• immune
  • HLA-DM-an endosomal and lysosomal chaperone for the immune system," Trends Biochem Sci, 24(4):150-154 (1999). (freepatentsonline.com)
  • Immune responses targeting these proteins could thus result in a limited or no generation of antigen-loss variants and, therefore, they may efficiently control in vivo tumor growth, thus meeting the requirements for an ideal TAA set forth above. (aacrjournals.org)
  • Subsequently, Baruj Benacerraf described the importance of these antigens in the immune response . (plos.org)
  • proteins
  • In fact, practically all the trials of immunotherapy of cancer (by and large of vaccination) conducted during the last 10 years were based on the use of TAAs encompassing normal proteins or peptides, to generate antitumor T cells mostly restricted by class I HLA ( 4 ). (aacrjournals.org)
  • Our prediction is that at least some of the CSC antigens will match proteins already known to serve as TAAs and expressed by embryo-fetal tissues (e.g., survivin, telomerase, cancer/testis antigens) reflecting common functions between embryonic stem cells and CSCs, i.e., multipotent differentiation, plasticity, and self-renewal. (aacrjournals.org)
  • bind
  • However, antiphospholipid antibodies bind phospholipids at sites similar to sites bound by anti-coagulants such as PAP1 sites and augment anti-coagulation activity. (wikipedia.org)
  • Some MG patients have antibodies that bind in a cross-striational pattern to skeletal and heart muscle tissue sections. (hindawi.com)
  • clinical
  • Detection of striational antibodies provides more specific and useful clinical information in MG patients. (hindawi.com)
  • The detection of these three striational antibodies can provide more specific clinical information and are associated with the subtypes of MG patients. (hindawi.com)
  • After a decade of cancer immunotherapy (both active and adoptive), based on the use of well-defined tumor-associated antigens (TAA), and despite the large amount of new information that has been collected both in preclinical and clinical settings, the clinical outcome of immunotherapy trials has been altogether disappointing ( 1 , 2 ). (aacrjournals.org)
  • marker
  • Anti-Kv1.4 antibody is a useful marker for the potential development of lethal autoimmune myocarditis and response to calcineurin inhibitors. (hindawi.com)
  • donors
  • Having identified the biologic mechanism of HLA class II antibody-induced TRALI, strategies to avoid plasma from immunized donors, such as women with a history of pregnancy, appear to be justified preventive measures. (bloodjournal.org)
  • 3 ⇓ - 5 A recently published literature review states that in 80% of all TRALI cases, white blood cell antibodies can be identified in the implicated blood donor, 6 and most implicated donors have been women with a history of pregnancy. (bloodjournal.org)
  • they are also critical in the field of transplant surgery where the donors and the recipients must be HLA-compatible [ 3 ]. (hindawi.com)
  • However
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
  • However, because these TAAs are expressed even by the majority of cancer cells of a given tumor, while CSCs encompass a small subpopulation of the tumor mass, CSCc may represent a better target if specifically enriched in cancer/testis, IAP-derived and/or mutated (unique) antigens in parallel with stem cell markers (e.g. (aacrjournals.org)
  • found
  • The MHC was first associated with disease in 1967 when HLA-B antigens were found at increased frequency in patients with Hodgkin's lymphoma . (plos.org)
  • patients
  • Although cardiac and skeletal muscle RyRs are antigenically different, anti-RyR antibodies in MG patients cross-react with both subtypes of the receptor [ 12 ]. (hindawi.com)
  • insulin
  • Most require 2 or more injections of insulin daily, with doses adjusted on the basis of self-monitoring of blood glucose levels. (medscape.com)
  • specific
  • This contrasts with the major, specific, activity of AAHA, defining a subset of anti-cardiolipin antibodies that specifically interacts with Apo-H. AHAA only inhibits the anti-coagulation activity in the presence of Apo-H and the AAHA component of ACLA correlates with a history of frequent thrombosis. (wikipedia.org)
  • Acquired myasthenia gravis (MG) in an organ-specific autoimmune disorder generally mediated by antiacetylcholine receptor (AChR) or less frequently by antimuscle-specific tyrosine antibodies at the neuromuscular junction [ 1 ]. (hindawi.com)
  • Recently, another group of TAAs was described that include antigens overexpressed by neoplastic and fetal cells, and was weakly expressed in a phase-specific way in a few normal cells ( 14 , 15 ). (aacrjournals.org)
  • either
  • The capability of antibodies recognizing either HNA 9 ⇓ - 11 or HLA class I 12 , 13 to precipitate TRALI has been proved in different animal models. (bloodjournal.org)
  • Cross-priming experiments showed that antigen-presenting cells pulsed with either mesothelioma or leukemia tumor lysates can process and present each of the CD4 + peptides identified. (aacrjournals.org)
  • different
  • Ninety percent of the titin mass is contained in a repetitive structure of 2 different 100-residue repeats [ 6 ]. (hindawi.com)
  • cases
  • Upon determination of the physical size of the region, it appeared that LD extended more than 2 Mb in some cases, but not all. (plos.org)
  • least
  • 7. The method of claim 1, wherein, in step (c), the proteolytic digestion is accomplished by a mixture of at least two proteinases. (freepatentsonline.com)
  • plasma
  • Synchronized inhibition of the phospholipid mediated autoactivation of factor XII in plasma by beta 2-glycoprotein I and anti-beta 2-glycoprotein I". Thromb. (wikipedia.org)
  • regions
  • The classical MHC encompasses approximately 3.6 megabasepairs (Mb) on 6p21.3 and is divided into three subregions: the telomeric class I, class III, and the centromeric class II regions. (plos.org)