCs encoding a thymidine kinase (TK)/nitroreductase (NTR) fusion protein produced prolonged TK-NTR expression in mammary carcinoma cells. (regenerativemedicine.net)
Formation2
  • tabaci supported that the functions of "protein secretion", "membrane part", "signal transducer activity", "locomotion", "chemotaxis" and "taxis" in bacteria, as well as the metabolic pathways of "bacterial chemotaxis", "two-component system", "biofilm formation", "ABC transporters" and "valine, leucine and isoleucine degradation" were significantly down-regulated by ZnO NPs. (bvsalud.org)
  • Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
Family1
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
Levels1
  • It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)