The invention relates to phenanthrene compounds comprising one or more arylamino groups. (justia.com)
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. (justia.com)
Selective3
Here, we present a systematic, multidisciplinary approach to the development of selective antiparasitic compounds. (bvsalud.org)
The approach yielded compounds showing apparent picomolar inhibition of T. brucei pteridine reductase 1 (PTR1), nanomolar inhibition of L. major PTR1, and selective submicromolar inhibition of parasite dihydrofolate reductase (DHFR) versus human DHFR. (bvsalud.org)
Compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (hereinafter referred to as TRPM8), having formula: Wherein R is selected from: H, Br, CN, NO2, SO2NH2, SO2NHR? (justia.com)
Organic3
The compound is preferably used in an electronic device, more preferably in an organic electroluminescent device (OLED). (justia.com)
The structure of OLEDs in which organic compounds are used as functional materials is described, for example, in U.S. Pat. (justia.com)
In general, the term OLEDs is understood to mean electronic devices which have one or more layers comprising organic compounds and emit light on application of electrical voltage. (justia.com)
Derivatives2
In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof. (justia.com)
Background: 2-amino-3-cyanopyridines are good starting reagents that have been used in synthesis of many heterocyclic compounds such as pyridopyrimidines, [1,2,4]triazolo and [1,2,3,4] tetrazolo derivatives which have biological activities as anti-microbial and cytotoxic activities. (eurekaselect.com)
Found3
Moreover, by combining design for polypharmacology with a property-based on-parasite optimization, we found three compounds that exhibited micromolar EC50 values against T. brucei brucei while retaining their target inhibition. (bvsalud.org)
The compounds found have one or more properties selected from very good hole-conducting properties, very good electron-blocking properties, high glass transition temperature, high oxidation stability, good solubility, low crystallinity and high thermal stability. (justia.com)
The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. (justia.com)
Application1
The present application relates to a phenanthrenyl-arylamino compound of a formula (I) defined in detail below. (justia.com)
Structure1
The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure. (justia.com)
Active1
Molecular docking using Tankyrase I enzyme as a target showed how the studied heterocyclic compounds act as a ligand interacting most of active sites on Tankyrase I with a type of interactions specified for H-bonding and VDW. (eurekaselect.com)
Aromatic1
Naphthyridine is a class of aromatic heterocyclic compounds whose chemical formula is C8H6N2. (chemenu.com)
Pyridine2
Pyridine is a six-membered heterocyclic compound containing one nitrogen heteroatom. (chemenu.com)
Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. (chemenu.com)
Organic1
This compound belongs to the class of organic compounds known as harmala alkaloids. (drugbank.com)
India1
6 Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, India. (nih.gov)